GLAUCYLARA REIS GEOVANINI

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Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/13 - Laboratório de Genética e Cardiologia Molecular, Hospital das Clínicas, Faculdade de Medicina

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Agora exibindo 1 - 10 de 23
  • article 7 Citação(ões) na Scopus
    Obstructive sleep apnoea is associated with myocardial injury in patients with refractory angina
    (2016) GEOVANINI, Glaucylara R.; PEREIRA, Alexandre C.; GOWDAK, Luis H. W.; DOURADO, Luciana Oliveira Cascaes; POPPI, Nilson T.; VENTURINI, Gabriela; DRAGER, Luciano F.; LORENZI-FILHO, Geraldo
    Objective To investigate the association between obstructive sleep apnoea (OSA) severity with markers of overnight myocardial injury in patients with refractory angina. Methods Patients with refractory angina were characterised clinically and they underwent ischaemia imaging stress tests by single-photon emission computed tomography (SPECT) and/or cardiac MRI. The patients were admitted to the hospital, remained under resting conditions for blood determination of high-sensitivity cardiac troponin T (hs-cTnT) at 14:00, 22:00 and after overnight polysomnography at 7:00. Results We studied 80 consecutive patients (age: 62 +/- 10 years; male: 66%; body mass index (BMI): 29.5 +/- 4 kg/m(2)) with well-established diagnosis of refractory angina. The mean apnoea-hypopnoea index (AHI) was 37 +/- 29 events/h and OSA (AHI >15 events/h) was present in 75% of the population. Morning detectable hs-cTnT and above 99th percentile was present in 88% and 36% of the population, respectively. Patients in the first to third quartiles of OSA severity did not have circadian variation of hs-cTnT. In contrast, patients in the fourth quartile (AHI >= 51 events/h) had a circadian variation of hs-cTnT with a morning peak of hs-cTnT that was two times higher than that in the remaining population (p = 0.02). The highest quartile of OSA severity remained associated with the highest quartile of hs-cTnT (p = 0.028) in multivariate analysis. Conclusion Very severe OSA is common and independently associated with overnight myocardial injury in patients with refractory angina.
  • conferenceObject
    Obstructive Sleep Apnea Is Extremely Common And Associated With Myocardial Ischemia In Patients With Refractory Angina
    (2014) GEOVANINI, G. R.; PEREIRA, A. C.; GOWDAK, L. H. W.; DOURADO, L. O.; POPPI, N.; CESAR, L. M.; DRAGER, L. F.; LORENZI-FILHO, G.
  • conferenceObject
    The Effectiveness To Treat Obstructive Sleep Apnea
    (2013) MONTES, M. I.; SARDINHA, P. S.; PIRES, T. B.; MARTINS, B. D.; GEOVANINI, G. R.; GENTA, P. R.; LORENZI-FILHO, G.
  • conferenceObject
    Obstructive Sleep Apnea In The Spectrum Of Coronary Artery Disease: Stable Versus Refractory Angina Patients
    (2013) GEOVANINI, G. R.; DANZI-SOARES, N.; DOURADO, L. O. C.; POPPI, N. T.; PEREIRA, A. C.; GOWDAK, L. W.; DRAGER, L. F.; LORENZI-FILHO, G.
  • bookPart
    Avaliação inical do paciente com marca-passo definitivo na emergência
    (2018) GOES, Creuza Macedo; GEOVANINI, Glaucylara Reis
  • article 6 Citação(ões) na Scopus
    Obstructive sleep apnea and its management in patients with atrial fibrillation: An International Collaboration of Sleep Apnea Cardiovascular Trialists (INCOSACT) global survey of practicing cardiologists
    (2022) FAULX, Michael D.; MEHRA, Reena; GEOVANINI, Glaucylara Reis; ANDO, Shin-ichi; ARZT, Michael; DRAGER, Luciano; FU, Michael; HOYOS, Camilla; HAI, Jo; HWANG, Juey-Jen; KARAOGUZ, Remzi; KIMOFF, John; LEE, Pei-Lin; MEDIANO, Olga; PATEL, Sanjay R.; PEKER, Yuksel; PEPIN, Jean Louis; SANCHEZ-DE-LA-TORRE, Manuel; SERIES, Frederic; STADLER, Stefan; STROLLO, Patrick; TAHRANI, A. A.; THUNSTROM, Erik; YAMAUCHI, Motoo; REDLINE, Susan; PHILLIPS, Craig L.
