FERNANDO MENDES PASCHOAL JUNIOR
Projetos de Pesquisa
Unidades Organizacionais
LIM/26 - Laboratório de Pesquisa em Cirurgia Experimental, Hospital das Clínicas, Faculdade de Medicina
5 resultados
Resultados de Busca
Agora exibindo 1 - 5 de 5
- Relationship between endothelial nitric oxide synthase (eNOS) and natural history of intracranial aneurysms: meta-analysis(2018) PASCHOAL, Eric Homero Albuquerque; YAMAKI, Vitor Nagai; TEIXEIRA, Renan Kleber Costa; PASCHOAL JUNIOR, Fernando Mendes; JONG-A-LIEM, Glaucia Suzanna; TEIXEIRA, Manoel Jacobsen; YAMADA, Elizabeth Sumi; RIBEIRO-DOS-SANTOS, Andrea; BOR-SENG-SHU, EdsonThe aneurysmal subarachnoid hemorrhage is a major public health problem described as a sudden drastic event with no warning symptoms and high morbidity and mortality rates. The role of the endothelial isoform of nitric oxide synthase gene polymorphism in intracranial aneurysms (IAs) is still a matter of controversy with divergent findings among European, American, and Asian populations. Our study purposed to test the association between intracranial aneurysms formation and nitric oxide gene polymorphisms through a systematic review and meta-analysis. Systematic search on Medline, Lilacs, and EMBASE was performed. The primary search resulted in 139 papers, out of which 9 met our inclusion criteria after a full text analysis. The dominant T786C model found a significant association with IA (OR 1.22, 95 % CI 1.04-1.44, p = 0.01), so did studies of the recessive T786C model (OR 0.37, 95 % CI 0.30-0.45, p < 0.0001) but with opposite effect. Our findings support the presence of the T786C polymorphism as a predictor for the development of intracranial aneurysm in the cerebral vascular system. More studies are necessary in order to elucidate the pathways of the endothelial nitric oxide synthase (eNOS) in cerebrovascular diseases and in defining how different allelic combinations of the eNOS gene single-nucleotide polymorphism (SNP) could favor this pathological process.
- Neck paraganglioma: Head rotation maneuver on transcranial Doppler ultrasonography(2015) PASCHOAL, Fernando Mendes; PASCHOAL, Eric Homero Albuquerque; ROGERIO, Ricardo Mendes; TEIXEIRA, Manoel Jacobsen; BOR-SENG-SHU, Edson
- Cerebral hemodynamic and metabolic changes in fulminant hepatic failure(2017) PASCHOAL JUNIOR, Fernando Mendes; NOGUEIRA, Ricardo de Carvalho; OLIVEIRA, Marcelo de Lima; PASCHOAL, Eric Homero Albuquerque; TEIXEIRA, Manoel Jacobsen; D'ALBUQUERQUE, Luiz Augusto Carneiro; BOR-SENG-SHU, EdsonIntracranial hypertension and brain swelling are a major cause of morbidity and mortality of patients suffering from fulminant hepatic failure (FHF). The pathogenesis of these complications has been investigated in man, in experimental models and in isolated cell systems. Currently, the mechanism underlying cerebral edema and intracranial hypertension in the presence of FHF is multi-factorial in etiology and only partially understood. The aim of this paper is to review the pathophysiology of cerebral hemodynamic and metabolism changes in FHF in order to improve understanding of intracranial dynamics complication in FHF.
- Embolic Signals during Routine Transcranial Doppler Ultrasonography in Aneurysmal Subarachnoid Hemorrhage(2015) PASCHOAL JR., Fernando Mendes; RONCONI, Karla de Almeida Lins; OLIVEIRA, Marcelo de Lima; NOGUEIRA, Ricardo de Carvalho; PASCHOAL, Eric Homero Albuquerque; TEIXEIRA, Manoel Jacobsen; FIGUEIREDO, Eberval Gadelha; BOR-SENG-SHU, EdsonIntroduction. Cerebral emboli may occur in subarachnoid hemorrhage (SAH) and intracranial aneurysm surgery. Although embolic signs (ES) have been reported in SAH, their origin remains unclear. The aim of this study was to report the detection of ES during routine TCD monitoring in patients with aneurysmal SAH. Methods. A total of 105 patients with aneurysmal SAH were submitted to TCD evaluation. Patients were monitored almost daily (5 times per week). In each monitoring session, one experienced operator performed TCD to detect or assess vasospasm and ES in arteries of the Willis polygon. Results. Four patients out of a total of 105 patients with aneurysmal SAH were found to present spontaneous cerebral embolization during routine TCD monitoring. The average age of the 4 patients (mean +/- standard deviation) was 59.5 +/- 8.34 years (range 49-68 ys); female patients predominated representing 75%(3/4) of subjects. Conclusion. Although detection of ES was relatively rare in this study, rates of emboli occurrence may be higher under systematic monitoring. The detection of ES after SAH surgery reinforces the need to study the role of embolus in this condition and may be an indicator for prophylactic antithrombotic treatment.
- Cerebral autoregulation in a fulminant hepatic failure patient who underwent liver transplantation(2019) PASCHOAL- JR., Fernando M.; NOGUEIRA, Ricardo C.; DE-LIMA-OLIVEIRA, Marcelo; PASCHOAL, Eric H.; TEIXEIRA, Manoel J.; D'ALBUQUERQUE, Luiz A.; BOR-SENG-SHU, Edson