MARCELO CAMARGO BATISTUZZO

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Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina
LIM/23 - Laboratório de Psicopatologia e Terapêutica Psiquiátrica, Hospital das Clínicas, Faculdade de Medicina

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  • article 1 Citação(ões) na Scopus
    Factor structure of the Dimensional Yale-Brown Obsessive-Compulsive Scale in a large sample of adults with obsessive-compulsive disorder
    (2022) BATISTUZZO, Marcelo C.; FONTENELLE, Leonardo; FERRAO, Ygor A.; ROSARIO, Maria C.; MIGUEL, Euripedes C.; FATORI, Daniel
    Objectives: Although the Dimensional Yale-Brown Obsessive-Compulsive Scale (DY-BOCS) is a widely used instrument for assessing different obsessive-compulsive symptom dimensions, its factor structure has never been studied in a Brazilian population. Thus, we aimed to assess the goodness-of fit indexes and factor loadings of two higher-order models of the DY-BOCS using confirmatory factor analysis (CFA) in a large obsessive-compulsive disorder (OCD) sample. Methods: We tested two CFA models in a sample of 955 adults with OCD who had been assessed with the DY-BOCS in a cross-sectional multi-site study. The first model encompassed the symptom checklist (present or absent), whereas the second focused on items related to severity scores. Results: Both models presented adequate goodness-of-fit indexes. The comparative fit index, Tucker Lewis index, and omega were 4 0.9, while the root mean square error of approximation was p 0.06 for both models. Factor loadings for each item of each dimension are presented and discussed. Conclusion: Higher-order factor models showed adequate goodness-of-fit indexes, indicating that they appropriately measured OCD dimensions in this Brazilian population.
  • conferenceObject
    Influences of Socioeconomic Status and Education on Intelligence Across 5 Multinational Sites
    (2022) DESERISY, Mariah; GOLDBERG, Terry; BATISTUZZO, Marcelo; KEYES, Katherine; JOODE, Niels de; LOCHNER, Christine; MARINCOWITZ, Clara; NARAYAN, Madhuri; ANAND, Nitin; RAPP, Amy; STEIN, Dan J.; WALL, Melanie; SIMPSON, H. Blair; MARGOLIS, Amy E.
  • article 0 Citação(ões) na Scopus
    Expanding the heuristic neurocircuit-based taxonomy to guide treatment for OCD: reply to the commentary ""Probing the genetic and molecular correlates of connectome alterations in obsessive-compulsive disorder""
    (2022) SHEPHARD, Elizabeth; STERN, Emily R.; HEUVEL, Odile A. van den; COSTA, Daniel L. C.; BATISTUZZO, Marcelo C.; GODOY, Priscilla B. G.; LOPES, Antonio C.; BRUNONI, Andre R.; HOEXTER, Marcelo Q.; SHAVITT, Roseli G.; REDDY, Y. C. Janardhan; LOCHNER, Christine; STEIN, Dan J.; SIMPSON, H. Blair; MIGUEL, Euripedes C.
