MILENA SALES PITOMBEIRA
Projetos de Pesquisa
Unidades Organizacionais
LIM/43 - Laboratório de Medicina Nuclear, Hospital das Clínicas, Faculdade de Medicina
12 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 12
conferenceObject C-11-pib pet showed a distinct cerebrospinal fluid pattern in patients with progressive multiple sclerosis(2020) PITOMBEIRA, M.; DURAN, F.; CAMPANHOLO, K.; SOUZA, A.; APOSTOLOS-PEREIRA, S.; RIMKUS, C. Medeiros; MENDES, M. F.; BUSATTO FILHO, G.; CALLEGARO, D.; BUCHPIGUEL, C.; FARIA, D. De PaulaconferenceObject Neuroimaging profile in pediatric Neuromyelitis Optica Spectrum Disorders (NMOSD)(2017) PAOLILO, R.; RIMKUS, C. D. M.; PAZ, J. A.; APOSTOLOS-PEREIRA, S. L.; ARAUJO, A. L. P. C.; GOMES, A. B.; VENTURA, L. M. Gomes De Brito; PITOMBEIRA, M. S.; MATOS, A. D. M. B.; REED, U. C.; CALLEGARO, D.; SATO, D. K.- Clinical Features and Inflammatory Markers in Autoimmune Encephalitis Associated With Antibodies Against Neuronal Surface in Brazilian Patients(2019) NOBREGA, Paulo Ribeiro; PITOMBEIRA, Milena Sales; MENDES, Lucas Silvestre; KRUEGER, Mariana Braatz; SANTOS, Carolina Figueiredo; MORAIS, Norma Martins de Menezes; SIMABUKURO, Mateus Mistieri; MAIA, Fernanda Martins; BRAGA-NETO, PedroAcute encephalitis is a debilitating neurological disorder associated with brain inflammation and rapidly progressive encephalopathy. Autoimmune encephalitis (AE) is increasingly recognized as one of the most frequent causes of encephalitis, however signs of inflammation are not always present at the onset which may delay the diagnosis. We retrospectively assessed patients with AE associated with antibodies against neuronal surface diagnosed in reference centers in Northeast of Brazil between 2014 to 2017. CNS inflammatory markers were defined as altered CSF (pleocytosis >5 cells/mm(3)) and/or any brain parenchymal MRI signal abnormality. Thirteen patients were evaluated, anti-NMDAR was the most common antibody found (10/13, 77%), followed by anti-LGI1 (2/13, 15%), and anti-AMPAR (1/13, 7%). Median time to diagnosis was 4 months (range 2-9 months). Among these 13 patients, 6 (46.1%) had inflammatory markers and when compared to those who did not present signs of inflammation, there were no significant differences regarding the age of onset, time to diagnosis and modified Rankin scale score at the last visit. Most of the patients presented partial or complete response to immunotherapy during follow-up. Our findings suggest that the presence of inflammatory markers may not correlate with clinical presentation or prognosis in patients with AE associated with antibodies against neuronal surface. Neurologists should be aware to recognize clinical features of AE and promptly request antibody testing even without evidence of inflammation in CSF or MRI studies.
