LANA LUIZA DA CRUZ SILVA
Projetos de Pesquisa
Unidades Organizacionais
LIM/53 - Laboratório de Micologia, Hospital das Clínicas, Faculdade de Medicina
10 resultados
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conferenceObject Epidermodysplasia verruciformis: Successful therapeutic approach of two squamous cell carcinomas with imiquimod(2015) OLIVEIRA, Walmar; SILVA, Lana Luiza; FESTA NETO, Cyro; TYRING, StephenconferenceObject Claudins expression profile in squamous cell carcinoma of epidermodysplasia verruciformis(2014) TANABE, Claudia Kwei Fong Dai; HALPERN, Ilana; SILVA, Lana Luiza da Cruz; MATTOS, Mayra Servilha Grion; SOTTO, Mirian N.; OLIVEIRA, Walmar Roncalli Pereira- Periungual furuncular myiasis: easily overlooked(2015) SILVA, Lana Luiza Da; LOMAQUIZ, Christian D. Cardozo; NICO, Marcello Menta Simonsen
- Post-kala-azar dermal leishmaniasis and leprosy: case report and literature review(2015) TRINDADE, Maria Angela Bianconcini; SILVA, Lana Luiza da Cruz; BRAZ, Lucia Maria Almeida; AMATO, Valdir Sabbaga; NAAFS, Bernard; SOTTO, Mirian NacagamiBackground: Post-kala-azar dermal leishmaniasis (PKDL) is a dermal complication of visceral leishmaniasis (VL), which may occur after or during treatment. It has been frequently reported from India and the Sudan, but its occurrence in South America has been rarely reported. It may mimic leprosy and its differentiation may be difficult, since both diseases may show hypo-pigmented macular lesions as clinical presentation and neural involvement in histopathological investigations. The co-infection of leprosy and VL has been reported in countries where both diseases are endemic. The authors report a co-infection case of leprosy and VL, which evolved into PKDL and discuss the clinical and the pathological aspects in the patient and review the literature on this disease. Case presentation: We report an unusual case of a 53-year-old female patient from Alagoas, Brazil. She presented with leprosy and a necrotizing erythema nodosum, a type II leprosy reaction, about 3 month after finishing the treatment (MDT-MB) for leprosy. She was hospitalized and VL was diagnosed at that time and she was successfully treated with liposomal amphotericin B. After 6 months, she developed a few hypo-pigmented papules on her forehead. A granulomatous inflammatory infiltrate throughout the dermis was observed at histopathological examination of the skin biopsy. It consisted of epithelioid histiocytes, lymphocytes and plasma cells with the presence of amastigotes of Leishmania in macrophages (Leishman's bodies). The diagnosis of post-kala-azar dermal leishmaniasis was established because at this time there was no hepatosplenomegaly and the bone marrow did not show Leishmania parasites thus excluding VL. About 2 years after the treatment of PKDL with liposomal amphotericin B the patient is still without PKDL lesions. Conclusion: Post-kala-azar dermal leishmaniasis is a rare dermal complication of VL that mimics leprosy and should be considered particularly in countries where both diseases are endemic. A co-infection must be seriously considered, especially in patients who are non-responsive to treatment or develop persistent leprosy reactions as those encountered in the patient reported here.
- Skin lesions in organ transplant recipients: a study of 177 consecutive Brazilian patients(2019) OLIVEIRA, Walmar R. P.; TIRICO, Maria C. C. P.; SOUZA, Anaisa A. V.; CODARIN, Felipe R.; SILVA, Lana L. C.; NETO, Cyro FestaBackground Skin lesions are very common among organ transplant recipients (OTR), particularly infections and tumors, because of the immunosuppressive state these patients are put in. Methods 177 OTR were examined. Skin lesions were categorized into neoplastic, infectious, and inflammatory diseases. Results The mean age of OTR was 52 years, the mean age at transplantation was 42.7 years, and kidney was the most common organ transplanted (72%). Skin lesions were found in 147 patients (83%). Cutaneous infections were seen in 106 patients (60%). Warts (30%) had the larger incidence and were associated with azathioprine (P = 0.026), cyclosporine (P = 0.006), and tacrolimus (P = 0.009). Superficial mycoses occurred in 16% of OTR, mostly onychomycosis, which was associated with tacrolimus (P = 0.040). Actinic keratosis (AK) occurred in 31% of patients and cutaneous tumors in 56%. Squamous cell carcinoma (SCC) was the most common tumor type affecting 36% of OTR (n = 64), with invasive SCC predominating over in situ SCC, whereas basal cell carcinoma (BCC) accounted for 17%. Both SCC and BCC were more numerous in patients' skin type I (P < 0.05). SCC was more frequent (36%) in combined kidney and liver recipients (P = 0.004), and BCC was associated with cyclosporine (P = 0.047). Inflammatory complications (acne, alopecia, hypertrichosis, and gingival overgrowth) were observed in 17.5% of patients. Conclusions Organ transplant recipients must be regularly evaluated by dermatologists, who should be alert to the onset of infections and skin (pre)malignant diseases in these patients.
