ANDRE MATHIAS BAPTISTA

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Instituto de Ortopedia e Traumatologia, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/41 - Laboratório de Investigação Médica do Sistema Músculoesquelético, Hospital das Clínicas, Faculdade de Medicina

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  • article 22 Citação(ões) na Scopus
    Validation of the Brazilian Version of the Musculoskeletal Tumor Society Rating Scale for Lower Extremity Bone Sarcoma
    (2013) REBOLLEDO, Daniel Cesar Seguel; VISSOCI, Joao Ricardo Nickenig; PIETROBON, Ricardo; CAMARGO, Olavo Pires de; BAPTISTA, Andre Mathias
    The Musculoskeletal Tumor Society (MSTS) rating scale is an English-language instrument used worldwide to assess functional evaluation of patients with musculoskeletal cancer. Despite its use in several studies in English-speaking countries, its validity for assessing patients in other languages is unknown. The translation and validation of widely used scales can facilitate the comparison across international patient samples. The objectives of this study were (1) to translate and culturally adapt the MSTS rating scale for functional evaluation in patients with lower extremity bone sarcomas to Brazilian Portuguese; (2) analyze its factor structure; and (3) test the reliability and (4) validity of this instrument. The MSTS rating scale for lower limbs was translated from English into Brazilian Portuguese. Translations were synthesized, translated back into English, and reviewed by a multidisciplinary committee for further implementation. The questionnaire was administered to 67 patients treated for malignant lower extremity bone tumors who were submitted to limb salvage surgery or amputation. They also completed a Brazilian version of the Toronto Extremity Salvage Score (TESS). Psychometric properties were analyzed including factor structure analysis, internal consistency, interobserver reliability, test-retest reliability, and construct validity (by comparing the adapted MSTS with TESS and discriminant validity). The MSTS rating scale for lower limbs was translated and culturally adapted to Brazilian Portuguese. The MSTS-BR proved to be adequate with only one latent dimension. The scale was also found to be reliable in a population that speaks Brazilian Portuguese showing good internal consistency (Cronbach's alpha = 0.84) and reliability (test-retest reliability and interobserver agreement of 0.92 and 0.98, respectively). Validity of the Brazilian MSTS rating scale was proved by moderate with TESS and good discriminant validity. The Brazilian version of the MSTS rating scale was translated and validated. It is a reliable tool to assess functional outcome in patients with lower extremity bone sarcomas. It can be used for functional evaluation of Brazilian patients and crosscultural comparisons.
