MARCELO CAMARGO BATISTUZZO
Projetos de Pesquisa
Unidades Organizacionais
Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina
LIM/23 - Laboratório de Psicopatologia e Terapêutica Psiquiátrica, Hospital das Clínicas, Faculdade de Medicina
LIM/23 - Laboratório de Psicopatologia e Terapêutica Psiquiátrica, Hospital das Clínicas, Faculdade de Medicina
11 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 11
conferenceObject Treatment Response Prediction in Pediatric Patients With OCD Using Structural Neuroimaging Correlates: Simple Linear Regression Versus Support Vector Regression(2017) VATTIMO, Edoardo; BARROS, Vivian; BATISTUZZO, Marcelo; REQUENA, Guaraci; SATO, Joao; FATORI, Daniel; SHAVITT, Roseli; MIGUEL, Euripedes; HOEXTER, MarceloconferenceObject Early Life Adverse Experiences and Obsessive-Compulsive Disorder: A Study With Patients, Siblings and Controls(2018) COSTA, Fabiana; CAPPI, Carolina; BATISTUZZO, Marcelo; SHAVITT, Roseli; REQUENA, Guaraci; MIGUEL, Euripedes; HOEXTER, MarceloconferenceObject Decrease in Thalamic Volumes of Refractory Patients with Obsessive-Compulsive Disorder who Were Submitted to Gamma Ventral Capsulotomy(2015) COSTA, Douglas; BATISTUZZO, Marcelo; DURAN, Fabio; GREENBERG, Benjamin; CANTERAS, Miguel; SHAVITT, Roseli; GENTIL, Andre; MIGUEL, Euripedes; LOPES, Antonio; HOEXTER, MarceloconferenceObject Different Brain Activation in Patients With OCD Compared to Healthy Participants During Conditioning: An fMRI Fear Extinction Paradigm(2021) DINIZ, Juliana; BAZAN, Paulo; PEREIRA, Carlos Alberto; SARAIVA, Erlandson; RAMOS, Paula; OLIVEIRA, Amanda; REIMER, Adriano; BRANDAO, Marcus; HOEXTER, Marcelo; SHAVITT, Roseli; MIGUEL, Euripedes; BATISTUZZO, MarceloconferenceObject Personality Changes in Refractory Patients With Obsessive-Compulsive Disorder Submitted to Gamma Ventral Capsulotomy(2016) PAIVA, Raquel; LOPES, Antonio C.; BATISTUZZO, Marcelo; MATHIS, Maria Eugenia de; CANTERAS, Miguel; GREENBERG, Benjamin; SHAVITT, Roseli; MIGUEL, Euripedes; HOEXTER, MarceloconferenceObject Myo-Inositol Reduction in Medial Prefrontal Cortex of Obsessive Compulsive Disorder: A Proton Magnetic Resonance Spectroscopy Study(2015) BATISTUZZO, Marcelo; HOEXTER, Marcelo; COSTA, Fabiana; SHAVITT, Roseli; LOPES, Antonio; CAPPI, Carolina; MATHIS, Alice De; NATASHA, Senc O.; HENNING, Anke; PASTORELLO, Bruno; LEITE, Claudia; MIGUEL, Euripedes; OTADUY, MariaconferenceObject Orbitofrontal Thickness as a Measure for Treatment Response Classification in Obsessive-Compulsive Disorder(2014) HOEXTER, Marcelo; DINIZ, Juliana; LOPES, Antonio; BATISTUZZO, Marcelo; SHAVITT, Roseli; DOUGHERTY, Darin; DURAN, Fabio; BRESSAN, Rodrigo; BUSATTO, Geraldo; MIGUEL, Euripedes; SATO, JoaoconferenceObject Subtle Neurocognitive Deficits Associated With Obsessive-Compulsive Symptoms During Childhood: A Latent Class Analysis Applied in a Brazilian High Risk Cohort(2017) BATISTUZZO, Marcelo; HOEXTER, Marcelo; VATTIMO, Eduardo; ALVARENGA, Pedro; SHAVITT, Roseli; TEIXEIRA, Lorenna; ROSARIO, Maria Conceicao do; MIGUEL, Euripedes; SALUM, Giovanni- Visuospatial Memory Improvement after Gamma Ventral Capsulotomy in Treatment Refractory Obsessive-Compulsive Disorder Patients(2015) BATISTUZZO, Marcelo C.; HOEXTER, Marcelo Q.; TAUB, Anita; GENTIL, Andre F.; CESAR, Raony C. C.; JOAQUIM, Marines A.; D'ALCANTE, Carina Chaubet; MCLAUGHLIN, Nicole C.; CANTERAS, Miguel M.; SHAVITT, Roseli G.; SAVAGE, Cary R.; GREENBERG, Benjamin D.; NOREN, Georg; MIGUEL, Euripedes C.; LOPES, Antonio C.Gamma ventral capsulotomy (GVC) radiosurgery is intended to minimize side effects