SAMIA ZAHI RACHED
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/09 - Laboratório de Pneumologia, Hospital das Clínicas, Faculdade de Medicina
LIM/09 - Laboratório de Pneumologia, Hospital das Clínicas, Faculdade de Medicina
11 resultados
Resultados de Busca
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bookPart DPOC exacerbada(2018) RACHED, Samia Zahi; ALMEIDA, Guilherme Eler de; CARVALHO, Carlos Roberto Ribeiro de- Determinants of Peripheral Muscle Strength and Activity in Daily Life in People With Bronchiectasis(2018) CAMARGO, Anderson Alves de; BOLDORINI, Jacqueline C.; HOLLAND, Anne E.; CASTRO, Rejane A. Silva de; LANZA, Fernanda de Cordoba; ATHANAZIO, Rodrigo A.; RACHED, Samia Z.; CARVALHO-PINTO, Regina; CUKIER, Alberto; STELMACH, Rafael; CORSO, Simone DalBackground. Bronchiectasis is characterized by a progressive structural lung damage, recurrent infections and chronic inflammation which compromise the exertion tolerance, and may have an impact on skeletal muscle function and physical function. Objective. The purpose of this study was to compare peripheral muscle strength, exercise capacity, and physical activity in daily life between participants with bronchiectasis and controls and to investigate the determinants of the peripheral muscle strength and physical activity in daily life in bronchiectasis. Design. This study used a cross-sectional design. Methods. The participants' quadriceps femoris and biceps brachii muscle strength was measured. They performed the incremental shuttle walk test (ISWT) and cardiopulmonary exercise testing, and the number of steps/day was measured by a pedometer. Results. Participants had reduced quadriceps femoris muscle strength (mean difference to control group = 7 kg, 95% CI = 3.8-10.1 kg), biceps brachii muscle strength (2.1 kg, 95% CI = 0.7-3.4 kg), ISWT (227 m, 95% CI = 174-281 m), peak VO2 (6.4 ml/Kg/min, 95% CI = 4.0-8.7 ml/Kg/min), and number of steps/day (3,332 steps/day, 95% CI = 1,758-4,890 steps/day). A lower quadriceps femoris strength is independently associated to an older age, female sex, lower body mass index (BMI), higher score on the modified Medical Research Council scale, and shorter distance on the ISWT (R-2 = 0.449). Biceps brachii strength is independently associated with sex, BMI, and dyspnea (R-2 = 0.447). The determinants of number of daily steps were dyspnea and distance walked in ISWT, explaining only 27.7% of its variance. Limitations. Number of steps per day was evaluated by a pedometer. Conclusion. People with bronchiectasis have reduced peripheral muscle strength, and reduced aerobic and functional capacities, and they also are less active in daily life. Modifiable variables such as BMI, dyspnea, and distance walked on the ISWT are associated with peripheral muscle strength and physical activity in daily life.
- The annual prognostic ability of FACED and E-FACED scores to predict mortality in patients with bronchiectasis(2018) CARRILLO, David de la Rosa; ATHANAZIO, Rodrigo; MORENO, Rosa Maria Giron; CARRO, Luis Maiz; OLVEIRA, Casilda; GRACIA, Javier de; VENDRELL, Montserrat; SANCHEZ, Concepcion Prados; GRAMBLICKA, Georgina; PEREIRA, Monica Corso; LUNDGREN, Fernando; FIGUEIREDO, Mara Fernandes De; ARANCIBIA, Francisco; RACHED, Samia; MARTINEZ-GARCIA, Miguel-Angel
conferenceObject Non Concordance Between Sputum and Pulmonary Explant Fragments Culture in Patients with Cystic Fibrosis After Lung Transplantation(2018) ATHANAZIO, R. A.; RACHED, S. Z.; STELMACH, R.; CUKIER, A.; CARVALHO-PINTO, R. M.; COSTA, A. N.; FERNANDES, F. L.; SAMANO, M. N.; TEIXEIRA, R. H.; CAMPOS, S. V.- COPD Assessment Test (CAT) is a Valid and Simple Tool to Measure the Impact of Bronchiectasis on Affected Patients(2018) LANZA, Fernanda C.; CASTRO, Rejane A. S.; CAMARGO, Anderson A. de; ZANATTA, Drielly J. M.; RACHED, Samia; ATHANAZIO, Rodrigo; CUKIER, Alberto; STELMACH, Rafael; CORSO, Simone DalThe COPD assessment test (CAT) is a short questionnaire developed to help patients and clinicians to assess the impact of symptoms in routine clinical practice. We aimed to validate and to test the reproducibility of CAT in patients with bronchiectasis and correlate with the severity of dyspnea, aerobic and functional capacity, and physical activity in daily life. This is a cross-sectional study, patients with bronchiectasis underwent spirometry, cardiopulmonary exercise test (CPET), incremental shuttle walk test (ISWT), Saint George`s Respiratory Questionnaire (SGRQ), and received pedometer. CAT was applied twice (CAT-1 and CAT-2, 7 to 10 days apart). The severity of bronchiectasis was assessed by E-FACED and bronchiectasis severity index (BSI). A total of 100 patients were evaluated (48 +/- 14 years, 59 women, FVC: 67 +/- 22% pred, FEV1: 52 +/- 25% pred). According to CAT, 14% patients presented low, 40% medium, 32% high, and 14% very high impact. The higher the CAT, the worse the severity of bronchiectasis, dyspnea, quality of life, performance on the CPET, and smaller the distance walked (DW) on the ISWT and number of steps (NS) per day. There was significant correlation between CAT and SGRQ, E-FACED, BSI, NS, ISWT, oxygen uptake, and workload at CPET. CAT-1 and CAT-2 presented similar values: 21 (13-26) and 19 (13-26), respectively. The CAT is a valid and reproducible instrument in patients with bronchiectasis presenting good correlation with clinical, functional, and quality of life measurements. This easy-to-use, easy-to-understand, quick, and useful tool may play an important role to assess the impact of bronchiectasis on both daily medical practice and clinical trial settings.
