MARCELO CAMARGO BATISTUZZO

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Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina
LIM/23 - Laboratório de Psicopatologia e Terapêutica Psiquiátrica, Hospital das Clínicas, Faculdade de Medicina

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  • article 1 Citação(ões) na Scopus
    Cross-National Harmonization of Neurocognitive Assessment Across Five Sites in a Global Study
    (2023) BATISTUZZO, Marcelo C.; SHESHACHALA, Karthik; ALSCHULER, Daniel M.; HEZEL, Dianne M.; LEWIS-FERNANDEZ, Roberto; JOODE, Niels T. de; VRIEND, Chris; LEMPERT, Karolina M.; NARAYAN, Madhuri; MARINCOWITZ, Clara; LOCHNER, Christine; STEIN, Dan J.; NARAYANASWAMY, Janardhanan C.; HEUVEL, Odile A. van den; SIMPSON, Helen Blair; WALL, Melanie
    Objective: Cross-national work on neurocognitive testing has been characterized by inconsistent findings, suggesting the need for improved harmonization. Here, we describe a prospective harmonization approach in an ongoing global collaborative study. Method: Visuospatial N-Back, Tower of London (ToL), Stop Signal task (SST), Risk Aversion (RA), and Intertemporal Choice (ITC) tasks were administered to 221 individuals from Brazil, India, the Netherlands, South Africa, and the USA. Prospective harmonization methods were employed to ensure procedural similarity of task implementation and processing of derived task measures across sites. Generalized linear models tested for between-site differences controlling for sex, age, education, and socioeconomic status (SES). Associations with these covariates were also examined and tested for differences by site with site-by-covariate interactions. Results: The Netherlands site performed more accurately on N-Back and ToL than the other sites, except for the USA site on the N-Back. The Netherlands and the USA sites performed faster than the other three sites during the go events in the SST. Finally, the Netherlands site also exhibited a higher tolerance for delay discounting than other sites on the ITC, and the India site showed more risk aversion than other sites on the RA task. However, effect size differences across sites on the five tasks were generally small (i.e., partial eta-squared < 0.05) after dropping the Netherlands (on ToL, N-Back, ITC, and SST tasks) and India (on the RA task). Across tasks, regardless of site, the N-Back (sex, age, education, and SES), ToL (sex, age, and SES), SST (age), and ITC (SES) showed associations with covariates. Conclusions: Four out of the five sites showed only small between-site differences for each task. Nevertheless, despite our extensive prospective harmonization steps, task score performance deviated from the other sites in the Netherlands site (on four tasks) and the India site (on one task). Because the procedural methods were standardized across sites, and our analyses were adjusted for covariates, the differences found in cognitive performance may indicate selection sampling bias due to unmeasured confounders. Future studies should follow similar cross-site prospective harmonization procedures when assessing neurocognition and consider measuring other possible confounding variables for additional statistical control.
