LUIS HENRIQUE WOLFF GOWDAK

(Fonte: Lattes)
Índice h a partir de 2011
14
Lattes
ResearcherID
ORCID
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/13 - Laboratório de Genética e Cardiologia Molecular, Hospital das Clínicas, Faculdade de Medicina

Filtros

Limpar filtros

Configurações

Indexador: WoS ×

Resultados de Busca

Agora exibindo 1 - 9 de 9
  • conferenceObject
    Impact of Coronary Atherosclerotic Burden on the Long-Term Prognosis of Patients With Chronic Kidney Disease Undergoing Renal Replacement Therapy
    (2023) GODINHO, Roger; CAMPOS, Carlos; ABIZAID, Alexandre; LIMA, Jose Jayme de; RIBEIRO, Henrique; LOPES, Neuza; MOTA, Gabriel; SANTOS, Luciano; GOWDAK, Luis; KALIL FILHO, Roberto; RIBEIRO, Expedito
  • article 0 Citação(ões) na Scopus
    Peripheral Artery Disease Diagnosed by Pulse Palpation as a Predictor of Coronary Artery Disease in Patients with Chronic Kidney Disease
    (2023) SANTOS, Daniel B. C. Dos; GOWDAK, Luis Henrique W.; DAVID-NETO, Elias; NATANIEL, Felizardo A.; LIMA, Jose J. G. De; BORTOLOTTO, Luiz A.
    There is a need of simple, inexpensive, and reliable noninvasive testing to predict coronary artery disease (CAD) in patients with chronic kidney disease (CKD), where the prevalence of cardiovascular (CV) events and death is elevated. We analyzed the association between peripheral artery disease (PAD) and CAD in 201 patients with stage 5 CKD on dialysis using a prospective observational cohort. Diagnosis of PAD by both palpation and USD were significantly correlated. In patients with PAD diagnosed by palpation, CAD was observed in 80%, while in those diagnosed by USD, CAD was present in 79.1%. The absence of a pulse by palpation predicted CAD with a sensitivity of 55% and a specificity of 76%; USD showed a sensitivity of 62% and specificity of 60% to predict CAD. The risk of combined serious CV events and death was significantly higher in subjects with PAD diagnosed by palpation, but not by USD. PAD assessed by palpation also correlated with the occurrence of multivessel CAD and with the probability of coronary intervention. Both methods are moderately useful for predicting CAD, but PAD diagnosis by palpation was a better predictor of combined CV events and death and was also associated with CAD severity and likelihood of intervention.
  • conferenceObject
    Cardiac rehabilitation in patients with refractory angina: preliminary results
    (2019) DOURADO, L.; ASSUMPCAO, C. R. A. A.; JORDAO, C. P.; VIEIRA, M. L. C.; GOWDAK, L. H. W.; CESAR, L. A. M.; MATOS, L. D. N. J.
  • conferenceObject
    Effectiveness and tolerability of trimetazidine 80mg once daily in patients with chronic coronary syndrome: the V-GOOD observational study
    (2023) GOWDAK, L. Wolff; DOURADO, P.; PRECOMA, D.; DUSILEK, C.; SILVA, F.; YUGAR-TOLEDO, J.; PENA, F.; GOMES, D.; CESTARIO, E.; GUIMARAES JR., O.; HOFFMANN FILHO, C.; ALMEIDA, C.; BRITO, F.; MARTINS, G.; FERREIRA, V.
  • article 2 Citação(ões) na Scopus
    Additional improvement in regional myocardial ischemia after intracardiac injection of bone marrow cells during CABG surgery
    (2023) GOWDAK, Luis Henrique Wolff; SCHETTERT, Isolmar Tadeu; ROCHITTE, Carlos Eduardo; CARVALHO, Leonardo P. de; VIEIRA, Marcelo Luiz Campos; DALLAN, Luis Alberto Oliveira; OLIVEIRA, Sergio Almeida de; CESAR, Luiz Antonio Machado; BRITO, Jose Oscar Reis; GUARITA-SOUZA, Luiz Cesar; CARVALHO, Antonio Carlos Campos de; KRIEGER, Jose Eduardo