    Background: Among international cardiologists it is unclear whether equipoise exists regarding the benefit of diagnosing and managing obstructive sleep apnea (OSA) to improve atrial fibrillation (AF) outcomes and whether clinical practice and equipoise are linked. Methods: Between January 2019 and June 2020 we distributed a web-based 12-question survey regarding OSA and AF management to practicing cardiologists in 16 countries. Results: The United States, Japan, Sweden, and Turkey accounted for two-thirds of responses. 863 cardiologists responded; half were general cardiologists, a quarter electrophysiologists. Responses regarding treating OSA with CPAP to improve AF endpoints were mixed. 33% of respondents referred AF patients for OSA screening. OSA was diagnosed in 48% of referred patients and continuous positive airway pressure (CPAP) was prescribed for 59% of them. Nearly 70% of respondents believed randomized controlled trials (RCTs) of OSA treatment in AF patients were necessary and indicated willingness to contribute to such trials. Conclusions: There was no clinical equipoise among surveyed cardiologists; a majority expressed certainty that combined OSA and AF treatment is superior to AF treatment alone for improving AF outcomes. However, a minority of surveyed cardiologists referred AF patients for OSA testing, and while half of screened AF patients had OSA, CPAP was prescribed in little more than half of them, reflecting the view that better clinical trial evidence is needed to support this practice. Our results underscore the need for larger, multi-national prospective studies of OSA treatment and AF outcomes to inform more uniform society guideline recommendations.
  • article 25 Citação(ões) na Scopus
    OSA and Depression Are Common and Independently Associated With Refractory Angina in Patients With Coronary Artery Disease
    (2014) GEOVANINI, Glaucylara R.; GOWDAK, Luis H. W.; PEREIRA, Alexandre C.; DANZI-SOARES, Naury de Jesus; DOURADO, Luciana O. C.; POPPI, Nilson T.; CESAR, Luiz Antonio Machado; DRAGER, Luciano F.; LORENZI-FILHO, Geraldo
    OBJECTIVE: Refractory angina is a severe form of coronary artery disease (CAD) characterized by persistent angina despite optimal medical therapy. OSA and depression are common in patients with stable CAD and may contribute to a poor prognosis. We hypothesized that OSA and depression are more common and more severe in patients with refractory angina than in patients with stable CAD. METHODS: We used standardized questionnaires and full polysomnography to compare consecutive patients with well-established refractory angina vs consecutive patients with stable CAD evaluated for coronary artery bypass graft surgery. RESULTS: Patients with refractory angina (n = 70) compared with patients with stable CAD (n = 70) were similar in sex distribution (male, 61.5% vs 75.5%; P = .07) and BMI (29.5 +/- 4 kg/m(2) vs 28.5 +/- 4 kg/ m(2), P = .06), and were older (61 +/- 10 y vs 57 +/- 7 y, P = .013), respectively. Patients with refractory angina had significantly more symptoms of daytime sleepiness (Epworth Sleepiness Scale score, 12 +/- 6 vs 8 +/- 5; P < .001), had higher depression symptom scores (Beck Depression Inventory score, 19 +/- 8 vs 10 +/- 8; P < .001) despite greater use of antidepressants, had a higher apnea-hypopnea index (AHI) (AHI, 37 +/- 30 events/h vs 23 +/- 20 events/h; P = .001), higher proportion of oxygen saturation < 90% during sleep (8% + 13 vs 4% + 9, P = .04), and a higher proportion of severe OSA (AHI >= 30 events/h, 48% vs 27%; P = .009) than patients with stable CAD. OSA (P = .017), depression (P < .001), higher Epworth Sleepiness Scale score (P = .007), and lower sleep efficiency (P = .016) were independently associated with refractory angina in multivariate analysis. CONCLUSIONS: OSA and depression are independently associated with refractory angina and may contribute to poor cardiovascular outcome.
