TANIT GANZ SANCHEZ
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Otorrinolaringologia e Oftalmologia, Faculdade de Medicina - Docente
LIM/32 - Laboratório de Otorrinolaringologia, Hospital das Clínicas, Faculdade de Medicina
LIM/32 - Laboratório de Otorrinolaringologia, Hospital das Clínicas, Faculdade de Medicina
24 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 24
- Management of hyperacusis in children - two case reports(2019) SANCHEZ, Tanit Ganz; PEREIRA, Isabella Marques
- Familial misophonia or selective sound sensitivity syndrome : evidence for autosomal dominant inheritance?(2018) SANCHEZ, Tanit Ganz; SILVA, Fulvia Eduarda daIntroduction: Misophonia is a recently described, poorly understood and neglected condition. It is characterized by strong negative reactions of hatred, anger or fear when subjects have to face some selective and low level repetitive sounds. The most common ones that trigger such aversive reactions are those elicited by the mouth (chewing gum or food, popping lips) or the nose (breathing, sniffing, and blowing) or by the fingers (typing, kneading paper, clicking pen, drumming on the table). Previous articles have cited that such individuals usually know at least one close relative with similar symptoms, suggesting a possible hereditary component. Objective: We found and described a family with 15 members having misophonia, detailing their common characteristics and the pattern of sounds that trigger such strong discomfort. Methods: All 15 members agreed to give us their epidemiological data, and 12 agreed to answer a specific questionnaire which investigated the symptoms, specific trigger sounds, main feelings evoked and attitudes adopted by each participant. Results: The 15 members belong to three generations of the family. Their age ranged from 9 to 73 years (mean 38.3 years; median 41 years) and 10 were females. Analysis of the 12 questionnaires showed that 10 subjects (83.3%) developed the first symptoms during childhood or adolescence. The mean annoyance score on the Visual Analog Scale from 0 to 10 was 7.3 (median 7.5). Individuals reported hatred/anger, irritability and anxiety in response to sounds, and faced the situation asking to stop the sound, leaving/avoiding the place and even fighting. The self-reported associated symptoms were anxiety (91.3%), tinnitus (50%), obsessive-compulsive disorder (41.6%), depression (33.3%), and hypersensitivity to sounds (25%). Conclusion: The high incidence of misophonia in this particular familial distribution suggests that it might be more common than expected and raises the possibility of having a hereditary etiology. (C) 2017 Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervico-Facial.
- Treatment of somatosensory tinnitus(2011) SANCHEZ, T. G.; ROCHA, C. B.Keypoints: 1. Treatment of somatosensory tinnitus often needs a multidisciplinary approach. 2. Treatment of patients who have signs of bone problems, muscular tension in the temporomandibular joint area or neck, should be directed to correct these problems as the first option. 3. If correction of bone or muscular disorders of -temporomandibular joint and neck fails in relieving tinnitus, symptomatic treatment should be initiated. © Springer Science+Business Media, LLC 2011.
- Tinnitus is associated with reduced sound level tolerance in adolescents with normal audiograms and otoacoustic emissions(2016) SANCHEZ, Tanit Ganz; MORAES, Fernanda; CASSEB, Juliana; COTA, Jaci; FREIRE, Katya; ROBERTS, Larry E.Recent neuroscience research suggests that tinnitus may reflect synaptic loss in the cochlea that does not express in the audiogram but leads to neural changes in auditory pathways that reduce sound level tolerance (SLT). Adolescents (N = 170) completed a questionnaire addressing their prior experience with tinnitus, potentially risky listening habits, and sensitivity to ordinary sounds, followed by psychoacoustic measurements in a sound booth. Among all adolescents 54.7% reported by questionnaire that they had previously experienced tinnitus, while 28.8% heard tinnitus in the booth. Psychoacoustic properties of tinnitus measured in the sound booth corresponded with those of chronic adult tinnitus sufferers. Neither hearing thresholds (<= 15 dB HL to 16 kHz) nor otoacoustic emissions discriminated between adolescents reporting or not reporting tinnitus in the sound booth, but loudness discomfort levels (a psychoacoustic measure of SLT) did so, averaging 11.3 dB lower in adolescents experiencing tinnitus in the acoustic chamber. Although risky listening habits were near universal, the teenagers experiencing tinnitus and reduced SLT tended to be more protective of their hearing. Tinnitus and reduced SLT could be early indications of a vulnerability to hidden synaptic injury that is prevalent among adolescents and expressed following exposure to high level environmental sounds.
