ALFREDO ELIAS GILIO
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Pediatria, Faculdade de Medicina - Docente
PAINT-62, Hospital Universitário
PAINT-62, Hospital Universitário
6 resultados
Resultados de Busca
Agora exibindo 1 - 6 de 6
- THE BACTERIAL MENINGITIS SCORE TO DISTINGUISH BACTERIAL FROM ASEPTIC MENINGITIS IN CHILDREN FROM SAO PAULO, BRAZIL(2013) MEKITARIAN FILHO, Eduardo; HORITA, Sergio Massaru; GILIO, Alfredo Elias; ALVES, Anna Claudia Dominguez; NIGROVIC, Lise E.In a retrospective cohort of 494 children with meningitis in Sao Paulo, Brazil, the Bacterial Meningitis Score identified all the children with bacterial meningitis (sensitivity 100%, 95% confidence interval: 92-100% and negative predictive value 100%, 95% confidence interval: 98-100%). Addition of cerebrospinal fluid lactate to the score did not improve clinical prediction rule performance.
conferenceObject Ventilatory Practices And Adjunctive Therapies In Children With Ards: A Prospective Observational Study(2014) BARREIRA, E. R.; SHIEH, H. H.; SUZUKI, A. S.; DEGASPARE, N. V.; CAVALHEIRO, P. O.; MUNOZ, G. O. C.; MARTINES, J. A. D. S.; LANE, C.; CARVALHO, W. B.; GILIO, A. E.; PRECIOSO, A. R.- Epidemiology and Outcomes of Acute Respiratory Distress Syndrome in Children According to the Berlin Definition: A Multicenter Prospective Study(2015) BARREIRA, Eliane R.; MUNOZ, Gabriela O. C.; CAVALHEIRO, Priscilla O.; SUZUKI, Adriana S.; DEGASPARE, Natalia V.; SHIEH, Huei H.; MARTINES, Joao A. D. S.; FERREIRA, Juliana C.; LANE, Christianne; CARVALHO, Werther B.; GILIO, Alfredo E.; PRECIOSO, Alexander R.Objectives: In 2012, a new acute respiratory distress syndrome definition was proposed for adult patients. It was later validated for infants and toddlers. Our objective was to evaluate the prevalence, outcomes, and risk factors associated with acute respiratory distress syndrome in children up to 15 years according to the Berlin definition. Design: A prospective, multicenter observational study from March to September 2013. Setting: Seventy-seven PICU beds in eight centers: two private hospitals and six public academic hospitals in Brazil. Patients: All children aged 1 month to 15 years admitted to the participating PICUs in the study period. Interventions: None. Measurements and Main Results: All children admitted to the PICUs were daily evaluated for the presence of acute respiratory distress syndrome according to the American-European - Consensus Conference and Berlin definitions. Of the 562 patients included, acute respiratory distress syndrome developed in 57 patients (10%) and 58 patients (10.3%) according to the Berlin definition and the American-European Consensus Conference definition, respectively. Among patients with acute respiratory distress syndrome according to the Berlin definition, nine patients (16%) were mild, 21 (37%) were moderate, and 27 (47%) were severe. Compared with patients without acute respiratory distress syndrome, patients with acute respiratory distress syndrome had significantly higher severity scores, longer PICU and hospital length of stay, longer duration of mechanical ventilation, and higher mortality (p < 0.001). The presence of two or more comorbidities and admission for medical reasons were associated with development of acute respiratory distress syndrome. Comparisons across the three the Berlin categories showed significant differences in the number of ventilator-free days (21, 20, and 5 d, p = 0.001) and mortality for severe acute respiratory distress syndrome (41%) in comparison with mild (0) and moderate (15%) acute respiratory distress syndrome(p = 0.02). No differences in PICU or hospital stay were observed across the groups. Conclusions: The Berlin definition can identify a subgroup of patients with distinctly worse outcomes, as shown by the increased mortality and reduced number of ventilator-free days in pediatric patients with severe acute respiratory distress syndrome.
- Aerosolized Intranasal Midazolam for Safe and Effective Sedation for Quality Computed Tomography Imaging in Infants and Children(2013) MEKITARIAN FILHO, Eduardo; CARVALHO, Werther Brunow de; GILIO, Alfredo Elias; ROBINSON, Fay; MASON, Keira P.This pilot study introduces the aerosolized route for midazolam as an option for infant and pediatric sedation for computed tomography imaging. This technique produced predictable and effective sedation for quality computed tomography imaging studies with minimal artifact and no significant adverse events.
- Intranasal Dexmedetomidine for Sedation for Pediatric Computed Tomography Imaging(2015) MEKITARIAN FILHO, Eduardo; ROBINSON, Fay; CARVALHO, Werther Brunow de; GILIO, Alfredo Elias; MASON, Keira P.This prospective observational pilot study evaluated the aerosolized intranasal route for dexmedetomidine as a safe, effective, and efficient option for infant and pediatric sedation for computed tomography imaging. The mean time to sedation was 13.4 minutes, with excellent image quality, no failed sedations, or significant adverse events.
conferenceObject Epidemiology And Outcomes Of Ards In Critically Ill Children According To The Berlin Definition: A Prospective Study(2014) BARREIRA, E. R.; SHIEH, H. H.; SUZUKI, A. S.; MUNOZ, G. O. C.; DEGASPARE, N. V.; CAVALHEIRO, P. O.; MARTINES, J. A. D. S.; LANE, C.; GILIO, A. E.; CARVALHO, W. B.; PRECIOSO, A. R.