ALEXANDRE LEOPOLD BUSSE
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/66, Hospital das Clínicas, Faculdade de Medicina
LIM/66, Hospital das Clínicas, Faculdade de Medicina
4 resultados
Resultados de Busca
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- Effects of Brazil nut consumption on selenium status and cognitive performance in older adults with mild cognitive impairment: a randomized controlled pilot trial (vol 55, pg 107, 2016)(2021) CARDOSO, Barbara Rita; APOLINARIO, Daniel; BANDEIRA, Veronica da Silva; BUSSE, Alexandre Leopold; MAGALDI, Regina Miksian; JACOB-FILHO, Wilson; COZZOLINO, Silvia Maria Franciscato
- Muscle strength and muscle mass as predictors of hospital length of stay in patients with moderate to severe COVID-19: a prospective observational study(2021) GIL, Saulo; JACOB FILHO, Wilson; SHINJO, Samuel Katsuyuki; FERRIOLLI, Eduardo; BUSSE, Alexandre Leopold; AVELINO-SILVA, Thiago Junqueira; LONGOBARDI, Igor; OLIVEIRA JUNIOR, Gersiel Nascimento de; SWINTON, Paul; GUALANO, Bruno; ROSCHEL, HamiltonBackground Strength and muscle mass are predictors of relevant clinical outcomes in critically ill patients, but in hospitalized patients with COVID-19, it remains to be determined. In this prospective observational study, we investigated whether muscle strength or muscle mass are predictive of hospital length of stay (LOS) in patients with moderate to severe COVID-19 patients. Methods We evaluated prospectively 196 patients at hospital admission for muscle mass and strength. Ten patients did not test positive for SARS-CoV-2 during hospitalization and were excluded from the analyses. Results The sample comprised patients of both sexes (50% male) with a mean age (SD) of 59 (+/- 15) years, body mass index of 29.5 (+/- 6.9) kg/m(2). The prevalence of current smoking patients was 24.7%, and more prevalent coexisting conditions were hypertension (67.7%), obesity (40.9%), and type 2 diabetes (36.0%). Mean (SD) LOS was 8.6 days (7.7); 17.0% of the patients required intensive care; 3.8% used invasive mechanical ventilation; and 6.6% died during the hospitalization period. The crude hazard ratio (HR) for LOS was greatest for handgrip strength comparing the strongest versus other patients (1.47 [95% CI: 1.07-2.03; P = 0.019]). Evidence of an association between increased handgrip strength and shorter hospital stay was also identified when handgrip strength was standardized according to the sex-specific mean and standard deviation (1.23 [95% CI: 1.06-1.43; P = 0.007]). Mean LOS was shorter for the strongest patients (7.5 +/- 6.1 days) versus others (9.2 +/- 8.4 days). Evidence of associations were also present for vastus lateralis cross-sectional area. The crude HR identified shorter hospital stay for patients with greater sex-specific standardized values (1.20 [95% CI: 1.03-1.39; P = 0.016]). Evidence was also obtained associating longer hospital stays for patients with the lowest values for vastus lateralis cross-sectional area (0.63 [95% CI: 0.46-0.88; P = 0.006). Mean LOS for the patients with the lowest muscle cross-sectional area was longer (10.8 +/- 8.8 days) versus others (7.7 +/- 7.2 days). The magnitude of associations for handgrip strength and vastus lateralis cross-sectional area remained consistent and statistically significant after adjusting for other covariates. Conclusions Muscle strength and mass assessed upon hospital admission are predictors of LOS in patients with moderate to severe COVID-19, which stresses the value of muscle health in prognosis of this disease.
- Indoor/outdoor particulate matter and health risk in a nursing community home in Sao Paulo, Brazil(2021) SOUSA, Natannael Almeida; SEGALIN, Bruna; BUSSE, Alexandre L.; FILHO, Wilson J.; FORNARO, Adalgiza; GONCALVES, Fabio L. T.The elderly spend more of their daily time indoors, especially at home, and due to this, air quality measurements where they live are extremely important. Thus, this study was conducted to evaluate indoor/outdoor size-segregated particulate matter (PM) mass concentrations, followed by black carbon (rBC) and trace elements analysis and health risk assessment estimate in quasi-ultrafine particles (q-UFP), in a OL nursing home in Sao Paulo, Brazil. The outdoor mass concentrations (32.0 mu g/m(3) for PM10 and 22.8 mu g/m(3) for PM2.5) were higher (p < 0.05) than those indoors (21.6 mu g/m(3) for PM10 and 14.6 mu g/m(3) for PM2.5), indicating the significant influence of outdoor sources reinforced by the strong correlation between indoor/outdoor, r(2) = 0.84 and 0.79 for PM10 and PM2.5, respectively. The daily PM2.5 and PM10 mass concentrations indoors and outdoors exceeded the World Health Organization (WHO) Guidelines during different seasons. The elements S, K and Na were the most abundant in all campaigns, with sulfur the highest, reaching 740 and 722 ng/m(3) outdoors and indoors, respectively. The Lifetime Carcinogenic Risk (LCR) values (2.2 x 10(-5) and 4.6 x 10(-5)/1.9 x 10(-5) and 3.8 x 10(-5)) exceeded the threshold value of 1 x 10(-6) under indoors and outdoors, on mean, for different scenarios (chronic and sub chronic). The particle deposition was found to be 32%, in the respiratory system, higher for elderly males than for females. Our study confirmed that both indoor and outdoor environments may be unsafe for the elderly health and the importance of reducing harmful air pollutants where populations have been living.
conferenceObject THE EFFECT OF PILATES METHOD OF AUTONOMIC MODULATION IN OLDER WOMEN(2021) ALVES, Tatiana Pereira; OLIV, Patrick Rodrigues Correia De; COSTA, Ana Carolina; BELARMINO, Giliane; LIMA, Cintia Taniguti; RODRIGUES, Gabriel Dias; WAITZBERG, Dan Linetzky; SOARES, Pedro Paulo Da Silva; BUSSE, Alexandre Leopold; IRIGOYEN, Maria Claudia; JACOB FILHO, Wilson; LACCHINI, Silvia