  • article 10 Citação(ões) na Scopus
    The functional connectome in obsessive-compulsive disorder: resting-state mega-analysis and machine learning classification for the ENIGMA-OCD consortium
    (2023) BRUIN, Willem B.; ABE, Yoshinari; ALONSO, Pino; ANTICEVIC, Alan; BACKHAUSEN, Lea L.; BALACHANDER, Srinivas; BARGALLO, Nuria; BATISTUZZO, Marcelo C.; BENEDETTI, Francesco; TRIQUELL, Sara Bertolin; BREM, Silvia; CALESELLA, Federico; COUTO, Beatriz; DENYS, Damiaan A. J. P.; ECHEVARRIA, Marco A. N.; ENG, Goi Khia; FERREIRA, Sonia; FEUSNER, Jamie D.; GRAZIOPLENE, Rachael G.; GRUNER, Patricia; GUO, Joyce Y.; HAGEN, Kristen; HANSEN, Bjarne; HIRANO, Yoshiyuki; HOEXTER, Marcelo Q.; JAHANSHAD, Neda; JASPERS-FAYER, Fern; KASPRZAK, Selina; KIM, Minah; KOCH, Kathrin; KWAK, Yoo Bin; KWON, Jun Soo; LAZARO, Luisa; LI, Chiang-Shan R.; LOCHNER, Christine; MARSH, Rachel; MARTINEZ-ZALACAIN, Ignacio; MENCHON, Jose M.; MOREIRA, Pedro S.; MORGADO, Pedro; NAKAGAWA, Akiko; NAKAO, Tomohiro; NARAYANASWAMY, Janardhanan C.; NURMI, Erika; ZORRILLA, Jose C. Pariente; PIACENTINI, John; PICO-PEREZ, Maria; PIRAS, Fabrizio; PIRAS, Federica; PITTENGER, Christopher; REDDY, Janardhan Y. C.; RODRIGUEZ-MANRIQUE, Daniela; SAKAI, Yuki; SHIMIZU, Eiji; SHIVAKUMAR, Venkataram; SIMPSON, Blair H.; SORIANO-MAS, Carles; SOUSA, Nuno M.; SPALLETTA, Gianfranco; STERN, Emily R.; STEWART, S. Evelyn; SZESZKO, Philip; TANG, Jinsong; I, Sophia Thomopoulos; THORSEN, Anders L.; TOKIKO, Yoshida; TOMIYAMA, Hirofumi; VAI, Benedetta; VEER, Ilya M.; VENKATASUBRAMANIAN, Ganesan; VETTER, Nora C.; VRIEND, Chris; WALITZA, Susanne; WALLER, Lea; WANG, Zhen; WATANABE, Anri; WOLFF, Nicole; YUN, Je-Yeon; ZHAO, Qing; LEEUWEN, Wieke A. van; MARLE, Hein J. F. van; MORTEL, Laurens A. van de; STRATEN, Anouk van der; WERF, Ysbrand D. van der; THOMPSON, Paul M.; STEIN, Dan J.; HEUVEL, Odile A. van den; WINGEN, Guido A. van
    Current knowledge about functional connectivity in obsessive-compulsive disorder (OCD) is based on small-scale studies, limiting the generalizability of results. Moreover, the majority of studies have focused only on predefined regions or functional networks rather than connectivity throughout the entire brain. Here, we investigated differences in resting-state functional connectivity between OCD patients and healthy controls (HC) using mega-analysis of data from 1024 OCD patients and 1028 HC from 28 independent samples of the ENIGMA-OCD consortium. We assessed group differences in whole-brain functional connectivity at both the regional and network level, and investigated whether functional connectivity could serve as biomarker to identify patient status at the individual level using machine learning analysis. The mega-analyses revealed widespread abnormalities in functional connectivity in OCD, with global hypo-connectivity (Cohen's d: -0.27 to -0.13) and few hyper-connections, mainly with the thalamus (Cohen's d: 0.19 to 0.22). Most hypo-connections were located within the sensorimotor network and no fronto-striatal abnormalities were found. Overall, classification performances were poor, with area-under-the-receiver-operating-characteristic curve (AUC) scores ranging between 0.567 and 0.673, with better classification for medicated (AUC = 0.702) than unmedicated (AUC = 0.608) patients versus healthy controls. These findings provide partial support for existing pathophysiological models of OCD and highlight the important role of the sensorimotor network in OCD. However, resting-state connectivity does not so far provide an accurate biomarker for identifying patients at the individual level.
