CAROLINA CAPPI
Projetos de Pesquisa
Unidades Organizacionais
LIM/23 - Laboratório de Psicopatologia e Terapêutica Psiquiátrica, Hospital das Clínicas, Faculdade de Medicina
45 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 45
conferenceObject Associations Between Medial Prefrontal Cerebral Metabolic Features and Clinical Characteristics in Obsessive-compulsive Disorder(2016) BATISTUZZO, Marcelo C.; HOEXTER, Marcelo; COSTA, Fabiana; SHAVITT, Roseli; LOPES, Antonio C.; CAPPI, Carolina; VATTIMO, Edoardo; MATHIS, Alice de; DINIZ, Juliana B.; HENNING, Anke; PASTORELLO, Bruno; MIGUEL, Euripedes C.; OTADUY, Maria C.conferenceObject Association between MAO-A and Obsessive-Compulsive Disorder related phenotypes(2013) SAMPAIO, A. S.; HOUNIE, A. G.; PETRIBU, K.; CAPPI, C.; MORAIS, I. A.; QUARANTINI, L. C.; FILHO, H. P. V.; ROSARIO, M. da Conceicao do; STEWART, S. E.; FARGENESS, J.; MATTHEWS, C.; ARNOLD, P.; RICHTER, M.; KENNEDY, J.; HANNA, G. L.; PAULS, D. L.; MIGUEL FILHO, E. C.- Association study between functional polymorphisms in the TNF-alpha gene and obsessive-compulsive disorder(2012) CAPPI, Carolina; MUNIZ, Renan Kawano; SAMPAIO, Aline Santos; CORDEIRO, Quirino; BRENTANI, Helena; PALACIOS, Selma A.; MARQUES, Andrea H.; VALLADA, Homero; MIGUEL, Euripedes Constantino; GUILHERME, Luiza; HOUNIE, Ana GabrielaObsessive-compulsive disorder (OCD) is a prevalent psychiatric disorder of unknown etiology. However, there is some evidence that the immune system may play an important role in its pathogenesis. In the present study, two polymorphisms (rs1800795 and rs361525) in the promoter region of the cytokine tumor necrosis factor-alpha (TNFA) gene were genotyped in 183 OCD patients and in 249 healthy controls. The statistical tests were performed using the PLINK (R) software. We found that the A allele of the TNFA rs361525 polymorphism was significantly associated with OCD subjects, according to the allelic x association test (p=0.007). The presence of genetic markers, such as inflammatory cytokines genes linked to OCD, may represent additional evidence supporting the rote of the immune system in its pathogenesis.
conferenceObject Fear Conditioning in Obsessive-compulsive Disorder Patients Treated with Sertraline: Preliminary Results(2015) DINIZ, Juliana B.; CAPPI, Carolina; COSTA, Daniel L. C.; REIMER, Adriano E.; OLIVEIRA, Amanda R. de; BRANDAO, Marcus L.; HOEXTER, Marcelo; MIGUEL, Euripedes C.; SHAVITT, Roseli G.