    Background: Post-procedure residual ischemia is associated with worse prognosis in patients with coronary artery diasease (CAD).Objective: We evaluated whether autologous bone marrow-derived cells (BMC) contribute to additional reduction in regional stress-induced myocardial ischemia (SIMI) in patients undergoing incomplete coronary artery bypass graft surgery (CABG).Methods: In a double-blind, randomized, placebo-controlled trial, we enrolled 143 patients (82% men, 58 & PLUSMN; 11 years) with stable CAD and not candidates for complete CABG. They received 100 million BMC (n = 77) or placebo (n = 66) injected into ischemic non-revascularized segments during CABG. The primary outcome was improvement on SIMI quantified as the area at risk in injected segments assessed by cardiovascular magnetic resonance (CMR) 1, 6, and 12 months after CABG.Results: The reduction in global SIMI after CABG was comparable (p = 0.491) in both groups indicating sustained beneficial effects of the surgical procedure over 12 month period. In contrast, we observed additional improvement in regional SIMI in BMC treated group (p = 0.047). Baseline regional SIMI values were comparable [18.5 (16.2-21.0) vs. 18.5 (16.5-20.7)] and reached the lowest values at 1 month [9.74 (8.25; 11.49) vs. 12.69 (10.84; 14.85)] for BMC and placebo groups, respectively. The ischemia's improvement from baseline represented a 50% difference in regional SIMI in favor of the BMC transplanted group at 30 days. We found no differences in clinical and LVEF% between groups during the 12 month follow-up period. The 1 month rate of major adverse cerebral and cardiovascular events (MACCE) (p = 0.34) and all-cause mortality (p = 0.08) did not differ between groups 1 month post intervention.Conclusion: We provided evidence that BMC leads to additional reduction in regional SIMI in chronic ischemic patients when injected in segments not subjected to direct surgical revascularization. This adjuvant therapy deserves further assessment in patients with advanced CAD especially in those with microcirculation dysfunction.
  • article 1 Citação(ões) na Scopus
    Incor Residency Program in Adult Cardiology in 2022: 40 Years Preparing Cardiologists for the Demands in Brazil
    (2022) LOTTENBERG, Marcos Pita; BICHUETTE, Luciana Dornfeld; BORTOLOTTO, Luiz Aparecido; GOWDAK, Luis Henrique Wolff; DARRIEUX, Francisco Carlos da Costa; BINOTTO, Maria Angelica; KALIL FILHO, Roberto; CARAMELLI, Bruno
    Background: Considering demographic data related to the cardiologist's fields of work in Brazil, the administrative board of the InCor medical residency program decided for an update of its curriculum content, to adapt the educational process to the cardiologist's work reality. Objective: This article aimed to describe the recent updates applied to the InCor medical residency program. Methods: In the article, we described the recent updates on the InCor residency program, and compared the current curriculum track with the previous one. We also presented the rationale for these changes, based on the literature on the participation of cardiologists in the labor market. Results: There was a reduction in the working hours of residents in training in the intensive care unit, and an increase in the outpatient activities of primary and secondary prevention. Also, the didactic content was reformulated and became organized by the corresponding division. Conclusion: The update of the curriculum track of the InCor medical residency program was required in order to adapt it to the Brazilian labor market. The commission in charge of this update is aware that this is a dynamic process that may need changes over time.
  • article 0 Citação(ões) na Scopus
    Interdialytic Blood Pressure and Risk of Cardiovascular Events and Death in Hemodialysis Patients
