ARIANA CAMPOS YANG
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/60 - Laboratório de Imunologia Clínica e Alergia, Hospital das Clínicas, Faculdade de Medicina
LIM/60 - Laboratório de Imunologia Clínica e Alergia, Hospital das Clínicas, Faculdade de Medicina
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bookPart Alergia alimentar(2021) YANG, Ariana Campos; DIAS, Paula Rezende Meireles; ARAúJO, Roberta Almeida Castro- Clinical Features and Disease Management in Adult Patients With Atopic Dermatitis Receiving Care at Reference Hospitals in Brazil: the ADAPT Study(2021) ARRUDA, L. K.; YANG, A. C.; AOKI, V; CRIADO, R. F. J.; PIRES, M. C.; LUPI, O.; FABRICIO, L. H. Z.; RICHMAN, D.; SILVI, S.Background: Atopic dermatitis is a chronic inflammatory skin disease with a prevalence of 0.02% to 8.1% in adults. Adult patients with moderate-to-severe atopic dermatitis are affected by frequent relapses and a significant disease burden. Objective: To determine the clinical, immunological, and therapeutic profile of Brazilian adults with atopic dermatitis. Methods: A multicenter, observational, retrospective, descriptive registry-based study was conducted at reference hospitals between December 2016 and October 2017. The data collected were demographics, personal and family history of atopic diseases, clinical manifestations, laboratory tests, disease severity and management. Results: Of the 187 patients included in the analysis, 56.1% were female and 71.7% were White, with a mean age of 24.7 years. Mean follow-up was 9 years. Asthma or other allergic diseases were reported by 80.2% of patients. The main comorbidity was hypertension (10.2%), and common disease manifestations included pruritus and erythema. Lesions generally affected flexural and nonflexural areas, with typical morphology. Around 83% of patients had moderate-to-severe disease, and 8.6% reported at least 1 hospitalization. Most patients received topical and/or systemic pharmacological therapies, including omalizumab (5.9%); 4.3% received phototherapy. Moreover, 66.8% of patients received adjuvant therapy, and 79.1% changed or discontinued treatment for atopic dermatitis due to remission (46.5%), poor effectiveness (33.7%), or lack of adherence (12.9%). Most patients presented characteristics of type 2 inflammation, with immunoglobulin E levels above 100 IU/mL (94.4%) and peripheral blood eosinophils above 5% (55.9%). Conclusion: Brazilian adult patients with severe atopic dermatitis need treatment to efficiently control the disease and improve quality of life.
- Evaluating the impacts of relaxation and mutation in the SARS-CoV-2 on the COVID-19 epidemic based on a mathematical model: a case study of Sao Paulo State (Brazil)(2021) YANG, Hyun Mo; LOMBARDI JUNIOR, Luis Pedro; CASTRO, Fabio Fernandes Morato; YANG, Ariana CamposAt the beginning of 2020, SARS-CoV-2 spread to all continents, and many countries adopted quarantine to flatten the COVID-19 outbreak, resulting in the containment of transmission. However, the persistent transmission of SARS-CoV-2, an RNA virus, resulted in the appearance of mutations in the original virus. The appearance of more virulent mutations in different regions of the world resulted in an increased number of severe COVID-19 cases. A mathematical model based on the COVID-19 natural history encompassing the mutations was applied to evaluate the SARS-CoV-2 epidemic. The model parameters were fitted against the observed data from Sao Paulo State (Brazil) considering quarantine, relaxation, and mutation. The estimated data from Sao Paulo State showed that the original SARS-CoV-2 transmission better explained the COVID-19 epidemic during the quarantine. However, the increased number of fatalities beyond that predicted by the relaxation indicated the occurrence of mutations. Hence, the relaxation in association with the transmission of a more virulent SARS-CoV-2 better estimated the COVID-19 epidemic from February 26, 2020, to June 15, 2021, in Sao Paulo State.
- Mathematical modeling of the transmission of SARS-CoV-2-Evaluating the impact of isolation in SAo Paulo State (Brazil) and lockdown in Spain associated with protective measures on the epidemic of CoViD-19(2021) YANG, Hyun Mo; LOMBARDI JUNIOR, Luis Pedro; CASTRO, Fabio Fernandes Morato; YANG, Ariana CamposCoronavirus disease 2019 (CoViD-19), with the fatality rate in elder (60 years old or more) being much higher than young (60 years old or less) patients, was declared a pandemic by the World Health Organization on March 11, 2020. A mathematical model considering young and elder subpopulations under different fatality rates was formulated based on the natural history of CoViD-19 to study the transmission of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The model considered susceptible, exposed, asymptomatic, pre-symptomatic, mild CoViD-19, severe CoViD-19, and recovered compartments, besides compartments of isolated individuals and those who were caught by test. This model was applied to study the epidemiological scenario resulting from the adoption of quarantine (isolation or lockdown) in many countries to control the rapid propagation of CoViD-19. We chose as examples the isolation adopted in SAo Paulo State (Brazil) in the early phase but not at the beginning of the epidemic, and the lockdown implemented in Spain when the number of severe CoViD-19 cases was increasing rapidly. Based on the data collected from SAo Paulo State and Spain, the model parameters were evaluated, and we obtained a higher estimation for the basic reproduction number R-0 (9.24 for SAo Paulo State, and 8 for Spain) compared to the currently accepted estimation of R-0 around 2 using the SEIR (susceptible, exposed, infectious, and recovered compartments) model. In comparison with the lockdown in Spain, the relatively early adoption of the isolation in SAo Paulo State resulted in enlarging the period of the first wave of the epidemic and delaying its peak. The model allowed to explain the flattening of the epidemic curves by quarantine when associated with the protective measures (face mask, washing hands with alcohol and gel, and social distancing) adopted by the population. The description of the epidemic under quarantine and protections can be a background to foreseen the epidemiological scenarios from the release strategies, which can help guide public health policies by decision-makers.
bookPart Gastrenteropatias eosinofílicas(2021) YANG, Ariana Campos; CóRDOVA, Pablo Michel Torres; BARBOSA, Adriana Marcia da Silva CunhabookPart Dermatite atópica(2021) YANG, Ariana Campos; SIMIS, Nathalia Pessoa de Barros; CUNHA, Patricia Salles