CLAUDIA SELLITTO PORTO
Índice h a partir de 2011
6
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
11 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 11
- Subjective memory complaints in the elderly: a sign of cognitive impairment?(2014) JACINTO, Alessandro Ferrari; BRUCKI, Sonia Maria Dozzi; PORTO, Claudia Sellitto; DE ARRUDA MARTINS, Milton; NITRINI, RicardoOBJECTIVES: Cognitive impairment in the elderly is frequently overlooked by general practitioners. The use of subjective memory complaints as a sign of cognitive impairment by the general practice is controversial. METHODS: Elderly individuals (N = 248) were asked whether they had memory complaints and underwent a cognitive impairment screening. Subjects classified as exhibiting “probable cognitive impairment” underwent a complete cognitive evaluation, and the final diagnoses were established by expert consensus. RESULTS: A total of 147 patients presented with subjective memory complaints, and 43 were further classified as demented or “cognitively impaired not demented”. Subjective memory complaints presented a sensitivity of 100% and a negative predictive value of 100%. CONCLUSION: Subjective memory complaints are an indicator for cognitive impairment screening.
- The pros and cons of early diagnosis of dementia(2013) JACINTO, Alessandro Ferrari; NITRINI, Ricardo; BRUCKI, Sonia Maria Dozzi; PORTO, Claudia Sellitto; FRANCO, Fabio Gazelato de Mello; CITERO, Vanessa de Albuquerque
- Suggested instruments for General Practitioners in countries with low schooling to screen for cognitive impairment in the elderly(2014) JACINTO, Alessandro Ferrari; BRUCKI, Sonia Maria Dozzi; PORTO, Claudia Sellitto; MARTINS, Milton de Arruda; CITERO, Vanessa de Albuquerque; NITRINI, RicardoBackground: General Practitioners (GPs) from underdeveloped countries apply cognitive impairment (CI) assessment tools translated and adapted to cultural setting from other idioms, mainly English. As schooling in elderly from underdeveloped countries tends to be relatively heterogeneous, it is necessary to establish normative and cut-off scores for these CI instruments that are based on studies conducted locally. Some CI screening instruments frequently used by Brazilian specialists in dementia were analyzed to determine which could be most useful to GPs in their working sets. Method: Two hundred forty-eight patients aged 65 years or older that had been assisted by GPs in a tertiary hospital in Brazil were evaluated. Based on the MMSE and/or Short-IQCODE scores, 52 probable cases were identified on the basis of clinical data, performances on the neuropsychological tests and questionnaires (Functional Assessment Questionnaire/FAQ, Category Verbal Fluency/CVF, Clock Drawing Test /CDT) and blood tests and brain CT. Results: The combination of a functional questionnaire with a cognitive instrument had higher sensitivity and specificity than using the instruments alone. A FAQ cut-off of 3 in conjunction with a CDT cut-off of 6 proved optimal (93% sensitivity and 92.5% specificity). A higher specificity (93.5%) was attained using a combination of the FAQ (cut-off of 3) with the CVF (cut-off of 10). Conclusions: For low schooling elderly, the combination of the FAQ and CVF represented a very simple method of increasing the chances of correct screening. For those with higher schooling, the combination of the FAQ and CDT was more suitable.
bookPart Escala de avaliação de demência(2018) PORTO, Cláudia Sellitto; OLIVEIRA, Maira Okada de- Mattis Dementia Rating Scale (DRS): Normative data for the Brazilian middle-age and elderly populations(2013) FOSS, Maria Paula; CARVALHO, Viviane Amaral de; MACHADO, Thais Helena; REIS, Geraldo Cássio dos; TUMAS, Vitor; CARAMELLI, Paulo; NITRINI, Ricardo; PORTO, Cláudia SellittoABSTRACT Objective: To expand norms for the Mattis Dementia Rating Scale (DRS) for the Brazilian middle-age and elderly populations. Methods: The DRS was administered to 502 individuals without cognitive deficits, 312 women and 190 men, aged 50 years or over and with educational level ranging from 0 to 13 years or more. The sample was composed of subjects who participated in other studies, from Caeté (Minas Gerais state), Ribeirão Preto (São Paulo state) and São Paulo (São Paulo state). Participants were divided into four schooling groups (illiterate, 1 to 4 years, 5 to 12 years and 13 years or more). The subjects were divided into four groups according to age (50 to 60, 61 to 70, 71 to 80, and 80 years or over). Results: Normative data for DRS scores are expressed as percentile values. The group with lowest schooling and subjects older than 80 years had the worst scores. Conclusion: As expected, age and education were strongly correlated with DRS scores. Illiterates and older old individuals performed worse than the other groups. These data might help to improve the accuracy of the diagnosis of cognitive impairment and dementia in Brazilian middle-age and elderly populations.
- Linguistic abilities in major vascular cognitive impairment: a comparative study with Alzheimer's disease(2018) FREITAS, Maria Isabel D'Avila; PORTO, Claudia S.; OLIVEIRA, Maira O.; BRUCKI, Sonia M. D.; MANSUR, Leticia L.; NITRINI, Ricardo; RADANOVIC, MarciaWe assessed the linguistic abilities of multi-infarct (cortical) dementia and subcortical ischemic vascular dementia (VaD) patients and compared the linguistic performance of VaD and Alzheimer's Disease (AD) patients. A total of 23 VaD patients, 20 mild AD patients, and 31 controls participated in the study. All were evaluated using the Arizona Battery for Communication Disorders of Dementia (ABCD). Neuropsychological testing was performed to ascertain that VaD and AD patients had comparable cognitive performance. Both dementia groups performed more poorly than controls in the ABCD measures, except for the comparative question subtest. Comparison between VaD and AD patients showed statistically significant differences only in the confrontation naming subtest (p < 0.05), where paraphasias and visual errors were the most prevalent. AD patients showed a trend towards more circumlocution errors than VaD patients (p = 0.0483). When compared to controls, linguistic abilities of VaD patients were impaired in all measures of linguistic expression and linguistic comprehension, except for the comparative question subtest. Linguistic differences between VaD and AD patients were observed only in the confrontation naming subtest.