    (2023) LIMA, Jose Jayme G. De; GOWDAK, Luis Henrique W.; JR, Jose Otto Reusing; DAVID-NETO, Elias; BORTOLOTTO, Luiz A.
    IntroductionNormal (120-140 mm Hg) systolic peridialysis blood pressure (BP) is associated with higher mortality in hemodialysis (HD) patients.AimWe explored the relationship between hypertension and BP on outcomes using data collected at the interdialytic period.MethodsThis was a single-center observational cohort study with 2672 HD patients. BP was determined at inception, in mid-week, between 2 consecutive dialysis sessions. Hypertension was defined as systolic BP >= 140 mm Hg and/or diastolic BP >= 90 mm Hg. Endpoints were major CV events and all-cause mortality.ResultsDuring a median follow-up of 31 months, 761 patients (28%) experienced CV events and 1181 (44%) died. Hypertensive patients had lower survival free of CV than normotensive patients (P = 0.031). No difference occurred in the incidence of death between groups. Compared with the reference category of SBP >= 171 mmHg, the incidence of cardiovascular events was reduced in patients with SBP 101-110 (HR 0.647, 95% CI 0.455 to 0.920), 111-120 (HR 0.663, 95%CI 0.492 to 0.894), 121-130 (HR 0.747, 95%CI 0.569 to 0.981), and 131-140 (HR 0.757, 95%CI 0.596 to 0.962). On multivariate analysis, systolic and diastolic BP were not independent predictors of CV events or death. Normal interdialytic BP was not associated with mortality or CV events, and hypertension predicted an increased probability of CV complications.ConclusionsInterdialytic BP may be preferred to guide treatment decisions, and HD patients should be treated according to guidelines for the general population until specific BP targets for this population are identified.
  • article 2 Citação(ões) na Scopus
    Does Myocardial Injury Occur After an Acute Aerobic Exercise Session in Patients with Refractory Angina?
    (2022) MONTENEGRO, Carla Giuliano de Sa Pinto; DOURADO, Luciana Oliveira Cascaes; JORDAO, Camila Paixao; VIEIRA, Marcelo Luiz Campos; ASSUMPCAO, Camila Regina Alves; GOWDAK, Luis Henrique Wolff; PEREIRA, Alexandre da Costa; NEGRAO, Carlos Eduardo; MATOS, Luciana Diniz Nagem Janot de
    Background: It is unclear whether exercise is safe in patients with more advanced forms of coronary artery disease, such as those with refractory angina (RA). Objective: We aimed to determine the effect of an acute aerobic exercise session (AAES) on high-sensitivity cardiac troponin T (hs-cTnT) levels in patients with RA. Methods: This was a longitudinal, non-randomized, and non-controlled clinical study. Participants were recruited from April 2015 to January 2019. On a visual pain scale from 0 to 10, pain rated up to 3 was considered as the top level allowed to continue exercising. We assessed hs-cTnT at baseline and 3 hours after the AAES. The protocol consisted of 5 minutes of warm-up, 30 minutes of continuous aerobic exercise at heart rate corresponding to the anaerobic threshold or angina threshold obtained in the cardiopulmonary exercise testing, and 5 minutes of cooling down. P values less than 0.05 were considered statistically significant. Results: Thirty-two patients with RA were included (61 +/- 9 years, 59.4% male). The baseline hs-cTnT concentration was 10.9 ng/L (95% confidence interval: 9.1 to 13.0 ng/L).The hs-cTnT collected 3 hours after the AAES was 11.1 ng/L (95% confidence interval: 9.1 to 13.5 ng/L). No difference occurred in hs-cTnT before and after AAES (p = 0.657). Conclusions: A single AAES performed at the angina threshold with corresponding visual pain scale did not alter hs-cTnT in patients with RA, suggesting that no significant myocardial injury was elicited by exercising and that this exercise protocol can be considered safe.
