VANDERSON GERALDO ROCHA

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Departamento de Clínica Médica, Faculdade de Medicina - Docente
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/31 - Laboratório de Genética e Hematologia Molecular, Hospital das Clínicas, Faculdade de Medicina - Líder

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Autor: GLUCKMAN, Eliane ×

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Agora exibindo 1 - 10 de 41
  • conferenceObject
    Impact of Refined Disease Risk Index after Single and Double Umbilical Cord Blood Transplantation in Adults with Hematological Malignancies
    (2016) PAVIGLIANITI, Annalisa; RUGGERI, Annalisa; SANZ, Guillermo; MILPIED, Noel; BLAISE, Didier; ESQUIROL, Albert; ARCESE, William; FERRA, Christelle; IFRAH, Norbert; BOURIS, Jean Henri; RAJ, Kavita; VEELKEN, Joan Hendrik; SICA, Simona; CONTENTIN, Nathalie; BLOOR, Adrian; VOLT, Fernanda; KENZEY, Chantal; ROCHA, Vanderson; GLUCKMAN, Eliane
  • conferenceObject
    Impact of Covid-19 Pandemic on Release of French Cord Blood Units. on Behalf The Agency of Biomedicine, Eurocord And The SFGM-TC
    (2021) AYOUBI, Hanadi Rafii-El; IONESCU, Irina; RUGGERI, Annalisa; GARNIER, Federico; BALLOT, Caroline; BENSOUSSAN, Daniele; CHABANNON, Christian; DAZEY, Bernard; VOS, John De; GAUTIER, Eric; GIRAUD, Christine; LARGHERO, Jerome; CRAS, Audrey; MIALOU, Valerie; PERSOONS, Virginie; POUTHIER, Fabienne; THIBERT, Jean-Baptiste; DALLE, Jean-Hugues; MICHEL, Gerard; VOLT, Fernanda; KENZEY, Chantal; ROCHA, Vanderson; BAY, Jacques-Olivier; RUBIO, Marie-Therese; FAUCHER, Catherine; MARRY, Evelyne; GLUCKMAN, Eliane
  • conferenceObject
    A Polymorphism in Toll-like Receptor 2 Gene Is Associated with Occurrence of Bacterial Infections in Sickle Cell Disease Patients
    (2018) TOZATTO-MAIO, Karina; GIROT, Robert; LY, Indou Deme; ROCHA, Vanderson; PINTO, Ana Cristina Silva; DIAGNE, Ibrahima; BENZERARA, Yahia; DINARDO, Carla Luana; KASHIMA, Simone; ARAUJO, Itaua Leston; KENZEY, Chantal; FONSECA, Guilherme Henrique Hencklain; RODRIGUES, Evandra; VOLT, Fernanda; JARDULI, Luciana Ribeiro; RUGGERI, Annalisa; MARIASELVAM, Christina Mary; GUALANDRO, Sandra Fatima Menosi; ELAYOUBI, Hanadi; CUNHA, Renato; CAPPELLI, Barbara; SIMOES, Belinda Pinto; GLUCKMAN, Eliane; TAMOUZA, Ryad
  • article 4 Citação(ões) na Scopus
    A Toll-like receptor 2 genetic variant modulates occurrence of bacterial infections in patients with sickle cell disease
    (2019) TOZATTO-MAIO, Karina; GIROT, Robert; LY, Indou D.; ROCHA, Vanderson; PINTO, Ana C. Silva; DIAGNE, Ibrahima; BENZERARA, Yahia; DINARDO, Carla L.; KASHIMA, Simone; LESTON-ARAUJO, Itaua; KENZEY, Chantal; FONSECA, Guilherme H. H.; RODRIGUES, Evandra S.; VOLT, Fernanda; JARDULI, Luciana R.; RUGGERI, Annalisa; MARIASELVAM, Christina M.; GUALANDRO, Sandra F. M.; ELAYOUBI, Hanadi; CUNHA, Renato; CAPPELLI, Barbara; MALMEGRIM, Kelen C. R.; SIMOES, Belinda P.; GLUCKMAN, Eliane; TAMOUZA, Ryad
    Despite adequate immunization and penicillin prophylaxis, bacterial infections remain a leading cause of morbidity and mortality in patients with sickle cell disease (SCD). Besides hyposplenism, inflammatory and genetic factors might modulate their susceptibility to bacterial infections. We performed a candidate gene association of single nucleotide polymorphisms (SNPs) located in Toll-like receptor (TLR) genes, encoding prominent molecules for innate immune responses, with the occurrence of bacterial infections in patients with SCD. A cohort followed in centres in Brazil, France and Senegal (n=430) was divided in two groups: patients who presented at least one episode of bacterial infection (n=235) and patients who never had bacterial infections (n=195). There were no differences in gender or age distribution among the groups. The frequency of the TLR2 rs4696480 TA genotype was significantly lower in the infected group (50% vs. 67%, odds ratio [OR]=050, 95% confidence interval [CI] 034-075, P<0001), and the TT genotype was significantly higher in the infected group (15% vs. 5%, OR=318, 95% CI 153-661, P<0001). Previous reports demonstrated higher secretion of inflammatory factors in cells from AA individuals, lower occurrence and severity of immune diseases in T carriers. The rs4696480 TA genotype might stand between deleterious effects of over inflammatory response (AA genotype) and inefficient responses (TT genotype) to infectious agents in SCD settings.