- Analysis of shared heritability in common disorders of the brain(2018) ANTTILA, Verneri; BULIK-SULLIVAN, Brendan; FINUCANE, Hilary K.; WALTERS, Raymond K.; BRAS, Jose; DUNCAN, Laramie; ESCOTT-PRICE, Valentina; FALCONE, Guido J.; GORMLEY, Padhraig; MALIK, Rainer; PATSOPOULOS, Nikolaos A.; RIPKE, Stephan; WEI, Zhi; YU, Dongmei; LEE, Phil H.; TURLEY, Patrick; GRENIER-BOLEY, Benjamin; CHOURAKI, Vincent; KAMATANI, Yoichiro; BERR, Claudine; LETENNEUR, Luc; HANNEQUIN, Didier; AMOUYEL, Philippe; BOLAND, Anne; DELEUZE, Jean-Francois; DURON, Emmanuelle; VARDARAJAN, Badri N.; REITZ, Christiane; GOATE, Alison M.; HUENTELMAN, Matthew J.; KAMBOH, M. Ilyas; LARSON, Eric B.; ROGAEVA, Ekaterina; GEORGE-HYSLOP, Peter St; HAKONARSON, Hakon; KUKULL, Walter A.; FARRER, Lindsay A.; BARNES, Lisa L.; BEACH, Thomas G.; DEMIRCI, F. Yesim; HEAD, Elizabeth; HULETTE, Christine M.; JICHA, Gregory A.; KAUWE, John S. K.; KAYE, Jeffrey A.; LEVERENZ, James B.; LEVEY, Allan I.; LIEBERMAN, Andrew P.; PANKRATZ, Vernon S.; POON, Wayne W.; QUINN, Joseph F.; SAYKIN, Andrew J.; SCHNEIDER, Lon S.; SMITH, Amanda G.; SONNEN, Joshua A.; STERN, Robert A.; DEERLIN, Vivianna M. Van; ELDIK, Linda J. Van; HAROLD, Denise; RUSSO, Giancarlo; RUBINSZTEIN, David C.; BAYER, Anthony; TSOLAKI, Magda; PROITSI, Petra; FOX, Nick C.; HAMPEL, Harald; OWEN, Michael J.; MEAD, Simon; PASSMORE, Peter; MORGAN, Kevin; NOETHEN, Markus M.; ROSSOR, Martin; LUPTON, Michelle K.; HOFFMANN, Per; KORNHUBER, Johannes; LAWLOR, Brian; MCQUILLIN, Andrew; AL-CHALABI, Ammar; BIS, Joshua C.; RUIZ, Agustin; BOADA, Merce; SESHADRI, Sudha; BEISER, Alexa; RICE, Kenneth; LEE, Sven J. van der; JAGER, Philip L. De; GESCHWIND, Daniel H.; RIEMENSCHNEIDER, Matthias; RIEDEL-HELLER, Steffi; ROTTER, Jerome I.; RANSMAYR, Gerhard; HYMAN, Bradley T.; CRUCHAGA, Carlos; ALEGRET, Montserrat; WINSVOLD, Bendik; PALTA, Priit; FARH, Kai-How; CUENCA-LEON, Ester; FURLOTTE, Nicholas; KURTH, Tobias; LIGTHART, Lannie; TERWINDT, Gisela M.; FREILINGER, Tobias; RAN, Caroline; GORDON, Scott D.; BORCK, Guntram; ADAMS, Hieab H. H.; LEHTIMAKI, Terho; WEDENOJA, Juho; BURING, Julie E.; SCHUERKS, Markus; HRAFNSDOTTIR, Maria; HOTTENGA, Jouke-Jan; PENNINX, Brenda; ARTTO, Ville; KAUNISTO, Mari; VEPSALAINEN, Salli; MARTIN, Nicholas G.; MONTGOMERY, Grant W.; KURKI, Mitja I.; HAMALAINEN, Eija; HUANG, Hailiang; HUANG, Jie; SANDOR, Cynthia; WEBBER, Caleb; MULLER-MYHSOK, Bertram; SCHREIBER, Stefan; SALOMAA, Veikko; LOEHRER, Elizabeth; GOEBEL, Hartmut; MACAYA, Alfons; POZO-ROSICH, Patricia; HANSEN, Thomas; WERGE, Thomas; KAPRIO, Jaakko; METSPALU, Andres; KUBISCH, Christian; FERRARI, Michel D.; BELIN, Andrea C.; MAAGDENBERG, Arn M. J. M. van den; ZWART, John-Anker; BOOMSMA, Dorret; ERIKSSON, Nicholas; OLESEN, Jes; CHASMAN, Daniel I.; NYHOLT, Dale R.; AVBERSEK, Andreja; BAUM, Larry; BERKOVIC, Samuel; BRADFIELD, Jonathan; BUONO, Russell; CATARINO, Claudia B.; COSSETTE, Patrick; JONGHE, Peter De; DEPONDT, Chantal; DLUGOS, Dennis; FERRARO, Thomas