VANDERSON GERALDO ROCHA
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Clínica Médica, Faculdade de Medicina - Docente
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/31 - Laboratório de Genética e Hematologia Molecular, Hospital das Clínicas, Faculdade de Medicina - Líder
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/31 - Laboratório de Genética e Hematologia Molecular, Hospital das Clínicas, Faculdade de Medicina - Líder
19 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 19
- The impact of low dose busulfan on gonodal function after allogeneic hematopoietic stem cell transplantation for aplastic anemia(2020) KERBAUY, Mariana Nassif; MARIANO, Livia; SEBER, Adriana; ROCHA, Vanderson
conferenceObject Donor-Recipient HLA Matching for Unrelated Donor Hematopoietic Stem Cell Transplantation Outcomes: A Study from the Cellular Therapy and Immunobiology Working Party (CTIWP) of the EBMT(2020) RUGGERI, Annalisa; MUELLER, Carlheninz; MAUFF, Katya; WREEDE, Lisbeth de; WIETEN, Lotte; VAGO, Luca; HOOGENBOOM, Jorinde; SOCIE, Gerard; NIITTYVUOPIO, Riitta; YAKOUBAGHA, Ibrahim; CRAWLEY, Charles; THOLOULI, Eleni; BULABOIS, Claude Eric; CHOI, Goda; FORCADE, Edouard; HUYNH, Anne; LENHOFF, Stig; GANDEMER, Virginie; CICERI, Fabio; KROEGER, Nicolaus; MAILLARD, Natacha; ITALA-REMES, Maija; ROCHA, Vanderson; BONINI, Chiara; CHABANNON, Christian; FLEISCHHAUER, KatharinaconferenceObject Impact of Covid-19 Pandemic on Release of French Cord Blood Units. on Behalf The Agency of Biomedicine, Eurocord And The SFGM-TC(2021) AYOUBI, Hanadi Rafii-El; IONESCU, Irina; RUGGERI, Annalisa; GARNIER, Federico; BALLOT, Caroline; BENSOUSSAN, Daniele; CHABANNON, Christian; DAZEY, Bernard; VOS, John De; GAUTIER, Eric; GIRAUD, Christine; LARGHERO, Jerome; CRAS, Audrey; MIALOU, Valerie; PERSOONS, Virginie; POUTHIER, Fabienne; THIBERT, Jean-Baptiste; DALLE, Jean-Hugues; MICHEL, Gerard; VOLT, Fernanda; KENZEY, Chantal; ROCHA, Vanderson; BAY, Jacques-Olivier; RUBIO, Marie-Therese; FAUCHER, Catherine; MARRY, Evelyne; GLUCKMAN, ElianeconferenceObject Influence of The SARS-COV-2 Pandemic on Bone Marrow Transplantation Centers And The Protocols Adopted In Brazil Between May And June 2020(2021) DUARTE, Fernando; SOUSA, Talyta Ellen Jesus Santos; HALLACK NETO, Abrahao Elias; SEBER, Adriana; VIGORITO, Afonso Celso; LOURENCO, Andre Luis Gervatoski; MELO, Andresa Lima; DUARTE, Beatrice Araujo; ARAUJO, Beatriz Stela Gomes Souza Pitombeira; BONFIM, Carmem; ARRAIS, Celso; BARIAN, Cesar; KUWAHARA, Cilmara; LERNER, Decio; PATON, Eduardo Jose de Alencar; VIEIRA, Garles Miller Matias; BARROS, George Mauricio Navarro; LOTH, Gisele; TEIXEIRA, Gustavo Machado; SCHMIDT FILHO, Jayr; FELICIANO, Joao Victor Piccolo; FOGLIATTO, Laura Maria; GRILO, Leandro Celso; MARTINS, Leticia Navarro Gordan Ferreira; DAUDT, Liane Esteves; BOUZAS, Luis Fernando da Silva; MONCAO, Marcio Soares; SALVINO, Marco Aurelio; MOREIRA, Maria Claudia; MACEDO, Maria Cristina M. Almeida; COUTINHO, Marina Assirati; HAMERSCHLAK, Nelson; CHIATTONE, Ricardo; SILVA, Roberto Luiz da; SOARES, Rodolfo; SCHAFFEL, Rony; PASSOS, Roselene Mesquita Augusto; VIANA, Thaisa Marjore Menezes; MONTEIRO, Tatiana Dias Marconi; FUNKE, Vaneuza Araujo Moreira; COLTURATO, Vergilio Antonio Rensi; ZECCHIN, Victor Gottardello; AZEVEDO, Wellington Morais