  • article 0 Citação(ões) na Scopus
    Right Prefrontal Cortical Thickness Is Associated With Response to Cognitive-Behavioral Therapy in Children With Obsessive-Compulsive Disorder
    (2023) BERTOLIN, Sara; ALONSO, Pino; MARTINEZ-ZALACAIN, Ignacio; MENCHON, Jose M.; JIMENEZ-MURCIA, Susana; BAKER, Justin T.; BARGALLO, Nuria; BATISTUZZO, Marcelo Camargo; BOEDHOE, Premika S. W.; BRENNAN, Brian P.; FEUSNER, Jamie D.; FITZGERALD, Kate D.; FONTAINE, Martine; HANSEN, Bjarne; HIRANO, Yoshiyuki; HOEXTER, Marcelo Q.; HUYSER, Chaim; JAHANSHAD, Neda; JASPERS-FAYER, Fern; KUNO, Masaru; KVALE, Gerd; LAZARO, Luisa; MACHADO-SOUSA, Mafalda; MARSH, Rachel; MORGADO, Pedro; NAKAGAWA, Akiko; NORMAN, Luke; NURMI, Erika L.; O'NEILL, Joseph; ORTIZ, Ana E.; PERRIELLO, Chris; PIACENTINI, John; PICO-PEREZ, Maria; SHAVITT, Roseli G.; SHIMIZU, Eiji; SIMPSON, Helen Blair; STEWART, S. Evelyn; THOMOPOULOS, Sophia I.; THORSEN, Anders Lillevik; WALITZA, Susanne; WOLTERS, Lidewij H.; THOMPSON, Paul M.; HEUVEL, Odile A. van den; STEIN, Dan J.; SORIANO-MAS, Carles
    Objective: Cognitive-behavioral therapy (CBT) is considered a first-line treatment for obsessive-compulsive disorder (OCD) in pediatric and adult populations. Nevertheless, some patients show partial or null response. The identification of predictors of CBT response may improve clinical management of patients with OCD. Here, we aimed to identify structural magnetic resonance imaging (MRI) predictors of CBT response in 2 large series of children and adults with OCD from the worldwide ENIGMA-OCD consortium. Method: Data from 16 datasets from 13 international sites were included in the study. We assessed which variations in baseline cortical thickness, cortical surface area, and subcortical volume predicted response to CBT (percentage of baseline to post-treatment symptom reduction) in 2 samples totaling 168 children and adolescents (age range 5-17.5 years) and 318 adult patients (age range 18-63 years) with OCD. Mixed linear models with random intercept were used to account for potential cross-site differences in imaging values. Results: Significant results were observed exclusively in the pediatric sample. Right prefrontal cortex thickness was positively associated with the percentage of CBT response. In a post hoc analysis, we observed that the specific changes accounting for this relationship were a higher thickness of the frontal pole and the rostral middle frontal gyrus. We observed no significant effects of age, sex, or medication on our findings. Conclusion: Higher cortical thickness in specific right prefrontal cortex regions may be important for CBT response in children with OCD. Our findings suggest that the right prefrontal cortex plays a relevant role in the mechanisms of action of CBT in children.
  • article 0 Citação(ões) na Scopus
    Brain activation during fear extinction recall in unmedicated patients with obsessive-compulsive disorder
    (2023) DINIZ, Juliana Belo; BAZAN, Paulo Rodrigo; PEREIRA, Carlos Alberto de Braganca; SARAIVA, Erlandson Ferreira; RAMOS, Paula Roberta Camargo; OLIVEIRA, Amanda Ribeiro de; REIMER, Adriano Edgar; HOEXTER, Marcelo Queiroz; MIGUEL, Euripedes Constantino; SHAVITT, Roseli Gedanke; BATISTUZZO, Marcelo Camargo
    Specific brain activation patterns during fear conditioning and the recall of previously extinguished fear responses have been associated with obsessive-compulsive disorder (OCD). However, further replication studies are necessary. We measured skin-conductance response and blood oxygenation level-dependent responses in unmedicated adult patients with OCD (n = 27) and healthy participants (n = 22) submitted to a two-day fear conditioning experiment comprising fear conditioning, extinction (day 1) and extinction recall (day 2). During conditioning, groups differed regarding the skin conductance reactivity to the aversive stimulus (shock) and regarding the activation of the right opercular cortex, insular cortex, putamen, and lingual gyrus in response to conditioned stimuli. During extinction recall, patients with OCD had higher responses to stimuli and smaller differences between responses to conditioned and neutral stimuli. For the entire sample, the higher the response delta between conditioned and neutral stimuli, the greater the dACC activation for the same contrast during early extinction recall. While activation of the dACC predicted the average difference between responses to stimuli for the entire sample, groups did not differ regarding the activation of the dACC during extinction recall. Larger unmedicated samples might be necessary to replicate the previous findings reported in patients with OCD.