  • article 25 Citação(ões) na Scopus
    Prophylactic antibiotic regimens in tumour surgery (PARITY) A PILOT MULTICENTRE RANDOMISED CONTROLLED TRIAL
    (2015) GHERT, M.; BHANDARI, M.; DEHESHI, B.; GUYATT, G.; HOLT, G.; O'SHEA, T.; RANDALL, R. L.; THABANE, L.; WUNDER, J.; EVANIEW, N.; MCKAY, P.; SCHNEIDER, P.; TURCOTTE, R.; MADDEN, K.; SCOTT, T.; SPRAGUE, S.; SIMUNOVIC, N.; SWINTON, M.; RACANO, A.; HEELS-ANSDELL, D.; BUCKINGHAM, L.; ROSE, P.; BRIGMAN, B.; PULLENAYEGUM, E.; GHERT, M.; EVANIEW, N.; MCKAY, P.; SCHNEIDER, P.; SOBHI, G.; CHAN, R.; BILJAN, M.; FERGUSON, P.; WUNDER, J.; GRIFFIN, A.; MANTAS, I.; WYLIE, A.; HAN, A.; GREWAL, G.; TURCOTTE, R.; GOULDING, K.; DANDACHLI, F.; MATTE, G.; WERIER, J.; ABDELBARY, H.; PAQUIN, K.; COSGROVE, H.; DUGAL, A-M.; FETZER, S.; AIKENS, W.; CLARKSON, P.; WANG, B.; KONDO, L.; YIP, J.; ISLER, M.; MOTTARD, S.; BARRY, J.; YVES, H. St; QUACH, M.; ASSAYAG, H.; DAOUST, K.; GOYETTE, K.; PROJEAN, D.; DION, N.; ARTEAU, A.; TURMEL, S.; BERTRAND, A.; GAGNON, N.; LABBE, V.; HOLT, G.; HALPERN, J.; SCHWARTZ, H.; ATKINSON, A.; DANIELS, J.; MOORE, M. S.; ANDERSON, M.; GEBHARDT, M.; WAGNER, K.; PATEL, H.; JOLIN, H.; ANDERSON, M.; GEBHARDT, M.; ALLAR, B.; NAQVI, M.; BENNETT, J.; ALBUQUERQUE, S.; RANDALL, R. L.; JONES, K.; CRABTREE, S.; DAVIS, R.; SORENSON, S.; HEALEY, J. H.; GALLE, J.; O'NEILL, G.; CORRAL, B. Del; LOPEZ, S.; SERRA, M. Galli; PARIZZIA, W.; PODRZAJ, A.; TORRES, M. Foa; CLAYER, M.; CHAI, Y.; SLOBODIAN, P.; BALACH, T.; COYLE, K.; LACASSE, R.; ABRAHAM, J.; MORRISON, T.; ANGELOS, M.; SAILOR, L.; SADAKA, R.; MILLER, B.; MILHEM, M.; MCCURDY, N.; KAIN, J.; NOHR, J.; JOHNSON, K.; MERRISS, A.; CHENG, E.; LUKE, D. G.; SCHARSCHMIDT, T. J.; CRIST, M. K.; DIMEO, A.; MARMON, L.; REIMER, N.; MONSON, D.; OSKOUEI, S.; LOMBA, C.; ROGERS, S.; AVEDIAN, R.; JORDAN, L.; CHINN, S.; HAMILTON, M.; GHERT, M.; EVANIEW, N.; MCKAY, P.; SCHNEIDER, P.; SOBHI, G.; CHAN, R.; BIL-JAN, M.; FERGUSON, P.; WUNDER, J.; GRIFFIN, A.; MANTAS, I.; WYLIE, A.; HAN, A.; GREWAL, G.; TURCOTTE, R.; GOULDING, K.; DANDACHLI, F.; MATTE, G.; WERIER, J.; ABDELBARY, H.; PAQUIN, K.; COSGROVE, H.; DUGAL, A-M.; FETZER, S.; AIKENS, W.; CLARKSON, P.; WANG, B.; KONDO, L.; YIP, J.; ISLER, M.; MOTTARD, S.; BARRY, J.; YVES, H. St.; QUACH, M.; ASSAYAG, H.; DAOUST, K.; GOYETTE, Kristine; PROJEAN, D.; DION, N.; ARTEAU, A.; TURMEL, S.; BERTRAND, A.; GAGNON, N.; LABBE, V.; HOLT, G.; HALPERN, J.; SCHWARTZ, H.; ATKINSON, A.; DANIELS, J.; MOORE, M. S.; ANDERSON, M