de; NOVIS, Yana Augusta S.; SILVA, Leandro de Padua; ZANETTE, Antonella; CUNHA, Renato Luiz Guerino; FAGUNDES, Evandro Maranhao; ATALLA, Angelo; ROCHA, Vanderson- Colistin-resistant Klebsiella pneumoniae co-harboring KPC and MCR-1 in a Hematopoietic Stem Cell Transplantation Unit(2019) HIGASHINO, Hermes Ryoiti; MARCHI, Ana Paula; MARTINS, Roberta Cristina Ruedas; BATISTA, Marjorie Vieira; PERDIGAO NETO, Lauro Vieira; LIMA, Victor Augusto Camarinha de Castro; ROSSI, Flavia; GUIMARAES, Thais; LEVIN, Anna Sara; ROCHA, Vanderson; COSTA, Silvia Figueiredo
conferenceObject Secondary neoplasms after umbilical cord blood transplantation. On behalf of eurocord and the european group for blood and marrow transplantation(2022) AYOUBI, H. Rafii El; RUGGERI, A.; KENZEY, C.; SANZ, J.; TOUR, R. Peffault De La; SIERRA, J.; MICHEL, G.; CHEVALLIER, P.; RUBIO, M. T.; CORNELISSEN, J.; MICHALLET, M.; VOLT, F.; SCIGLIUOLO, G. M.; CAPPELLI, B.; ROCHA, V.; GLUCKMAN, E.- Steroid-refractory chronic graft-versus-host disease: treatment options and patient management(2021) WOLFF, Daniel; FATOBENE, Giancarlo; ROCHA, Vanderson; KROEGER, Nicolaus; FLOWERS, Mary E.Chronic graft-versus-host disease (cGVHD) is one of the major causes of late mortality after allogenic hematopoietic stem cell transplantation. Moderate-to-severe cGVHD is associated with poor health-related quality of life and substantial disease burden. While corticosteroids with or without calcineurin inhibitors comprise the first-line treatment option, the prognosis for patients with steroid-refractory cGVHD (SR-cGVHD) remains poor. The mechanisms underlying steroid resistance are unclear, and there are no standard second-line treatment guidelines for patients with SR-cGVHD. In this review, we provide an overview on current treatment options of cGVHD and use a series of theoretical case studies to elucidate the rationale of choices of second- and third-line treatment options for patients with SR-cGVHD based on individual patient profiles.
- Telehealth in hematopoietic cell transplantation: perspective from patients at a public hospital in Brazil(2022) CORDEIRO, Ana; FATOBENE, Giancarlo; MARIANO, Livia; ROCHA, Vanderson
- COVID-19 in HSCT recipients: a collaborative study of the Brazilian Society of Marrow Transplantation (SBTMO)(2022) DAUDT, Liane Esteves; CORSO, Mariana Cristina Moraes; KERBAUY, Mariana Nassif; ASSIS, Luiz Henrique dos Santos de; RECHENMACHER, Ciliana; COLTURATO, Iago; BARBIERI, Fernanda Rodrigues; ROCHA, Vanderson; MARIANO, Livia; GARCIA, Julia Lopes; DANTAS, Vanessa Esther Cavalcanti Barreto; LOTH, Gisele; FUNKE, Vaneuza Araujo Moreira; PELEGRINA, Polliany Roberta Dorini; DUARTE, Fernando Barroso; SILVA, Roberto Luiz da; ARAUJO, Marco Aurelio Salvino; CARLESSE, Fabianne Altruda de Moraes Costa; SOUSA, Ana Virginia Lopes de; MAIA, Luana Azevedo; FERNANDES, Juliana Folloni; RODRIGUES, Celso Arrais; BONFIM, Carmem; MARTINS, Leticia Navarro Gordan Ferreira; CIPOLOTTI, Rosana; XAVIER, Erick Menezes; GOMES, Alessandra Araujo; MORALES, Hugo Manuel Paz; SIMIONI, Anderson J.; SOARES, Victor Jablonski; MICHALOWSKI, Mariana Bohns; HAMERSCHLAK, Nelson; MACHADO, Clarisse MartinsIn the COVID-19 scenario, patients undergoing hematopoietic stem cell transplantation (HSCT) infected with SARS-CoV-2 may have an increased risk of