ANGELA MAGGIO DA FONSECA
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Obstetrícia e Ginecologia, Faculdade de Medicina - Docente
LIM/58 - Laboratório de Ginecologia Estrutural e Molecular, Hospital das Clínicas, Faculdade de Medicina
LIM/58 - Laboratório de Ginecologia Estrutural e Molecular, Hospital das Clínicas, Faculdade de Medicina
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bookPart Hiperprolactinemia: diagnóstico e tratamento(2016) HAYASHIDA, Sylvia Asaka Yamashita; FASSOLAS, George; NEVES, Erika Mendonça das; MASSABKI, Josefina Odete Polak; SOUZA, Marilene Alicia; FONSECA, Angela Maggio dabookPart Hiperprolactinemia em adolescente(2021) HAYASHIDA, Sylvia Asaka Yamashita; FONSECA, Ângela Maggio da; BAGNOLI, Vicente Renato; MACIEL, Gustavo Arantes Rosa- Dyslipidemia in women with polycystic ovary syndrome: incidence, pattern and predictors(2011) ROCHA, Michelle P.; MARCONDES, Jose A. M.; BARCELLOS, Cristiano R. G.; HAYASHIDA, Sylvia A. Y.; CURI, Daniela D. G.; FONSECA, Angela M. da; BAGNOLI, Vicente R.; BARACAT, Edmund C.One hundred forty-two women with polycystic ovary syndrome (PCOS) with an average body mass index (BMI) of 29.1 kg/m(2) and average age of 25.12 years were studied. By BMI, 30.2% were normal, 38.0% were overweight and 31.6% were obese. Thirty-one eumenorrheic women matched for BMI and age, with no evidence of hyperandrogenism, were recruited as controls. The incidence of dyslipidemia in the PCOS group was twice that of the Control group (76.1% versus 32.25%). The most frequent abnormalities were low high-density lipoprotein cholesterol (HDL-C; 57.6%) and high triglyceride (TG) (28.3%). HDL-C was significantly lower in all subgroups of women with PCOS when compared to the subgroups of normal women. No significant differences were seen in the total cholesterol (p = 0.307), low-density lipoprotein cholesterol (LDL-C; p = 0.283) and TGs (p = 0.113) levels among the subgroups. An independent effect on HDL-C was detected for glucose (p = 0.004) and fasting insulin (p = 0.01); on TG for age (p = 0.003) and homeostatic model assessment insulin resistance (p = 0.03) and on total cholesterol and LDL-C for age (p = 0.02 and p = 0.033, respectively). In conclusion, dyslipidemia is common in women with PCOS, mainly due to low HDL-C levels. BMI has a significant impact on this abnormality.
bookPart Síndrome dos ovários policísticos: diagnóstico e tratamento(2016) NEVES, Erika Mendonça das; FONSECA, Angela Maggio da; MACIEL, Gustavo Arantes Rosa; MORAES, Sandra Dircinha Teixeira de Araújo; HAYASHIDA, Sylvia Asaka Yamashita; BAGNOLI, Vicente Renato; JúNIOR, José Maria Soares- Influence of LH and high-density lipoprotein cholesterol (HDL-C) on metformin response in women with polycystic ovary syndrome(2011) MACIEL, Gustavo Arantes Rosa; HAYASHIDA, Sylvia Asaka Yamashita; COSTA, Lia Cruz Vaz da; MARCONDES, Jose Antonio Miguel; FONSECA, Angela Maggio da; SOARES JR., Jose Maria; BARACAT, Edmund ChadaObjective: To search for predictors of metformin response in women with polycystic ovary syndrome (PCOS) through a detailed analysis of clinical and laboratory parameters. Study design: We designed a prospective study to investigate clinical and laboratory parameters to search for predictors of metformin response in women with PCOS. A total of 53 PCOS patients were given metformin 850 mg twice a day for 6 months, after which patients were classified as responders or non-responders. Parameters analyzed for comparison between the two groups were: plasma fasting insulin glucose/insulin ratio; oral glucose tolerance test (OGTT) with insulin (120 min); HOMA and QUICKI tests; total cholesterol and fractions, triglycerides; LH, FSH, estradiol, progesterone, testosterone, androstenedione, 17-OH progesterone, and DHEAS. Results: From all patients, 30(56.6%) were responders and 23(43.3%) were non-responders. Multinomial analysis showed that the positive response to metformin was associated with higher levels of basal LH (p = 0.038) and lower levels of high-density lipoprotein cholesterol (HDL-C) (p = 0.015). Conclusion: In weight-matched PCOS subjects, laboratory markers might predict the metformin response. Higher levels of basal LH and lower levels of HDL-C are correlated with a positive response to metformin treatment in PCOS subjects.
- The clinical, structural, and biological features of neovaginas: a comparison of the Frank and the McIndoe techniques(2015) HAYASHIDA, Sylvia A.; SOARES- JR., Jose Maria; COSTA, Elaine M. F.; FONSECA, Angela M. da; MACIEL, Gustavo A. R.; MENDONCA, Berenice B.; BARACAT, Edmund C.Objective: To compare two methods of neovagina construction, the Frank and McIndoe techniques, in terms of structural and biological aspects. Study design: A total of 55 subjects were included in this retrospective study: 43 underwent the Frank technique (FT) and 12 underwent the McIndoe technique (MT). A clinical evaluation and a comparison of the structural (color, shine, presence of hair, and histology) and biological (bacteriological, pH, and hormonal determinations) features were performed. Statistical analysis was performed using the Fisher and Mann-Whitney tests. Results: The time to achieve a functional neovagina using the FT was longer than when using the MT (9.8 +/- 5.3 versus 5.8 +/- 2.9 months) (p = 0.01). The neovaginal wall of the MT skin grafts was more rigid and drier, and it did not exhibit a shine in the way that the FT skin grafts did. The lining of the cavity formed by the FT in all subjects was similar to that of vaginal mucosa, whereas the lining formed by the MT persisted as a skin graft in 83.3% of the cases. The pH was lower for the FT (p < 0.01), and Doderlein bacilli were present in 90% of the FT neovaginas but absent from the MT neovaginas. In the latter, flora with anaerobic bacteria was present. Hormonal cytology showed estrogen activity in 100% of the FT neovaginas, but there was no such activity in the MT neovaginas. Conclusions: Our data suggest that the FT may be clinically, structurally, and biologically superior to the MT for the creation of neovaginas and is also less costly.
bookPart Osteoporose da pós-menopausa(2014) CONDI, Fernanda Lopes De Freitas; HAYASHIDA, Sylvia Asaka Yamashita; BAGNOLI, Vicente Renato; FONSECA, Angela Maggio da; JúNIOR, José Maria Soares; BARACAT, Edmund Chada