ISABELLA IBRAHIM DOCHE SOARES
Projetos de Pesquisa
Unidades Organizacionais
12 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 12
- Evidence for neurogenic inflammation in lichen planopilaris and frontal fibrosing alopecia pathogenic mechanism(2020) DOCHE, Isabella; WILCOX, George L.; ERICSON, Marna; VALENTE, Neusa S.; ROMITI, Ricardo; MCADAMS, Brian. D.; HORDINSKY, Maria K.Lichen planopilaris (LPP) and frontal fibrosing alopecia (FFA) are lymphocytic scarring alopecias affecting primarily the scalp. Although both diseases may share some clinical and histopathological features, in the last decade, FFA has become an ""epidemic"" particularly in Europe, North and South America with unique clinical manifestations compared to LPP, thus, raising the idea that this disease may have a different pathogenesis. Symptoms such as scalp burning, pruritus or pain are usually present in both diseases, suggesting a possible role for nerves and neuropeptides in the pathogenesis of both diseases. Based on some previous studies, neuropeptides, such as substance P (SP) and calcitonin gene-related peptide (CGRP), have been associated with lipid metabolism and many chronic inflammatory disorders. In this study, we asked if these neuropeptides are associated with LPP and FFA scalp lesions. Alteration in the expression of SP and CGRP in affected and unaffected scalp skin from patients with both diseases was found with examination of sections using immunohistochemical techniques and confocal microscopy. We then quantitatively assessed and compared SP and CGRP expression from control, LPP and FFA scalp biopsies. Although LPP and FFA share similar histopathologic findings, opposite results were found in affected and unaffected scalp in the ELISA tests, suggesting that these diseases may have different pathogenic mechanisms. We also found presence of histopathological inflammation irrespective of evident clinical lesions, which raises the possibility that both diseases may be more generalized processes affecting the scalp.
- Alopecia areata and novel biologic agents: report of four cases and future directions(2021) GERLERO, Paula; DOCHE, Isabella; REBEIS, Marina; MACEDO, Thalita; RIVITTI-MACHADO, Maria C.
- Trichoscopic findings of eyebrow alopecia in patients with multibacillary leprosy(2019) DOCHE, Isabella; TOSTI, Antonella; NETO, Cyro F.; TRINDADE, Maria Angela B.; RIVITTI-MACHADO, Maria Cecilia M.; AVANCINI, Joao
- Occipital Fibrosing Alopecia in a Young Male: A Case Report(2021) DOCHE, Isabella; REBEIS, Marina; VALENTE, Neusa; RIVITTI-MACHADO, Maria CeciliaIntroduction: Lichen planopilaris (LPP) is a primary lymphocytic cicatricial alopecia with 3 recognized clinical variants. Lately, LPP clinical spectrum has expanded with new and overlapping clinical variants. First considered as a subtype of LPP affecting postmenopausal women, the increasing worldwide incidence of FFA including atypical lesions in young female and male suggests a different pathomechanism for this disease. Although LPP-spectrum disorders may share similar histopathological findings, clinical features and prognosis are different. Case Report: A 26-year-old Caucasian male presented with occipital scarring alopecia and pruritus for the last 6 months. The patient had been treated for an associated androgenetic alopecia and superficial recurrent scalp folliculitis over the vertex scalp for the last 5 years. Trichoscopy of the occipital scalp showed mild diffuse erythema, moderate peripilar scaling, and absence of follicular openings, suggestive of a scarring process. The patient underwent an occipital scalp biopsy that confirmed the diagnosis of a LPP-spectrum disorder. Discussion/Conclusion: Both LPP and FFA mostly affect the anterior-mid scalp of females. However, recent reports on FFA also in premenopausal women and men should make physicians aware of atypical features of this disease and unusual clinical presentation.
- Clinical features and sex hormone profile in male patients with frontal fibrosing alopecia: A multicenter retrospective study with 33 patients(2022) DOCHE, Isabella; NICO, Marcello M. S.; GERLERO, Paula; REBEIS, Marina; MELO, Daniel F.; TORTELLY, Violeta; RAMOS, Paulo M.; LARRONDO, Jorge; MARDONES, Felipe; GONZALEZ, Martha L.; TOSTI, Antonella; RIVITTI-MACHADO, Maria Cecilia
- Multivariate analysis of clinical characteristics and prognostic factors in early-onset alopecia areata: a retrospective study with 82 Brazilian patients(2023) DOCHE, Isabella; GERLERO, Paula; MAGALHAES, Tiara; THIEN, Chan I.; MACEDO, Thalita; RIVITTI-MACHADO, Maria Cecilia
- Epidermolysis Bullosa Pruriginosa Associated with Folliculitis Decalvans: Case Report and Review of the Literature(2018) RIVITTI-MACHADO, Maria Cecilia; TOMA, Juliana T.; POMPEU, Vivianne M. A.; VALENTE, Neusa Y. S.; DOCHE, Isabella
- Normal-appearing scalp areas are also affected in lichen planopilaris and frontal fibrosing alopecia: An observational histopathologic study of 40 patients(2020) DOCHE, Isabella; ROMITI, Ricardo; HORDINSKY, Maria K.; VALENTE, Neusa S.Lichen planopilaris (LPP) and frontal fibrosing alopecia (FFA) are lymphocyte-mediated scarring alopecias which clinically affect primarily the anterior and mid-scalp. However, unaffected scalp areas have not yet been investigated in a systemic manner. In this study, we assessed histopathologic changes in affected and unaffected scalp in both diseases and healthy control subjects and compared these findings with clinical signs and scalp symptoms. We have demonstrated that ""normal-appearing"" scalp that is devoid of clinical lesions of LPP and FFA showed lymphocytic perifollicular inflammation around the isthmus/infundibulum areas in 65% of biopsy specimens, perifollicular fibrosis in 15% and mucin deposits in 7.5% of the cases. None of these findings were found in control samples. No direct correlation was found between the degree of histopathological inflammation, scalp symptoms and clinical lesions in the corresponding affected scalp areas. This preliminary study suggests that both diseases may be more generalized processes which affect the scalp and therefore need systemic or total scalp therapy.
- Acne keloidalis nuchae and folliculitis decalvans: same process affecting the follicle or coexisting diseases? A retrospective study(2019) DOCHE, Isabella; COELHO, Elisa Q.; QUARESMA, Maria Victoria; RIVITTI-MACHADO, Maria Cecilia da Matta
- Dissecting cellulitis in women: a retrospective multicenter study with 17 patients(2022) MELO, Daniel Fernandes; RAMOS, Paulo Muller; MACHADO, Carla Jorge; ANZAI, Alessandra; BLANCO, Aline; MULINARI-BRENNER, Fabiane; PINTO, Giselle Martins; ABRAHAM, Leonardo Spagnol; ALVES, Lorena Dourado; RIGATTI, Marcelo; RIVITTI-MACHADO, Maria Cecilia; KAKIZAKI, Priscila; MINOTTO, Renan; MACEDO, Thalita Barbosa; SANTOS, Thuany Silva; DOCHE, Isabella