PEDRO PAULO PEREIRA
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/57 - Laboratório de Fisiologia Obstétrica, Hospital das Clínicas, Faculdade de Medicina
LIM/57 - Laboratório de Fisiologia Obstétrica, Hospital das Clínicas, Faculdade de Medicina
44 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 44
bookPart Cesárea(2020) YOSHIZAKI, Carlos Tadashi; OSMUNDO JUNIOR, Gilmar de Souza; PEREIRA, Pedro Paulo; FRANCISCO, Rossana Pulcineli Vieira; MIYADAHIRA, Seizo; MARTINELLI, Silvio; BUNDUKI, VictorbookPart Hemorragia pós-parto(2020) YOSHIZAKI, Carlos Tadashi; OSMUNDO JUNIOR, Gilmar de Souza; PEREIRA, Pedro Paulo; FRANCISCO, Rossana Pulcineli Vieira; MIYADAHIRA, Seizo; MARTINELLI, Silvio; BUNDUKI, VictorbookPart Planejamento familiar(2020) YOSHIZAKI, Carlos Tadashi; OSMUNDO JUNIOR, Gilmar de Souza; PEREIRA, Pedro Paulo; FRANCISCO, Rossana Pulcineli Vieira; MIYADAHIRA, Seizo; MARTINELLI, Silvio; BUNDUKI, VictorbookPart Obesidade e gravidez(2020) YOSHIZAKI, Carlos Tadashi; TESTA, Carolina Burgarelli; PAGANOTI, Cristiane de Freitas; BAPTISTA, Fernanda Spadotto; OSMUNDO JUNIOR, Gilmar de Souza; LIN, Lawrence Hsu; GALLETTA, Marco Aurélio Knippel; BORTOLOTTO, Maria Rita de Figueiredo Lemos; PEREIRA, Pedro Paulo; COSTA, Rafaela Alkmin da; RIBEIRO, Renata Lopes; FRANCISCO, Rossana Pulcineli VieirabookPart Fórcipe(2020) YOSHIZAKI, Carlos Tadashi; OSMUNDO JUNIOR, Gilmar de Souza; PEREIRA, Pedro Paulo; FRANCISCO, Rossana Pulcineli Vieira; MIYADAHIRA, Seizo; MARTINELLI, Silvio; BUNDUKI, VictorbookPart Doenças endócrinas(2020) YOSHIZAKI, Carlos Tadashi; TESTA, Carolina Burgarelli; PAGANOTI, Cristiane de Freitas; BAPTISTA, Fernanda Spadotto; OSMUNDO JUNIOR, Gilmar de Souza; LIN, Lawrence Hsu; GALLETTA, Marco Aurélio Knippel; BORTOLOTTO, Maria Rita de Figueiredo Lemos; PEREIRA, Pedro Paulo; COSTA, Rafaela Alkmin da; RIBEIRO, Renata Lopes; FRANCISCO, Rossana Pulcineli Vieira- Serum concentration of vascular endothelial growth factor and depth of trophoblastic invasion in ampullary ectopic pregnancy(2016) CABAR, Fabio Roberto; TESHIMA, Decio Roberto Kamio; PEREIRA, Pedro Paulo; ANTONANGELO, Leila; SCHULTZ, Regina; FRANCISCO, Rossana PulcineliOBJECTIVE: To evaluate the association between the depth of trophoblastic infiltration and serum vascular endothelial growth factorconcentration in patients with an ampullary pregnancy. METHODS: This prospective cross-sectionalstudy involved 34 patients with an ampullary ectopic pregnancy who underwent salpingectomy between 2012 and 2013. Maternal serum vascular endothelial growth factor concentrations were measured using Luminex technology. Trophoblastic invasion was classified histologically as follows: stage I, limited to the tubal mucosa; stage II, reaching the muscle layer; and stage III, involving the full thickness. The qualitative data were compared using Fisher's exact test. The nonparametric Kruskal-Wallis and Mann-Whitney tests were used to evaluate differences in serum vascular endothelial growth factor among the degrees of trophoblastic invasion. ROC curves were constructed to determine vascular endothelial growth factor cut-off values that predict the degree of tubal invasion based on the best sensitivity and specificity. RESULTS: Eight patients had stage I trophoblastic invasion, seven had stage II, and 19 had stage III. The median serum vascular endothelial growth factorconcentration was 69.88 pg/mL for stage I, 14.53 pg/mL for stage II and 9.08 pg/mL for stage III, with a significant difference between stages I and III. Based on the ROC curve, a serum vascular endothelial growth factor concentration of 25.9 pg/mL best differentiated stage I from stages II and III with asensitivity of 75.0%, specificity of 76.9%, and area under the curve of 0.798. CONCLUSIONS: The depth of trophoblastic penetration into the tubal wall isassociated with serum vascular endothelial growth factor concentration in ampullary pregnancies.
- Expression of matrix metalloproteinases and their inhibitors at the implantation site in ampullary ectopic pregnancies(2021) GOMEZ, Ursula Trovato; BRIZOT, Maria de Lourdes; PEREIRA, Pedro Paulo; RODRIGUES, Agatha Sacramento; SCHULTZ, Regina; HOSHIDA, Mara Sandra; FRANCISCO, Rossana Pulcineli Vieira; CABAR, Fabio RobertoObjective: This study investigated the qualitative and semi-quantitative expression of metalloproteinases (MMP) and their tissue inhibitors (TIMP) in trophoblastic tissue during ampullary ectopic pregnancies and correlated that expression with the degree of tubal invasion. Study design: It is a prospective study that included 34 patients diagnosed with ampullary tubal pregnancy who underwent salpingectomy. A histological evaluation of the depth of trophoblastic invasion in the tubes obtained was performed. Subsequently, the expression of the MMP-2, MMP-9, MMP-14, TIMP-1, TIMP-2 and TIMP-3 markers was qualitatively and semi-quantitatively evaluated by indirect immunohistochemistry. In addition, the degree of trophoblastic invasion was correlated with the expression of each marker and with the metalloproteinase/inhibitor ratios. Results: MMP-2 (11.2 %; 3.6-17.9) was the marker with greater expression at the implantation site, both in the qualitative and semi-quantitative assessment, while MMP-9 (2.23 %; 0.2-5.4) and TIMP-3 (2.53 %; 0.1-15.3) were only weakly expressed. Conclusion: There was wide variation in expression among the markers and metalloproteinase/inhibitor ratios studied compared to the degrees of invasion.
bookPart Puerpério normal(2020) YOSHIZAKI, Carlos Tadashi; OSMUNDO JUNIOR, Gilmar de Souza; PEREIRA, Pedro Paulo; FRANCISCO, Rossana Pulcineli Vieira; MIYADAHIRA, Seizo; MARTINELLI, Silvio; BUNDUKI, VictorbookPart Doenças tromboembólicas(2020) YOSHIZAKI, Carlos Tadashi; TESTA, Carolina Burgarelli; PAGANOTI, Cristiane de Freitas; BAPTISTA, Fernanda Spadotto; OSMUNDO JUNIOR, Gilmar de Souza; LIN, Lawrence Hsu; GALLETTA, Marco Aurélio Knippel; BORTOLOTTO, Maria Rita de Figueiredo Lemos; PEREIRA, Pedro Paulo; COSTA, Rafaela Alkmin da; RIBEIRO, Renata Lopes; FRANCISCO, Rossana Pulcineli Vieira