.; GEBHARDT, M.; WAGNER, K.; PATEL, H.; JOLIN, H.; ANDERSON, M.; GEBHARDT, M.; ALLAR, B.; NAQVI, M.; BENNETT, J.; ALBUQUERQUE, S.; RANDALL, R. L.; JONES, K.; CRABTREE, S.; DAVIS, R.; SORENSON, S.; HEALEY, J. H.; GALLE, J.; O'NEILL, G.; CORRAL, B. Del; LOPEZ, S.; SERRA, M. Galli; PARIZZIA, W.; PODRZAJ, A.; TORRES, M. Foa; CLAYER, M.; TRAN, N.; SLOBODIAN, P.; BALACH, T.; COYLE, K.; LACASSE, R.; ABRAHAM, J.; MORRISON, T.; ANGELOS, M.; SAILOR, L.; SADAKA, R.; MILLER, B.; MILHEM, M.; MCCURDY, N.; KAIN, J.; NOHR, J.; JOHNSON, K.; MERRISS, A.; CHENG, E.; LUKE, D. G.; SCHARSCHMIDT, T. J.; CRIST, M. K.; DIMEO, A.; MARMON, L.; REIMER, N.; MONSON, D.; OSKOUEI, S.; LOMBA, C.; ROGERS, S.; GELLER, D.; HOANG, B.; TINGLING, J.; SOLORZANO, C.; AVEDIAN, R.; JORDAN, L.; CHINN, S.; HAMILTON, M.; PULOSKI, S.; MONUMENT, M.; CARCARY, K.; CAMERON, C.; ABOULAFIA, A.; LOO-MIS, M.; BOSLEY, J.; BONVEGNA, R.; KASSA, M.; DAMRON, T.; CRAIG, T.; REALE, M.; GOODMAN, H. J.; CULBERTSON, M. Deza; CARUSO, P.; GARLING, E.; SCHWAB, J.; FIORE, A.; PHUKAN, R.; PARK, C.; JOSHI, L.; ABOULAFIA, A.; WALLACE, M.; FLACK, J.; VAUGHAN, K.; AVERGAS, A.; BRADY, M.; BROWN, S.; SCHADIE, N.; BATTERSBY, R.; WEISS, K.; GOODMAN, M.; HEYL, A.; YESCHKE, C. A.; SUMIC, P.; DUDGEON, M.; PROSSER, R.; KORENOSKI, C.; DICAPRIO, M.; PALMER, B.; CIOPPA, E.; SCHAEFFER, T. M.; PAUL, P.; TORESON, J.; CUMMINGS, J.; SCHWARTZ, L.; ZAHNER, B.; MORRIS, C.; LALJANI, V.; MESKO, N.; JOYCE, M.; LIETMAN, S.; WUSTRACK, R.; O'DONNELL, R.; STEVENSON, C.; CARMODY, E.; TYLER, W.; MCINTYRE, A.; SPIGUEL, A.; SCARBOROUGH, M.; GIBBS, C. P.; STESHYN, J.; NUNN, B.; ROSENTHAL, H.; HAYNES, K.; LEDDY, L.; WALTON, Z.; DOUNG, Y-C.; HAYDEN, J.; VELEZ, R.; AGUIRRE, M.; PEREZ, M.; BARRERA, S.; LOPEZ, A. Garca; GRIMER, R.; DUNN, K.; VIRDEE, H.; RANKIN, K.; BECKINGSALE, T.; GERRAND, C.; CAMPBELL, I.; ALLEN, M.; KHAN, S. Alam; BAKSHI, S.; RASTOGI, S.; POUDEL, R.; KUMAR, V. Sampath; RAI, A.; BAPTISTA, A. M.; CAMARGO, O. P. de; MARAIS, L.; RODSETH, R.; FERREIRA, N.; RAJAH, C.; GUMEDE, S.; GORTZAK, Y.; STERNHEIM, A.; BICKELS, J.; KOLANDER, Y.; LEV, S.; HETTWER, W.; PETERSEN, M. M.; GRUM-SCHWENSEN, T.; JUTTE, P.; PLOEGMAKERS, J. J. W.; STEVENS, M.; MAHENDRA, A.; GUPTA, S.; BERGOVEC, M.; LEITHNER, A.; FUNOVICS, P.; DIJKSTRA, P. D. S.; SANDE, M. Van De; HOOGENSTRAATEN, A.; LEIJERZAPF, N.; STEADMAN, P.; STEADMAN, P.; BOFFANO, M.; PIANA, R.; MARONE, S.; ALBERTINI, U.; BOUX, E.; MAIELLO, A.; REPSA, L.; ZILE, S.; ASTON, W.; POLLOCK, R.; COOL, P.; GIBBONS, M.; WHIT-WELL, D.; COSKER, T.; HEMINGWAY, J.; PORTER, D.; PATTON, S.; NAVIA, J.; BETANCUR, A. F.; LAITENEN, M.; PAKARINEN, K.; NIEMINEN, J.; YLA-MONONEN, S.; RAUTIAINEN, S.; FIORENZA, F.
