ROSSANA PULCINELI VIEIRA FRANCISCO
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Obstetrícia e Ginecologia, Faculdade de Medicina - Docente
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/57 - Laboratório de Fisiologia Obstétrica, Hospital das Clínicas, Faculdade de Medicina - Líder
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/57 - Laboratório de Fisiologia Obstétrica, Hospital das Clínicas, Faculdade de Medicina - Líder
237 resultados
Resultados de Busca
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bookPart Cesárea(2020) YOSHIZAKI, Carlos Tadashi; OSMUNDO JUNIOR, Gilmar de Souza; PEREIRA, Pedro Paulo; FRANCISCO, Rossana Pulcineli Vieira; MIYADAHIRA, Seizo; MARTINELLI, Silvio; BUNDUKI, VictorbookPart Analgesia e anestesia(2016) YOSHIZAKI, Carlos Tadashi; FITTIPALDI, Felipe Silva; OSMUNDO JUNIOR, Gilmar de Souza; FRANCISCO, Rossana Pulcineli Vieira; MARTINELLI, Silvio; BUNDUKI, Victor- Variant rs17619600 in the gene encoding serotonin receptor 2B (HTR2B) increases the risk of gestational diabetes mellitus: a case-control study(2023) PENNO, Juliana Regina Chamlian Zucare; SANTOS-BEZERRA, Daniele Pereira; CAVALEIRO, Ana Mercedes; SOUSA, Ana Maria da Silva; ZACCARA, Tatiana Assuncao; COSTA, Rafaela Alkmin da; FRANCISCO, Rossana Pulcineli Vieira; CORREA-GIANNELLA, Maria LuciaBackgroundDuring pregnancy, the increase in maternal insulin resistance is compensated by hyperplasia and increased function of maternal pancreatic beta cells; the failure of this compensatory mechanism is associated with gestational diabetes mellitus (GDM). Serotonin participates in beta cell adaptation, acting downstream of the prolactin pathway; the blocking of serotonin receptor B (HTR2B) signaling in pregnant mice impaired beta cell expansion and caused glucose intolerance. Thus, given the importance of the serotoninergic system for the adaptation of beta cells to the increased insulin demand during pregnancy, we hypothesized that genetic variants (single nucleotide polymorphisms [SNPs]) in the gene encoding HTR2B could influence the risk of developing GDM.MethodsThis was a case-control study. Five SNPs (rs4973377, rs765458, rs10187149, rs10194776, and s17619600) in HTR2B were genotyped by real-time polymerase chain reaction in 453 women with GDM and in 443 pregnant women without GDM.ResultsOnly the minor allele C of SNP rs17619600 conferred an increased risk for GDM in the codominant model (odds ratio [OR] 2.15; 95% confidence interval [CI] 1.53-3.09; P < 0.0001) and in the rare dominant model (OR 2.32; CI 1.61-3.37; P < 0.0001). No associations were found between the SNPs and insulin use, maternal weight gain, newborn weight, or the result of postpartum oral glucose tolerance test (OGTT). In the overall population, carriers of the XC genotype (rare dominant model) presented a higher area under the curve (AUC) of plasma glucose during the OGTT, performed for diagnostic purposes, compared with carriers of the TT genotype of rs17619600.ConclusionsSNP rs17619600 in the HTR2B gene influences glucose homeostasis, probably affecting insulin release, and the presence of the minor allele C was associated with a higher risk of GDM.
- Fetal gastroschisis: Maternal and fetal methylation profile(2021) FREITAS, Amanda Brasil de; FRANCISCO, Rossana Pulcineli Vieira; CENTOFANTI, Sandra Frankfurt; DAMASCENO, Jullian Gabriel; CHEHIMI, Samar Nasser; OSMUNDO JUNIOR, Gilmar de Souza; KULIKOWSKI, Leslie Domenici; BRIZOT, Maria de LourdesObjective The purpose of this study was to describe the genomic deoxyribonucleic acid (DNA) methylation profile in fetuses with gastroschisis, determine whether the profile was inherited, and investigate any possible correlations with maternal risk factors. Method Genome-wide DNA methylation analysis of 96 blood samples was performed using the Illumina Human Methylation 850K BeadChip. The blood samples were collected as follows: 32 from the umbilical cord of fetuses with gastroschisis, 32 from their respective mothers, 16 from the umbilical cord of fetuses without malformation, and 16 from their respective mothers. Results The differential DNA methylation analysis showed a significant difference between the groups. The enrichment analysis resulted in 12 sites related to T-cell activation (p = 0.0128). The sites with different methylation status contained 10 genes, three of which were related to the beta-2-microglobulin gene. The methylation profile observed in the fetuses with gastroschisis was not inherited from the mothers. In addition, there was no association between maternal urinary tract infection, smoking, and alcohol use and different methylated sites. Conclusion We established the methylation profile of gastroschisis fetuses, which differs from that of normal fetuses. The profile was not inherited and did not correlate with maternal risk factors.