  • article 0 Citação(ões) na Scopus
    Expanding the heuristic neurocircuit-based taxonomy to guide treatment for OCD: reply to the commentary ""Probing the genetic and molecular correlates of connectome alterations in obsessive-compulsive disorder""
    (2022) SHEPHARD, Elizabeth; STERN, Emily R.; HEUVEL, Odile A. van den; COSTA, Daniel L. C.; BATISTUZZO, Marcelo C.; GODOY, Priscilla B. G.; LOPES, Antonio C.; BRUNONI, Andre R.; HOEXTER, Marcelo Q.; SHAVITT, Roseli G.; REDDY, Y. C. Janardhan; LOCHNER, Christine; STEIN, Dan J.; SIMPSON, H. Blair; MIGUEL, Euripedes C.
  • article 1 Citação(ões) na Scopus
    Gamma knife capsulotomy for intractable OCD: Neuroimage analysis of lesion size, location, and clinical response
    (2023) MCLAUGHLIN, N. C. R.; MAGNOTTI, J. F.; BANKS, G. P.; NANDA, P.; HOEXTER, M. Q.; LOPES, A. C.; BATISTUZZO, M. C.; ASAAD, W. F.; STEWART, C.; PAULO, D.; NOREN, G.; GREENBERG, B. D.; MALLOY, P.; SALLOWAY, S.; CORREIA, S.; PATHAK, Y.; SHEEHAN, J.; MARSLAND, R.; GORGULHO, A.; SALLES, A. De; MIGUEL, E. C.; RASMUSSEN, S. A.; SHETH, S. A.
    Obsessive-compulsive disorder (OCD) affects 2-3% of the population. One-third of patients are poorly responsive to conventional therapies, and for a subgroup, gamma knife capsulotomy (GKC) is an option. We examined lesion characteristics in patients previously treated with GKC through well-established programs in Providence, RI (Butler Hospital/Rhode Island Hospital/Alpert Medical School of Brown University) and Sao Paulo, Brazil (University of Sao Paolo). Lesions were traced on T1 images from 26 patients who had received GKC targeting the ventral half of the anterior limb of the internal capsule (ALIC), and the masks were transformed into MNI space. Voxel-wise lesion-symptom mapping was performed to assess the influence of lesion location on Y-BOCS ratings. General linear models were built to compare the relationship between lesion size/location along different axes of the ALIC and above or below-average change in Y-BOCS ratings. Sixty-nine percent of this sample were full responders (>= 35% improvement in OCD). Lesion occurrence anywhere within the targeted region was associated with clinical improvement, but modeling results demonstrated that lesions occurring posteriorly (closer to the anterior commissure) and dorsally (closer to the mid-ALIC) were associated with the greatest Y-BOCS reduction. No association was found between Y-BOCS reduction and overall lesion volume. GKC remains an effective treatment for refractory OCD. Our data suggest that continuing to target the bottom half of the ALIC in the coronal plane is likely to provide the dorsal-ventral height required to achieve optimal outcomes, as it will cover the white matter pathways relevant to change. Further analysis of individual variability will be essential for improving targeting and clinical outcomes, and potentially further reducing the lesion size necessary for beneficial outcomes.