- Fenômenos alucinatórios auditivos em pacientes com zumbido: relações afetivas e aspectos depressivos(2012) SANTOS, Rosa Maria Rodrigues dos; SANCHEZ, Tanit Ganz; BENTO, Ricardo Ferreira; LUCIA, Mara Cristina Souza deINTRODUCTION: Over the last few years, our Tinnitus Research Group has identified an increasing number of patients with tinnitus who also complained of repeated perception of complex sounds, such as music and voices. Such hallucinatory phenomena motivated us to study their possible relation to the patients' psyches. AIMS: To assess whether hallucinatory phenomena were related to the patients' psychosis and/or depression, and clarify their content and function in the patients' psyches. METHOD: Ten subjects (8 women; mean age = 65.7 years) were selected by otolaryngologists and evaluated by the same psychologists through semi-structured interviews, the Hamilton Depression Rating Scale, and psychoanalysis interviews. RESULTS: We found no association between auditory hallucinations and psychosis; instead, this phenomenon was associated with depressive aspects. The patients' discourse revealed that hallucinatory phenomena played unconscious roles in their emotional life. In all cases, there was a remarkable and strong tendency to recall/repeat unpleasant facts/situations, which tended to exacerbate the distress caused by the tinnitus and hallucinatory phenomena and worsen depressive aspects. CONCLUSIONS: There is an important relationship between tinnitus, hallucinatory phenomena, and depression based on persistent recall of facts/situations leading to psychic distress. The knowledge of such findings represents a further step towards the need to adapt the treatment of this particular subgroup of tinnitus patients through interdisciplinary teamwork. Prospective.
- Tinnitus in adolescents: the start of the vulnerability of the auditory pathways(2015) SANCHEZ, Tanit Ganz; OLIVEIRA, Juliana Casseb; KII, Márcia Akemi; FREIRE, Katya; COTA, Jaci; MORAES, Fernanda Vieira deINTRODUCTION: Although tinnitus is an increasingly common symptom, few studies have assessed its prevalence or incidence among adolescents. PURPOSE: To assess whether the presence of tinnitus in adolescents is associated with minimal hearing damage, evaluated through high-frequency audiometry (HFA), otoacoustic emission (OAE), and loudness discomfort level (LDL). METHODS: The sample comprised 168 adolescents of a private school (61.3% boys; mean age 14.1 years old; standard deviation=2). All of them completed a questionnaire about tinnitus and hypersensitivity to sounds (sound intolerance), and then underwent otoscopy, pure-tone audiometry, HFA, LDL, transient and distortion product otoacoustic emissions (TOAE and DPOAE), and tinnitus pitch/loudness matching (the latter only in those with tinnitus). Participants were later divided into three groups: with no tinnitus (n=73, 43.4%), with sporadic tinnitus (n=47, 28%), and with constant tinnitus (n=48, 28.6%). RESULTS: No significant difference was observed between the groups regarding audiometry thresholds in frequencies from 0.25 to 16 kHz, or TOAE and DPOAE. However, the LDL in adolescents with constant tinnitus was significantly lower than that in other groups, suggesting hypersensitivity to sounds. CONCLUSION: There was no evidence of minimal hearing damage in the audiometry and OAE. Nonetheless, the decreased LDL in adolescents with constant tinnitus suggests that their auditory system is more sensitive. Therefore, this may be the first sign of vulnerability to sounds. Future medium- to long-term monitoring of these students may show whether they will begin a process of functional impairment, altering hearing thresholds, and OAE.
- Diagnostic Criteria for Somatosensory Tinnitus: A Delphi Process and Face-to-Face Meeting to Establish Consensus(2018) MICHIELS, Sarah; SANCHEZ, Tanit Ganz; ORON, Yahav; GILLES, Annick; HAIDER, Haula F.; ERLANDSSON, Soly; BECHTER, Karl; VIELSMEIER, Veronika; BIESINGER, Eberhard; NAM, Eui-Cheol; OITICICA, Jeanne; MEDEIROS, Italo Roberto T. de; ROCHA, Carina Bezerra; LANGGUTH, Berthold; HEYNING, Paul Van de; HERTOGH, Willem De; HALL, Deborah A.Since somatic or somatosensory tinnitus (ST) was first described as a subtype of subjective tinnitus, where altered somatosensory afference from the cervical spine or temporomandibular area causes or changes a patient's tinnitus perception, several studies in humans and animals have provided a neurophysiological explanation for this type of tinnitus. Due to a lack of unambiguous clinical tests, many authors and clinicians use their own criteria for diagnosing ST. This resulted in large differences in prevalence figures in different studies and limits the comparison of clinical trials on ST treatment. This study aimed to reach an international consensus on diagnostic criteria for ST among experts, scientists and clinicians using a Delphi survey and face-to-face consensus meeting strategy. Following recommended procedures to gain expert consensus, a two-round Delphi survey was delivered online, followed by an in-person consensus meeting. Experts agreed upon a set of criteria that strongly suggest ST. These criteria comprise items on somatosensory modulation, specific tinnitus characteristics, and symptoms that can accompany the tinnitus. None of these criteria have to be present in every single patient with ST, but in case they are present, they strongly suggest the presence of ST. Because of the international nature of the survey, we expect these criteria to gain wide acceptance in the research field and to serve as a guideline for clinicians across all disciplines. Criteria developed in this consensus paper should now allow further investigation of the extent of somatosensory influence in individual tinnitus patients and tinnitus populations.