  • article 17 Citação(ões) na Scopus
    The thalamus and its subnuclei-a gateway to obsessive-compulsive disorder
    (2022) WEELAND, Cees J.; KASPRZAK, Selina; JOODE, Niels T. de; ABE, Yoshinari; ALONSO, Pino; AMEIS, Stephanie H.; ANTICEVIC, Alan; ARNOLD, Paul D.; BALACHANDER, Srinivas; BANAJ, Nerisa; BARGALLO, Nuria; BATISTUZZO, Marcelo C.; BENEDETTI, Francesco; BEUCKE, Jan C.; BOLLETTINI, Irene; BRECKE, Vilde; BREM, Silvia; CAPPI, Carolina; CHENG, Yuqi; CHO, Kang Ik K.; COSTA, Daniel L. C.; DALLASPEZIA, Sara; DENYS, Damiaan; ENG, Goi Khia; FERREIRA, Sonia; FEUSNER, Jamie D.; FONTAINE, Martine; FOUCHE, Jean-Paul; GRAZIOPLENE, Rachael G.; GRUNER, Patricia; HE, Mengxin; HIRANO, Yoshiyuki; HOEXTER, Marcelo Q.; HUYSER, Chaim; HU, Hao; JASPERS-FAYER, Fern; KATHMANN, Norbert; KAUFMANN, Christian; KIM, Minah; KOCH, Kathrin; KWAK, Yoo Bin; KWON, Jun Soo; LAZARO, Luisa; LI, Chiang-Shan R.; LOCHNER, Christine; MARSH, Rachel; MARTINEZ-ZALACAIN, Ignacio; MATAIX-COLS, David; MENCHON, Jose M.; MINNUZI, Luciano; MOREIRA, Pedro Silva; MORGADO, Pedro; NAKAGAWA, Akiko; NAKAMAE, Takashi; NARAYANASWAMY, Janardhanan C.; NURMI, Erika L.; ORTIZ, Ana E.; PARIENTE, Jose C.; PIACENTINI, John; PICO-PEREZ, Maria; PIRAS, Fabrizio; PIRAS, Federica; PITTENGER, Christopher; REDDY, Y. C. Janardhan; RODRIGUEZ-MANRIQUE, Daniela; SAKAI, Yuki; SHIMIZU, Eiji; SHIVAKUMAR, Venkataram; SIMPSON, Helen Blair; SORENI, Noam; SORIANO-MAS, Carles; SOUSA, Nuno; SPALLETTA, Gianfranco; STERN, Emily R.; STEVENS, Michael C.; STEWART, S. Evelyn; SZESZKO, Philip R.; TAKAHASHI, Jumpei; TANAMATIS, Tais; TANG, Jinsong; THORSEN, Anders Lillevik; TOLIN, David; WERF, Ysbrand D. van der; MARLE, Hein van; WINGEN, Guido A. van; VECCHIO, Daniela; VENKATASUBRAMANIAN, G.; WALITZA, Susanne; WANG, Jicai; WANG, Zhen; WATANABE, Anri; WOLTERS, Lidewij H.; XU, Xiufeng; YUN, Je-Yeon; ZHAO, Qing; WHITE, Tonya; THOMPSON, Paul M.; STEIN, Dan J.; HEUVEL, Odile A. van den; VRIEND, Chris
    Larger thalamic volume has been found in children with obsessive-compulsive disorder (OCD) and children with clinical-level symptoms within the general population. Particular thalamic subregions may drive these differences. The ENIGMA-OCD working group conducted mega- and meta-analyses to study thalamic subregional volume in OCD across the lifespan. Structural T-1-weighted brain magnetic resonance imaging (MRI) scans from 2649 OCD patients and 2774 healthy controls across 29 sites (50 datasets) were processed using the FreeSurfer built-in ThalamicNuclei pipeline to extract five thalamic subregions. Volume measures were harmonized for site effects using ComBat before running separate multiple linear regression models for children, adolescents, and adults to estimate volumetric group differences. All analyses were pre-registered (https://osf.io/73dvy) and adjusted for age, sex and intracranial volume. Unmedicated pediatric OCD patients (<12 years) had larger lateral (d = 0.46), pulvinar (d = 0.33), ventral (d = 0.35) and whole thalamus (d = 0.40) volumes at unadjusted p-values <0.05. Adolescent patients showed no volumetric differences. Adult OCD patients compared with controls had smaller volumes across all subregions (anterior, lateral, pulvinar, medial, and ventral) and smaller whole thalamic volume (d = -0.15 to -0.07) after multiple comparisons correction, mostly driven by medicated patients and associated with symptom severity. The anterior thalamus was also significantly smaller in patients after adjusting for thalamus size. Our results suggest that OCD-related thalamic volume differences are global and not driven by particular subregions and that the direction of effects are driven by both age and medication status.