N.; FRENCH, Jacqueline; HJALGRIM, Helle; JAMNADAS-KHODA, Jennifer; KALVIAINEN, Reetta; KUNZ, Wolfram S.; LERCHE, Holger; LEU, Costin; LINDHOUT, Dick; LO, Warren; LOWENSTEIN, Daniel; MCCORMACK, Mark; MOLLER, Rikke S.; MOLLOY, Anne; NG, Ping-Wing; OLIVER, Karen; PRIVITERA, Michael; RADTKE, Rodney; RUPPERT, Ann-Kathrin; SANDER, Thomas; SCHACHTER, Steven; SCHANKIN, Christoph; SCHEFFER, Ingrid; SCHOCH, Susanne; SISODIYA, Sanjay M.; SMITH, Philip; SPERLING, Michael; STRIANO, Pasquale; SURGES, Rainer; THOMAS, G. Neil; VISSCHER, Frank; WHELAN, Christopher D.; ZARA, Federico; HEINZEN, Erin L.; MARSON, Anthony; BECKER, Felicitas; STROINK, Hans; ZIMPRICH, Fritz; GASSER, Thomas; GIBBS, Raphael; HEUTINK, Peter; MARTINEZ, Maria; MORRIS, Huw R.; SHARMA, Manu; RYTEN, Mina; MOK, Kin Y.; PULIT, Sara; BEVAN, Steve; HOLLIDAY, Elizabeth; ATTIA, John; BATTEY, Thomas; BONCORAGLIO, Giorgio; THIJS, Vincent; CHEN, Wei-Min; MITCHELL, Braxton; ROTHWELL, Peter; SHARMA, Pankaj; SUDLOW, Cathie; VICENTE, Astrid; MARKUS, Hugh; KOURKOULIS, Christina; PERA, Joana; RAFFELD, Miriam; SILLIMAN, Scott; PERICA, Vesna Boraska; THORNTON, Laura M.; HUCKINS, Laura M.; RAYNER, N. William; LEWIS, Cathryn M.; GRATACOS, Monica; RYBAKOWSKI, Filip; KESKI-RAHKONEN, Anna; RAEVUORI, Anu; HUDSON, James I.; REICHBORN-KJENNERUD, Ted; MONTELEONE, Palmiero; KARWAUTZ, Andreas; MANNIK, Katrin; BAKER, Jessica H.; O'TOOLE, Julie K.; TRACE, Sara E.; DAVIS, Oliver S. P.; HELDER, Sietske G.; EHRLICH, Stefan; HERPERTZ-DAHLMANN, Beate; DANNER, Unna N.; ELBURG, Annemarie A. van; CLEMENTI, Maurizio; FORZAN, Monica; DOCAMPO, Elisa; LISSOWSKA, Jolanta; HAUSER, Joanna; TORTORELLA, Alfonso; MAJ, Mario; GONIDAKIS, Fragiskos; TZIOUVAS, Konstantinos; PAPEZOVA, Hana; YILMAZ, Zeynep; WAGNER, Gudrun; COHEN-WOODS, Sarah; HERMS, Stefan; JULIA, Antonio; RABIONET, Raquel; DICK, Danielle M.; RIPATTI, Samuli; ANDREASSEN, Ole A.; ESPESETH, Thomas; LUNDERVOLD, Astri J.; STEEN, Vidar M.; PINTO, Dalila; SCHERER, Stephen W.; ASCHAUER, Harald; SCHOSSER, Alexandra; ALFREDSSON, Lars; PADYUKOV, Leonid; HALMI, Katherine A.; MITCHELL, James; STROBER, Michael; BERGEN, Andrew W.; KAYE, Walter; SZATKIEWICZ, Jin Peng; CORMAND, Bru; RAMOS-QUIROGA, Josep Antoni; SANCHEZ-MORA, Cristina; RIBASES, Marta; CASAS, Miguel; HERVAS, Amaia; ARRANZ, Maria Jesus; HAAVIK, Jan; ZAYATS, Tetyana; JOHANSSON, Stefan; WILLIAMS, Nigel; DEMPFLE, Astrid; ROTHENBERGER, Aribert; KUNTSI, Jonna; OADES, Robert D.; BANASCHEWSKI, Tobias; FRANKE, Barbara; BUITELAAR, Jan K.; VASQUEZ, Alejandro Arias; DOYLE, Alysa E.; REIF, Andreas; LESCH, Klaus-Peter; FREITAG, Christine; RIVERO, Olga; PALMASON, Haukur; ROMANOS, Marcel; LANGLEY, Kate; RIETSCHEL, Marcella; WITT, Stephanie H.; DALSGAARD, Soeren; BORGLUM, Anders