  • bookPart
    Complicações associadas à estimulação cardíaca artificial
    (2016) LEAL, Tatiana de Carvalho Andreucci Torres; GEOVANINI, Glaucylara Reis
  • article 22 Citação(ões) na Scopus
    Poor sleep quality and lipid profile in a rural cohort (The Baependi Heart Study)
    (2019) GEOVANINI, Glaucylara Reis; LORENZI-FILHO, Geraldo; PAULA, Lilian K. de; OLIVEIRA, Camila Maciel; ALVIM, Rafael de Oliveira; BEIJAMINI, Felipe; NEGRAO, Andre Brooking; SCHANTZ, Malcolm von; KNUTSON, Kristen L.; KRIEGER, Jose Eduardo; PEREIRA, Alexandre Costa
    Aim: To test the association between cardiometabolic risk factors and subjective sleep quality assessed by the Pittsburgh sleep quality index (PSQI), independent of obstructive sleep apnea (OSA) and sleep duration. Methods: A total of 573 participants from the Baependi Heart Study, a rural cohort from Brazil, completed sleep questionnaires and underwent polygraphy for OSA evaluation. Multivariable linear regression analysis tested the association between cardiovascular risk factors (outcome variables) and sleep quality measured by PSQI, adjusting for OSA and other potential confounders (age, sex, race, salary/wage, education, marital status, alcohol intake, obesity, smoking, hypertension, and sleep duration). Results: The sample mean age was 43 +/- 16 years, 66% were female, and mean body mass index (BMI) was 26 +/- 5 kg/m(2). Only 20% were classified as obese (BMI >= 30). Overall, 50% of participants reported poor sleep quality as defined by a PSQI score >= 5. A high PSQI score was significantly associated with higher very-low-density lipoprotein (VLDL) cholesterol levels (beta = 0.392, p = 0.012) and higher triglyceride levels (beta = 0.017, p = 0.006), even after adjustments, including the apneaehypopnea index. Further adjustments accounting for marital status, alcohol intake, and medication use did not change these findings. No significant association was observed between PSQI scores and glucose or blood pressure. According to PSQI components, sleep disturbances (beta = 1.976, p = 0.027), sleep medication use (beta = 1.121, p = 0.019), and daytime dysfunction (beta = 1.290, p = 0.024) were significantly associated with higher VLDL serum levels. Only the daytime dysfunction domain of the PSQI components was significantly associated with higher triglyceride levels (beta = 0.066, p = 0.004). Conclusion: Poorer lipid profile was independently associated with poor sleep quality, assessed by the PSQI questionnaire, regardless of a normal sleep duration and accounting for OSA and socio-economic status.
  • article 18 Citação(ões) na Scopus
    1st Brazilian Positioning on the Impact of Sleep Disorders on Cardiovascular Diseases of the Brazilian Society of Cardiology
    (2018) DRAGER, Luciano E.; LORENZI-FILHO, Geraldo; CINTRA, Fatima Dumas; PEDROSA, Rodrigo P.; BITTENCOURT, Lia R. A.; POYARES, Dalva; CARVALHO, Carolina Gonzaga; MOURA, Sonia Maria Guimaraes Pereira Togeiro; SANTOS-SILVA, Rogerio; BRUIN, Pedro F. C. de; GEOVANINI, Glaucylara R.; ALBUQUERQUE, Felipe N.; OLIVEIRA, Vvercules Antonio Alves de; MOREIRA, Gustavo A.; UENO, Linda Massako; NERBASS, Flavia Baggio; RONDON, Maria Urbana Pinto Brandao; BARBOSA, Fine Rozaria Ferreira; BERTOLAMI, Adriana; PAOLA, Angelo Amato Vincenzo de; MARQUES, Betania Braga Silva; RIZZI, Camila Futado; NEGRAO, Carlos Eduardo; UCHOA, Carlos Henrique Gomes; MAKI-NUNES, Cristiane; MARTINEZ, Denis; FERNANDEZ, Edmundo Arteaga; MAROJA, Fabrizio U.; ALMEIDA, Fernanda R.; TROMBETTA, Ivani C.; STORTI, Luciana J.; BORTOLOTTO, Luiz Aparecido; MELLO, Marco Tulio de; BORGES, Melania Aparecida; ANDERSEN, Monica Levy; PORTILHO, Natanael de Paula; MACEDO, Paula; ALVES, Rosana; TUFIK, Sergio; FAGONDES, Simone C.; RISSO, Thais Telles