conferenceObject Rituximab treatment in antiAQP4 positive patients with a 6-month reinfusion protocol(2017) TORRETTA, P. H. B.; APOSTOLOS-PEREIRA, S. L.; PITOMBEIRA, M. S.; JORGE, F. M. H.; SATO, D. K.; CALLEGARO, D.conferenceObject Generating PET-derived maps of myelin content from clinical MRI using Generative Adversarial Networks(2023) SOULIER, Theodore; HAMZAOUI, Mariem; PITOMBEIRA, Milena Sales; FARIA, Daniele; YAZDAN-PANAH, Arya; TONIETTO, Matteo; BOTTLAENDER, Michel; LEROY, Claire; BODINI, Benedetta; AYACHE, Nicholas; COLLIOT, Olivier; STANKOFF, Bruno- Persistent MOG-IgG positivity is a predictor of recurrence in MOG-IgG-associated optic neuritis, encephalitis and myelitis(2019) OLIVEIRA, Luana Michelli; APOSTOLOS-PEREIRA, Samira Luisa; PITOMBEIRA, Milena Sales; TORRETTA, Pedro Henrique Bruel; CALLEGARO, Dagoberto; SATO, Douglas KazutoshiBackground: MOG-IgG-associated optic neuritis, encephalitis and myelitis (MONEM) is a recently recognized group of inflammatory central nervous system (CNS) disorders distinct from multiple sclerosis and neuromyelitis optica spectrum disorders. Limited data are available regarding the predictors of relapse in this condition. Objective: We aimed to evaluate the longitudinal serostatus of patients with MOG-IgG and to correlate serostatus with long-term clinical outcomes. Methods: Of 574 consecutive patients who presented with demyelinating inflammatory CNS disorders, we included 31 patients who were MOG-IgG-positive. Patients with MOG-IgG were followed up from 2011 to 2017 at the School of Medicine, University of SAo Paulo, Brazil. Results: Relapsing disease occurred in 23 out of 31 patients (74%), while 8 (26%) exhibited a monophasic course. All monophasic patients, as well as the majority of relapsing patients, became seronegative during clinical remission. Patients exhibiting disease activity in the last 2years were more likely to remain positive, with higher medium titres than those found in patients in clinical remission. Conclusion: MOG-IgG patients usually present with a relapsing course, and the risk of relapse was associated with longitudinally persistent MOG-IgG seropositivity. In contrast, patients who experienced a single attack became spontaneously seronegative for MOG-IgG during long-term follow-up.
conferenceObject BCTRIMS: Impact of the Covid 19 pandemic on healthcare access for people with MS(2022) PITOMBEIRA, M. SalesconferenceObject Five-year follow-up of pediatric onset Neuromyelitis Optica Spectrum Disorders (NMOSD)(2017) PAOLILO, R. B.; PAZ, J. A.; APOSTOLOS-PEREIRA, S. L.; RIMKUS, C. D. M.; ARAUJO, A. L. P. C.; VENTURA, L. M. G. D. B.; PITOMBEIRA, M. S.; GOMES, A. B.; MATOS, A. D. M. B.; TORRETTA, P. H. B.; REED, U. C.; CALLEGARO, D.; SATO, D. K.conferenceObject Case series: a specialty center 10 year experience with use of azathioprine in neuromielytis optica spectrum disorders (NMOSD)(2017) GOMES, A. B. A. G. R.; MATOS, A. de Moura Brasil; VENTURA, L. M. Gomes de Brito; PITOMBEIRA, M. Sales; PAOLILO, R. Barbosa; TORRETTA, P. H. Bruel; JORGE, F. Menucci de Haidar; SATO, D. Kazutoshi; CALLEGARO, D.; PEREIRA, S. L. Apostolos- Myelin imaging measures as predictors of cognitive impairment in MS patients: A hybrid PET-MRI study(2022) CAMPANHOLO, K. R.; PITOMBEIRA, M. S.; RIMKUS, C. M.; MENDES, M. F.; APOSTOLOS-PEREIRA, S. L.; BUSATTO FILHO, G.; CALLEGARO, D.; BUCHPIGUEL, C. A.; DURAN, F. L. S.; FARIA, D. De PaulaBackground: Cognitive impairment is one of the concerns of Multiple Sclerosis (MS) and has been related to myelin loss. Different neuroimaging methods have been used to quantify myelin and relate it to cognitive dysfunctions, among them Magnetization Transfer Ratio (MTR), Diffusion Tensor Imaging (DTI), and, more recently, Positron Emission Tomography (PET) with C-11-PIB. Objective: To investigate different myelin imaging modalities as predictors of cognitive dysfunction. Methods: Fifty-one MS patients and 24 healthy controls underwent clinical and neuropsychological assessment and MTR, DTI (Axial Diffusion-AD and Fractional Anisotropy-FA maps), and C-11-PIB PET images in a PET/MR hybrid system. Results: MTR and DTI(FA) differed in patients with or without cognitive impairment. There was an association of DTI(FA) and DTI(AD) with cognition and psychomotor speed for progressive MS, and of C-11-PIB uptake and MTR for relapsing-remitting MS. MTR in the Thalamus (beta=-0.51, p=0.021) and Corpus Callosum (beta=-0.24, p=0.033) were predictive of cognitive impairment. DTI-FA in the Caudate (beta=-26.93, p=0.006) presented abnormal predictive result. Conclusion: Lower myelin content by C-11-PIB uptake was associated with worse cognitive status. MTR was predictive of cognitive impairment in MS.