JOEL CLAUDIO HEIMANN

(Fonte: Lattes)
Índice h a partir de 2011
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Departamento de Clínica Médica, Faculdade de Medicina - Docente
LIM/16 - Laboratório de Fisiopatologia Renal, Hospital das Clínicas, Faculdade de Medicina - Líder

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Assunto: Biochemistry & Molecular Biology ×

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Agora exibindo 1 - 10 de 22
  • conferenceObject
    Fine particulate matter in the inspired air within the limits recommended by WHO alters placental structure
    (2014) SOTO, Sonia; LOPES, Karen; VERAS, Mariana; HEIMANN, Joel
  • conferenceObject
    Myocardial AT1 gene expression is increased in a model of left ventricular hypertrophy induced by high salt intake
    (2013) PEREIRA, Rafael Canavel; KATAYAMA, Isis Akemi; HEIMANN, Joel Claudio
    Objective: To evaluate gene expression of the renin-angiotensin system components in a model of left ventricular hypertrophy induced by high salt intake demonstrated in a previous study. Methods: Wistar rats were fed normal (NS1.3% NaCl) or high (HS 8%) salt diet since weaning. From the 7th week of age, two HS subgroups received hydralazine or losartan (HZ 15 and LOS 20mg/kg/day). Angiotensinogen, renin, ACE, ACE2, AT1 and AT2 gene expression in left ventricle were measured. Data are reported as mean±SEM. Means in row with superscripts without a common letter differ, P<0.05. Conclusion: High salt intake increases AT1 gene expression, however it is prevented by losartan treatment.
  • conferenceObject
    Effect of an angiotensin II type 2 receptor agonist on myocardial hypertrophy and fibrosis induced by high salt diet
    (2017) DOPONA, Ellen Priscila Brito; ROCHA, Veronica Favoni; OLIVEIRA, Ivone Braga de; FURUKAWA, Luzia Naoko Shinohara; HEIMANN, Joel Claudio
  • conferenceObject
    Small litter size at birth is associated with insulin resistance and low energy expenditure in adulthood
    (2013) TAVARES, Neuziane Kloos Amorim; AGUIAR, Fernanda de Jesus; FURUKAWA, Luzia Naoko; HEIMANN, Joel Claudio
    Objective: To evaluate the effect of litter size standardization at birth on adult metabolic parameters.Methods: Female Wistar rats became pregnant at 12 weeks of age. Offspring were divided into control(C), G8(8) and G4(4 newborns/litter) groups. At 12 weeks of age, food intake (FI,g/day), glucose (G,mg/dL), insulin (I,pM), cholesterol (Chol,mg/dL), triacylglycerols (TAG,mg/dL) levels, white and brown adipose tissue (BAT) masses (g/100g) adiposity index (AI,% body weight) were determined. Conclusion: Results suggest that changes in litter size is associated with energy balance, carbohydrate and lipid disorders, insulin resistance and alterations in blood pressure in adult male and female.
  • conferenceObject
    Fine particulate matter in the air within the limits recommended by WHO alters placental structure
    (2015) SOTO, Sonia; MARCHESI, Guilherme; LOPES, Karen; VERAS, Mariana; HEIMANN, Joel
  • conferenceObject
    Salt intake during pregnancy influences offspring organ growth
    (2014) PERES, Maria; OLIVEIRA, Ivone de; FURUKAWA, Luzia; GUIMARAES, Carina; HEIMANN, Joel
  • conferenceObject
    Effects of exposure do air pollution on placental structure
    (2013) SOTO, Sonia de Fatima; LOPES, Karen; VERAS, Mariana Matera; HEIMANN, Joel
  • conferenceObject
    Transgenerational Effects of High Salt Diet During Gestation
    (2016) PERES, Maria Angelica; OLIVEIRA, Ivone Braga de; FURUKAWA, Luzia Naoko Shinohara; HEIMANN, Joel
  • conferenceObject
    Mitochondria function and structure in brown adipose tissue is influenced by maternal low salt intake during the perinatal period
    (2012) LOPES, Karen Lucasechi; SANTOS, Elisabete Alcantara Dos; FURUKAWA, Luzia Naoko Shinohara; HEIMANN, Joel Claudio
  • article 42 Citação(ões) na Scopus
    Identification of intracellular peptides in rat adipose tissue: Insights into insulin resistance
    (2012) BERTI, Denise A.; RUSSO, Lilian C.; CASTRO, Leandro M.; CRUZ, Lilian; GOZZO, Fabio C.; HEIMANN, Joel C.; LIMA, Fabio B.; OLIVEIRA, Ariclecio C.; ANDREOTTI, Sandra; PRADA, Patricia O.; HEIMANN, Andrea S.; FERRO, Emer S.
    Intracellular peptides generated by the proteasome and oligopeptidases have been suggested to function in signal transduction and to improve insulin resistance in mice fed a high-caloric diet. The aim of this study was to identify specific intracellular peptides in the adipose tissue of Wistar rats that could be associated with the physiological and therapeutic control of glucose uptake. Using semiquantitative mass spectrometry and LC/MS/MS analyses, we identified ten peptides in the epididymal adipose tissue of the Wistar rats; three of these peptides were present at increased levels in rats that were fed a high-caloric Western diet (WD) compared with rats fed a control diet (CD). The results of affinity chromatography suggested that in the cytoplasm of epididymal adipose tissue from either WD or CD rats, distinctive proteins bind to these peptides. However, despite the observed increase in the WD animals, the evaluated peptides increased insulin-stimulated glucose uptake in 3T3-L1 adipocytes treated with palmitate. Thus, intracellular peptides from the adipose tissue of Wistar rats can bind to specific proteins and facilitate insulin-induced glucose uptake in 3T3-L1 adipocytes.