ALFREDO ELIAS GILIO
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Pediatria, Faculdade de Medicina - Docente
PAINT-62, Hospital Universitário
PAINT-62, Hospital Universitário
18 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 18
conferenceObject AGE AND GENDER DIFFERENCES IN THE ETIOLOGY OF COMMUNITY-ACQUIRED URINARY TRACT INFECTIONS(2016) LO, D.; GARCIA, D.; GUIDA, S.; BALABAKIS, A.; GILIO, A.- Number Needed to Treat in Fluconazole Prophylaxis in the Neonatal Intensive Care Unit(2011) SHIEH, Huei Hsin; IBIDI, Silvia Maria; GILIO, Alfredo Elias
- Risk factors for neurological complications and sequelae in childhood acute bacterial meningitis(2012) SHIEH, Huei H.; RAGAZZI, Selma L. B.; GILIO, Alfredo E.
conferenceObject ANTIMICROBIAL SUSCEPTIBILITY OF 784 ESCHERICHIA COLI ISOLATES FROM COMMUNITY-ACQUIRED URINARY TRACT INFECTION IN BRAZIL(2016) LO, D.; SANTOS, V.; SANTOS, S.; MACHADO, J.; GILIO, A.- THE BACTERIAL MENINGITIS SCORE TO DISTINGUISH BACTERIAL FROM ASEPTIC MENINGITIS IN CHILDREN FROM SAO PAULO, BRAZIL(2013) MEKITARIAN FILHO, Eduardo; HORITA, Sergio Massaru; GILIO, Alfredo Elias; ALVES, Anna Claudia Dominguez; NIGROVIC, Lise E.In a retrospective cohort of 494 children with meningitis in Sao Paulo, Brazil, the Bacterial Meningitis Score identified all the children with bacterial meningitis (sensitivity 100%, 95% confidence interval: 92-100% and negative predictive value 100%, 95% confidence interval: 98-100%). Addition of cerebrospinal fluid lactate to the score did not improve clinical prediction rule performance.
- High Frequency of Staphylococcus Saprophyticus Urinary Tract Infections Among Female Adolescents(2015) LO, Denise Swei; SHIEH, Huei Hsin; BARREIRA, Eliane Roseli; RAGAZZI, Selma Lopes Betta; GILIO, Alfredo EliasStaphylococcus saprophyticus is a rarely reported agent of urinary tract infection (UTI) in the pediatric population. In our retrospective 3-year study, S. saprophyticus comprised 24.5% of 106 isolates of UTIs in female adolescents 12-15 years of age who attended an emergency department. Clinicians should be aware of the high prevalence of this etiology when empirically treating UTIs in female adolescents.
- Respiratory viral infections in infants with clinically suspected pertussis(2013) FERRONATO, Angela E.; GILIO, Alfredo E.; VIEIRA, Sandra E.Objective: to evaluate the frequency of respiratory viral infections in hospitalized infants with clinical suspicion of pertussis, and to analyze their characteristics at hospital admission and clinical outcomes. Methods: a historical cohort study was performed in a reference service for pertussis, in which the research of respiratory viruses was also a routine for infants hospitalized with respiratory problems. All infants reported as suspected cases of pertussis were included. Tests for Bordetella pertussis (BP) (polymerase chain reaction/culture) and for respiratory viruses (RVs) (immunofluorescence) were performed. Patients who received macrolides before hospitalization were excluded. Clinical data were obtained from medical records. Results: among the 67 patients studied, BP tests were positive in 44%, and 26% were positive for RV. There was no etiological identification in 35%, and RV combined with BP was identified in 5%. All patients had similar demographic characteristics. Cough followed by inspiratory stridor or cyanosis was a strong predictor of pertussis, as well as prominent leukocytosis and lymphocytosis. Rhinorrhea and dyspnea were more frequent in viral infections. Macrolides were discontinued in 40% of patients who tested positive for RV and negative for BP. Conclusion: the results suggest that viral infection can be present in hospitalized infants with clinical suspicion of pertussis, and etiological tests may enable a reduction in the use of macrolides in some cases. However, the etiological diagnosis of respiratory virus infection, by itself, does not exclude the possibility of infection with BP.
