SAMIA ZAHI RACHED
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/09 - Laboratório de Pneumologia, Hospital das Clínicas, Faculdade de Medicina
LIM/09 - Laboratório de Pneumologia, Hospital das Clínicas, Faculdade de Medicina
22 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 22
- Comparação entre medidas objetivas do tabagismo e tabagismo autodeclarado em pacientes com asma ou DPOC: será que nossos pacientes dizem a verdade?(2015) STELMACH, Rafael; FERNANDES, Frederico Leon Arrabal; CARVALHO-PINTO, Regina Maria; ATHANAZIO, Rodrigo Abensur; RACHED, Samia Zahi; PRADO, Gustavo Faibischew; CUKIER, AlbertoObjective: Smoking prevalence is frequently estimated on the basis of self-reported smoking status. That can lead to an underestimation of smoking rates. The aim of this study was to evaluate the difference between self-reported smoking status and that determined through the use of objective measures of smoking at a pulmonary outpatient clinic. Methods: This was a cross-sectional study involving 144 individuals: 51 asthma patients, 53 COPD patients, 20 current smokers, and 20 never-smokers. Smoking status was determined on the basis of self-reports obtained in interviews, as well as through tests of exhaled carbon monoxide (eCO) and urinary cotinine. Results: All of the asthma patients and COPD patients declared they were not current smokers. In the COPD and asthma patients, the median urinary cotinine concentration was 167 ng/mL (range, 2-5,348 ng/mL) and 47 ng/mL (range, 5-2,735 ng/mL), respectively (p < 0.0001), whereas the median eCO level was 8 ppm (range, 0-31 ppm) and 5 ppm (range, 2-45 ppm), respectively (p < 0.05). In 40 (38%) of the patients with asthma or COPD (n = 104), there was disagreement between the self-reported smoking status and that determined on the basis of the urinary cotinine concentration, a concentration > 200 ng/mL being considered indicative of current smoking. In 48 (46%) of those 104 patients, the self-reported non-smoking status was refuted by an eCO level > 6 ppm, which is also considered indicative of current smoking. In 30 (29%) of the patients with asthma or COPD, the urinary cotinine concentration and the eCO level both belied the patient claims of not being current smokers. Conclusions: Our findings suggest that high proportions of smoking pulmonary patients with lung disease falsely declare themselves to be nonsmokers. The accurate classification of smoking status is pivotal to the treatment of lung diseases. Objective measures of smoking could be helpful in improving clinical management and counseling.
- Pulmonary arterial enlargement is a predictor of higher risk of exacerbations in non-cystic fibrosis bronchiectasis patients(2021) FREITAS, Leonardo Vinicius De; NUNES, Blenda; MIRANDA, Renato; MAIA, Ana Luisa; RACHED, Samia; CUKIER, Alberto; STELMACH, Rafael; PINTO, Regina Carvalho; ATHANAZIO, Rodrigo
conferenceObject Clinical, Radiological And Functional Features In Mounier Kuhn Syndrome(2013) MAIORANO, M. C. N. T.; RACHED, S. Z.; ATHANAZIO, R. A.; CARVALHO-PINTO, R. M.; STELMACH, R.; CUKIER, A.- Determinants of Peripheral Muscle Strength and Activity in Daily Life in People With Bronchiectasis(2018) CAMARGO, Anderson Alves de; BOLDORINI, Jacqueline C.; HOLLAND, Anne E.; CASTRO, Rejane A. Silva de; LANZA, Fernanda de Cordoba; ATHANAZIO, Rodrigo A.; RACHED, Samia Z.; CARVALHO-PINTO, Regina; CUKIER, Alberto; STELMACH, Rafael; CORSO, Simone DalBackground. Bronchiectasis is characterized by a progressive structural lung damage, recurrent infections and chronic inflammation which compromise the exertion tolerance, and may have an impact on skeletal muscle function and physical function. Objective. The purpose