RAFAEL LOCH BATISTA
Projetos de Pesquisa
Unidades Organizacionais
Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina - Médico
Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/42 - Laboratório de Hormônios e Genética Molecular, Hospital das Clínicas, Faculdade de Medicina
Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/42 - Laboratório de Hormônios e Genética Molecular, Hospital das Clínicas, Faculdade de Medicina
3 resultados
Resultados de Busca
Agora exibindo 1 - 3 de 3
conferenceObject Gonadal Tumor Risk, Bone Mineral Density, and Genetics, Clinical, Hormonal, and Psychosexual Aspects of a Large Androgen Insensitivity Syndrome Cohort(2021) BATISTA, Rafael Loch; RAMOS, Raquel Martinez; NISHI, Miriam; DALLAGO, Renata; ELIAS, Felipe; RODRIGUES, Andresa di Santi; DOMENICE, Sorahia; MENDONCA, Berenice B.- Vasculometabolic effects in patients with congenital growth hormone deficiency with and without GH replacement therapy during adulthood(2021) BISCOTTO, Isabela Peixoto; HONG, Valeria Aparecida Costa; BATISTA, Rafael Loch; MENDONCA, Berenice Bilharinho; ARNHOLD, Ivo Jorge Prado; BORTOLOTTO, Luiz Aparecido; CARVALHO, Luciani Renata SilveiraPurpose To evaluated the metabolic profiles and vascular properties in congenital growth hormone (GH) deficiency (GHD) and its replacement in adults. Patients and methods Cross-sectional study conducted in a single tertiary center for pituitary diseases. Eighty-one adult subjects were divided into three groups: (1) 29 GHD patients with daily subcutaneous GH replacement therapy (GHRT) during adulthood; (2) 20 GHD patients without GHRT during adulthood and (3) 32 controls. Only patients with adequate adherence to others pituitary hormone deficiencies were included. Anthropometric parameters, body composition by dual-energy X-ray absorptiometry, metabolic profiles and vascular properties (carotid intima media thickness, pulse wave velocity and flow-mediated dilation) were compared among the groups. Results Waist-to-height ratio (WHR), body fat percentages and fat mass index (FMI) were lower in patients with GHRT than patients without GHRT during adulthood (0.49 +/- 0.06 vs. 0.53 +/- 0.06 p = 0.026, 30 +/- 10 vs. 40 +/- 11 p = 0.003 and 7.3 +/- 4 vs. 10 +/- 3.5 p = 0.041, respectively). In addition, association between longer GHRT and lower body fat percentage was observed (r = - 0.326, p = 0.04). We found higher triglyceride (113.5 +/- 62 vs. 78 +/- 36, p = 0.025) and lower HDL cholesterol (51 +/- 17 vs. 66 +/- 23, p = 0.029) levels in patients without GHRT during adulthood in comparison to controls. No statistical differences were observed for vascular properties among the groups. Conclusions No differences in vascular properties were observed in congenital GHD adult patients with or without GHRT despite patients without GHRT had an unfavorable body composition. GHRT currently remains an individualized decision in adults with GHD and these findings bring new insight into the treatment and follow-up of these patients.
- Complete Androgen Insensitivity in Girls with Inguinal Hernias: A Serendipity Opportunity for Early Diagnosis(2021) BATISTA, Rafael Loch