  • article 4 Citação(ões) na Scopus
    Associations of medication with subcortical morphology across the lifespan in OCD: Results from the international ENIGMA Consortium
    (2022) IVANOV, Iliyan; BOEDHOE, Premika S. W.; ABE, Yoshinari; ALONSO, Pino; AMEIS, Stephanie H.; ARNOLD, Paul D.; BALACHANDER, Srinivas; BAKER, Justin T.; BANAJ, Nerisa; BARGALLO, Nuria; BATISTUZZO, Marcelo C.; BENEDETTI, Francesco; BEUCKE, Jan C.; BOLLETTINI, Irene; BREM, Silvia; BRENNAN, Brian P.; BUITELAAR, Jan; CALVO, Rosa; CHENG, Yuqi; CHO, Kang Ik K.; DALLASPEZIA, Sara; DENYS, Damiaan; DINIZ, Juliana B.; ELY, Benjamin A.; FEUSNER, Jamie D.; FERREIRA, Sonia; FITZGERALD, Kate D.; FONTAINE, Martine; GRUNER, Patricia; HANNA, Gregory L.; HIRANO, Yoshiyuki; HOEXTER, Marcelo Q.; HUYSER, Chaim; IKARI, Keisuke; JAMES, Anthony; JASPERS-FAYER, Fern; JIANG, Hongyan; KATHMANN, Norbert; KAUFMANN, Christian; KIM, Minah; KOCH, Kathrin; KWON, Jun Soo; LAZARO, Luisa; LIU, Yanni; LOCHNER, Christine; MARSH, Rachel; MARTINEZ-ZALACAIN, Ignacio; MATAIX-COLS, David; MENCHON, Jose M.; MINUZZI, Luciano; MORER, Astrid; MORGADO, Pedro; NAKAGAWA, Akiko; NAKAMAE, Takashi; NAKAO, Tomohiro; NARAYANASWAMY, Janardhanan C.; NURMI, Erika L.; OH, Sanghoon; PERRIELLO, Chris; PIACENTINI, John C.; PICO-PEREZ, Maria; PIRAS, Fabrizio; PIRAS, Federica; REDDY, Y. C. Janardhan; MANRIQUE, Daniela Rodriguez; SAKAI, Yuki; SHIMIZU, Eiji; SIMPSON, H. Blair; SORENI, Noam; SORIANO-MAS, Carles; SPALLETTA, Gianfranco; STERN, Emily R.; STEVENS, Michael C.; STEWART, S. Evelyn; SZESZKO, Philip R.; TOLIN, David F.; ROOIJ, Daan van; VELTMAN, Dick J.; WERF, Ysbrand D. van der; WINGEN, Guido A. van; VENKATASUBRAMANIAN, Ganesan; WALITZA, Susanne; WANG, Zhen; WATANABE, Anri; WOLTERS, Lidewij H.; XU, Xiufeng; YUN, Je-Yeon; ZAREI, Mojtaba; ZHANG, Fengrui; ZHAO, Qing; JAHANSHAD, Neda; I, Sophia Thomopoulos; THOMPSON, Paul M.; STEIN, Dan J.; HEUVEL, Odile A. van den; O'NEILL, Joseph
    Background: Widely used psychotropic medications for obsessive-compulsive disorder (OCD) may change the volumes of subcortical brain structures, and differently in children vs. adults. We measured subcortical volumes cross-sectionally in patients finely stratified for age taking various common classes of OCD drugs. Methods: The ENIGMA-OCD consortium sample (1081 medicated/1159 unmedicated OCD patients and 2057 healthy controls aged 6-65) was divided into six successive 6-10-year age-groups. Individual structural MRIs were parcellated automatically using FreeSurfer into 8 regions-of-interest (ROIs). ROI volumes were compared between unmedicated and medicated patients and controls, and between patients taking serotonin reuptake inhibitors (SRIs), tricyclics (TCs), antipsychotics (APs), or benzodiazepines (BZs) and unmedicated patients. Results: Compared to unmedicated patients, volumes of accumbens, caudate, and/or putamen were lower in children aged 6-13 and adults aged 50-65 with OCD taking SRIs (Cohen's d = 0.24 to 0.74). Volumes of putamen, pallidum (d = 0.18-0.40), and ventricles (d = 0.31-0.66) were greater in patients aged 20-29 receiving APs. Hippocampal volumes were smaller in patients aged 20 and older taking TCs and/or BZs (d = 0.27 to 1.31). Conclusions: Results suggest that TCs and BZs could potentially aggravate hippocampal atrophy of normal aging in older adults with OCD, whereas SRIs may reduce striatal volumes in young children and older adults. Similar to patients with psychotic disorders, OCD patients aged 20-29 may experience subcortical nuclear and ventricular hypertrophy in relation to APs. Although cross-sectional, present results suggest that commonly prescribed agents exert macroscopic effects on subcortical nuclei of unknown relation to therapeutic response.