conferenceObject Long-Term Follow-Up of Non CF Bronchiectasis Patients After Lung Transplantation in a Single Brazilian Center(2018) SERRA, J. P.; JESUS, R. M. De; ATHANAZIO, R. A.; RACHED, S. Z.; CAMPOS, S. V.; COSTA, A. N.; AFONSO, J. E.; CARRARO, R. M.; TEIXEIRA, R. D.; FERNANDES, L. M.; ABDALLA, L.; SAMANO, M. N.bookPart DPOC exacerbada(2018) RACHED, Samia Zahi; ALMEIDA, Guilherme Eler de; CARVALHO, Carlos Roberto de- Exercise capacity can predict exacerbations and hospitalizations in a 1-year follow up in non-cystic fibrosis bronchiectasis adults(2018) RACHED, Samia; CASTRO, Rejane Agnelo Silva De; CAMARGO, Anderson Alves De; ATHANAZIO, Rodrigo; CUKIER, Alberto; CORSO, Simone Dal; STELMACH, Rafael
- Reduced Physical Activity With Bronchiectasis(2018) JOSE, Anderson; RAMOS, Tamires Machado; CASTRO, Rejane Agnelo Silva de; OLIVEIRA, Cristiane Santos de; CAMARGO, Anderson Alves de; ATHANAZIO, Rodrigo Abensur; RACHED, Samia Zahi; STELMACH, Rafael; CORSO, Simone DalBACKGROUND: Bronchiectasis leads to reduced functional capacity, which might have implications for physical activity. The impact of dyspnea and long-term oxygen therapy on physical activity has never been investigated in subjects with bronchiectasis. Based on these findings, specific strategies could be applied to allow individuals to be more active in their daily life. In this study we aimed to evaluate physical activity, the impact of dyspnea and long-term oxygen therapy on physical activity, and the determinants of physical activity in subjects with bronchiectasis. METHODS: We performed a cross-sectional study in 139 subjects with bronchiectasis (age 45 +/- 13 y, FVC 70 +/- 22% of predicted, FEV1 54 +/- 25% of predicted) and 49 healthy subjects as controls. Physical activity was assessed using steps per day (measured with a pedometer), spirometry, incremental shuttle walking test (ISWT), and dyspnea. RESULTS: Reduced physical activity was observed in subjects with bronchiectasis, who recorded a median (interquartile range) of 8,007(5,131-10,432) steps/d compared with controls, who recorded 10,994(8,551-14,078) steps/d (P < .001). Significant correlations were observed between physical activity and FVC (r = 0.43), FEV1 (r = 0.36), ISWT (r = 037), and dyspnea (r = -0.48). Determinants for reduced physical activity included pulmonary function (R-2 = 0.150), dyspnea (R-2 = 0.075), ISWT (R-2 = 0.044), and long-term oxygen therapy (R-2 = 0.038); these factors explained 32% of the physical activity. CONCLUSION: Subjects with bronchiectasis exhibited reduced physical activity compared with healthy peers. Dyspnea has a negative impact on physical activity. Independent factors associated with physical activity included pulmonary function, dyspnea, functional capacity, and long-term oxygen therapy. These findings will guide strategies to enhance daily physical activity and to encourage subjects with bronchiectasis to be more active.
conferenceObject Pulmonary Actinomyces Infection, an Atypical Case Report(2018) JESUS, R. M. De; ENDLICH, B. N.; SERRA, J. P.; LIMA, R. M.; ATHANAZIO, R. A.; RACHED, S. Z.; PINTO, R. C.; CUKIER, A.; STELMACH, R.