  • article 10 Citação(ões) na Scopus
    Neurocircuit models of obsessive-compulsive disorder: limitations and future directions for research
    (2022) SHEPHARD, Elizabeth; BATISTUZZO, Marcelo C.; HOEXTER, Marcelo Q.; STERN, Emily R.; ZUCCOLO, Pedro F.; OGAWA, Carolina Y.; SILVA, Renata M.; BRUNONI, Andre R.; COSTA, Daniel L.; DORETTO, Victoria; SARAIVA, Leonardo; CAPPI, Carolina; SHAVITT, Roseli G.; SIMPSON, H. Blair; HEUVEL, Odile A. van den; MIGUEL, Euripedes C.
    Obsessive-compulsive disorder (OCD) is a common psychiatric condition classically characterized by obsessions (recurrent, intrusive and unwanted thoughts) and compulsions (excessive, repetitive and ritualistic behaviors or mental acts). OCD is heterogeneous in its clinical presentation and not all patients respond to first-line treatments. Several neurocircuit models of OCD have been proposed with the aim of providing a better understanding of the neural and cognitive mechanisms involved in the disorder. These models use advances in neuroscience and findings from neuropsychological and neuroimaging studies to suggest links between clinical profiles that reflect the symptoms and experiences of patients and dysfunctions in specific neurocircuits. Several models propose that treatments for OCD could be improved if directed to specific neurocircuit dysfunctions, thereby restoring efficient neurocognitive function and ameliorating the symptomatology of each associated clinical profile. Yet, there are several important limitations to neurocircuit models of OCD. The purpose of the current review is to highlight some of these limitations, including issues related to the complexity of brain and cognitive function, the clinical presentation and course of OCD, etiological factors, and treatment methods proposed by the models. We also provide suggestions for future research to advance neurocircuit models of OCD and facilitate translation to clinical application.
  • article 4 Citação(ões) na Scopus
    Associations of medication with subcortical morphology across the lifespan in OCD: Results from the international ENIGMA Consortium
    (2022) IVANOV, Iliyan; BOEDHOE, Premika S. W.; ABE, Yoshinari; ALONSO, Pino; AMEIS, Stephanie H.; ARNOLD, Paul D.; BALACHANDER, Srinivas; BAKER, Justin T.; BANAJ, Nerisa; BARGALLO, Nuria; BATISTUZZO, Marcelo C.; BENEDETTI, Francesco; BEUCKE, Jan C.; BOLLETTINI, Irene; BREM, Silvia; BRENNAN, Brian P.; BUITELAAR, Jan; CALVO, Rosa; CHENG, Yuqi; CHO, Kang Ik K.; DALLASPEZIA, Sara; DENYS, Damiaan; DINIZ, Juliana B.; ELY, Benjamin A.; FEUSNER, Jamie D.; FERREIRA, Sonia; FITZGERALD, Kate D.; FONTAINE, Martine; GRUNER, Patricia; HANNA, Gregory L.; HIRANO, Yoshiyuki; HOEXTER, Marcelo Q.; HUYSER, Chaim; IKARI, Keisuke; JAMES, Anthony; JASPERS-FAYER, Fern; JIANG, Hongyan; KATHMANN, Norbert; KAUFMANN, Christian; KIM, Minah; KOCH, Kathrin; KWON, Jun Soo; LAZARO, Luisa; LIU, Yanni; LOCHNER, Christine; MARSH, Rachel; MARTINEZ-ZALACAIN, Ignacio; MATAIX-COLS, David; MENCHON, Jose M.; MINUZZI, Luciano; MORER, Astrid; MORGADO, Pedro; NAKAGAWA, Akiko; NAKAMAE, Takashi; NAKAO, Tomohiro; NARAYANASWAMY, Janardhanan C.; NURMI, Erika L.; OH, Sanghoon; PERRIELLO, Chris; PIACENTINI, John C.; PICO-PEREZ, Maria; PIRAS, Fabrizio; PIRAS, Federica; REDDY, Y. C. Janardhan; MANRIQUE, Daniela Rodriguez; SAKAI, Yuki; SHIMIZU, Eiji; SIMPSON, H. Blair; SORENI, Noam; SORIANO-MAS, Carles; SPALLETTA, Gianfranco; STERN, Emily R.; STEVENS, Michael C.; STEWART, S. Evelyn; SZESZKO, Philip R.; TOLIN, David F.; ROOIJ, Daan van; VELTMAN, Dick J.; WERF, Ysbrand D. van der; WINGEN, Guido A. van; VENKATASUBRAMANIAN, Ganesan; WALITZA, Susanne; WANG, Zhen; WATANABE, Anri; WOLTERS, Lidewij H.; XU, Xiufeng; YUN, Je-Yeon; ZAREI, Mojtaba; ZHANG, Fengrui; ZHAO, Qing; JAHANSHAD, Neda; I, Sophia Thomopoulos; THOMPSON, Paul M.; STEIN, Dan J.; HEUVEL, Odile A. van den; O'NEILL, Joseph
