JORGE SIMAO DO ROSARIO CASSEB
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Dermatologia, Faculdade de Medicina - Docente
LIM/56 - Laboratório de Investigação em Dermatologia e Imunodeficiências, Hospital das Clínicas, Faculdade de Medicina - Líder
LIM/56 - Laboratório de Investigação em Dermatologia e Imunodeficiências, Hospital das Clínicas, Faculdade de Medicina - Líder
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- Association between muscle strength and the cardiopulmonary status of individuals living with HIV/AIDS(2013) RASO, Vagner; SHEPHARD, Roy J.; CASSEB, Jorge; DUARTE, Alberto Jose da Silva; SILVA, Paulo Roberto Santos; GREVE, Julia Maria D'AndreaOBJECTIVE: The purpose of this study was to compare aerobic function [ anaerobic threshold (%(V) over dotO(2)-AT), respiratory compensation point (%(V) over dotO(2)-RCP) and peak oxygen uptake ((V) over dotO(2peak))] between physically active patients with HIV/AIDS and matched controls and to examine associations between disease status, poor muscle strength, depression (as estimated by the profile of mood states questionnaire) and the aerobic performance of patients. METHODS: Progressive treadmill test data for %(V) over dotO(2)-AT (V-slope method), RCP and ((V) over dotO(2peak)) were compared between 39 male patients with HIV/AIDS (age 40.6 +/- 1.4 years) and 28 male controls (age 44.4 +/- 2.1 years) drawn from the same community and matched for habitual physical activity. Within-patient data were also examined in relation to CD4(+) counts (nadir and current data) and peak isokinetic knee torque. RESULTS: AT, RCP and ((V) over dotO(2peak)) values were generally similar for patients and controls. Within the patient sample, binary classification suggested that AT, RCP and ((V) over dotO(2peak)) values were not associated with either the nadir or current CD4(+) count, but treadmill test variables were positively associated with peak isokinetic knee torque. CONCLUSION: The aerobic performance of physically active patients with HIV/AIDS is generally well conserved. Nevertheless, poor muscle strength is observed in some HIV/AIDS patients, which is associated with lower anaerobic power and ((V) over dotO(2peak)), suggesting the possibility of enhancing the aerobic performance of patients with weak muscles through appropriate muscle-strengthening activities.
article 11 Citação(ões) na Scopus Aerobic power and muscle strength of individuals living with HIV/AIDS(2014) RASO, V.; SHEPHARD, R. J.; CASSEB, J. S. R.; DUARTE, A. J. S.; GREVE, J. M. D'A.Aim. We wished to evaluate any continuing adverse effects upon peak aerobic power and muscle strength associated with either HAART therapy or persistently low CD4+ counts in men living with HIV/AIDS. Methods. We studied 39 HIV/AIDS patients with an average disease history of 6.1 years, and 28 normal sedentary volunteers. All subjects performed tests of peak aerobic power and isokinetic muscle force, and the HIV/AIDS group also completed the Profile of Mood States (POMS) and WHO Quality of Life questionnaires. Blood was sampled for standard measures of immune function (CD4+ and CD8+ counts) and viral load. Results. Patient values were generally as in the normal subjects and appeared to be uninfluenced by the CD4+ nadir or the use of HAART therapy. However, the isokinetic muscle strength was lower in individuals with a low current CD4+ count. Isokinetic strength was also negatively correlated with current CD4+ and CD8+ counts. Conclusion. HAART therapy does not appear to have an adverse long-term effect on either aerobic power or muscle strength. Many ambulatory volunteers living with HIV/AIDS have a normal peak aerobic power. However, isokinetic strength can remain low, particularly in those with low current T-cell counts.- Handgrip Force Offers a Measure of Physical Function in Individuals Living With HIV/AIDS(2013) RASO, Vagner; SHEPHARD, Roy J.; CASSEB, Jorge S. do Rosario; DUARTE, Alberto J. da Silva; GREVE, Julia M. D'Andrea