  • article 0 Citação(ões) na Scopus
    The functional connectome in obsessive-compulsive disorder: resting-state mega-analysis and machine learning classification for the ENIGMA-OCD consortium (May, 10.1038/s41380-023-02077-0, 2023)
    (2023) BRUIN, Willem; ABE, Yoshinari; ALONSO, Pino; ANTICEVIC, Alan; BACKHAUSEN, Lea; BALACHANDER, Srinivas; BARGALLO, Nuria; BATISTUZZO, Marcelo; BENEDETTI, Francesco D.; TRIQUELL, Sara G. Bertolin; BREM, Silvia; CALESELLA, Federico Y.; COUTO, Beatriz; DENYS, Damiaan A. J. P.; ECHEVARRIA, Marco A. N.; ENG, Goi Khia Q.; FERREIRA, Sonia; FEUSNER, Jamie; GRAZIOPLENE, Rachael; GRUNER, Patricia; GUO, Joyce; HAGEN, Kristen; HANSEN, Bjarne; HIRANO, Yoshiyuki; HOEXTER, Marcelo; JAHANSHAD, Neda; JASPERS-FAYER, Fern; KASPRZAK, Selina; KIM, Minah M.; KOCH, Kathrin S.; KWAK, Yoo Bin; KWON, Jun Soo; LAZARO, Luisa; LI, Chiang-Shan R. C.; LOCHNER, Christine L.; MARSH, Rachel; MARTINEZ-ZALACAIN, Ignacio; MENCHON, Jose; MOREIRA, Pedro; MORGADO, Pedro; NAKAGAWA, Akiko; NAKAO, Tomohiro; NARAYANASWAMY, Janardhanan; NURMI, Erika; ZORRILLA, Jose C. Pariente; PIACENTINI, John; PICO-PEREZ, Maria H.; PIRAS, Fabrizio; PIRAS, Federica; PITTENGER, Christopher; REDDY, Janardhan Y. C. R.; RODRIGUEZ-MANRIQUE, Daniela; SAKAI, Yuki R.; SHIMIZU, Eiji; SHIVAKUMAR, Venkataram I.; SIMPSON, Blair L.; SORIANO-MAS, Carles; SOUSA, Nuno; SPALLETTA, Gianfranco; STERN, Emily M.; STEWART, S. Evelyn; SZESZKO, Philip C.; TANG, Jinsong; THOMOPOULOS, Sophia; THORSEN, Anders; YOSHIDA, Tokiko; TOMIYAMA, Hirofumi; VAI, Benedetta; VEER, Ilya; VENKATASUBRAMANIAN, Ganesan; VETTER, Nora A.; VRIEND, Chris; WALITZA, Susanne A.; WALLER, Lea; WANG, Zhen D.; WATANABE, Anri; WOLFF, Nicole; YUN, Je-Yeon; ZHAO, Qing; LEEUWEN, Wieke van; MARLE, Hein J. F. van; MORTEL, Laurens van de; STRATEN, Anouk van der; WERF, Ysbrand van der; ARAI, Honami C.; BOLLETTINI, Irene; ESCALONA, Rosa Calvo; COELHO, Ana; COLOMBO, Federica; DARWICH, Leila; FONTAINE, Martine; IKUTA, Toshikazu; IPSER, Jonathan; JUANEDA-SEGUI, Asier; KITAGAWA, Hitomi; KVALE, Gerd; MACHADO-SOUSA, Mafalda R.; MORER, Astrid; NAKAMAE, Takashi G.; NARUMOTO, Jin J.; O'NEILL, Joseph; OKAWA, Sho A.; REAL, Eva; ROESSNER, Veit A.; SATO, Joao; SEGALAS, Cinto D.; SHAVITT, Roseli A.; VELTMAN, Dick A.; YAMADA, Kei M.; THOMPSON, Paul J.; STEIN, Dan A.; HEUVEL, Odile A. van den; WINGEN, Guido van
  • article 1 Citação(ões) na Scopus
    Global multi-center and multi-modal magnetic resonance imaging study of obsessive-compulsive disorder: Harmonization and monitoring of protocols in healthy volunteers and phantoms
    (2023) POUWELS, Petra J. W.; VRIEND, Chris; LIU, Feng; JOODE, Niels T. de; OTADUY, Maria C. G.; PASTORELLO, Bruno; ROBERTSON, Frances C.; VENKATASUBRAMANIAN, Ganesan; IPSER, Jonathan; LEE, Seonjoo; BATISTUZZO, Marcelo C.; HOEXTER, Marcelo Q.; LOCHNER, Christine; MIGUEL, Euripedes C.; NARAYANASWAMY, Janardhanan C.; RAO, Rashmi; REDDY, Y. C. Janardhan; SHAVITT, Roseli G.; SHESHACHALA, Karthik; STEIN, Dan J.; BALKOM, Anton J. L. M. van; WALL, Melanie; SIMPSON, Helen Blair; HEUVEL, Odile A. van den