    Objective Clinical studies of patients with bone sarcomas have been challenged by insufficient numbers at individual centres to draw valid conclusions. Our objective was to assess the feasibility of conducting a definitive multi-centre randomised controlled trial (RCT) to determine whether a five-day regimen of post-operative antibiotics, in comparison to a 24-hour regimen, decreases surgical site infections in patients undergoing endoprosthetic reconstruction for lower extremity primary bone tumours. Methods We performed a pilot international multi-centre RCT. We used central randomisation to conceal treatment allocation and sham antibiotics to blind participants, surgeons, and data collectors. We determined feasibility by measuring patient enrolment, completeness of follow-up, and protocol deviations for the antibiotic regimens. Results We screened 96 patients and enrolled 60 participants (44 men and 16 women) across 21 sites from four countries over 24 months (mean 2.13 participants per site per year, standard deviation 2.14). One participant was lost to follow-up and one withdrew consent. Complete data were obtained for 98% of eligible patients at two weeks, 83% at six months, and 73% at one year (the remainder with partial data or pending queries). In total, 18 participants missed at least one dose of antibiotics or placebo post-operatively, but 93% of all postoperative doses were administered per protocol. Conclusions It is feasible to conduct a definitive multi-centre RCT of post-operative antibiotic regimens in patients with bone sarcomas, but further expansion of our collaborative network will be critical. We have demonstrated an ability to coordinate in multiple countries, enrol participants, maintain protocol adherence, and minimise losses to follow-up.
  • article 1 Citação(ões) na Scopus
    Imaging of solitary and multiple osteochondromas: From head to toe - A review
    (2023) PONTES, Irline Cordeiro de Macedo; LEAO, Renata Vidal; LOBO, Carlos Felipe Teixeira; PAULA, Vitor Tavares; YAMACHIRA, Viviane Sayuri; BAPTISTA, Andre Mathias; HELITO, Paulo Victor Partezani
    Osteochondromas account for 20%-50% of all benign bone lesions. These tumors may present as solitary non-hereditary lesions, which are the most common presentation, or as multiple tumors associated with hereditary conditions. Plain radiography is the imaging method of choice and demonstrates the typical cortical and med-ullary continuity of the tumor with the underlying bone. Magnetic resonance imaging is often performed to evaluate cartilage cap thickness, which correlates with malignant transformation. Other local complications include compression of adjacent neurovascular bundles, muscles, and tendons, bursitis, tendon tears, stalk fracture, and angular or rotational long bone deformities. Although the imaging features of osteochondromas are largely known, only a few papers in the literature have focused on their main complications and image-based follow-up. This paper aimed to illustrate the main complications of osteochondromas, suggest an image-based algorithm for management and follow-up and discuss differential diagnosis.
  • article 5 Citação(ões) na Scopus
    VALUES OF ALKALINE PHOSPHATASE AND LACTATE DEHYDROGENASE IN EWING'S SARCOMA
    (2016) BAPTISTA, Andre Mathias; ZUMARRAGA, Juan Pablo; SANTOS, Renan Pires Negrao dos; HAUBERT, Guilherme de Oliveira; CAMARGO, Olavo Pires de
    Objective: To study the relationship between the serum levels of alkaline phosphatase (AP) and lactate dehydrogenase (LDH), and the percentage of tumor necrosis (TN) in patients with Ewing's Sarcoma (ES). Methods: This is a case series with retrospective evaluation of patients with diagnosis of ES divided into 2 groups: Group 1, patients whose serum levels of alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) were obtained in the staging phase before preoperative chemotherapy (CT), and Group 2, patients whose values were measured after completion of the preoperative CT. The percentage of tumor necrosis (TN) of surgical specimens extracted in surgery was also evaluated. Results: Eighty four medical records from 1995 to 2015 were included. Both AP as LDH decreased in the patients studied, the pre CT value being higher than the post CT value. The average decrease of LHD was 272.95 U/L and AP was 10.17 U/L. The average tumor necrosis was 65.12 %. There was no statistical correlation between serums levels and the tumor necrosis percentage. Conclusion: The serum levels values of AP and LDH are not predictors for chemotherapy-induced necrosis in patients with ES.