while maintaining the efficacy of traditional thermocoagulation techniques for the treatment of refractory obsessive-compulsive disorder (OCD). Neuropsychological outcomes are not clear based on previous studies and, therefore, we investigated the effects of GVC on cognitive and motor performance. A double-blind, randomized controlled trial (RCT) was conducted with 16 refractory OCD patients allocated to active treatment (n = 8) and sham (n = 8) groups. A comprehensive neuropsychological evaluation including intellectual functioning, attention, verbal and visuospatial learning and memory, visuospatial perception, inhibitory control, cognitive flexibility, and motor functioning was applied at baseline and one year after the procedure. Secondary analysis included all operated patients: eight from the active group, four from the sham group who were submitted to surgery after blind was broken, and five patients from a previous open pilot study (n = 5), totaling 17 patients. In the RCT, visuospatial memory (VSM) performance significantly improved in the active group after GVC (p = 0.008), and remained stable in the sham group. Considering all patients operated, there was no decline in cognitive or motor functioning after one year of follow-up. Our initial results after 1 year of follow-up suggests that GVC not only is a safe procedure in terms of neuropsychological functioning but in fact may actually improve certain neuropsychological domains, particularly VSM performance, in treatment refractory OCD patients.
- Efficacy and safety of transcranial direct current stimulation as an add-on treatment for obsessive-compulsive disorder: a randomized, sham-controlled trial(2021) SILVA, Renata de Melo Felipe da; BRUNONI, Andre R.; GOERIGK, Stephan; BATISTUZZO, Marcelo Camargo; COSTA, Daniel Lucas da Conceicao; DINIZ, Juliana Belo; PADBERG, Frank; D'URSO, Giordano; MIGUEL, Euripedes Constantino; SHAVITT, Roseli GedankeObsessive-compulsive disorder (OCD) is a frequent, disabling disorder with high rates of treatment resistance. Transcranial direct current stimulation (tDCS) is a safe, tolerable noninvasive neuromodulation therapy with scarce evidence for OCD. This double-blind, randomized, and sham-controlled study investigates the efficacy of tDCS as add-on treatment for treatment-resistant OCD (failure to respond to at least one previous pharmacological treatment). On 20 consecutive weekdays (4 weeks), 43 patients with treatment-resistant OCD underwent 30 min active or sham tDCS sessions, followed by a 8 week follow-up. The cathode was positioned over the supplementary motor area (SMA) and the anode over the left deltoid. The primary outcome was the change in baseline Y-BOCS score at week 12. Secondary outcomes were changes in mood and anxiety and the occurrence of adverse events. Response was evaluated considering percent decrease of baseline Y-BOCS scores and the Improvement subscale of the Clinical Global Impression (CGI-I) between baseline and week 12. Patients that received active tDCS achieved a significant reduction of OCD symptoms than sham, with mean (SD) Y-BOCS score changes of 6.68 (5.83) and 2.84 (6.3) points, respectively (Cohen's d: 0.62 (0.06-1.18), p = 0.03). We found no between-group differences in responders (four patients in the active tDCS and one in the sham group). Active tDCS of the SMA was not superior to sham in reducing symptoms of depression or anxiety. Patients in both groups reported mild adverse events. Our results suggest that cathodal tDCS over the SMA is an effective add-on strategy in treatment-resistant OCD.