EDSON BOR-SENG SHU
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/26 - Laboratório de Pesquisa em Cirurgia Experimental, Hospital das Clínicas, Faculdade de Medicina
LIM/26 - Laboratório de Pesquisa em Cirurgia Experimental, Hospital das Clínicas, Faculdade de Medicina
4 resultados
Resultados de Busca
Agora exibindo 1 - 4 de 4
- Transcranial sonography findings in spinocerebellar ataxia type 3 (Machado-Joseph disease): A cross-sectional study(2011) PEDROSO, Jose Luiz; BOR-SENG-SHU, Edson; FELICIO, Andre Carvalho; BRAGA-NETO, Pedro; TEIXEIRA, Manoel Jacobsen; BARSOTTINI, Orlando GrazianiFew studies on transcranial brain sonography have been performed in hereditary and non-hereditary ataxias. The objective of the present study was to report transcranial brain sonography findings in a sample of clinically and molecularly proven Machado-Joseph disease patients and to compare these data against those of an age- and gender-matched control group. A cross-sectional study on transcranial brain sonography was conducted in 30 Machado-Joseph disease patients. Transcranial brain sonography was performed by an experienced sonographer blinded to the clinical, genetic, and neuroimaging data. The results were compared with those of a control group of 44 healthy subjects matched for age and gender. The sonographic findings were also correlated with clinical features and genetic data in Machado-Joseph disease group. A significantly higher frequency of substantia nigra and lenticular nucleus hyperechogenicity was found in the Machado-Joseph disease group compared to an age- and gender-matched healthy control group (p < 0.001). The substantia nigra echogenic area proved to be the best predictor for differentiating cases from controls. Third and lateral ventricles were significantly larger in the Machado-Joseph disease patients than in the control subjects. No significant correlations were found between transcranial brain sonography findings and Machado-Joseph disease demographic/clinical data. Transcranial brain sonography findings in Machado-Joseph disease patients differed significantly to those in age- and gender-matched controls. Substantia nigra hyperechogenicity occurred frequently in Machado-Joseph disease patients and was found to be the best predictor for differentiating cases from controls. Additionally, this data describes the occurrence of brain atrophy in Machado-Joseph disease group.
- Heterozygous exon 3 deletion in the Parkin gene in a patient with clinical and radiological MSA-C phenotype(2011) BARSOTTINI, Orlando Graziani Povoas; FELICIO, Andre Carvalho; AGUIAR, Patricia de Carvalho; GODEIRO-JUNIOR, Clecio; PEDROSO, Jose Luiz; AQUINO, Camila Catherine Henriques de; BOR-SENG-SHU, Edson; ANDRADE, Luiz Augusto Franco de
- Predicting Symptomatic Cerebral Vasospasm After Aneurysmal Subarachnoid Hemorrhage(2011) BOR-SENG-SHU, Edson; DE-LIMA-OLIVEIRA, Marcelo; TEIXEIRA, Manoel Jacobsen; PANERAI, Ronney B.
article 19 Citação(ões) na Scopus Continuous ventricular cerebrospinal fluid drainage with intracranial pressure monitoring for management of posttraumatic diffuse brain swelling(2011) ANDRADE, Almir Ferreira de; PAIVA, Wellingson Silva; AMORIM, Robson Luis Oliveira de; FIGUEIREDO, Eberval Gadelha; ALMEIDA, Antonio Nogueira de; BROCK, Roger Schmidt; BOR-SENG-SHU, Edson; TEIXEIRA, Manoel JacobsenBackground: Ventricular drainage has played an important role in the management of traumatic brain-injured patients. The aim of the present study was describe outcomes in a series of 57 patients with diffuse brain swelling underwent to intracranial pressure (ICP) monitoring. Method: Fifty-eight patients with diffuse posttraumatic brain swelling, were evaluated prospectively. The Glasgow Coma Scale (GCS) scores of patients varied from 4 to 12. Patients groups divided according to GCS and age. Patient neurological assessment was classified as favorable, unfavorable, and death. Results: Mechanisms of injury were vehicle accidents in 72.4% and falls in 15.6%. 54% of patients had GCS scores between 6 and 8. There were no statistical differences, regarding outcome, between groups separated by age. In the adults group (n=47), 44.7% evolved favorably. Conclusion: Our results indicate a poor prognosis in patients with brain swelling. We believe that continuous ventricular CSF drainage with ICP monitoring is a simple method as an adjunct in the management of these patients.