death. Through a national multicenter study, we aimed to describe the impact of COVID-19 on the survival of HSCT recipients in Brazil. Eighty-six patients with a confirmed diagnosis of SARS-CoV-2 (92% by RT-PCR) were included. There were 24 children and 62 adults receiving an autologous (n = 25) and allogeneic (n = 61) HSCT for malignant (n = 72) and non-malignant (n = 14) disorders. Twenty-six patients died, (10 on autologous (38%) and 16 patients (62%) on allogeneic group). The estimated overall survival (OS) at day 40 was 69%. Adults had decreased OS compared to children (66% vs 79%, p = 0.03). The severity of symptoms at the time of diagnosis, ECOG score, laboratory tests (C-reactive protein, urea values) were higher in patients who died (p < 0.05). In conclusion, HSCT recipients infected with SARS-CoV-2 have a high mortality rate mainly in adults and patients with critical initial COVID-19 presentation. These findings show the fragility of HSCT recipients with SARS-CoV-2 infection. Therefore, the importance of adherence to preventive measures is evident, in addition to prioritizing the vaccination of family members and the HSCT team.
- Impact of mother donor, peripheral blood stem cells and measurable residual disease on outcomes after haploidentical hematopoietic cell transplantation with post-transplant cyclophosphamide in children with acute leukaemia(2021) ROCHA, V; ARCURI, L. J.; SEBER, A.; COLTURATO, V; ZECCHIN, V. G.; KUWAHARA, C.; NICHELE, S.; GOUVEIA, R.; FERNANDES, J. F.; V, A. Macedo; TAVARES, R.; DAUDT, L.; SOUZA, M. P. De; DARRIGO-JR, L. G.; VILLELA, N. C.; MARIANO, L. C. B.; GINANI, V. C.; ZANETTE, A.; LOTH, G.; GOMES, A. A.; HAMERSCHLAK, N.; FLOWERS, M. E.; BONFIM, C.Haploidentical hematopoietic-cell transplantation using post-transplant cyclophosphamide(Haplo-PTCy) is a feasible procedure in children with haematologic malignancies. However, data of a large series of children with acute leukaemia(AL) in this setting is missing. We analysed 144 AL Haplo-PTCy paediatric recipients; median age was 10 years. Patients had acute lymphoblastic(ALL; n = 86) or myeloblastic leukaemia(AML; n = 58) and were transplanted in remission(CR1: n = 40; CR2: n = 57; CR3+: n = 27) or relapse (n = 20). Bone marrow was the graft source in 57%; donors were father (54%), mother (35%), or sibling (11%). Myeloablative conditioning was used in 87%. Median follow-up was 31 months. At day +100, cumulative incidence (CI) of neutrophil recovery and acute GVHD (II-IV) were 94% and 40%, respectively. At 2-years, CI of chronic GVHD and relapse, were 31%, 40%, and estimated 2-year overall survival (OS), leukaemia-free survival (LFS) and graft-versus-host-relapse-free survival (GRFS) were 52%, 44% and 34% respectively. For patients transplanted in remission, positive measurable residual disease (MRD) prior to transplant was associated with decreased LFS (p = 0.05) and GRFS (p = 0.003) and increased risk of relapse (p = 0.02). Mother donor was associated with increased risk of chronic GVHD (p = 0.001), decreased OS (p = 0.03) and GRFS (p = 0.004). Use of PBSC was associated with increased risk of chronic GVHD (p = 0.04). In conclusion, achieving MRD negativity pre-transplant, avoiding use of mother donors and PBSC as graft source may improve outcomes of Haplo-PTCy in children with AL.