LUIZA FUOCO DA ROCHA
Projetos de Pesquisa
Unidades Organizacionais
7 resultados
Resultados de Busca
Agora exibindo 1 - 7 de 7
- Survival, Causes of Death, and Prognostic Factors in Systemic Sclerosis: Analysis of 947 Brazilian Patients(2012) SAMPAIO-BARROS, Percival D.; BORTOLUZZO, Adriana B.; MARANGONI, Roberta G.; ROCHA, Luiza F.; RIO, Ana Paula T. Del; SAMARA, Adil M.; YOSHINARI, Natalino H.; MARQUES-NETO, Joao FranciscoObjective. To analyze survival, prognostic factors, and causes of death in a large cohort of patients with systemic sclerosis (SSc). Methods. From 1991 to 2010, 947 patients with SSc were treated at 2 referral university centers in Brazil. Causes of death were considered SSc-related and non-SSc-related. Multiple logistic regression analysis was used to identify prognostic factors. Survival at 5 and 10 years was estimated using the Kaplan-Meier method. Results. One hundred sixty-eight patients died during the followup. Among the 110 deaths considered related to SSc, there was predominance of lung (48.1%) and heart (24.5%) involvement. Most of the 58 deaths not related to SSc were caused by infection, cardiovascular or cerebrovascular disease, and cancer. Male sex, modified Rodnan skin score (mRSS) > 20, osteoarticular involvement, lung involvement, and renal crisis were the main prognostic factors associated to death. Overall survival rate was 90% for 5 years and 84% for 10 years. Patients presented worse prognosis if they had diffuse SSc (85% vs 92% at 5 yrs, respectively, and 77% vs 87% at 10 yrs, compared to limited SSc), male sex (77% vs 90% at 5 yrs and 64% vs 86% at 10 yrs, compared to female sex), and mRSS > 20 (83% vs 90% at 5 yrs and 66% vs 86% at 10 yrs, compared to mRSS <20). Conclusion. Survival was worse in male patients with diffuse SSc, and lung and heart involvement represented the main causes of death in this South American series of patients with SSc. (First Release Aug 15 2012; J Rheumatol 2012;39:1971-8; doi:10.3899/jrheum.111582)
conferenceObject ASSOCIATION WITH OTHER AUTOIMMUNE DISEASES IS FREQUENT IN A COHORT OF 901 BRAZILIAN PATIENTS WITH SSc(2012) SAMPAIO-BARROS, P.; MARANGONI, R.; ROCHA, L.; RIO, A. P. Del; YOSHINARI, N.; MARQUES-NETO, J. F.- Cross-cultural adaptation and validation of the Brazilian version of the Scleroderma Health Assessment Questionnaire (SHAQ)(2014) ROCHA, Luiza F.; MARANGONI, Roberta G.; SAMPAIO-BARROS, Percival D.; LEVY-NETO, Mauricio; YOSHINARI, Natalino H.; BONFA, Eloisa; STEEN, Virginia; KOWALSKI, Sergio C.The Scleroderma Health Assessment Questionnaire (SHAQ) is a feasible multisystem specific tool that has been extensively used as an additional assessment for systemic sclerosis (SSc). The aim of this study is to cross-culturally adapt and validate the Brazilian version of the SHAQ. Construct validity was assessed based on the correlations between SHAQ and both the Medical Outcomes Survey Short Form 36 version 2 (SF-36v2 (TM)) and the Health Assessment Questionnaire Disability Index (HAQ-DI). The correlation between the SHAQ and disease severity was assessed by Spearman's correlation coefficient. The reproducibility of the SHAQ was evaluated by the intraclass correlation coefficient (ICC). Among the 151 consecutive outpatients evaluated, 59 % had limited SSc subtype. The overall disease severity visual analog scale (VAS) of the SHAQ was statistically significantly correlated to HAQ-DI, pain VAS, and the SF-36v2 (TM) physical component summary score (r = 0.595, r = 0.612, and r = -0.582, respectively; p < 0.001). Further analysis of all SF-36v2 (TM) components revealed statistically significant correlations between overall disease severity VAS and bodily pain (r = -0.621, p < 0.001), vitality (r = -0.544, p < 0.001), physical function (r = -0.510, p < 0.001), and role limitation-physical dimensions (r = -0.505, p < 0.001). Moreover, digestive, pulmonary, and overall disease severity VASs were statistically significantly correlated to the number of organs involved (r = 0.178, p = 0.029; r = 0.214, p = 0.008; r = 0.282, p < 0.001). We also demonstrated high reproducibility for SHAQ (ICC = 0.757, 95 % confidence interval = 0.636-0.842). The Brazilian version of the SHAQ demonstrated both construct and discriminant validities as well as good reproducibility.