- Algorithm for the diagnostic and therapeutic management of tinnitus(2011) LANGGUTH, B.; BIESINGER, E.; BO, L. Del; RIDDER, D. De; GOODEY, R.; HERRAIZ, C.; KLEINJUNG, T.; LAINEZ, M. J. A.; LANDGREBE, M.; PAOLINO, M.; QUESTIER, B.; SANCHEZ, T. G.; SEARCHFIELD, G. D.Keypoints: 1. Tinnitus can be a symptom of a wide range of different underlying pathologies and accompanied by many different comorbidities, indicating the need for comprehensive multidisciplinary diagnostic assessment. 2. Basic diagnostics should include a detailed case history, assessment of tinnitus severity, clinical ear examination, and audiological measurement of hearing function. For a considerable number of patients, these first diagnostic steps in combination with counseling will be sufficient. 3. Further diagnostic steps are indicated if the findings of basic diagnostics point to acute tinnitus onset, a potentially dangerous underlying condition (e.g., carotid dissection), a possible causal treatment option, or relevant subjective impairment. 4. Further diagnostic management should be guided by clinical features. There is increasing evidence that phenomenologic and etiologic aspects determine the pathophysiology and the clinical course of tinnitus. In a hierarchical diagnostic algorithm, the first differentiation should be between pulsatile vs. non-pulsatile tinnitus. In case of non-pulsatile tinnitus, differentiation between acute tinnitus with hearing loss, paroxysmal tinnitus, and chronic tinnitus is recommended. Further diagnostic procedures of constant non-pulsatile tinnitus will depend on concomitant symptoms and etiological conditions. 5. All diagnostic and therapeutic steps should be accompanied by empathic and insightful counseling. 6. The ultimate treatment goal is the complete relief from tinnitus. If causally oriented treatment options are available, these should be preferred. However, in many cases, only symptomatic therapies can be offered, and then the treatment goal in clinical practice will be defined as the best possible reduction of unpleasant hearing sensations and accompanying symptoms, that is, to improve quality of life. © Springer Science+Business Media, LLC 2011.
- Tinnitus and cell phones: the role of electromagnetic radiofrequency radiation(2016) MEDEIROS, Luisa Nascimento; SANCHEZ, Tanit GanzIntroduction: Tinnitus is a multifactorial condition and its prevalence has increased on the past decades. The worldwide progressive increase of the use of cell phones has exposed the peripheral auditory pathways to a higher dose of electromagnetic radiofrequency radiation (EMRFR). Some tinnitus patients report that the abusive use of mobiles, especially when repeated in the same ear, might worsen ipsilateral tinnitus. Objective: The aim of this study was to evaluate the available evidence about the possible causal association between tinnitus and exposure to electromagnetic waves. Methods: A literature review was performed searching for the following keywords: tinnitus, electromagnetic field, mobile phones, radio frequency, and electromagnetic hypersensitivity. We selected 165 articles that were considered clinically relevant in at least one of the subjects. Results: EMRFR can penetrate exposed tissues and safety exposure levels have been established. These waves provoke proved thermogenic effects and potential biological and genotoxic effects. Some individuals are more sensitive to electromagnetic exposure (electrosensitivity), and thus, present earlier symptoms. There may be a common pathophysiology between this electrosensitivity and tinnitus. Conclusion: There are already reasonable evidences to suggest caution for using mobile phones to prevent auditory damage and the onset or worsening of tinnitus.
- Long-lasting total remission of tinnitus: A systematic collection of cases(2021) SANCHEZ, Tanit Ganz; VALIM, Caroline C. A.; SCHLEE, WinfriedBackground: Clinical observation suggests that total remission of tinnitus may exist, but a systematic analysis of these cases is missing. We aimed to identify subjects with long lasting total remission of tinnitus. Methods: By publishing announcements, we included volunteers of any gender and age who have had daily perception of tinnitus for over 3 months and have been in total remission (lack of tinnitus perception, even in silence and with deliberate attention to it) for over 6 months. We excluded individuals in a state of habituation or masking. We applied a structured interview to standardize information about tinnitus and its remission. Follow-up interviews took place after 6, 12, and 18 months. Results: Eighty individuals (56 females; age = 54.2 +/- 16.8 years) were included. History of bilateral tinnitus accounted for 51.4% of cases. Total remission occurred in subjects whose tinnitus lasted for 49.0 +/- 73.5 months. Remission occurred gradually in 78.6% of cases and suddenly in 22%. During the further 18-month follow-up, 7.9% reported recurrence of tinnitus and 92.1% remained symptom free. Conclusion: Different than the knowledge obtained from clinical trials, this study showed that long-lasting total remission of tinnitus may occur. This status was reached by individuals of any gender and age range, with any location and duration of tinnitus, mostly as a gradual process. Future studies should better clarify how each treatment modality may achieve the best results.
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