of this study was to compare peripheral muscle strength, exercise capacity, and physical activity in daily life between participants with bronchiectasis and controls and to investigate the determinants of the peripheral muscle strength and physical activity in daily life in bronchiectasis. Design. This study used a cross-sectional design. Methods. The participants' quadriceps femoris and biceps brachii muscle strength was measured. They performed the incremental shuttle walk test (ISWT) and cardiopulmonary exercise testing, and the number of steps/day was measured by a pedometer. Results. Participants had reduced quadriceps femoris muscle strength (mean difference to control group = 7 kg, 95% CI = 3.8-10.1 kg), biceps brachii muscle strength (2.1 kg, 95% CI = 0.7-3.4 kg), ISWT (227 m, 95% CI = 174-281 m), peak VO2 (6.4 ml/Kg/min, 95% CI = 4.0-8.7 ml/Kg/min), and number of steps/day (3,332 steps/day, 95% CI = 1,758-4,890 steps/day). A lower quadriceps femoris strength is independently associated to an older age, female sex, lower body mass index (BMI), higher score on the modified Medical Research Council scale, and shorter distance on the ISWT (R-2 = 0.449). Biceps brachii strength is independently associated with sex, BMI, and dyspnea (R-2 = 0.447). The determinants of number of daily steps were dyspnea and distance walked in ISWT, explaining only 27.7% of its variance. Limitations. Number of steps per day was evaluated by a pedometer. Conclusion. People with bronchiectasis have reduced peripheral muscle strength, and reduced aerobic and functional capacities, and they also are less active in daily life. Modifiable variables such as BMI, dyspnea, and distance walked on the ISWT are associated with peripheral muscle strength and physical activity in daily life.
conferenceObject Do physically active and not physically active adult subjects with bronchiectasis have different clinical and functional characteristics?(2013) ATHANAZIO, Rodrigo; RACHED, Samia Zahi; CAMARGO, Anderson Alves de; AMARAL, Tatiane Soares; LANZA, Fernanda de Cordoba; SAMPAIO, Luciana Malosa; CUKIER, Alberto; CARVALHO-PINTO, Regina; CARVALHO, Celso Ricardo Fernandes; STELMACH, Rafael; CORSO, Simone DalconferenceObject Non Concordance Between Sputum and Pulmonary Explant Fragments Culture in Patients with Cystic Fibrosis After Lung Transplantation(2018) ATHANAZIO, R. A.; RACHED, S. Z.; STELMACH, R.; CUKIER, A.; CARVALHO-PINTO, R. M.; COSTA, A. N.; FERNANDES, F. L.; SAMANO, M. N.; TEIXEIRA, R. H.; CAMPOS, S. V.conferenceObject Mycobacterium Parascrofulaceum in a Patient with Alpha 1 Antitrypsin Deficiency: Case Report(2020) BRIDI, G. D.; JESUS, R. M. De; SCHUBSKY, J.; LEIBEL, T.; ENDLICH, B. N.; RACHED, S. Z.; ATHANAZIO, R. A.; PINTO, R. M. De Carvalho; STELMACH, R.; CUKIER, A.conferenceObject The impact of dyspnea on exercise capacity, physical activity in daily life, and health-related quality of life in adult subjects with non-cystic fibrosis bronchiectasis(2013) RACHED, Samia Zahi; ATHANAZIO, Rodrigo; CAMARGO, Anderson Alves de; AMARAL, Tatiane Soares; LANZA, Fernanda de Cordoba; COSTA, Dirceu; CUKIER, Alberto; CARVALHO-PINTO, Regina; CARVALHO, Celso Ricardo Fernandes; STELMACH, Rafael; CORSO, Simone DalconferenceObject A Successful Case Report Of Linezolid For Pulmonary Nocardiosis(2015) PEDRAO, N. B.; NOBUO, M. S. D. P. F.; RACHED, S. Z.; ATHANAZIO, R. A.; CARVALHO-PINTO, R. M.; STELMACH, R.; CUKIER, A.conferenceObject A Rare Case Of Association Between Bronchiolitis, Rheumatoid Arthritis And Vogt-Koyanagi-Harada Syndrome(2013) ATHANAZIO, R.; RACHED, S. Z.; MAIORANO, M. N. T.; LEON, P.; LIMA, E.; CARVALHO-PINTO, R.; STELMACH, R.
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