D.; WALDMAN, Irwin; WILMOT, Beth; MOLLY, Nikolas; BAU, Claiton H. D.; CROSBIE, Jennifer; SCHACHAR, Russell; K., Sandra; MCGOUGH, James J.; GREVET, Eugenio H.; MEDLAND, Sarah E.; ROBINSON, Elise; WEISS, Lauren A.; BACCHELLI, Elena; BAILEY, Anthony; BAL, Vanessa; BATTAGLIA, Agatino; BETANCUR, Catalina; BOLTON, Patrick; CANTOR, Rita; CELESTINO-SOPER, Patricia; DAWSON, Geraldine; RUBEIS, Silvia De; DUQUE, Frederico; GREEN, Andrew; KLAUCK, Sabine M.; LEBOYER, Marion; LEVITT, Pat; MAESTRINI, Elena; MANE, Shrikant; MORENO-DE-LUCA, Daniel; PARR, Jeremy; REGAN, Regina; REICHENBERG, Abraham; SANDIN, Sven; VORSTMAN, Jacob; WASSINK, Thomas; WIJSMAN, Ellen; COOK, Edwin; SANTANGELO, Susan; DELORME, Richard; ROGE, Bernadette; MAGALHAES, Tiago; ARKING, Dan; SCHULZE, Thomas G.; THOMPSON, Robert C.; STROHMAIER, Jana; MATTHEWS, Keith; MELLE, Ingrid; MORRIS, Derek; BLACKWOOD, Douglas; MCINTOSH, Andrew; BERGEN, Sarah E.; SCHALLING, Martin; JAMAIN, Stephane; MAASER, Anna; FISCHER, Sascha B.; REINBOLD, Celine S.; FULLERTON, Janice M.; GUZMAN-PARRA, Jose; MAYORAL, Fermin; SCHOFIELD, Peter R.; CICHON, Sven; MUHLEISEN, Thomas W.; DEGENHARDT, Franziska; SCHUMACHER, Johannes; BAUER, Michael; MITCHELL, Philip B.; GERSHON, Elliot S.; RICE, John; POTASH, James B.; ZANDI, Peter P.; CRADDOCK, Nick; FERRIER, I. Nicol; ALDA, Martin; ROULEAU, Guy A.; TURECKI, Gustavo; OPHOFF, Roel; PATO, Carlos; ANJORIN, Adebayo; STAHL, Eli; LEBER, Markus; CZERSKI, Piotr M.; CRUCEANU, Cristiana; JONES, Ian R.; POSTHUMA, Danielle; ANDLAUER, Till F. M.; FORSTNER, Andreas J.; STREIT, Fabian; BAUNE, Bernhard T.; AIR, Tracy; SINNAMON, Grant; WRAY, Naomi R.; MACINTYRE, Donald J.; PORTEOUS, David; HOMUTH, Georg; RIVERA, Margarita; GROVE, Jakob; MIDDELDORP, Christel M.; HICKIE, Ian; PERGADIA, Michele; MEHTA, Divya; SMIT, Johannes H.; JANSEN, Rick; GEUS, Eco de; DUNN, Erin; LI, Qingqin S.; NAUCK, Matthias; SCHOEVERS, Robert A.; BEEKMAN, Aartjan T. F.; KNOWLES, James A.; VIKTORIN, Alexander; ARNOLD, Paul; BARR, Cathy L.; BEDOYA-BERRIO, Gabriel; BIENVENU, O. Joseph; BRENTANI, Helena; BURTON, Christie; CAMARENA, Beatriz; CAPPI, Carolina; CATH, Danielle; CAVALLINI, Maria; CUSI, Daniele; DARROW, Sabrina; DENYS, Damiaan; DERKS, Eske M.; DIETRICH, Andrea; FERNANDEZ, Thomas; FIGEE, Martijn; FREIMER, Nelson; GERBER, Gloria; GRADOS, Marco; GREENBERG, Erica; HANNA, Gregory L.; HARTMANN, Andreas; HIRSCHTRITT, Matthew E.; HOEKSTRA, Pieter J.; HUANG, Alden; HUYSER, Chaim; ILLMANN, Cornelia; JENIKE, Michael; KUPERMAN, Samuel; LEVENTHAL, Bennett; LOCHNER, Christine; LYON, Gholson J.; MACCIARDI, Fabio; MADRUGA-GARRIDO, Marcos; MALATY, Irene A.; MARAS, Athanasios; MCGRATH, Lauren; MIGUEL, Euripedes