MARIA CONCEPCION GARCIA OTADUY
Projetos de Pesquisa
Unidades Organizacionais
Instituto de Radiologia, Hospital das Clínicas, Faculdade de Medicina
LIM/44 - Laboratório de Ressonância Magnética em Neurorradiologia, Hospital das Clínicas, Faculdade de Medicina
LIM/44 - Laboratório de Ressonância Magnética em Neurorradiologia, Hospital das Clínicas, Faculdade de Medicina
5 resultados
Resultados de Busca
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- A Longitudinal MRI-study of the Effects of Lithium on Cortical Thickness and Brain Volume and its association with Clinical Response in Bipolar Disorder(2019) COSTA, Sabrina C. da; ZANETTI, Marcus V.; SUCHTING, Robert; SOUZA, Rafael T. de; OTADUY, Maria C.; LEITE, Claudia C.; BUSATTO, Geraldo F.; GATTAZ, Wagner F.; SOARES, Jair C.; MACHADO-VIEIRA, Rodrigo
conferenceObject Brain aging in bipolar disorder: An analysis of data from the ENIGMA Bipolar Disorder Working Group(2019) EYLER, L. T.; ABE, C.; BAUNE, B.; BOEN, B.; BONIN, M.; BUSATTO, G.; CHAIM-AVANCINI, T.; DANNLOWSKI, U.; ELVSASHAGEN, T.; FULLERTON, J.; OTADUY, M. Garcia; GOIKOLEA, J.; GROTEGERD, D.; HAHN, T.; HENRY, C.; HOUENOU, J.; HOWELLS, F.; JIMENEZ, E.; LAFER, B.; LANDEN, M.; MACHADO-VIEIRA, R.; MALT, U.; MITCHELL, P.; OVERS, B.; POMAROL-CLOTET, E.; ROBERTS, G.; ROSA, P.; SATTERTHWAITE, T.; SOEIRO-DE-SOUZA, M.; STEIN, D.; TEMMINGH, H.; THOMOPOULOS, S.; UHLMANN, A.; VIETA, E.; WOLF, D.; ZANETTI, M.; HAN, L.; SCHMAAL, L.; THOMPSON, P.; CHING, C.; ANDREASSEN, O.- Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases(2019) BETTS, Matthew J.; KIRILINA, Evgeniya; OTADUY, Maria C. G.; IVANOV, Dimo; ACOSTA-CABRONERO, Julio; CALLAGHAN, Martina F.; LAMBERT, Christian; CARDENAS-BLANCO, Arturo; PINE, Kerrin; PASSAMONTI, Luca; LOANE, Clare; KEUKEN, Max C.; TRUJILLO, Paula; LUESEBRINK, Falk; MATTERN, Hendrik; LIU, Kathy Y.; PRIOVOULOS, Nikos; FLIESSBACH, Klaus; DAHL, Martin J.; MAASS, Anne; MADELUNG, Christopher F.; MEDER, David; EHRENBERG, Alexander J.; SPECK, Oliver; WEISKOPF, Nikolaus; DOLAN, Raymond; INGLIS, Ben; TOSUN, Duygu; MORAWSKI, Markus; ZUCCA, Fabio A.; SIEBNER, Hartwig R.; MATHER, Mara; ULUDAG, Kamil; HEINSEN, Helmut; POSER, Benedikt A.; HOWARD, Robert; ZECCA, Luigi; ROWE, James B.; GRINBERG, Lea T.; JACOBS, Heidi I. L.; DUEZEL, Emrah; HAEMMERER, DorotheaPathological alterations to the locus coeruleus, the major source of noradrenaline in the brain, are histologically evident in early stages of neurodegenerative diseases. Novel MRI approaches now provide an opportunity to quantify structural features of the locus coeruleus in vivo during disease progression. In combination with neuropathological biomarkers, in vivo locus coeruleus imaging could help to understand the contribution of locus coeruleus neurodegeneration to clinical and pathological manifestations in Alzheimer's disease, atypical neurodegenerative dementias and Parkinson's disease. Moreover, as the functional sensitivity of the noradrenergic system is likely to change with disease progression, in vivo measures of locus coeruleus integrity could provide new pathophysiological insights into cognitive and behavioural symptoms. Locus coeruleus imaging also holds the promise to stratify patients into clinical trials according to noradrenergic dysfunction. In this article, we present a consensus on how non-invasive in vivo assessment of locus coeruleus integrity can be used for clinical research in neurodegenerative diseases. We outline the next steps for in vivo, post-mortem and clinical studies that can lay the groundwork to evaluate the potential of locus coeruleus imaging as a biomarker for neurodegenerative diseases.
bookPart Fisíca Médica(2019) OTADUY, Maria Concepción Garcia; CHAIM, Khallil Taverna; FRANCISCO NETO, Miguel José; MORENO, Raquel Andrade- Diffusion Tensor Imaging Biomarkers to Predict Motor Outcomes in Stroke: A Narrative Review(2019) MOURA, Luciana M.; LUCCAS, Rafael; PAIVA, Joselisa P. Q. de; AMARO JR., Edson; LEEMANS, Alexander; LEITE, Claudia da C.; OTADUY, Maria C. G.; CONFORTO, Adriana B.Stroke is a leading cause of disability worldwide. Motor impairments occur in most of the patients with stroke in the acute phase and contribute substantially to disability. Diffusion tensor imaging (DTI) biomarkers such as fractional anisotropy (FA) measured at an early phase after stroke have emerged as potential predictors of motor recovery. In this narrative review, we: (1) review key concepts of diffusion MRI (dMRI); (2) present an overview of state-of-art methodological aspects of data collection, analysis and reporting; and (3) critically review challenges of DTI in stroke as well as results of studies that investigated the correlation between DTI metrics within the corticospinal tract and motor outcomes at different stages after stroke. We reviewed studies published between January, 2008 and December, 2018, that reported correlations between DTI metrics collected within the first 24 h (hyperacute), 2-7 days (acute), and >7-90 days (early subacute) after stroke. Nineteen studies were included. Our review shows that there is no consensus about gold standards for DTI data collection or processing. We found great methodological differences across studies that evaluated DTI metrics within the corticospinal tract. Despite heterogeneity in stroke lesions and analysis approaches, the majority of studies reported significant correlations between DTI biomarkers and motor impairments. It remains to be determined whether DTI results could enhance the predictive value of motor disability models based on clinical and neurophysiological variables.