    Objectives We describe the harmonized MRI acquisition and quality assessment of an ongoing global OCD study, with the aim to translate representative, well-powered neuroimaging findings in neuropsychiatric research to worldwide populations. Methods We report on T1-weighted structural MRI, resting-state functional MRI, and multi-shell diffusion-weighted imaging of 140 healthy participants (28 per site), two traveling controls, and regular phantom scans. Results Human image quality measures (IQMs) and outcome measures showed smaller within-site variation than between-site variation. Outcome measures were less variable than IQMs, especially for the traveling controls. Phantom IQMs were stable regarding geometry, SNR, and mean diffusivity, while fMRI fluctuation was more variable between sites. Conclusions Variation in IQMs persists, even for an a priori harmonized data acquisition protocol, but after pre-processing they have less of an impact on the outcome measures. Continuous monitoring IQMs per site is valuable to detect potential artifacts and outliers. The inclusion of both cases and healthy participants at each site remains mandatory.
  • article 1 Citação(ões) na Scopus
    Spatial normalization discrepancies between native and MNI152 brain template scans in gamma ventral capsulotomy patients
    (2023) GIFF, Alexis; NOREN, Georg; MAGNOTTI, John; LOPES, Antonio Carlos; BATISTUZZO, Marcelo Camargo; HOEXTER, Marcelo; GREENBERG, Benjamin; MARSLAND, Richard; MIGUEL, Euripedes Constantino; RASMUSSEN, Steven; MCLAUGHLIN, Nicole
    In neurosurgery, spatial normalization emerged as a tool to minimize inter-subject variability and study target point locations based on standard coordinates. The Montreal Neurological Institute's 152 brain template (MNI152) has become the most widely utilized in neuroimaging studies, but has been noted to introduce partial volume effects, distortions, and increase structure size in all directions (x/y/z axes). These discrepancies question the accuracy of the MNI template, as well as its utility for studies that examine and form conclusions from group -level data. Given that surgical precision in obsessive-compulsive disorder is essential to patient outcomes, we retrospectively investigated lesion size and location in patients (n = 21) who underwent capsulotomy for intractable OCD, comparing deviations in the native scans to those in standard space. MNI measurements were significantly larger than native measurements across several structures in both coronal and axial slices, and we found that MNI transformation increases the size of many subcortical structures in a significant and proportional way for both females and males. These findings urge caution when using MNI as a reference space, as well as a stronger consideration of population-specific brain templates when examining connectivity-based networks.