  • article 11 Citação(ões) na Scopus
    BIOACTIVE GLASS IN CAVITARY BONE DEFECTS: A COMPARATIVE EXPERIMENTAL STUDY IN RABBITS
    (2015) CAMARGO, Andre Ferrari de Franca; BAPTISTA, Andre Mathias; NATALINO, Renato; CAMARGO, Olavo Pires de
    Objectives: To compare bioactive glass and autograft regarding their histomorphometric characteristics. Methods: The authors conducted a prospective case-control experimental study on animals in order to compare the histomorphometric characteristics of bioactive glass versus autograft. Eight rabbits underwent surgery in which a cavitary defect was created in both proximal femurs. One side was filled with bioactive glass granules and the other, with autograft grafted from the contralateral side. The sides were randomized. Fourteen days after surgery, the animals were euthanized. Results: Histologic analysis revealed that bone neoformation was equivalent among the two groups and the osteoblasts cell-count was higher in the femurs treated with bioactive glass. The osteocytes cell-count, however, was lower. The similarity in bone formation between both groups was consistent to literature findings. Conclusion: Bioactive glass is similar to autograft regarding bone neoformation in this animal model of cavitary bone defects.
  • article 6 Citação(ões) na Scopus
    PRIMARY BONE LYMPHOMAS: RETROSPECTIVE ANALYSIS OF 42 CONSECUTIVE CASES
    (2018) SANTOS, Telma Murias Dos; ZUMARRAGA, Juan Pablo; REAES, Fabio Mazetti; MACANEIRO JUNIOR, Carlos Henrique; BAPTISTA, Andre Mathias; CAMARGO, Olavo Pires De
    Objective: It is difficult to define parameters for management and factors associated with primary bone lymphoma (PBL). This article presents the experience in a single institution with 42 patients with PBL over a 16-year period (2000-2016). Methods: Fifty-five patients were retrospectively evaluated, and forty-two were included (76.3%). Results: Median age at diagnosis was 51.5 years, and median follow-up was 102.7 months. One patient had HIV. Pain in the affected site was the most prevalent symptom. The average time between symptom onset and diagnosis was 5.4 months. The vertebrae were most affected (n=16, 33.3%). According to the International Prognostic Index Score (IPI), 64.3% of the patients were classified as having low-grade lymphoma and 25.7% as low-intermediate. The most common histology was diffuse large B cell lymphoma (DLBCL) (85.7%). Immunophenotyping was CD20 positive in 93.5% of patients, and 11 patients had pathological fracture. All patients received chemotherapy and 30% of the regimens included rituximab. Thirty-eight percent of patients received radiation therapy. Overall survival was 50%, and survival median time was 80 months. Age and chemotherapy regimen influenced patient survival. Younger patients and patients who received RCHOP had better prognoses. Conclusions: The choice of chemotherapy regimen associated with age influenced survival for patients with PBL.
  • article 0 Citação(ões) na Scopus
  • article 0 Citação(ões) na Scopus
    IMMUNOHISTOCHEMICAL ANALYSIS BY KI67 AND IDH1 IN PATIENTS WITH CHONDROSARCOMA
    (2023) RIBEIRO, Marcelo Barbosa; IBIAPINA, Jerusia Oliveira; BAPTISTA, Andre Mathias; CAMARGO, Olavo Pires de
    Objective: To perform an immunohistochemical evaluation using the IDH1 and Ki67 markers in patients who underwent treatment for chondrosarcoma in a reference service center in Brazil. Methods: Retrospective analytical observational study using medical records of patients diagnosed with chondrosarcoma. Besides the epidemiological and clinical profile, important variables for prognosis and correlation with immunohistochemical analysis results with Ki67 and IDH1 markers were evaluated. Results: Histopathological examinations by immunohistochemistry of 56 patients were analyzed, 52% of which were women, with the age group 20-60 years being more prevalent. Grade 1 and 2 histological subtypes corresponded to most chondrosarcomas. The femur, humerus, and tibia were the most frequent anatomical sites. Most tumors (59%) were larger than 8 cm. Ki67 expression was very low (< 10%) in 98% of patients. The analysis of IDH1 was positive in 43% of the cases. The correlation between IDH1 positivity and tumor size was statistically significant, but regarding survival, we observed no significance. Conclusion: Immunohistochemical analysis using IDH1 and Ki67 markers in patients with conventional chondrosarcoma is not useful for prognostic guidance.