    Background: Widely used psychotropic medications for obsessive-compulsive disorder (OCD) may change the volumes of subcortical brain structures, and differently in children vs. adults. We measured subcortical volumes cross-sectionally in patients finely stratified for age taking various common classes of OCD drugs. Methods: The ENIGMA-OCD consortium sample (1081 medicated/1159 unmedicated OCD patients and 2057 healthy controls aged 6-65) was divided into six successive 6-10-year age-groups. Individual structural MRIs were parcellated automatically using FreeSurfer into 8 regions-of-interest (ROIs). ROI volumes were compared between unmedicated and medicated patients and controls, and between patients taking serotonin reuptake inhibitors (SRIs), tricyclics (TCs), antipsychotics (APs), or benzodiazepines (BZs) and unmedicated patients. Results: Compared to unmedicated patients, volumes of accumbens, caudate, and/or putamen were lower in children aged 6-13 and adults aged 50-65 with OCD taking SRIs (Cohen's d = 0.24 to 0.74). Volumes of putamen, pallidum (d = 0.18-0.40), and ventricles (d = 0.31-0.66) were greater in patients aged 20-29 receiving APs. Hippocampal volumes were smaller in patients aged 20 and older taking TCs and/or BZs (d = 0.27 to 1.31). Conclusions: Results suggest that TCs and BZs could potentially aggravate hippocampal atrophy of normal aging in older adults with OCD, whereas SRIs may reduce striatal volumes in young children and older adults. Similar to patients with psychotic disorders, OCD patients aged 20-29 may experience subcortical nuclear and ventricular hypertrophy in relation to APs. Although cross-sectional, present results suggest that commonly prescribed agents exert macroscopic effects on subcortical nuclei of unknown relation to therapeutic response.
  • article 4 Citação(ões) na Scopus
    Taboo obsessions and their association with suicidality in obsessive-compulsive disorder
    (2022) CERVIN, Matti; ROSARIO, Maria Conceicao do; FONTENELLE, Leonardo F.; FERRAO, Ygor A.; BATISTUZZO, Marcelo C.; TORRES, Albina R.; DAMIANO, Rodolfo F.; CRUZ, Lorena Fernandez de la; MIGUEL, Euripedes C.; MATAIX-COLS, David
    Individuals with obsessive-compulsive disorder (OCD) more often think about, attempt, and die by suicide than individuals from the general population. Sexual and religious obsessions (i.e., taboo obsessions) have been linked to increased risk of suicidality, but it is unclear if they explain additional risk over and above other risk factors. We refined the recently proposed multidimensional hierarchical model of OCD and explored how each symptom dimension in the model was associated with suicidality in a random half (n = 500) of a well-characterized cohort of patients with OCD. Symptom dimensions and other risk factors significantly associated with suicidality were included in a confirmatory multivariable model conducted with the other half of the sample (n = 501). The predictive confirmatory model accounted for 19% of the variance in suicidality. Taboo obsessions, the general OCD factor (i.e., having many different OCD symptoms at the same time), lifetime major depression, and lifetime substance use disorders significantly predicted suicidality in this model. Lifetime major depression explained most unique variance in suicidality (5.6%) followed by taboo obsessions and the general OCD factor (1.9% each). Taboo obsessions explain a small but significant proportion of variance in suicidality and should be considered an independent risk factor for suicidality in patients with OCD.
