MARIO TERRA FILHO
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Cardio-Pneumologia, Faculdade de Medicina - Docente
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/09 - Laboratório de Pneumologia, Hospital das Clínicas, Faculdade de Medicina - Líder
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/09 - Laboratório de Pneumologia, Hospital das Clínicas, Faculdade de Medicina - Líder
76 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 76
- Cases series on nontuberculous mycobacterial (NTM) lung disease and silicosis in Brazil(2017) RANGEL, Diana Arrais de Souza; GARCIA, Marcos Vinicius Fernandes; MIZUTANI, Rafael Futoshi; SALES, Roberta Karla Barbosa; SANTOS, Ubiratan de Paula; TERRA-FILHO, Mario
- Update on pulmonary arteriovenous malformations(2023) SALIBE-FILHO, William; OLIVEIRA, Francini Rossetto de; TERRA-FILHO, MarioThis review aimed to provide an overview of pulmonary arteriovenous malformations, including the major clinical and radiological presentations, investigation, and treatment algorithm of the condition. The primary etiology of pulmonary arteriovenous malformations is hereditary hemorrhagic telangiectasia (HHT), also known as RenduOsler-Weber syndrome, with mutations in the ENG gene on chromosome 9 (HHT type 1) or in the ACVRL1/ ALK1 complex ( HHT type 2). Epistaxis should always be evaluated when repeated, when associated with anemia, and in some cases of hypoxemia. In the investigation, contrast echocardiography and chest CT are essential for evaluating this condition. Embolization is the best treatment choice, especially for correction in cases of hypoxemia or to avoid systemic infections. Finally, disease management was addressed in special conditions such as pregnancy. CT follow-up should be performed every 3- 5 years, depending on the size of the afferent and efferent vessels, and antibiotic prophylactic care should always be oriented. Ultimately, knowledge of the disease by health professionals is a crucial point for the early diagnosis of these patients in clinical practice, which can potentially modify the natural course of the disease.
- Burnt sugarcane harvesting is associated with acute renal dysfunction(2015) SANTOS, Ubiratan Paula; ZANETTA, Dirce Maria T.; TERRA-FILHO, Mario; BURDMANN, Emmanuel A.Sugarcane harvesting has been associated with an epidemic of chronic kidney disease in Central America mainly affecting previously healthy young workers. Repeated episodes of acute kidney dysfunction are hypothesized to be one of the possible mechanisms for this phenomenon. Therefore, this exploratory study aimed to assess the acute effects of burnt sugarcane harvesting on renal function among 28 healthy non-African Brazilian workers. Urine and blood samples were collected at the beginning and at the end of the harvesting season and before and at the end of a harvesting workday. All individuals decreased their estimated glomerular filtration rate by similar to 20% at the end of the daily shift, and 18.5% presented with serum creatinine increases consistent with acute kidney injury. Those changes were associated with increased serum creatine phosphokinase (a known marker for exertional rhabdomyolysis) and oxidative stress-associated malondialdehyde levels, increased peripheral blood white cell counts, decreased urinary and serum sodium, decreased calculated fractional sodium excretion, and increased urine density. Thus, burnt sugarcane harvesting caused acute renal dysfunction in previously healthy workers. This was associated with a combination of dehydration, systemic inflammation, oxidative stress, and rhabdomyolysis.