  • article 4 Citação(ões) na Scopus
    PROGNOSTIC FACTORS IN PATIENTS WITH APPENDICULAR MYXOFIBROSARCOMA
    (2018) ZUMARRAGA, Juan Pablo; BATISTA, Felipe Augusto Ribeiro; BAPTISTA, Andre Mathias; CAIERO, Marcelo Tadeu; MARTINO, Luis Pablo De La Rosa; CAMARGO, Olavo Pires De
    Objective: Myxofibrosarcoma (MFS) is a common soft tissue sarcoma (STS) that affects the extremities in elderly patients. The objective was to analyze the prognostic factors and outcomes of patients with MFS treated at a single institution. Methods: We retrospectively reviewed the records of 75 patients with MFS. We compared age, sex, tumor size and location, grade and stage of the disease. Median age was 49.7 years (range, 1 to 88 y). Location: upper extremity (25.4%), lower extremity (66.6%) and pelvis (8%). Patients had high-grade tumors in 46.7% of the reports. Margins were negative in 76% of the cases. Bivariate Cox regression analysis was used to determine associations between clinical and treatment factors with local recurrence (LR). Results: Median follow-up time was 30.7 months (range, 1.8 to 383.8 m). We found 26.7% of LR. Distant metastasis (DM) was reported in 27 (36%) patients. Lung was the most common site of DM, reported in 92.6% of patients. Overall survival (OS) with metastasis was 21.2 months (range, 4.8 to 114.8 m). Predictors of OS were grade, LR (hazard ratio [FIR] 5.13, 95% confidence interval, 2.15-12.24, P <0.001), and DM (HR 540.97, 95% confidence interval, 5.04-58112.03, P< 0.001). Conclusions: Tumor grade, LR, positive margins and DM were significant predictors of poor OS prognosis.
  • article 16 Citação(ões) na Scopus
    CORRELATION BETWEEN THE EXPRESSION OF VEGF AND SURVIVAL IN OSTEOSARCOMA
    (2014) BAPTISTA, Andre Mathias; CAMARGO, Andre Ferrari de Franca; FILIPPI, Renee Zon; OLIVEIRA, Claudia Regina Gomes Cardim Mendes de; AZEVEDO NETO, Raymundo Soares de; CAMARGO, Olavo Pires de
    Objective: To present a series of 50 consecutive patients with non-metastatic extremity osteosarcoma, and attempt to correlate expression of the vascular endothelial growth factor (VEGF) protein in biopsy tissue to their prognosis regarding overall survival, disease-free survival and local recurrence. Methods: Fifty cases of non-metastatic osteosarcoma of the extremities treated between 1986 and 2006 at Instituto de Ortopedia e Traumatologia da Universidade de Sao Paulo, Sao Paulo, Brasil, were evaluated regarding expression of the VEGF protein. There were 19 females and 31 males. The mean age was 16 years old (range 5-28 years old) and the mean follow-up was 60.6 months (range 25-167 months). The variables studied were age, gender, anatomic location, type of surgery, surgical margins, tumor size, post chemotherapy necrosis, local recurrence, pulmonary metastasis and death. Results: Thirty-six patients showed VEGF expression on 30% or less cells (low), and the remaining 14 cases had VEGF expression above 30% (high). Among the 36 patients with low VEGF expression, nine developed pulmonary metastasis and four died (11.1%). Among the 14 patients with high VEGF expression, six developed pulmonary metastasis and three died (21.4%). Conclusion: There was no statistically significant correlation between the expression of VEGF and any of the variables studied.