  • article
    Using supervised machine learning on neuropsychological data to distinguish OCD patients with and without sensory phenomena from healthy controls (vol 60, pg 77, 2021)
    (2022) STAMATIS, C. A.; BATISTUZZO, M. C.; TANAMATIS, T.; MIGUEL, E. C.; HOEXTER, M. Q.; TIMPANO, K. R.
  • article 2 Citação(ões) na Scopus
    Shape analysis of subcortical structures in obsessive-compulsive disorder and the relationship with comorbid anxiety, depression, and medication use: A meta-analysis by the OCD Brain Imaging Consortium
    (2022) FOUCHE, Jean-Paul; GROENEWOLD, Nynke A.; SEVENOAKS, Tatum; HEANY, Sarah; LOCHNER, Christine; ALONSO, Pino; BATISTUZZO, Marcelo C.; CARDONER, Narcis; CHING, Christopher R. K.; WIT, Stella J. de; GUTMAN, Boris; HOEXTER, Marcelo Q.; JAHANSHAD, Neda; KIM, Minah; KWON, Jun Soo; MATAIX-COLS, David; MENCHON, Jose M.; MIGUEL, Euripedes C.; NAKAMAE, Takashi; PHILLIPS, Mary L.; PUJOL, Jesus; SAKAI, Yuki; YUN, Je-Yeon; SORIANO-MAS, Carles; THOMPSON, Paul M.; YAMADA, Kei; VELTMAN, Dick J.; HEUVEL, Odile A. van den; STEIN, Dan J.
    Objective Neuroimaging studies of obsessive-compulsive disorder (OCD) patients have highlighted the important role of deep gray matter structures. Less work has however focused on subcortical shape in OCD patients. Methods Here we pooled brain MRI scans from 412 OCD patients and 368 controls to perform a meta-analysis utilizing the ENIGMA-Shape protocol. In addition, we investigated modulating effects of medication status, comorbid anxiety or depression, and disease duration on subcortical shape. Results There was no significant difference in shape thickness or surface area between OCD patients and healthy controls. For the subgroup analyses, OCD patients with comorbid depression or anxiety had lower thickness of the hippocampus and caudate nucleus and higher thickness of the putamen and pallidum compared to controls. OCD patients with comorbid depression had lower shape surface area in the thalamus, caudate nucleus, putamen, hippocampus, and nucleus accumbens and higher shape surface area in the pallidum. OCD patients with comorbid anxiety had lower shape surface area in the putamen and the left caudate nucleus and higher shape surface area in the pallidum and the right caudate nucleus. Further, OCD patients on medication had lower shape thickness of the putamen, thalamus, and hippocampus and higher thickness of the pallidum and caudate nucleus, as well as lower shape surface area in the hippocampus and amygdala and higher surface area in the putamen, pallidum, and caudate nucleus compared to controls. There were no significant differences between OCD patients without co-morbid anxiety and/or depression and healthy controls on shape measures. In addition, there were also no significant differences between OCD patients not using medication and healthy controls. Conclusions The findings here are partly consistent with prior work on brain volumes in OCD, insofar as they emphasize that alterations in subcortical brain morphology are associated with comorbidity and medication status. Further work is needed to understand the biological processes contributing to subcortical shape.