  • article 1 Citação(ões) na Scopus
    Use of letermovir in umbilical cord blood transplantation based on risk scores
    (2023) FRANCO, Monica M. Rivera; RAFII, Hanadi; VOLT, Fernanda; KENZEY, Chantal; CAPPELLI, Barbara; SCIGLIUOLO, Graziana Maria; ROCHA, Vanderson; RAUS, Nicole; DALLE, Jean-Hugues; CHEVALLIER, Patrice; ROBIN, Marie; RUBIO, Marie Therese; RUGGERI, Annalisa; GLUCKMAN, Eliane
  • article 5 Citação(ões) na Scopus
    HLA-Matched Unrelated Donors for Patients with Sickle Cell Disease: Results of International Donor Searches
    (2020) TOZATTO-MAIO, Karina; TORRES, Margareth Afonso; DEGAIDE, Neifi Hassan Saloum; CARDOSO, Juliana Fernandes; VOLT, Fernanda; PINTO, Ana Cristina Silva; OLIVEIRA, Danielli; ELAYOUBI, Hanadi; KASHIMA, Simone; LOISEAU, Pascale; VEELKEN, Hendrik; FERSTER, Alina; CAPPELLI, Barbara; RODRIGUES, Evandra Strazza; SCIGLIUOLO, Graziana Maria; KENZEY, Chantal; RUGGERI, Annalisa; ROCHA, Vanderson; SIMOES, Belinda Pinto; TAMOUZA, Ryad; GLUCKMAN, Eliane
    Sickle cell disease (SCD) is the most common inherited hemoglobinopathy. Hematopoietic stem cell transplantation (HCT) is the sole curative therapy for SCD, but few patients will have a matched sibling donor. Patients with SCD are mostly of African origin and thus are less likely to find a matched unrelated donor in international registries. Using HaploStats, we estimated HLA haplotypes for 185 patients with SCD (116 from a Brazilian center and 69 from European Society for Blood and Marrow Transplantation [EBMT] centers) and classified the ethnic origin of haplotypes. Then we assessed the probability of finding an HLA-matched unrelated adult donor (MUD), considering loci A, B, and DRB1 (6/6), in international registries. Most haplotypes were African, but Brazilians showed a greater ethnic admixture than EBMT patients. Nevertheless, the chance of finding at least one 6/6 potential allelic donor was 47% for both groups. Most potential allelic donors were from the US National Marrow Donor Program registry and from the Brazilian REDOME donor registry. Although the probability of finding a donor is higher than previously reported, strategies are needed to improve ethnic diversity in registries. Moreover, predicting the likelihood of having an MUD might influence SCD management. (C) 2020 American Society for Transplantation and Cellular Therapy.
  • article 9 Citação(ões) na Scopus
    Risk factors affecting outcome of unrelated cord blood transplantation for children with familial haemophagocytic lymphohistiocytosis
    (2019) FURTADO-SILVA, Juliana Montibeller; PAVIGLIANILI, Annalisa; RUGGERI, Annalisa; BOELENS, Jaap Jan; VEYS, Paul; AHMARI, Ali Abdallah; ZECCA, Marco; LOCATELLI, Franco; MICHEL, Gerard; VOLT, Fernanda; KENZEY, Chantal; SEDLACEK, Petr; RAO, Kanchan; LANKESTER, Arjan; GLUCKMAN, Eliane; ROCHA, Vanderson
    Allogeneic haematopoietic stem cell transplantation is still the only available curative option for Familial Haemophagocytic Lymphohistiocytosis (FHLH). Most studies report outcomes after bone marrow or peripheral blood stem cell transplantation. We analysed the outcomes of 118 children with FHLH undergoing single-unit umbilical cord blood transplantation performed from 1996 to 2014. Myeloablative conditioning regimen was given to 90% of the patients, and was mostly busulfan-based (n = 81, 76%), including anti-thymocyte globulin or alemtuzumab (n = 102, 86%). The cumulative incidence of Day 60 neutrophil engraftment was 85%; and that of non-relapse mortality and acute graft-versus-host disease (GvHD) was 21% and 33% at 100 days, respectively. The 6-year cumulative incidence of chronic GvHD was 17% and the 6-year probability of overall survival was 55%. In multivariate analysis, children receiving a graft with a total nucleated cell dose greater than 9 center dot 9 x 10(7)/kg had a better overall survival (hazard ratio [HR]: 0 center dot 49, 95% CI: 0 center dot 27-0 center dot 88, P = 0 center dot 02). Degree of human leucocyte antigen (HLA) matching was associated with improved disease-free survival (5/6 vs. 6/6 HR: 2 center dot 11, 95% confidence interval [CI]: 1 center dot 01-4 center dot 4, P = 0 center dot 05 and <= 4/6 vs. 6/6, HR: 2 center dot 82, CI: 1 center dot 27-6 center dot 23, P = 0 center dot 01). Umbilical cord blood transplantation with a high cell dose and good HLA match is a suitable alternative option to haematopoietic stem cell transplantation in children with FHLH who lack a HLA-matched donor.
