SANARELLY PIRES ADONIAS BORGES DE QUEIROZ
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- Increased expression of MMP-9 and IL-8 are correlated with poor prognosis of Bladder Cancer(2012) REIS, Sabrina Thalita; LEITE, Katia Ramos M.; PIOVESAN, Luis Felipe; PONTES-JUNIOR, Jose; VIANA, Nayara Izabel; ABE, Daniel Kanda; CRIPPA, Alexandre; MOURA, Caio Martins; ADONIAS, Sanarelly Pires; SROUGI, Miguel; DALL'OGLIO, Marcos FranciscoBackground: Extracellular matrix homeostasis is strictly maintained by a coordinated balance between the expression of metalloproteinases (MMPs) and their inhibitors. The purpose of this study was to investigate whether the expression of MMP-9, MMP-2 and its specific inhibitors, are expressed in a reproducible, specific pattern and if the profiles are related to prognosis in Bladder Cancer (BC). Methods: MMP-9, MMP-2 and its specific inhibitors expression levels were analyzed by quantitative real-time polymerase chain reaction (qRT-PCR) in fresh-frozen malignant tissue collected from 40 patients with BC submitted to transurethral resection of bladder. The control group consisted of normal bladder tissue from five patients who had undergone retropubic prostatectomy to treat benign prostatic hyperplasia. Results: MMP-9 was overexpressed in 59.0 % of patients, and MMP-2, TIMP-1, TIMP-2, MMP-14, RECK and IL-8 was underexpressed in most of the patients. Regarding prognostic parameters we observed that high-grade tumors exhibited significantly higher levels of MMP-9 and IL-8 (p = 0.012, p = 0.003). Invasive tumors (pT1-pT2) had higher expression levels of MMP-9 than superficial tumors (pTa) (p = 0.026). The same was noted for IL-8 that was more expressed by invasive tumors (p = 0.015, p = 0.048). Most importantly tumor recurrence was related with higher levels of both MMP-9 (p = 0.003) and IL-8 (p = 0.005). Conclusion: We have demonstrated that the overexpression of MMP-9 and higher expression of IL-8 are related to unfavorable prognostic factors of urothelial bladder cancer and tumor recurrence and may be useful in the follow up of the patients.
conferenceObject OCCUPATIONAL RISK FOR INITIAL BLADDER CANCER DIAGNOSIS IN BRAZIL(2012) ADONIAS, Sanarelly; CHADE, Daher C.; SANT'ANNA, Alexandre C.; REIS, Sabrina T.; ABE, Daniel K.; AREAS, Flavio G. M.; SUZAKI, T. T.; LEITE, Katia R.; SROUGI, Miguel; DALL'OGLIO, Marcos F.conferenceObject PROSPECTIVE RANDOMIZED TRIAL COMPARING OPEN TO LAPAROSCOPIC PARTIAL NEPHRECTOMY, INTERIM ANALYSIS. (NCT01809119)(2016) GUGLIELMETTI, Giuliano; ADONIAS, Sanarelly; COELHO, Rafael; CORDEIRO, Mauricio; BORGES, Leonardo; COLOMBO, Jose Roberto; PESSOA, Rodrigo; NEVES, Luiz; PONTES, Jose; NESRALLAH, Adriano; SROUGI, Miguel; NAHAS, William- Nomograms using a small panel of genes for predicting the diagnosis and aggressiveness of prostate cancer(2020) LEITE, Katia R. M.; ORTEGA, Fabio L.; DAMIANI, Lucas P.; GUIMARAES, Vanessa; VIANA, Nayara; SILVA, Iran A.; REIS, Sabrina T.; PIMENTA, Ruan; ADONIAS, Sanarelly P.; CHAMMAS, Cristina; SROUGI, Miguel; NAHAS, Willian
- Comparative Effectiveness of Intravesical BCG-Tice and BCG-Moreau in Patients With Non-muscle-invasive Bladder Cancer(2020) D'ANDREA, David; SORIA, Francesco; ABUFARAJ, Mohammad; PONES, Mario; GONTERO, Paolo; MACHADO, Andre T.; WAKSMAN, Ricardo; ENIKEEV, Dmitry V.; GLYBOCHKO, Petr V.; ADONIAS, Sanarelly Pires; NAHAS, William Carlos; SHARIAT, Shahrokh F.; CHADE, Daher C.We compared the oncologic outcomes of patients treated with bacillus Calmette-Guerin (BCG)-Tice versus BCG-Moreau for non-muscle-invasive bladder cancer using inverse-probability survival analyses and found no significant difference in recurrence- and progression-free survival between strains. However, the use of maintenance cycles was significantly associated with improved recurrence- and progression-free survival. Prospective