ISABELLA IBRAHIM DOCHE SOARES
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- Evidence for neurogenic inflammation in lichen planopilaris and frontal fibrosing alopecia pathogenic mechanism(2020) DOCHE, Isabella; WILCOX, George L.; ERICSON, Marna; VALENTE, Neusa S.; ROMITI, Ricardo; MCADAMS, Brian. D.; HORDINSKY, Maria K.Lichen planopilaris (LPP) and frontal fibrosing alopecia (FFA) are lymphocytic scarring alopecias affecting primarily the scalp. Although both diseases may share some clinical and histopathological features, in the last decade, FFA has become an ""epidemic"" particularly in Europe, North and South America with unique clinical manifestations compared to LPP, thus, raising the idea that this disease may have a different pathogenesis. Symptoms such as scalp burning, pruritus or pain are usually present in both diseases, suggesting a possible role for nerves and neuropeptides in the pathogenesis of both diseases. Based on some previous studies, neuropeptides, such as substance P (SP) and calcitonin gene-related peptide (CGRP), have been associated with lipid metabolism and many chronic inflammatory disorders. In this study, we asked if these neuropeptides are associated with LPP and FFA scalp lesions. Alteration in the expression of SP and CGRP in affected and unaffected scalp skin from patients with both diseases was found with examination of sections using immunohistochemical techniques and confocal microscopy. We then quantitatively assessed and compared SP and CGRP expression from control, LPP and FFA scalp biopsies. Although LPP and FFA share similar histopathologic findings, opposite results were found in affected and unaffected scalp in the ELISA tests, suggesting that these diseases may have different pathogenic mechanisms. We also found presence of histopathological inflammation irrespective of evident clinical lesions, which raises the possibility that both diseases may be more generalized processes affecting the scalp.
- Alopecia areata and novel biologic agents: report of four cases and future directions(2021) GERLERO, Paula; DOCHE, Isabella; REBEIS, Marina; MACEDO, Thalita; RIVITTI-MACHADO, Maria C.
- Trichoscopic findings of eyebrow alopecia in patients with multibacillary leprosy(2019) DOCHE, Isabella; TOSTI, Antonella; NETO, Cyro F.; TRINDADE, Maria Angela B.; RIVITTI-MACHADO, Maria Cecilia M.; AVANCINI, Joao
- Evidence for lymphocytic inflammation in non-lesional scalp of folliculitis decalvans: an observational study of 25 patients(2022) DOCHE, I.; HORDINSKY, M. K.; VALENTE, N. S.; SOTTO, M. N.; MIOTTO, I.; REBEIS, M.; RIVITTI-MACHADO, M. C.
- Guidelines for clinical trials of frontal fibrosing alopecia: consensus recommendations from the International FFA Cooperative Group (IFFACG)(2021) OLSEN, E. A.; HARRIES, M.; TOSTI, A.; BERGFELD, W.; BLUME-PEYTAVI, U.; CALLENDER, V.; CHASAPI, V.; CORREIA, O.; COTSARELIS, G.; DHURAT, R.; DLOVA, N.; DOCHE, I.; ENECHUKWU, N.; GRIMALT, R.; ITAMI, S.; HORDINSKY, M.; KHOBZEI, K.; LEE, W. -S.; MALAKAR, S.; MESSENGER, A.; MCMICHAEL, A.; MIRMIRANI, P.; OVCHARENKO, Y.; PAPANIKOU, S.; PINTO, G. M.; PIRACCINI, B. M.; PIRMEZ, R.; REYGAGNE, P.; ROBERTS, J.; RUDNICKA, L.; SACEDA-CORRALO, D.; SHAPIRO, J.; SILYUK, T.; SINCLAIR, R.; SOARES, R. O.; SOUISSI, A.; VOGT, A.; WASHENIK, K.; ZLOTOGORSKI, A.; CANFIELD, D.; VANO-GALVAN, S.Background Frontal fibrosing alopecia (FFA) has become one of the most common causes of cicatricial alopecia worldwide. However, there is a lack of clear aetiology and robust clinical trial evidence for the efficacy and safety of agents currently used for treatment. Objectives To enable data to be collected worldwide on FFA using common criteria and assessment methods. Methods A multicentre, international group of experts in hair loss was convened by email to create consensus recommendations for clinical trials. Consensus was defined at > 90% agreement on each recommended part of these guidelines. Results Standardized diagnostic criteria, severity rating, staging, and investigator and patient assessment of scalp hair loss and other clinical features of FFA were created. Conclusions These guidelines should allow the collection of reliable aggregate data on FFA and advance efforts in both clinical and basic research to close knowledge gaps in this condition.
- Occipital Fibrosing Alopecia in a Young Male: A Case Report(2021) DOCHE, Isabella; REBEIS, Marina; VALENTE, Neusa; RIVITTI-MACHADO, Maria CeciliaIntroduction: Lichen planopilaris (LPP) is a primary lymphocytic cicatricial alopecia with 3 recognized clinical variants. Lately, LPP clinical spectrum has expanded with new and overlapping clinical variants. First considered as a subtype of LPP affecting postmenopausal women, the increasing worldwide incidence of FFA including atypical lesions in young female and male suggests a different pathomechanism for this disease. Although LPP-spectrum disorders may share similar histopathological findings, clinical features and prognosis are different. Case Report: A 26-year-old Caucasian male presented with occipital scarring alopecia and pruritus for the last 6 months. The patient had been treated for an associated androgenetic alopecia and superficial recurrent scalp folliculitis over the vertex scalp for the last 5 years. Trichoscopy of the occipital scalp showed mild diffuse erythema, moderate peripilar scaling, and absence of follicular openings, suggestive of a scarring process. The patient underwent an occipital scalp biopsy that confirmed the diagnosis of a LPP-spectrum disorder. Discussion/Conclusion: Both LPP and FFA mostly affect the anterior-mid scalp of females. However, recent reports on FFA also in premenopausal women and men should make physicians aware of atypical features of this disease and unusual clinical presentation.
- Acute hair matting: case report and trichoscopy findings(2017) MARTINS, S. Sales; ABRAHAM, L. Spagnol; DOCHE, I.; PIRACCINI, B. M.; VINCENZI, C.; TOSTI, A.
- Clinical features and sex hormone profile in male patients with frontal fibrosing alopecia: A multicenter retrospective study with 33 patients(2022) DOCHE, Isabella; NICO, Marcello M. S.; GERLERO, Paula; REBEIS, Marina; MELO, Daniel F.; TORTELLY, Violeta; RAMOS, Paulo M.; LARRONDO, Jorge; MARDONES, Felipe; GONZALEZ, Martha L.; TOSTI, Antonella; RIVITTI-MACHADO, Maria Cecilia
- It's not all traction: the pseudo 'fringe sign' in frontal fibrosing alopecia(2015) PIRMEZ, R.; DUQUE-ESTRADA, B.; ABRAHAM, L. S.; PINTO, G. M.; FARIAS, D. C. de; KELLY, Y.; DOCHE, I.
- Trichoscopic and imaging study of lipedematous alopecia: report of five cases(2020) DOCHE, I.; MIOTTO, I.; RIVITTI-MACHADO, M. C.; MELO, D. F.; LARRONDO, J.; CABRERA, R.; RAJABI-ESTARABADI, A.; TOSTI, A.
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