MARCELO CAMARGO BATISTUZZO
Projetos de Pesquisa
Unidades Organizacionais
Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina
LIM/23 - Laboratório de Psicopatologia e Terapêutica Psiquiátrica, Hospital das Clínicas, Faculdade de Medicina
LIM/23 - Laboratório de Psicopatologia e Terapêutica Psiquiátrica, Hospital das Clínicas, Faculdade de Medicina
6 resultados
Resultados de Busca
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conferenceObject Associations Between Medial Prefrontal Cerebral Metabolic Features and Clinical Characteristics in Obsessive-compulsive Disorder(2016) BATISTUZZO, Marcelo C.; HOEXTER, Marcelo; COSTA, Fabiana; SHAVITT, Roseli; LOPES, Antonio C.; CAPPI, Carolina; VATTIMO, Edoardo; MATHIS, Alice de; DINIZ, Juliana B.; HENNING, Anke; PASTORELLO, Bruno; MIGUEL, Euripedes C.; OTADUY, Maria C.- Epigenetic evidence for involvement of the oxytocin receptor gene in obsessive-compulsive disorder(2016) CAPPI, Carolina; DINIZ, Juliana Belo; REQUENA, Guaraci L.; LOURENCO, Tiaya; LISBOA, Bianca Cristina Garcia; BATISTUZZO, Marcelo Camargo; MARQUES, Andrea H.; HOEXTER, Marcelo Q.; PEREIRA, Carlos A.; MIGUEL, Euripedes Constantino; BRENTANI, HelenaBackground: Obsessive-compulsive disorder (OCD) is a chronic neurodevelopmental disorder that affects up to 3% of the general population. Although epigenetic mechanisms play a role in neurodevelopment disorders, epigenetic pathways associated with OCD have rarely been investigated. Oxytocin is a neuropeptide involved in neurobehavioral functions. Oxytocin has been shown to be associated with the regulation of complex socio-cognitive processes such as attachment, social exploration, and social recognition, as well as anxiety and other stress-related behaviors. Oxytocin has also been linked to the pathophysiology of OCD, albeit inconsistently. The aim of this study was to investigate methylation in two targets sequences located in the exon III of the oxytocin receptor gene (OXTR), in OCD patients and healthy controls. We used bisulfite sequencing to quantify DNA methylation in peripheral blood samples collected from 42 OCD patients and 31 healthy controls. Results: We found that the level of methylation of the cytosine-phosphate-guanine sites in two targets sequences analyzed was greater in the OCD patients than in the controls. The higher methylation in the OCD patients correlated with OCD severity. We measured DNA methylation in the peripheral blood, which prevented us from drawing any conclusions about processes in the central nervous system. Conclusion: To our knowledge, this is the first study investigating DNA methylation of the OXTR in OCD. Further studies are needed to evaluate the roles that DNA methylation and oxytocin play in OCD.
conferenceObject Cortico-Basal Ganglia-Thalamo-Cortical Circuitry Structural Correlates of Treatment Response in Children with Obsessive-Compulsive Disorder(2016) VATTIMO, Edoardo F. Q.; BATISTUZZO, Marcelo C.; SATO, Joao R.; SA, Daniel G. F. de; SHAVITT, Roseli G.; MIGUEL, Euripedes C.; HOEXTER, Marcelo Q.conferenceObject Personality Changes in Refractory Patients With Obsessive-Compulsive Disorder Submitted to Gamma Ventral Capsulotomy(2016) PAIVA, Raquel; LOPES, Antonio C.; BATISTUZZO, Marcelo; MATHIS, Maria Eugenia de; CANTERAS, Miguel; GREENBERG, Benjamin; SHAVITT, Roseli; MIGUEL, Euripedes; HOEXTER, Marcelo- Gamma Knife Surgery: Clinical Results(2016) LOPES, A. C.; BATISTUZZO, M.; GENTIL, A. F.; HOEXTER, M. Q.; MIGUEL, E. C.Albeit a traditional ablative procedure, Gamma Knife radiosurgery continues to be indicated for some severe and otherwise untreatable psychiatric disorders, especially obsessive-compulsive disorder. The majority of studies published so far have used lesions at the anterior limb of the internal capsule and consisted of case series. However, a placebo-controlled, double-blind randomized trial was recently published. Symptom improvements have been described in 25-80% of patients, suggesting that it is probably as efficacious as deep brain stimulation. Refinements of the radiosurgical techniques have allowed to lesion smaller volumes of white matter tissue, and thus a decreased incidence of severe adverse events has been reported. Nevertheless, aberrant radionecrotic reactions, such as brain cysts, are sporadically observed in a long-term follow-up. © 2016 John Wiley & Sons, Ltd. All rights reserved.
- PREDICTING OBSESSIVE-COMPULSIVE DISORDER TREATMENT RESPONSE IN PEDIATRIC PATIENTS USING STRUCTURAL NEUROIMAGING CORRELATES: A COMPARISON BETWEEN SIMPLE LINEAR REGRESSION AND SUPPORT VECTOR REGRESSION(2016) VATTIMO, Edoardo F.; BARROS, Vivian B.; REQUENA, Guaraci; SATO, Joao R.; BATISTUZZO, Marcelo Camargo; SHAVITT, Roseli G.; FATORI, Daniel; MIGUEL, Euripedes; HOEXTER, Marcelo Q.