C.; MIR, Pablo; NESTADT, Gerald; NICOLINI, Humberto; OKUN, Michael S.; PAKSTIS, Andrew; PASCHOU, Peristera; PIACENTINI, John; PITTENGER, Christopher; PLESSEN, Kerstin; RAMENSKY, Vasily; RAMOS, Eliana M.; REUS, Victor; RICHTER, Margaret A.; RIDDLE, Mark A.; ROBERTSON, Mary M.; ROESSNER, Veit; ROSARIO, Maria; SAMUELS, Jack F.; SANDOR, Paul; STEIN, Dan J.; TSETSOS, Fotis; NIEUWERBURGH, Filip Van; WEATHERALL, Sarah; WENDLAND, Jens R.; WOLANCZYK, Tomasz; WORBE, Yulia; ZAI, Gwyneth; GOES, Fernando S.; MCLAUGHLIN, Nicole; NESTADT, Paul S.; GRABE, Hans-Jorgen; DEPIENNE, Christel; KONKASHBAEV, Anuar; LANZAGORTA, Nuria; VALENCIA-DUARTE, Ana; BRAMON, Elvira; BUCCOLA, Nancy; CAHN, Wiepke; CAIRNS, Murray; CHONG, Siow A.; COHEN, David; CRESPO-FACORRO, Benedicto; CROWLEY, James; DAVIDSON, Michael; DELISI, Lynn; DINAN, Timothy; DONOHOE, Gary; DRAPEAU, Elodie; DUAN, Jubao; HAAN, Lieuwe; HOUGAARD, David; KARACHANAK-YANKOVA, Sena; KHRUNIN, Andrey; KLOVINS, Janis; KUCINSKAS, Vaidutis; KEONG, Jimmy Lee Chee; LIMBORSKA, Svetlana; LOUGHLAND, Carmel; LONNQVIST, Jouko; MAHER, Brion; MATTHEISEN, Manuel; MCDONALD, Colm; MURPHY, Kieran C.; NENADIC, Igor; OS, Jim van; PANTELIS, Christos; PATO, Michele; PETRYSHEN, Tracey; QUESTED, Digby; ROUSSOS, Panos; SANDERS, Alan R.; SCHALL, Ulrich; SCHWAB, Sibylle G.; SIM, Kang; SO, Hon-Cheong; STOEGMANN, Elisabeth; SUBRAMANIAM, Mythily; TONCHEVA, Draga; WADDINGTON, John; WALTERS, James; WEISER, Mark; CHENG, Wei; CLONINGER, Robert; CURTIS, David; GEJMAN, Pablo V.; HENSKENS, Frans; MATTINGSDAL, Morten; OH, Sang-Yun; SCOTT, Rodney; WEBB, Bradley; BREEN, Gerome; CHURCHHOUSE, Claire; BULIK, Cynthia M.; DALY, Mark; DICHGANS, Martin; FARAONE, Stephen V.; GUERREIRO, Rita; HOLMANS, Peter; KENDLER, Kenneth S.; KOELEMAN, Bobby; MATHEWS, Carol A.; PRICE, Alkes; SCHARF, Jeremiah; SKLAR, Pamela; WILLIAMS, Julie; WOOD, Nicholas W.; COTSAPAS, Chris; PALOTIE, Aarno; SMOLLER, Jordan W.; SULLIVAN, Patrick; ROSAND, Jonathan; CORVIN, Aiden; NEALE, Benjamin MDisorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants and assessed their relationship to 17 phenotypes from 1,191,588 individuals. Psychiatric disorders share common variant risk, whereas neurological disorders appear more distinct from one another and from the psychiatric disorders. We also identified significant sharing between disorders and a number of brain phenotypes, including cognitive measures. Further, we conducted simulations to explore how statistical power, diagnostic misclassification, and phenotypic heterogeneity affect genetic correlations. These results highlight the importance of common genetic variation as a risk factor for brain disorders and the value of heritability-based methods in understanding their etiology.
