ISABELLA IBRAHIM DOCHE SOARES
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- Alopecia areata and novel biologic agents: report of four cases and future directions(2021) GERLERO, Paula; DOCHE, Isabella; REBEIS, Marina; MACEDO, Thalita; RIVITTI-MACHADO, Maria C.
- Guidelines for clinical trials of frontal fibrosing alopecia: consensus recommendations from the International FFA Cooperative Group (IFFACG)(2021) OLSEN, E. A.; HARRIES, M.; TOSTI, A.; BERGFELD, W.; BLUME-PEYTAVI, U.; CALLENDER, V.; CHASAPI, V.; CORREIA, O.; COTSARELIS, G.; DHURAT, R.; DLOVA, N.; DOCHE, I.; ENECHUKWU, N.; GRIMALT, R.; ITAMI, S.; HORDINSKY, M.; KHOBZEI, K.; LEE, W. -S.; MALAKAR, S.; MESSENGER, A.; MCMICHAEL, A.; MIRMIRANI, P.; OVCHARENKO, Y.; PAPANIKOU, S.; PINTO, G. M.; PIRACCINI, B. M.; PIRMEZ, R.; REYGAGNE, P.; ROBERTS, J.; RUDNICKA, L.; SACEDA-CORRALO, D.; SHAPIRO, J.; SILYUK, T.; SINCLAIR, R.; SOARES, R. O.; SOUISSI, A.; VOGT, A.; WASHENIK, K.; ZLOTOGORSKI, A.; CANFIELD, D.; VANO-GALVAN, S.Background Frontal fibrosing alopecia (FFA) has become one of the most common causes of cicatricial alopecia worldwide. However, there is a lack of clear aetiology and robust clinical trial evidence for the efficacy and safety of agents currently used for treatment. Objectives To enable data to be collected worldwide on FFA using common criteria and assessment methods. Methods A multicentre, international group of experts in hair loss was convened by email to create consensus recommendations for clinical trials. Consensus was defined at > 90% agreement on each recommended part of these guidelines. Results Standardized diagnostic criteria, severity rating, staging, and investigator and patient assessment of scalp hair loss and other clinical features of FFA were created. Conclusions These guidelines should allow the collection of reliable aggregate data on FFA and advance efforts in both clinical and basic research to close knowledge gaps in this condition.
- Occipital Fibrosing Alopecia in a Young Male: A Case Report(2021) DOCHE, Isabella; REBEIS, Marina; VALENTE, Neusa; RIVITTI-MACHADO, Maria CeciliaIntroduction: Lichen planopilaris (LPP) is a primary lymphocytic cicatricial alopecia with 3 recognized clinical variants. Lately, LPP clinical spectrum has expanded with new and overlapping clinical variants. First considered as a subtype of LPP affecting postmenopausal women, the increasing worldwide incidence of FFA including atypical lesions in young female and male suggests a different pathomechanism for this disease. Although LPP-spectrum disorders may share similar histopathological findings, clinical features and prognosis are different. Case Report: A 26-year-old Caucasian male presented with occipital scarring alopecia and pruritus for the last 6 months. The patient had been treated for an associated androgenetic alopecia and superficial recurrent scalp folliculitis over the vertex scalp for the last 5 years. Trichoscopy of the occipital scalp showed mild diffuse erythema, moderate peripilar scaling, and absence of follicular openings, suggestive of a scarring process. The patient underwent an occipital scalp biopsy that confirmed the diagnosis of a LPP-spectrum disorder. Discussion/Conclusion: Both LPP and FFA mostly affect the anterior-mid scalp of females. However, recent reports on FFA also in premenopausal women and men should make physicians aware of atypical features of this disease and unusual clinical presentation.
- Novel blue blotch lesions in folliculitis decalvans - a clinical, histopathological and immunohistochemical study of seven cases(2021) DOCHE, I.; REBEIS, M. M.; GERLERO, P.; VALENTE, N. Y. S.; RIVITTI-MACHADO, M. C.