BRUNO TADEU MARTINS DE OLIVEIRA
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/20 - Laboratório de Terapêutica Experimental, Hospital das Clínicas, Faculdade de Medicina
LIM/20 - Laboratório de Terapêutica Experimental, Hospital das Clínicas, Faculdade de Medicina
6 resultados
Resultados de Busca
Agora exibindo 1 - 6 de 6
conferenceObject Plant proteinase from Bauhinia bauhinioides Kallikrein inhibitor (BbKI) attenuates mechanics, inflammation and remodelling induced by elastase in mice(2012) OLIVEIRA, Bruno Martins; ALMEIDA-REIS, Rafael; THEODORO, Osmar A.; OLIVA, Leandro V.; RODRIGUES, Daniel Flisch; PINHEIRO, Nathalia; OLIVA, Maria L. V.; PRADO, Carla M.; MARTINS, Milton M.; TIBERIO, Iolanda F. L. C.conferenceObject Plant proteinase inhibitor from Enterolobium contortisiliquum (EcTI) attenuates elastase-induced pulmonary inflammatory, remodeling and mechanical alterations in mice(2012) THEODORO-JUNIOR, Osmar A.; MARQUES, Ricardo Henrique; ALMEIDA-REIS, Rafael; MARTINS-OLIVEIRA, Bruno T.; OLIVA, Leandro V.; LOPES, Tales; PRADO, Carla M.; OLIVA, Maria L. V.; MARTINS, Milton; TIBERIO, Iolanda F. L. C.- A plant proteinase inhibitor from Crataeva tapia (CrataBL) attenuates elastase-induced pulmonary inflammatory, remodeling, and mechanical alterations in mice(2015) OLIVA, Leandro V.; ALMEIDA-REIS, Rafael; THEODORO-JUNIOR, Osmar; OLIVEIRA, Bruno M.; LEICK, Edna A.; PRADO, Carla M.; BRITO, Marlon V.; CORREIA, Maria Tereza dos Santos; PAIVA, Patricia M. G.; MARTINS, Milton A.; OLIVA, Maria Luiza V.; TIBERIO, Iolanda F. L. C.Chronic obstructive pulmonary disease (COPD) can lead to chronic and obstructive bronchitis and emphysema resulting in decreased bronchial lumen size. This study evaluated the effect of CrataBL, a protein isolated from the bark of Crataeva tapia, on lung mechanics, inflammation, and remodeling after elastase-induced pulmonary alterations in mice. The use of CrataBL led to decreased mechanical alterations, alveolar septum disruption (Lm), number of macrophage and neutrophil cells in the BALF, and TNF-alpha, MMP-9, MMP-12, TIMP-1, eNOS, and iNOS positive cells in the airways and alveolar walls compared to the animals in the ELA group. Moreover, a reduction in MUC-5-positive cells in the airway walls was observed. In conclusion, CrataBL attenuates changes in lung mechanics, inflammation, extracellular lung remodeling, and oxidative stress responses induced by the administration of elastase and decreased the volume fraction of isoprostane, collagen, and elastic fibers in the airways and alveolar walls compared to the animals in the ELA groups. Therefore, CrataBL is a potential therapeutic tool in the treatment of COPD.
conferenceObject Treatment with proteinase inhibitor, BbCI, modulates inflammatory response, mechanic alterations, and remodeling on elastase-induced emphysema in mice(2012) ALMEIDA-REIS, Rafael; OLIVEIRA, Bruno T. M.; THEODORO-JUNIOR, Osmar A.; OLIVA, Leandro V.; PINHEIRO, Nathalia; BRITO, Marlon V.; LOPES, Fernanda D. Q. T.; PRADO, Carla M.; MARTINS, Milton A.; OLIVA, Maria Luiza V.; TIBERIO, Iolanda F. L. C.conferenceObject Plant proteinase from bauhinia bauhinioides kallikrein inhibitor (BbKI) attenuates inflammation and remodelling induced by elastase in mice(2013) LEICK, Edna A.; OLIVEIRA, Bruno Tadeu Martins; ALMEIDA-REIS, Rafael; OLIVA, Leandro Vilela; THEODORO JR., Osmar A.; PRADO, Carla Maximo; MARTINS, Milton A.; OLIVA, Maria Luiza Vilela; TIBERIO, Iolanda F. L. C.conferenceObject Plant Kunitz proteinase inhibitor allenuates inflammation, oxidative stress and remodeling induced by elastase in mice(2014) LEICK, Edna K.; THEODORO-JUNIOR, Osmar A.; RIGHETTI, Renato F.; ALMEIDA-REIS, Rafael; OLIVA, Leandro; OLIVEIRA, Bruno T. Martins; PINHEIRO, Natalia M.; PRADO, Carla Maximo; OLIVA, Maria Luiza Vilela; MARTINS, Milton A.; TIBERIO, Iolanda F. L. C.