- Prevalence of cognitive impairment in tremembe, Brazil(2015) CESAR, K. G.; BRUCKI, S. M. D.; TAKADA, L. T.; OLIVEIRA, M. O.; PORTO, F. H. G.; SENAHA, M. L. H.; BAHIA, V. S.; SILVA, T. B. L.; CECCHINI, M. A.; CASSIMIRO, L.; SMID, J.; PORTO, C. S.; CARTHERY-GOULART, M. T.; YASSUDA, M. S.; MANSUR, L. L.; NITRINI, R.
- Prefrontal damage in childhood and changes in the development of personality: A case report(2013) BAHIA, Valéria Santoro; TAKADA, Leonel Tadao; CAIXETA, Leonardo; LUCATO, Leandro Tavares; PORTO, Claudia Sellitto; NITRINI, RicardoABSTRACT Frontal lobe lesions are associated with behavioral abnormalities and executive dysfunction. When these lesions occur early in life, the symptoms are even more severe as the anatomical and functional substrates underlying personality and behavior are damaged, distorting normal modulation by interaction with the psychosocial environment. We present a case of a 40-year-old man who suffered a frontal lobe lesion at the age of nine years and developed impulsivity, disinhibition and inappropriate behaviors while showing some preservation of insight. Brain MRI revealed lesions to bilateral orbitofrontal cortex, ventromedial prefrontal cortex, anterior cingulate gyri and genu of the corpus callosum , which were more extensive on the right side. The right prefrontal dorsolateral cortex was severely damaged, whereas the right ventrolateral prefrontal cortex was spared. We will discuss the correlation of the damaged pre frontal regions with the symptoms presented by the patient.
- Primary progressive aphasia: Classification of variants in 100 consecutive Brazilian cases(2013) SENAHA, Mirna Lie Hosogi; CARAMELLI, Paulo; BRUCKI, Sonia M.D.; SMID, Jerusa; TAKADA, Leonel T.; PORTO, Claudia S.; CÉSAR, Karolina G.; MATIOLI, Maria Niures P.; SOARES, Roger T.; MANSUR, Letícia L.; NITRINI, RicardoABSTRACT Primary progressive aphasia (PPA) is a neurodegenerative clinical syndrome characterized primarily by progressive language impairment. Recently, consensus diagnostic criteria were published for the diagnosis and classification of variants of PPA. The currently recognized variants are nonfluent/agrammatic (PPA-G), logopenic (PPA-L) and semantic (PPA-S). Objective: To analyze the demographic data and the clinical classification of 100 PPA cases. Methods: Data from 100 PPA patients who were consecutively evaluated between 1999 and 2012 were analyzed. The patients underwent neurological, cognitive and language evaluation. The cases were classified according to the proposed variants, using predominantly the guidelines proposed in the consensus diagnostic criteria from 2011. Results: The sample consisted of 57 women and 43 men, aged at onset 67.2±8.1 years (range of between 53 and 83 years). Thirty-five patients presented PPA-S, 29 PPA-G and 16 PPA-L. It was not possible to classify 20% of the cases into any one of the proposed variants. Conclusion: It was possible to classify 80% of the sample into one of the three PPA variants proposed. Perhaps the consensus classification requires some adjustments to accommodate cases that do not fit into any of the variants and to avoid overlap where cases fit more than one variant. Nonetheless, the established current guidelines are a useful tool to address the classification and diagnosis of PPA and are also of great value in standardizing terminologies to improve consistency across studies from different research centers.
- Screening of cognitive impairment by general internists using two simple instruments(2012) JACINTO, Alessandro Ferrari; BRUCKI, Sonia Maria Dozzi; PORTO, Claudia Sellitto; MARTINS, Milton de Arruda; NITRINI, RicardoABSTRACT General internists (GIs) tend to overlook cognitive impairment in the elderly. Lack of time to diagnose and/or poor knowledge on how to use screening instruments may be the reasons for this shortcoming. Objectives: To verify the efficacy of simple instruments in the screening of cognitive impairment in elders. Methods: In a previous study, 248 patients aged ≥65 that had been assisted by GIs within outpatient services of a public university hospital in São Paulo, Brazil, were evaluated. The Mini-Mental State Examination and/or the Informant Questionnaire on Cognitive Decline in the Elderly (short-IQCODE) were employed to classify patients into probable cognitively impaired cases or otherwise. Other tests and questionnaires were also applied, but were not used to perform this classification. After full assessment and consensus meetings, cases were classified into dementia, cognitively impaired not demented, and without cognitive impairment. In this study, the sensitivity and specificity of the combined use of the category fluency test (CFT) and the Functional Activities Questionnaire (FAQ) was evaluated as if used as screening instruments for the whole sample. Results: The combined use of the CFT and/or FAQ showed sensitivity of 88.3% and specificity of 76.5% in the screening of cognitive impairment for the whole sample. Conclusions: Two simple and easy-to-apply instruments showed high sensitivity and reasonable specificity, and are probably useful for the screening of cognitive impairment in the elderly in outpatient services.