ELOISA MARIA MELLO SANTIAGO GEBRIM

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Instituto de Radiologia, Hospital das Clínicas, Faculdade de Medicina - Médico

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Colaboração internacional: Alemanha ×

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  • article 2 Citação(ões) na Scopus
    Cervical Lymph Node Metastases from Central Nervous System Tumors: A Systematic Review
    (2022) COCA-PELAZ, Andres; BISHOP, Justin A.; ZIDAR, Nina; AGAIMY, Abbas; GEBRIM, Eloisa Maria Mello Santiago; MONDIN, Vanni; COHEN, Oded; STROJAN, Primoz; RINALDO, Alessandra; SHAHA, Ashok R.; BREE, Remco de; HAMOIR, Marc; MAKITIE, Antti A.; KOWALSKI, Luiz P.; SABA, Nabil F.; FERLITO, Alfio
    Introduction: Lymph node metastasis (LNM) from primary tumors of the central nervous system (CNS) is an infrequent condition, and classically it was thought that CNS tumors could not spread via the lymphatic route. Recent discoveries about this route of dissemination make its knowledge necessary for surgeons and pathologists to avoid delays in diagnosis and unnecessary treatments. The aim of this paper is to review the literature and to discuss the relevant pathogenetic mechanism and the cytologic features along with recommendations for surgical treatment of these cervical LNM. Materials and Methods: Using PRISMA guidelines, we conducted a systematic review of the literature published from 1944 to 2021, updating the comprehensive review published in 2010 by our group. Results: Our review includes data of 143 articles obtaining 174 patients with LNM from a primary CNS tumor. The mean age of the patients was 31.9 years (range, 0.1-87) and there were 61 females (35.1%) and 103 males (59.2%), and in 10 cases (5.7%) the gender was not specified. The more frequent sites of distant metastasis were bones (23%), lungs (11.5%) and non-cervical lymph nodes (11%). Conclusion: Cervical LNM from CNS tumors is infrequent. Pathologic diagnosis can be obtained by fine-needle aspiration cytology in most cases, giving surgeons the option to plan the appropriate surgical treatment. Given the poor prognosis of these cases, the most conservative possible cervical dissection is usually the treatment of choice.
  • article 31 Citação(ões) na Scopus
    Organ doses evaluation for chest computed tomography procedures with TL dosimeters: Comparison with Monte Carlo simulations
    (2019) GIANSANTE, Louise; MARTINS, Juliana C.; NERSISSIAN, Denise Y.; KIERS, Karen C.; KAY, Fernando U.; SAWAMURA, Marcia V. Y.; LEE, Choonsik; GEBRIM, Eloisa M. M. S.; COSTA, Paulo R.
    Purpose: To evaluate organ doses in routine and low-dose chest computed tomography (CT) protocols using an experimental methodology. To compare experimental results with results obtained by the National Cancer Institute dosimetry system for CT (NCICT) organ dose calculator. To address the differences on organ dose measurements using tube current modulation (TCM) and fixed tube current protocols. Methods: An experimental approach to evaluate organ doses in pediatric and adult anthropomorphic phantoms using thermoluminescent dosimeters (TLDs) was employed in this study. Several analyses were performed in order to establish the best way to achieve the main results in this investigation. The protocols used in this study were selected after an analysis of patient data collected from the Institute of Radiology of the School of Medicine of the University of Sao Paulo (InRad). The image quality was evaluated by a radiologist from this institution. Six chest adult protocols and four chest pediatric protocols were evaluated. Lung doses were evaluated for the adult phantom and lung and thyroid doses were evaluated for the pediatric phantom. The irradiations were performed using both a GE and a Philips CT scanner. Finally, organ doses measured with dosimeters were compared with Monte Carlo simulations performed with NCICT. Results: After analyzing the data collected from all CT examinations performed during a period of 3 yr, the authors identified that adult and pediatric chest CT are among the most applied protocol in patients in that clinical institution, demonstrating the relevance on evaluating organ doses due to these examinations. With regards to the scan parameters adopted, the authors identified that using 80 kV instead of 120 kV for a pediatric chest routine CT, with TCM in both situations, can lead up to a 28.7% decrease on the absorbed dose. Moreover, in comparison to the standard adult protocol, which is performed with fixed mAs, TCM, and ultra low- dose protocols resulted in dose reductions of up to 35.0% and 90.0%, respectively. Finally, the percent differences found between experimental and Monte Carlo simulated organ doses were within a 20% interval. Conclusions: The results obtained in this study measured the impact on the absorbed dose in routine chest CT by changing several scan parameters while the image quality could be potentially preserved.