conferenceObject Early Life Adverse Experiences and Obsessive-Compulsive Disorder: A Study With Patients, Siblings and Controls(2018) COSTA, Fabiana; CAPPI, Carolina; BATISTUZZO, Marcelo; SHAVITT, Roseli; REQUENA, Guaraci; MIGUEL, Euripedes; HOEXTER, Marcelo- Epigenetic evidence for involvement of the oxytocin receptor gene in obsessive-compulsive disorder(2016) CAPPI, Carolina; DINIZ, Juliana Belo; REQUENA, Guaraci L.; LOURENCO, Tiaya; LISBOA, Bianca Cristina Garcia; BATISTUZZO, Marcelo Camargo; MARQUES, Andrea H.; HOEXTER, Marcelo Q.; PEREIRA, Carlos A.; MIGUEL, Euripedes Constantino; BRENTANI, HelenaBackground: Obsessive-compulsive disorder (OCD) is a chronic neurodevelopmental disorder that affects up to 3% of the general population. Although epigenetic mechanisms play a role in neurodevelopment disorders, epigenetic pathways associated with OCD have rarely been investigated. Oxytocin is a neuropeptide involved in neurobehavioral functions. Oxytocin has been shown to be associated with the regulation of complex socio-cognitive processes such as attachment, social exploration, and social recognition, as well as anxiety and other stress-related behaviors. Oxytocin has also been linked to the pathophysiology of OCD, albeit inconsistently. The aim of this study was to investigate methylation in two targets sequences located in the exon III of the oxytocin receptor gene (OXTR), in OCD patients and healthy controls. We used bisulfite sequencing to quantify DNA methylation in peripheral blood samples collected from 42 OCD patients and 31 healthy controls. Results: We found that the level of methylation of the cytosine-phosphate-guanine sites in two targets sequences analyzed was greater in the OCD patients than in the controls. The higher methylation in the OCD patients correlated with OCD severity. We measured DNA methylation in the peripheral blood, which prevented us from drawing any conclusions about processes in the central nervous system. Conclusion: To our knowledge, this is the first study investigating DNA methylation of the OXTR in OCD. Further studies are needed to evaluate the roles that DNA methylation and oxytocin play in OCD.
conferenceObject Does Inflammation Play a Role in Obsessive-Compulsive Disorder?(2013) SILVERMAN, Marni; CASSAB, Raony; MUNIZ, Renan; SHAVITT, Roseli G.; TOLEDO, Maria Cecilia; CAPPI, Carolina; THAYER, Julian; MATHIS, Maria Alice de; DINIZ, Juliana B.; HOEXTER, Marcelo Q.; D'ALCANTE, Carina C.; BORCATO, Sonia; HOUNIE, Ana G.; WHITFIELD, Jessie; BELYAVSKAYA, Elena; STERNBERG, Esther; MIGUEL, Euripedes; MARQUES, Andrea H.- Whole-exome Sequencing in Obsessive-compulsive Disorder Identifies Rare Mutations and Immunological Pathways(2014) CAPPI, Carolina; BRENTANI, Helena; LIMA, Leandro; SANDERS, Stephan J.; DINIZ, Juliana; WALKER, Michael; REIS, Viviane N. S.; HOUNIE, Ana G.; MARIANI, Daniel; OKI, Fabio H.; SHAVITT, Roseli G.; PAULS, David L.; MIGUEL, Euripedes C.; FERNANDEZ, Thomas V.
conferenceObject PHARMACOGENETICS OF ANTIDEPRESSANT RESPONSE IN OBSESSIVE-COMPULSIVE AND RELATED DISORDERS(2017) ZAIL, Gwyneth; CAPPI, Carolina; PHILLIPS, Katharine; GONCALVES, Vanessa; ZAI, Clement; SHAVITT, Roseli; MIGUEL, Euripedes; RICHTER, Margaret (Peggy); KENNEDY, James L.