ALFREDO ELIAS GILIO
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Pediatria, Faculdade de Medicina - Docente
PAINT-62, Hospital Universitário
PAINT-62, Hospital Universitário
7 resultados
Resultados de Busca
Agora exibindo 1 - 7 de 7
- Lipid profiles of children and adolescents with inflammatory response in a paediatric emergency department(2016) MURAMOTO, Giovana; DELGADO, Artur Figueiredo; SOUZA, Eloisa Correa de; GILIO, Alfredo Elias; CARVALHO, Werter Brunow de; MARANHAO, Raul CavalcanteBackground: To compare the lipid profile between patients with and without inflammatory process in according nutritional status, gender and age. Methods: One hundred and twenty-four children and adolescents in the emergency department were separated into two groups according to the levels of C-reactive protein (CRP). Total cholesterol, high-density lipoprotein (HDL) and low-density lipoprotein (LDL), triglycerides (TG) and albumin in patients with CRP < 5 mg/L were compared with patients with CRP >= 5 mg/L. Nutritional status was assessed by anthropometric measurements. Results: Patients were mostly classified as well-nourished (76.5%) and had low levels of HDL (70%). There was no significant difference in lipid profile between the two groups of CRP. Linear regression analysis, however, it became clear that for each increase of 1 mg/L in the values of CRP expected an average reduction of 0.072 mg/dL of HDL, the 0.083 mg/dL of LDL, the 0.002 g/dL albumin and an average increase of 0.564 mg/dL of TG. Conclusions: Patients with an inflammatory process exhibit changes in the serum levels of the lipids HDL, LDL and TG that are related to the degree of inflammation. These changes occurred regardless of nutritional status.
conferenceObject Ventilatory Practices And Adjunctive Therapies In Children With Ards: A Prospective Observational Study(2014) BARREIRA, E. R.; SHIEH, H. H.; SUZUKI, A. S.; DEGASPARE, N. V.; CAVALHEIRO, P. O.; MUNOZ, G. O. C.; MARTINES, J. A. D. S.; LANE, C.; CARVALHO, W. B.; GILIO, A. E.; PRECIOSO, A. R.- Epidemiology and Outcomes of Acute Respiratory Distress Syndrome in Children According to the Berlin Definition: A Multicenter Prospective Study(2015) BARREIRA, Eliane R.; MUNOZ, Gabriela O. C.; CAVALHEIRO, Priscilla O.; SUZUKI, Adriana S.; DEGASPARE, Natalia V.; SHIEH, Huei H.; MARTINES, Joao A. D. S.; FERREIRA, Juliana C.; LANE, Christianne; CARVALHO, Werther B.; GILIO, Alfredo E.; PRECIOSO, Alexander R.Objectives: In 2012, a new acute respiratory distress syndrome definition was proposed for adult patients. It was later validated for infants and toddlers. Our objective was to evaluate the prevalence, outcomes, and risk factors associated with acute respiratory distress syndrome in children up to 15 years according to the Berlin definition. Design: A prospective, multicenter observational study from March to September 2013. Setting: Seventy-seven PICU beds in eight centers: two private hospitals and six public academic hospitals in Brazil. Patients: All children aged 1 month to 15 years admitted to the participating PICUs in the study period. Interventions: None. Measurements and Main Results: All children admitted to the PICUs were daily evaluated for the presence of acute respiratory distress syndrome according to the American-European - Consensus Conference and Berlin definitions. Of the 562 patients included, acute respiratory distress syndrome developed in 57 patients (10%) and 58 patients (10.3%) according to the Berlin definition and the American-European Consensus Conference definition, respectively. Among patients with acute respiratory distress syndrome according to the Berlin definition, nine patients (16%) were mild, 21 (37%) were moderate, and 27 (47%) were severe. Compared with patients without acute respiratory distress syndrome, patients with acute respiratory distress syndrome had significantly higher severity scores, longer PICU and hospital length of stay, longer duration of mechanical ventilation, and higher mortality (p < 0.001). The presence of two or more comorbidities and admission for medical reasons were associated with development of acute respiratory distress syndrome. Comparisons across the three the Berlin categories showed significant differences in the number of ventilator-free days (21, 20, and 5 d, p = 0.001) and mortality for severe acute respiratory distress syndrome (41%) in comparison with mild (0) and moderate (15%) acute respiratory distress syndrome(p = 0.02). No differences in PICU or hospital stay were observed across the groups. Conclusions: The Berlin definition can identify a subgroup of patients with distinctly worse outcomes, as shown by the increased mortality and reduced number of ventilator-free days in pediatric patients with severe acute respiratory distress syndrome.
- Aerosolized Intranasal Midazolam for Safe and Effective Sedation for Quality Computed Tomography Imaging in Infants and Children(2013) MEKITARIAN FILHO, Eduardo; CARVALHO, Werther Brunow de; GILIO, Alfredo Elias; ROBINSON, Fay; MASON, Keira P.This pilot study introduces the aerosolized route for midazolam as an option for infant and pediatric sedation for computed tomography imaging. This technique produced predictable and effective sedation for quality computed tomography imaging studies with minimal artifact and no significant adverse events.
- Intranasal Dexmedetomidine for Sedation for Pediatric Computed Tomography Imaging(2015) MEKITARIAN FILHO, Eduardo; ROBINSON, Fay; CARVALHO, Werther Brunow de; GILIO, Alfredo Elias; MASON, Keira P.This prospective observational pilot study evaluated the aerosolized intranasal route for dexmedetomidine as a safe, effective, and efficient option for infant and pediatric sedation for computed tomography imaging. The mean time to sedation was 13.4 minutes, with excellent image quality, no failed sedations, or significant adverse events.
conferenceObject Epidemiology And Outcomes Of Ards In Critically Ill Children According To The Berlin Definition: A Prospective Study(2014) BARREIRA, E. R.; SHIEH, H. H.; SUZUKI, A. S.; MUNOZ, G. O. C.; DEGASPARE, N. V.; CAVALHEIRO, P. O.; MARTINES, J. A. D. S.; LANE, C.; GILIO, A. E.; CARVALHO, W. B.; PRECIOSO, A. R.- Update on the diagnosis and management of COVID-19 in pediatric patients(2020) CARLOTTI, Ana Paula de Carvalho Panzeri; CARVALHO, Werther Brunow de; JOHNSTON, Cintia; GILIO, Alfredo Elias; MARQUES, Heloisa Helena de Sousa; FERRANTI, Juliana Ferreira; RODRIGUEZ, Isadora Souza; DELGADO, Artur FigueiredoCoronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), became a pandemic in March 2020, affecting millions of people worldwide. However, COVID-19 in pediatric patients represents 1-5% of all cases, and the risk for developing severe disease and critical illness is much lower in children with COVID-19 than in adults. Multisystem inflammatory syndrome in children (MIS-C), a possible complication of COVID-19, has been described as a hyperinflammatory condition with multiorgan involvement similar to that in Kawasaki disease or toxic shock syndrome in children with evidence of SARS-CoV-2 infection. This review presents an update on the diagnostic methods for COVID-19, including reverse-transcriptase polymerase chain reaction (RT-PCR) tests, serology tests, and imaging, and summarizes the current recommendations for the management of the disease. Particular emphasis is placed on respiratory support, which includes noninvasive ventilation and invasive mechanical ventilation strategies according to lung compliance and pattern of lung injury. Pharmacological treatment, including pathogen-targeted drugs and host-directed therapies, has been addressed. The diagnostic criteria and management of MIS-C are also summarized.