  • conferenceObject
    Development of a Risk Score for Prediction of Overall Survival Following Umbilical Cord Blood Transplantation in Acute Leukemia Patients: A Study from the Acute Leukemia Working Party (WP) and Paediatric Disease WP of the European Society for Blood and Marrow Transplantation (EBMT), and Eurocord
    (2016) SHOUVAL, Roni; RUGGERI, Annalisa; LABOPIN, Myriam; MOHTY, Mohamad; SANZ, Guillermo; MICHEL, Gerard; PETERSEN, Eefke; CHEVALLIER, Patrice; AL-SERAIHY, Amal; MILPIED, Noel-Jean; RUBIO, Cristina Diaz de Heredia; ARCESE, William; BLAISE, Didier; ROCHA, Vanderson; FEIN, Joshua; UNGER, Ron; BARON, Frederic; BADER, Peter; GLUCKMAN, Eliane; NAGLER, Arnon
  • article 9 Citação(ões) na Scopus
    Evaluation of a disease risk index for adult patients undergoing umbilical cord blood transplantation for haematological malignancies
    (2017) PAVIGLIANITI, Annalisa; RUGGERI, Annalisa; VOLT, Fernanda; SANZ, Guillermo; MILPIED, Noel; FURST, Sabine; ESQUIROL, Albert; ARCESE, William; PICARDI, Alessandra; FERRA, Christelle; IFRAH, Norbert; BOURHIS, Jean H.; RAJ, Kavita; BORNE, Peter A. von dem; SICA, Simona; MENARD, Anne-lise; BLOOR, Adrian; KENZEY, Chantal; GLUCKMAN, Eliane; ROCHA, Vanderson
    A disease risk index (DRI) has been defined for stratifying heterogeneous cohorts of patients undergoing allogeneic haematopoietic stem cell transplantation (HSCT). This index defines 4 distinct groups with different outcomes, dividing patients by disease type and status and considering cytogenetics for acute myeloid leukaemia and myelodysplastic syndromes (MDS). Recently, the DRI has been refined to include rare diseases and improve MDS stratification by blast percentage and response to prior therapy. Previous reports on DRI include only a small number of UCBT recipients. The current study aims to determine the applicability of the DRI for patients undergoing unrelated cord blood transplantation (UCBT). We retrospectively analysed 2530 adults receiving UCBT between 2004 and 2014. Diagnosis was acute leukaemia (AL) in 66% of the cases. Overall survival (OS) at 2 years was 56 +/- 3% for patients with low DRI (n = 352), 46 +/- 1% for intermediate DRI (n = 1403), 28 +/- 2% for high (n = 489) and 20 +/- 4% for very high DRI (n = 109) (P < 0.001). In the multivariate model, DRI remained an independent risk factor for OS. Similar findings were observed for PFS and DRI. Our results show the applicability of DRI for stratifying UCBT recipients and confirm the prognostic value of this simple and robust tool in this setting.
  • article 45 Citação(ões) na Scopus
    Risk factors and outcomes according to age at transplantation with an HLA-identical sibling for sickle cell disease
    (2019) CAPPELLI, Barbara; VOLT, Fernanda; TOZATTO-MAIO, Karina; SCIGLIUOLO, Graziana Maria; FERSTER, Alina; DUPONT, Sophie; SIMOES, Belinda Pinto; AL-SERAIHY, Amal; ALJURF, Mahmoud D.; ALMOHAREB, Fahad; BELENDEZ, Cristina; MATTHES, Susanne; DHEDIN, Nathalie; PONDARRE, Corinne; DALLE, Jean-Hugues; BERTRAND, Yves; VANNIER, Jean Pierre; KUENTZ, Mathieu; LUTZ, Patrick; MICHEL, Gerard; RAFII, Hanadi; NEVEN, Benedicte; ZECCA, Marco; BADER, Peter; CAVAZZANA, Marina; LABOPIN, Myriam; LOCATELLI, Franco; MAGNANI, Alessandra; RUGGERI, Annalisa; ROCHA, Vanderson; BERNAUDIN, Francoise; FUENTE, Josu de la; CORBACIOGLU, Selim; GLUCKMAN, Eliane