bookPart Placenta, sistema amniótico e cordão umbilical(2020) PAGANOTI, Cristiane de Freitas; CABAR, Fábio Roberto; MIKAMI, Fernanda Cristina Ferreira; COSTA, Rafaela Alkmin da; RIBEIRO, Renata Lopes; FRANCISCO, Rossana Pulcineli Vieira; BUNDUKI, Victor- Prenatal detection and postnatal management of an intranasal glioma(2012) OKUMURA, Maria; FRANCISCO, Rossana Pulcineli Vieira; LUCATO, Leandro Tavares; ZERBINI, Maria Claudia Nogueira; ZUGAIB, MarceloNasal gliomas are rare benign congenital midline tumors composed of heterotopic neuroglial tissue. They have potential for intracranial extension through a bony defect in the skull base. Neuroimaging is essential for identifying nasal lesions and for determining their exact location and any possible intracranial extension. Computed tomography is often the initial imaging study obtained because it provides good visualization of the bony landmarks of the skull base; it is not, however, well suited for soft tissue imaging. Magnetic resonance imaging has better soft tissue resolution and may be the best initial study in patients seen early in life because the anterior skull base consists of an unossified cartilage and may falsely appear as if there is a bony dehiscence on computed tomography. A frontal craniotomy approach is recommended if intracranial extension is identified, followed by a transnasal endoscopic approach for intranasal glioma. A case is presented of a huge fetal facial mass that was shown by ultrasound that protruded through the left nostril at 33 weeks of gestation. Computed tomography of the neonate suggested a transethmoidal encephalocele. Magnetic resonance imaging showed a huge mass occupying the nasopharynx and the nasal cavity and protruding externally to the face but ruled out bony discontinuity in the skull base and, therefore, any intracranial connection. The infant underwent an endoscopic resection of the mass via oral and nasal routes and pathologic examination revealed intranasal glioma.
- The complex search for the cause of gastroschisis(2022) FREITAS, Amanda Brasil de; FRANCISCO, Rossana Pulcineli Vieira; HOSHIDA, Mara Sandra; OLIVEIRA, Yanca Gasparini De; KULIKOWSKI, Leslie Domenici; BRIZOT, Maria de LourdesBackground To reveal the complex etiology of gastroschisis through two independent cases. Cases Case 1 involves gastroschisis recurrence in a consanguineous marriage, and Case 2 concerns a fetus with gastroschisis whose mother had undergone gastroplasty. Methylation array was carried out in both cases (two fetuses with gastroschisis, their two mothers, one father from the consanguineous marriage), and in 16 controls (fetuses and their respective mothers). Conclusion The two cases presented different noninherited methylation profiles.
bookPart Hemorragia pós-parto(2020) YOSHIZAKI, Carlos Tadashi; OSMUNDO JUNIOR, Gilmar de Souza; PEREIRA, Pedro Paulo; FRANCISCO, Rossana Pulcineli Vieira; MIYADAHIRA, Seizo; MARTINELLI, Silvio; BUNDUKI, VictorbookPart Ultrassonografia(2016) ROLNIK, Daniel Lorber; BAPTISTA, Fernanda Spadotto; BRIZOT, Maria de Lourdes; CARVALHO, Mário Henrique Burlacchini de; FRANCISCO, Rossana Pulcineli VieirabookPart Planejamento familiar(2020) YOSHIZAKI, Carlos Tadashi; OSMUNDO JUNIOR, Gilmar de Souza; PEREIRA, Pedro Paulo; FRANCISCO, Rossana Pulcineli Vieira; MIYADAHIRA, Seizo; MARTINELLI, Silvio; BUNDUKI, Victor