- Multisystem Inflammatory Syndrome Associated With COVID-19 With Neurologic Manifestations in a Child: A Brief Report(2020) PAULIS, Milena De; OLIVEIRA, Danielle Bruna Leal; VIEIRA, Rodolfo P.; PINTO, Isabella Coutinho; MACHADO, Rafael Rahal Guaragna; CAVALCANTI, Mariana Pauferro; SOARES, Camila Pereira; ARAUJO, Ananda Medeiros Pereira de; ARAUJO, Danielle Bastos; BACHI, Andre Luis Lacerda; LEAL, Fabyano Bruno; DORLASS, Erick Gustavo; GILIO, Alfredo Elias; DURIGON, Edison Luiz; BARREIRA, Eliane RoseliAlthough first considered a benign infection, recent studies have disclosed severe and potentially lethal inflammatory manifestations of COVID-19 in children. We report the case of a 4-year-old child with a post-infectious multisystem inflammatory syndrome associated with COVID-19, with a Kawasaki-like shock and prominent neurologic features, for whom a cytokine storm and reduced brain-derived neurotrophic factor were well documented.
- Impacto do uso da prova rápida para estreptococo beta-hemolítico do grupo A no diagnóstico e tratamento da faringotonsilite aguda em pronto-socorro de Pediatria(2013) CARDOSO, Débora Morais; GILIO, Alfredo Elias; HSIN, Shieh Huei; MACHADO, Beatriz Marcondes; PAULIS, Milena De; LOTUFO, João Paulo B.; MARTINEZ, Marina Baquerizo; GRISI, Sandra Josefina E.OBJECTIVE: To evaluate the impact of the routine use of rapid antigen detection test in the diagnosis and treatment of acute pharyngotonsillitis in children. METHODS: This is a prospective and observational study, with a protocol compliance design established at the Emergency Unit of the University Hospital of Universidade de São Paulo for the care of children and adolescents diagnosed with acute pharyngitis. RESULTS: 650 children and adolescents were enrolled. Based on clinical findings, antibiotics would be prescribed for 389 patients (59.8%); using the rapid antigen detection test, they were prescribed for 286 patients (44.0%). Among the 261 children who would not have received antibiotics based on the clinical evaluation, 111 (42.5%) had positive rapid antigen detection test. The diagnosis based only on clinical evaluation showed 61.1% sensitivity, 47.7% specificity, 44.9% positive predictive value, and 57.5% negative predictive value. CONCLUSIONS: The clinical diagnosis of streptococcal pharyngotonsillitis had low sensitivity and specificity. The routine use of rapid antigen detection test led to the reduction of antibiotic use and the identification of a risk group for complications of streptococcal infection, since 42.5% positive rapid antigen detection test patients would not have received antibiotics based only on clinical diagnosis.
- Analysis of invasive pneumonia-causing strains of Streptococcus pneumoniae: serotypes and antimicrobial susceptibility(2011) YOSHIOKA, Cristina R. M.; MARTINEZ, Marina B.; BRANDILEONE, Maria C. C.; RAGAZZI, Selma B.; GUERRA, Maria L. L. S.; SANTOS, Silvia R.; SHIEH, Huei H.; GILIO, Alfredo E.Objectives: To identify the most common pneumococcal serotypes in children hospitalized with invasive pneumonia, correlate isolated serotypes with those included in conjugate vaccines, and ascertain the sensitivity of the isolated pneumococcal strains to penicillin and other antibiotics. Methods: From January 2003 to October 2008, a retrospective study of hospitalized children with a diagnosis of Streptococcus pneumoniae pneumonia was conducted at the university hospital of Universidade de Sao Paulo. Criteria for inclusion were: age greater than 29 days and less than 15 years, radiological and clinical diagnosis of pneumonia, and isolation of Streptococcus pneumoniae in blood cultures and/or pleural effusion. Results: The study included 107 children. The most common serotypes were 14 (36.5%), 1 (16%), 5 (14.6%), 6B (6.3%) and 3 (4.2%). The proportion of identified serotypes contained in the heptavalent, 10-valent and 13-valent conjugate vaccines was 53.1, 86.5, and 96.9%, respectively. Pneumococcal strains were sensitive to penicillin (minimum inhibitory concentration, MIC <= 2 mu g/mL) in 100 cases (93.5%) and displayed intermediate resistance (MIC = 4 mu g/mL) in 7 cases (6.5%). No strains were penicillin-resistant (MIC >= 8 mu g/mL) according to the Clinical and Laboratory Standards Institute 2008 standards. Tested isolates were highly sensitive to vancomycin, rifampicin, ceftriaxone, clindamycin, erythromycin, and chloramphenicol. Conclusions: Our results confirm a significant potential impact of conjugate vaccines, mainly 10-valent and 13-valent, on invasive pneumonia. Furthermore, susceptibility testing results show that penicillin is still the treatment of choice for invasive pneumonia in our setting.