bookPart Pneumoconiose por Poeira Mista e Silicatoses(2014) LOMBARDI, Elisa Maria Siqueira; CHATE, Rodrigo Caruso; SANTOS, Ubiratan de Paula; TERRA FILHO, Mário- Silicosis with acute renal injury and glomerulonephritis: a case report(2017) COCCOLIN, Fernanda; SOARES, Fernando; MIZUTANI, Rafael; DIAS, Cristiane; GARCIA, Marcos; TERRA-FILHO, Mario; SANTOS, Ubiratan; PINHEIRO, Rafaela
conferenceObject Chronic thromboembolic pulmonary hypertension global cross-sectional scientific survey (CLARITY) - Interim results on the adoption and perception of guidelines(2022) SKORO-SAJER, N.; KOPEC, G.; ABE, K.; FORFIA, P.; HERESI, G.; JEVNIKAR, M.; SHEARES, K.; TERRA-FILHO, M.; WHITFORD, H.; ZHAI, Z.; BEAUDET, A.; GRESSIN, V; MEIJER, C.; MOISEEVA, O.- Use of medical therapies before pulmonary endarterectomy in chronic thromboembolic pulmonary hypertension patients with severe hemodynamic impairment(2020) CASTRO, Marcela Araujo; PILOTO, Bruna; FERNANDES, Caio Julio Cesar dos Santos; JARDIM, Carlos; SALIBE FILHO, William; OLEAS, Francisca Gavilanes; ALVES, Jose Leonidas; MORINAGA, Luciana Tamie Kato; HOETTE, Susana; TERRA FILHO, Mario; FREITAS FILHO, Orival; JATENE, Fabio Biscegli; SOUZA, RogerioChronic thromboembolic pulmonary hypertension (CTEPH) is a rare complication of acute pulmonary embolism, characterized by non-resolving fibro-thrombotic obstructions of large pulmonary arteries. Pulmonary endarterectomy (PEA) is the treatment of choice for the disease, significantly improving survival. Patients with worse hemodynamic profile have worse prognosis after surgery, raising the question of whether the use of medical therapy prior to surgery to optimize hemodynamics could improve outcomes. The aim of this study was to evaluate the role of medical therapy pre-PEA, according to the hemodynamic profile at the diagnosis. We retrospectively analyzed all patients submitted to PEA, from January 2013 to December 2017. Functional, clinical and hemodynamic data were collected to evaluate the main prognostic determinants. Patients were stratified according to the hemodynamic severity and use of targeted therapies prior to surgery. A total of 108 patients were included. Thirty-five patients (32,4%) used targeted therapy pre-PEA. The use of medical therapy delayed the surgical procedure by about 7 months. There was no difference in overall survival between patients that received targeted therapy and those treated only with supportive therapy (87.8% vs 80.3%, respectively, p = 0.426). Nevertheless, when analyzing the group of patients with severe hemodynamic impairment, defined by low cardiac output(< 3.7L/min) at baseline, patients treated with targeted therapies presented a significantly better one-year survival. In higher-risk CTEPH patients, characterized by the presence of low cardiac output, the use of targeted therapies prior to PEA was associated with better outcome, suggesting a potential role for pre-operative use of medical treatment in this particular subgroup.
conferenceObject Heart rate and ventilation in a group of burned sugar cane cutters (Brazil): Estimative of particulate matter (PM2,5) exposure load(2012) COZZA, Izabela; NAMBU, Danilo; FERNANDES, Frederico; BUSSACOS, Marcos; PACELI, Renato; PRADO, Gustavo; TERRA-FILHO, Mario; SANTOS, Ubiratan- Chronic thromboembolic pulmonary hypertension: the impact of advances in perioperative techniques in patient outcomes(2021) SCUDELLER, Paula Gobi; TERRA-FILHO, Mario; FILHO, Orival Freitas; GALAS, Filomena Regina Barbosa Gomes; ANDRADE, Tiago Dutra de; NICOTARI, Daniela Odnicki; GOBBO, Laura Michelin; GAIOTTO, Fabio Antonio; HAJJAR, Ludhmila Abrahao; JATENE, Fabio BiscegliObjectives: Pulmonary endarterectomy (PEA) is the gold standard treatment for chronic thromboembolic pulmonary hypertension (CTEPH). This study aimed at reporting outcomes of CTEPH patients undergoing PEA within 10 years, focusing on advances in anesthetic and surgical techniques. Methods: We evaluated 102 patients who underwent PEA between January 2007 and May 2016 at the Instituto do Coracao do Hospital das Clinicas da Universidade de Sao Paulo. Changes in techniques included longer cardiopulmonary bypass, heating, and cooling times and mean time of deep hypothermic circulatory arrest and shortened reperfusion time. Patients were stratified according to temporal changes in anesthetic and surgical techniques: group 1 (January 2007December 2012), group 2 (January 2013-March 2015), and group 3 (April 2015-May 2016). Clinical outcomes were any occurrence of complications during hospitalization. Results: Groups 1, 2, and 3 included 38, 35, and 29 patients, respectively. Overall, 62.8% were women (mean age, 49.1 years), and 65.7% were in New York Heart Association functional class III-IV. Postoperative complications were less frequent in group 3 than in groups 1 and 2: surgical complications (10.3% vs. 34.2% vs. 31.4%, p=0.035), bleeding (10.3% vs. 31.5% vs. 25.7%, p=0.047), and stroke (0 vs. 13.2% vs. 0, p=0.01). Between 3 and 6 months post-discharge, 85% were in NYHA class I-II. Conclusion: Improvements in anesthetic and surgical procedures were associated with better outcomes in CTEPH patients undergoing PEA during the 10-year period.
- Work-related asthma (WRA) has worst socioeconomic status, quality of life and asthma control: a brazilian study(2019) ROIO, Lavinia Clara Del; TERRA-FILHO, Mario; ALGRANTI, Eduardo; GALVAO, Clovis Eduardo Santos; FREITAS, Jefferson Benedito Pires De; SANTOS, Ubiratan Paula