LANA LUIZA DA CRUZ SILVA
Projetos de Pesquisa
Unidades Organizacionais
LIM/53 - Laboratório de Micologia, Hospital das Clínicas, Faculdade de Medicina
5 resultados
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conferenceObject Epidermodysplasia verruciformis: Successful therapeutic approach of two squamous cell carcinomas with imiquimod(2015) OLIVEIRA, Walmar; SILVA, Lana Luiza; FESTA NETO, Cyro; TYRING, Stephen- Skin lesions in organ transplant recipients: a study of 177 consecutive Brazilian patients(2019) OLIVEIRA, Walmar R. P.; TIRICO, Maria C. C. P.; SOUZA, Anaisa A. V.; CODARIN, Felipe R.; SILVA, Lana L. C.; NETO, Cyro FestaBackground Skin lesions are very common among organ transplant recipients (OTR), particularly infections and tumors, because of the immunosuppressive state these patients are put in. Methods 177 OTR were examined. Skin lesions were categorized into neoplastic, infectious, and inflammatory diseases. Results The mean age of OTR was 52 years, the mean age at transplantation was 42.7 years, and kidney was the most common organ transplanted (72%). Skin lesions were found in 147 patients (83%). Cutaneous infections were seen in 106 patients (60%). Warts (30%) had the larger incidence and were associated with azathioprine (P = 0.026), cyclosporine (P = 0.006), and tacrolimus (P = 0.009). Superficial mycoses occurred in 16% of OTR, mostly onychomycosis, which was associated with tacrolimus (P = 0.040). Actinic keratosis (AK) occurred in 31% of patients and cutaneous tumors in 56%. Squamous cell carcinoma (SCC) was the most common tumor type affecting 36% of OTR (n = 64), with invasive SCC predominating over in situ SCC, whereas basal cell carcinoma (BCC) accounted for 17%. Both SCC and BCC were more numerous in patients' skin type I (P < 0.05). SCC was more frequent (36%) in combined kidney and liver recipients (P = 0.004), and BCC was associated with cyclosporine (P = 0.047). Inflammatory complications (acne, alopecia, hypertrichosis, and gingival overgrowth) were observed in 17.5% of patients. Conclusions Organ transplant recipients must be regularly evaluated by dermatologists, who should be alert to the onset of infections and skin (pre)malignant diseases in these patients.
conferenceObject Skin lesions in organ transplant recipients: a study of 177 consecutive Brazilian patients(2017) OLIVEIRA, Walmar; SOUZA, Anaisa; CODARIN, Felipe; CRUZ, Lana; NETO, Cyro- Deleterious Effect of Radiation Therapy on Epidermodysplasia Verruciformis Patients(2015) OLIVEIRA, Walmar Roncalli de; SILVA, Lana Luiza da Cruz; FESTA NETO, Cyro; TYRING, StephenBackground: Epidermodysplasia verruciformis (EV) is a rare genodermatosis caused by specific human papillomavirus (HPV) types associated with the development of multiple squamous cell carcinomas (SCC). The treatment for this skin tumour may be difficult. Among the therapy options, radiotherapy (RT) should be avoided due to its deleterious effects on HPV-induced carcinogenesis. Objective: To describe 4 patients with EV who underwent radiotherapy to treat cutaneous SCC. Methods: This is a retrospective study. The evolution of cutaneous SCC after adjuvant radiotherapy in 4 patients with EV was observed. Results: This study included 4 patients with diagnosis of EV. All 4 of the patients had cutaneous SCC. They underwent surgical resection and adjuvant radiotherapy. Over a period of up to 2 years, there was aggressive tumour recurrence. Conclusion: Radiotherapy might be associated with progression of SCC in patients with EV, and it is recommended that radiotherapy should be avoided in this patient population.
- High-risk mucosal HPV types associated with squamous cell carcinoma on the nose tip in an immunocompetent young man(2018) GAVIOLI, Camila Fatima Biancardi; NETO, Cyro Festa; TYRING, Stephen K.; SILVA, Lana Luiza da Cruz; OLIVEIRA, Walmar Roncalli Pereira deThe oncogenic role of high-risk HPV in anogenital, head and neck, and cervical cancer is well recognized, but not in skin cancer in the general population. Some authors have demonstrated their appearance mainly on the hands and feet, particularly in the area of the nail bed, which could be due to contamination with HPV types from anogenital regions. Here, we describe a case of genital HPV associated with SCC on the nose tip in an immunocompetent young man, which was confirmed by histopathological findings and in situ hybridization. The importance of this report is to highlight the potential role of HPV in the etiology of skin cancer in an immunocompetent individual.