CID YAZIGI SABBAG
Projetos de Pesquisa
Unidades Organizacionais
LIM/20 - Laboratório de Terapêutica Experimental, Hospital das Clínicas, Faculdade de Medicina
6 resultados
Resultados de Busca
Agora exibindo 1 - 6 de 6
- Decreased brain-derived neurotrophic factor plasma levels in psoriasis patients(2015) BRUNONI, A. R.; LOTUFO, P. A.; SABBAG, C.; GOULART, A. C.; SANTOS, I. S.; BENSENOR, I. M.Brain-derived neurotrophic factor (BDNF) is associated with neuroplasticity and synaptic strength, and is decreased in conditions associated with chronic stress. Nevertheless, BDNF has not yet been investigated in psoriasis, a chronic inflammatory systemic disease that is exacerbated by stress. Therefore, our aim was to determine BDNF plasma levels in psoriasis patients and healthy controls. Adult patients (n = 94) presenting with psoriasis for at least 1 year were enrolled, and age-and gender-matched with healthy controls (n = 307) from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Participants had neither a previous history of coronary artery disease nor current episode of major depression. BDNF plasma levels were determined using the Promega ELISA kit. A general linear model was used to compare BDNF levels in psoriasis patients and controls, with age, gender, systolic blood pressure, serum fasting glucose, blood lipid levels, triglycerides, smoking status, and body mass index examined. After adjusting for clinical and demographic variables, significantly decreased BNDF plasma levels were observed in psoriasis patients (P = 0.01) (estimated marginal means of 3922 pg/mL; 95% CI = 2660-5135) compared with controls (5788 pg/mL; 95% CI = 5185-6442). Similar BDNF levels were found in both mild and severe cases of psoriasis. Our finding, that BDNF is decreased in psoriasis, supports the concept of a brain-skin connection in psoriasis. Further studies should determine if BDNF is increased after specific psoriasis treatments, and associated with different disease stages.
conferenceObject SUBCLINICAL ATHEROSCLEROSIS AND PSORIASIS(2013) STANIAK, Henrique; SABBAG, Cid; BITTENCOURT, Marcio; SHAROVSKI, Rodolfo; SOUZA, Angelita; LOTUFO, Paulo; BENSENOR, Isabela- Psoriasis severity and hypothalamic-pituitary-adrenal axis function: results from the CALIPSO study(2014) BRUNONI, A. R.; SANTOS, I. S.; SABBAG, C.; LOTUFO, P. A.; BENSENOR, I. M.Psoriasis is a chronic inflammatory disease that significantly impacts life quality, being associated with stress and mental disorders. We investigated whether the activity of the hypothalamic-pituitary-adrenal (HPA) axis was associated with psoriasis severity, daily life stress and anxiety, and depressive symptoms. In this ancillary study, which was part of the CALIPSO (coronary artery calcium in psoriasis) study, saliva was collected from 102 patients with psoriasis immediately upon awakening, 30, and 60 min after awakening, at 2:00 pm and at bedtime (five time points) to determine salivary cortisol levels. We used Pearson's correlation coefficient to evaluate the association of clinical and psychopathological variables with HPA activity. We found a direct correlation between bedtime cortisol and psoriasis severity evaluated by the psoriasis area severity index (PASI; r=0.39, P<0.001). No correlations between other clinical and psychopathological variables or with other cortisol assessments were observed. The findings indicated that HPA dysfunction may be present in psoriasis, as bedtime cortisol was correlated with psoriasis severity. Our study is limited by the lack of a control group; therefore, we were not able to explore whether these cortisol values were different compared with a concurrent, healthy sample.
conferenceObject Decreased plasma Brain-Derived Neurotrophic Factor (BDNF) levels in psoriasis: a case-control study(2015) BRUNONI, Andre; SABBAG, Cid; LOTUFO, Paulo; GOULART, Alessandra; SANTOS, Itamar; BENSENOR, Isabela- Association between psoriasis and coronary calcium score(2014) STANIAK, Henrique L.; BITTENCOURT, Marcio Sommer; SANTOS, Itamar de Souza; SHAROVSKY, Rodolfo; SABBAG, Cid; GOULART, Alessandra C.; LOTUFO, Paulo A.; BENSENOR, Isabela M.Background: Emerging data suggests that chronic inflammatory disease, such as psoriasis, may be associated to coronary artery disease (CAD). Objective: Analyze the association between psoriasis and subclinical atherosclerosis using coronary calcium score (CAC). Methods: We investigated 221 participants with psoriasis and 718 age-and sex-matched controls without prior known CAD. All participants completed a questionnaire and underwent laboratory tests and a CAC exam. Logistic regression models adjusted for Framingham risk score (FRS) and C-reactive protein (hs-CRP) were built. CAC was included in the models as a binary variable with different cut off values. Results: Body-mass index, race, hypertension, HDL, LDL and hs-CRP were significantly associated with psoriasis presence and severity. Psoriasis severity was significantly associated with CAC (p = 0.04), particularly for very high CAC (>400) (p <0.01). The OR for severe psoriasis and CAC >400 was 2.45 (95%CI: 1.26-4.75) in unadjusted models. In a model adjusted for the FRS, this association was no longer significant, but a trend was noted (p = 0.09). No significant changes in the association were noted after the inclusion of hs-CRP in the model. Conclusion: Psoriasis is associated with higher CAC values, mainly in individuals with severe psoriasis. The current findings also suggest the potential involvement of other mechanisms beyond classical cardiovascular risk factors and inflammation in this association.
conferenceObject The impact of psoriasis on subclinical atherosclerosis assessed by carotid intima-media thickness using the ultrasound technique: a large cohort study(2016) SABBAG, C. Y.; BITTENCOURT, M.; STANIAK, H.; SANTOS, I.; SHAROVSKY, R.; GOULART, A.; BENSENOR, I.; LOTUFO, P.