conferenceObject Skin lesions in organ transplant recipients: a study of 177 consecutive Brazilian patients(2017) OLIVEIRA, Walmar; SOUZA, Anaisa; CODARIN, Felipe; CRUZ, Lana; NETO, Cyro- Persistent eyelid edema and erythema as manifestation of lupus erythematosus: a series of six cases(2015) SILVA, Lana Luiza da Cruz; ROMITI, Ricardo; NICO, Marcello Menta Simonsen
- Deleterious Effect of Radiation Therapy on Epidermodysplasia Verruciformis Patients(2015) OLIVEIRA, Walmar Roncalli de; SILVA, Lana Luiza da Cruz; FESTA NETO, Cyro; TYRING, StephenBackground: Epidermodysplasia verruciformis (EV) is a rare genodermatosis caused by specific human papillomavirus (HPV) types associated with the development of multiple squamous cell carcinomas (SCC). The treatment for this skin tumour may be difficult. Among the therapy options, radiotherapy (RT) should be avoided due to its deleterious effects on HPV-induced carcinogenesis. Objective: To describe 4 patients with EV who underwent radiotherapy to treat cutaneous SCC. Methods: This is a retrospective study. The evolution of cutaneous SCC after adjuvant radiotherapy in 4 patients with EV was observed. Results: This study included 4 patients with diagnosis of EV. All 4 of the patients had cutaneous SCC. They underwent surgical resection and adjuvant radiotherapy. Over a period of up to 2 years, there was aggressive tumour recurrence. Conclusion: Radiotherapy might be associated with progression of SCC in patients with EV, and it is recommended that radiotherapy should be avoided in this patient population.
- High-risk mucosal HPV types associated with squamous cell carcinoma on the nose tip in an immunocompetent young man(2018) GAVIOLI, Camila Fatima Biancardi; NETO, Cyro Festa; TYRING, Stephen K.; SILVA, Lana Luiza da Cruz; OLIVEIRA, Walmar Roncalli Pereira deThe oncogenic role of high-risk HPV in anogenital, head and neck, and cervical cancer is well recognized, but not in skin cancer in the general population. Some authors have demonstrated their appearance mainly on the hands and feet, particularly in the area of the nail bed, which could be due to contamination with HPV types from anogenital regions. Here, we describe a case of genital HPV associated with SCC on the nose tip in an immunocompetent young man, which was confirmed by histopathological findings and in situ hybridization. The importance of this report is to highlight the potential role of HPV in the etiology of skin cancer in an immunocompetent individual.
- Claudin expression profile in flat wart and cutaneous squamous cell carcinoma in epidermodysplasia verruciformis(2020) SILVA, Lana Luiza da Cruz; OLIVEIRA, Walmar Roncalli Pereira de; PEREIRA, Naiura Vieira; HALPERN, Ilana; TANABE, Claudia Kwei-Fong Dai; MATTOS, Mayra Servilha Grion; SOTTO, Mirian N.Epidermodysplasia verruciformis (EV) is a genodermatosis related to human beta-papillomavirus (beta-HPV), with a high risk of cutaneous squamous cell carcinoma (cSCC). Claudins are transmembrane proteins expressed in epithelia and may be altered during carcinogenesis. For a better understanding of the role of beta-HPV in cutaneous carcinogenesis, this claudin expression study was conducted on lesions of patients with and without EV. In this study, claudins-1, -2, -3, -4, -5, -7 and -11 expressions were analyzed by applying the immunohistochemistry technique, in samples of 108 normal skin, 39 flat warts and 174 cSCC. The cSCC samples were organized in tissue microarrays. We found that claudin-1 and claudin-3 focal expressions were associated with cSCC (p<0.001), and claudin-2 focal or negative expression with flat wart (p<0.001), in EV and NEV (non-EV) groups. For claudin-5, EV group showed a lower chance of focal and negative expression (p<0.001), and its negative expression was associated with flat wart (p<0.001) and lower mean age (p<0.001). Claudins-4, -7 and -11 showed a diffuse expression in almost all studied samples. Our findings suggest that claudin-5 increased expression observed on normal skin, flat wart and cSCC showed association with EV. Claudin-1 and -3 down expression were also observed, but they could not be related to beta-HPV infection.