designed trials are required to confirm these findings in light of the BCG shortage. Background: The purpose of this study was to compare the efficacy of 2 bacillus Calmette-Guerin (BCG) strains, BCG-Tice and BCG-Moreau, in the treatment of non-muscle-invasive bladder cancer (NMIBC). Materials and Methods: We retrospectively reviewed clinical data from patients treated with BCG for NMIBC at 3 academic centers. Inverse probability of treatment weighting (IPTW)-adjusted Kaplan-Meier curves and Cox proportional hazards regression analyses were used to compare recurrence-free (RFS) and progression-free survival (PFS) of patients in the 2 treatment groups. In addition, we performed exploratory analyses of treatment effect according to the receipt of adequate BCG treatment, high-risk disease, age, gender, smoking status, pathologic stage, and pathologic grade. Results: A total of 321 (48.6%) patients were treated with BCG-Tice and 339 (51.4%) with BCG-Moreau. IPTW-adjusted Cox proportional hazard regression analysis did not show a difference in RFS (hazard ratio, 0.88; 95% confidence interval, 0.56-1.38; P = .58) or PFS (hazard ratio, 0.55; 95% confidence interval, 0.25-1.21, P = .14) between BCG-Tice and BCG-Moreau. On subgroup analyses, we could not identify an association of BCG strain with outcomes. Conclusions: There was no difference in RFS and PFS between BCG-Tice and BCG-Moreau strains in the adjuvant treatment of NMIBC. However, we confirmed the importance of maintenance therapy for achieving a sustainable response in patients with intermediate- and high-risk NMIBC.
- Effectiveness of the Moreau strain of Bacillus Calmette-Guerin (BCG) for nonmuscle invasive bladder cancer.(2017) CHADE, Daher Cezar; MACHADO, Andre; WAKSMAN, Ricardo; GARCIA, Guilherme; ESTEVES, Paulo; ADONIAS, Sanarelly; BOTELHO, Luis; CORDEIRO, Mauricio; MURTA, Claudio; RIBEIRO-FILHO, Leopoldo; SARKIS, Alvaro; BASTOS, Diogo Assed; DZIK, Carlos; SROUGI, Miguel; NAHAS, William Carlos
- Human papillomavirus vaccination and prevention of intraepithelial neoplasia and penile cancer: review article(2020) NUNES, Joao F. da Costa; PIRES, Sanarelly; CHADE, Daher C.Purpose of review The objective of the current article is to promote a literature revision of the relationship between the prevention of intraepithelial neoplasms (PeIN) and invasive penile cancer, and human papillomavirus (HPV) vaccination, aiming to enumerate the pros and cons of immunization. Recent findings The immunization against the HPV is sufficiently safe and many countries have incorporated the vaccine to their immunization calendar. Compared with men, the sampling size and the evidence quality of scientific researches among the female population are more robust. Some randomized and nonrandomized studies suggest that vaccination reduces the incidence of genital warts and no PeIN and penile cancer cases were developed in the vaccinal group. However, 70% of patients can evolve with the neoplasia despite having been immunized and even among HPV infected patients, only 1% will develop cancer. The studies about vaccination against HPV and prevention on penile cancer are conflicting and the main academic urology societies still have not incorporated vaccination of men in their guidelines. Future studies are necessary to confirm the efficiency and cost-benefit of the vaccine in men to prevent intraepithelial neoplasms and invasive penile cancer.
conferenceObject BLOOD-BASED BIOMARKERS AS PREDICTORS OF ONCOLOGIC OUTCOMES FOR NON-MUSCLE-INVASIVE UROTHELIAL BLADDER CARCINOMA(2017) CHADE, Daher; MACHADO, Andre; WAKSMAN, Ricardo; GARCIA, Guilherme; ESTEVES, Paulo; ADONIAS, Sanarelly; AREAS, Flavio; BOTELHO, Luis; CORDEIRO, Mauricio; MURTA, Claudio; RIBEIRO-FILHO, Leopoldo; SARKIS, Alvaro; SHARIAT, Shahrokh; BASTOS, Diogo; DZIK, Carlos; SROUGI, Miguel; NAHAS, William