conferenceObject SURVIVAL, CAUSES OF DEATH AND PROGNOSTIC FACTORS IN SSc: ANALYSIS OF 947 PATIENTS(2012) SAMPAIO-BARROS, P.; BORTOLUZZO, A.; MARANGONI, R.; ROCHA, L.; RIO, A. P. Del; SAMARA, A.; YOSHINARI, N.; MARQUES-NETO, J. F.conferenceObject LOW FREQUENCY OF MALIGNANCIES IN A LARGE BRAZILIAN COHORT OF PATIENTS WITH SSc(2012) SAMPAIO-BARROS, P.; ROCHA, L.; MARANGONI, R.; RIO, A. P. Del; YOSHINARI, N.; MARQUES-NETO, J. F.conferenceObject INFLUENCE OF GENDER, ETHNICITY AND AGE AT ONSET IN THE CLINICAL PRESENTATION OF SYSTEMIC SCLEROSIS IN A LARGE BRAZILIAN COHORT OF 1017 PATIENTS(2014) SAMPAIO-BARROS, P.; MARANGONI, R.; ROCHA, L.; BORTOLUZZO, A.; SEGURO, L.; RIO, A. P. Del; ANDRADE, D.; NASCIMENTO, I.; FOELKEL, A. L.; MARQUES-NETO, J. F.- Systemic sclerosis sine scleroderma: distinct features in a large Brazilian cohort(2013) MARANGONI, Roberta Goncalves; ROCHA, Luiza Fuoco; RIO, Ana Paula T. Del; YOSHINARI, Natalino H.; MARQUES-NETO, Joao Francisco; SAMPAIO-BARROS, Percival D.Objective. Systemic sclerosis sine scleroderma (ssSSc) is an infrequent SSc variant characterized by visceral and immunological manifestations of SSc in the absence of clinically detectable skin involvement. We sought to delineate the characteristics of ssSSc in a cohort of Brazilian patients and contrast them with those in the literature. Methods. SSc patients seen at two academic medical centres in Brazil were retrospectively analysed. Patients were classified as ssSSc if they presented with RP, positive ANAs and at least one visceral involvement typical of SSc in the absence of skin thickening. Demographics, clinical and laboratory data were obtained by chart review. Literature review was performed by searching available original studies up until June 2012. Results. Among the 947 consecutive patients with SSc, 79 (8.3%) were classified as ssSSc. Oesophagus was the most frequently affected organ (83.1%), followed by pulmonary involvement (63.2%). Compared with the limited cutaneous form of SSc, telangiectasia was the only variable significantly different after multivariate logistic regression analyses (odds ratio 0.46; 95% CI 0.27, 0.81). Compared with the diffuse cutaneous form of SSc, multivariate analyses revealed that ssSSc patients were less likely to be male (odds ratio 0.15; 95% CI 0.04, 0.57), have digital ulcers (odds ratio 0.26; 95% CI 0.13, 0.51) or anti-Scl70 antibodies (odds ratio 0.19; 95% CI 0.07, 0.55) and less frequently treated with CYC (odds ratio 0.23; 95% CI 0.12, 0.43). These features were comparable to those in the published literature. Conclusion. In this series, patients with ssSSc had a relatively mild disease with good prognosis.