  • article 0 Citação(ões) na Scopus
    Primary results of the brazilian registry of atherothrombotic disease (NEAT)
    (2024) SILVA, Pedro G. M.; NASCIMENTO, Charlene Troiani do; PEDROSA, Rodrigo Pinto; NAKAZONE, Marcelo Arruda; NASCIMENTO, Michel Ulloffo do; MELO, Leiliandry de Araujo; JUNIOR, Osvaldo Lourenco Silva; ZIMMERMANN, Sergio Luiz; MELO, Rodrigo Morel Vieira de; BERGO, Ricardo Reinaldo; PRECOMA, Dalton Bertolim; TRAMUJAS, Lucas; LIMA, Eduardo Gomes; DANTAS, Joao Miguel Malta; BARUZZI, Antonio Claudio do Amaral; FLUMIGNAN, Ronald Luiz Gomes; PAIVA, Maria Sanali Moura de Oliveira; GOWDAK, Luis Henrique Wolff; CARVALHO, Priscila Nasser de; FIGUEIREDO NETO, Jose Albuquerque de; SILVESTRE, Odilson Marcos; FIORANELLI, Alexandre; VIEIRA, Ricardo D. 'Oliveira; HORAK, Ana Clara Peneluppi; MIYADA, Debora Harumi Kodama; KOJIMA, Flavia Cristina Soares; OLIVEIRA, Julia Souza de; SILVA, Leila de Oliveira; PAVANELLO, Ricardo; RAMACCIOTTI, Eduardo; LOPES, Renato D.; NASCIMENTO, Charlene Troiani do; PEDROSA, Rodrigo Pinto; NAKAZONE, Marcelo Arruda; NASCIMENTO, Michel Ulloffo do; MELO, Leiliandry de Araujo; JUNIOR, Osvaldo Lourenco Silva; ZIMMERMANN, Sergio Luiz; MELO, Rodrigo Morel Vieira de; BERGO, Ricardo Reinaldo; PRECOMA, Dalton Bertolim; TRAMUJAS, Lucas; DANTAS, Joao Miguel Malta; BARUZZI, Antonio Claudio do Amaral; FLUMIGNAN, Ronald Luiz Gomes; PAIVA, Maria Sanali Moura de Oliveira; CARVALHO, Priscila Nasser de; FIGUEIREDO NETO, Jose Albuquerque de; SILVESTRE, Odilson Marcos; FIORANELLI, Alexandre; VIEIRA, Ricardo D. 'Oliveira; FORTES, Jose Augusto Ribas; RITT, Luiz Eduardo Fonteles; REQUIAO-MOURA, Lucio R.; BORGES, Fabricio Assami; BERNOCHE, Claudia; POMPILIO, Mauricio Antonio
    There is limited contemporary prospective real-world evidence of patients with chronic arterial disease in Latin America. The Network to control atherothrombosis (NEAT) registry is a national prospective observational study of patients with known coronary (CAD) and/or peripheral arterial disease (PAD) in Brazil. A total of 2,005 patients were enrolled among 25 sites from September 2020 to March 2022. Patient characteristics, medications and laboratorial data were collected. Primary objective was to assess the proportion of patients who, at the initial visit, were in accordance with good medical practices (domains) for reducing cardiovascular risk in atherothrombotic disease. From the total of patients enrolled, 2 were excluded since they did not meet eligibility criteria. Among the 2,003 subjects included in the analysis, 55.6% had isolated CAD, 28.7% exclusive PAD and 15.7% had both diagnoses. Overall mean age was 66.3 (+/- 10.5) years and 65.7% were male patients. Regarding evidence-based therapies (EBTs), 4% were not using any antithrombotic drug and only 1.5% were using vascular dose of rivaroxaban (2.5 mg bid). Only 0.3% of the patients satisfied all the domains of secondary prevention, including prescription of EBTs and targets of body-mass index, blood pressure, LDL-cholesterol, and adherence of lifestyle recommendations. The main barrier for prescription of EBTs was medical judgement. Our findings highlight that the contemporary practice does not reflect a comprehensive approach for secondary prevention and had very low incorporation of new therapies in Brazil. Large-scale populational interventions addressing these gaps are warranted to improve the use of evidence-based therapies and reduce the burden of atherothrombotic disease.ClinicalTrials.gov NCT04677725