Integration of miRNA and gene expression profiles suggest a role for miRNAs in the pathobiological processes of acute Trypanosoma cruzi infection

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorFERREIRA, Ludmila Rodrigues Pinto
dc.contributor.authorFERREIRA, Frederico Moraes
dc.contributor.authorLAUGIER, Laurie
dc.contributor.authorCABANTOUS, Sandrine
dc.contributor.authorNAVARRO, Isabela Cunha
dc.contributor.authorCANDIDO, Darlan da Silva
dc.contributor.authorRIGAUD, Vagner Carvalho
dc.contributor.authorREAL, Juliana Monte
dc.contributor.authorPEREIRA, Glaucia Vilar
dc.contributor.authorPEREIRA, Isabela Resende
dc.contributor.authorRUIVO, Leonardo
dc.contributor.authorPANDEY, Ramendra Pati
dc.contributor.authorSAVOIA, Marilda
dc.contributor.authorKALIL, Jorge
dc.contributor.authorLANNES-VIEIRA, Joseli
dc.contributor.authorNAKAYA, Helder
dc.contributor.authorCHEVILLARD, Christophe
dc.contributor.authorCUNHA-NETO, Edecio
dc.date.accessioned2018-03-06T15:14:52Z
dc.date.available2018-03-06T15:14:52Z
dc.date.issued2017
dc.description.abstractChagas disease, caused by the parasite Trypanosoma cruzi, is endemic in Latin America. Its acute phase is associated with high parasitism, myocarditis and profound myocardial gene expression changes. A chronic phase ensues where 30% develop severe heart lesions. Mouse models of T. cruzi infection have been used to study heart damage in Chagas disease. The aim of this study was to provide an interactome between miRNAs and their targetome in Chagas heart disease by integrating gene and microRNA expression profiling data from hearts of T. cruzi infected mice. Gene expression profiling revealed enrichment in biological processes and pathways associated with immune response and metabolism. Pathways, functional and upstream regulator analysis of the intersections between predicted targets of differentially expressed microRNAs and differentially expressed mRNAs revealed enrichment in biological processes and pathways such as IFN gamma, TNF alpha, NF-kappa B signaling signatures, CTL-mediated apoptosis, mitochondrial dysfunction, and Nrf2-modulated antioxidative responses. We also observed enrichment in other key heart disease-related processes like myocarditis, fibrosis, hypertrophy and arrhythmia. Our correlation study suggests that miRNAs may be implicated in the pathophysiological processes taking place the hearts of acutely T. cruzi-infected mice.
dc.description.indexMEDLINE
dc.description.sponsorshipInstitut National de la Sante et de la Recherche Medicale (INSERM)
dc.description.sponsorshipAix-Marseille University (Direction des Relations Internationales)
dc.description.sponsorshipUSP-COFECUB
dc.description.sponsorshipARCUS II PACA
dc.description.sponsorshipCNPq (Brazilian National Council for Scientific and Technological Development)
dc.description.sponsorshipFAPESP (Sao Paulo State Research Funding Agency-Brazil) [2013/50302-3]
dc.description.sponsorshipplan << Laboratoire d'Excellence (LabEx) ParaFrap >> [ANR-11-LABX-0024]
dc.description.sponsorshipFrench (Agence Nationale de Recherche-ANR)
dc.description.sponsorshipBrazilian (FAPESP)
dc.description.sponsorshipCNPq
dc.identifier.citationSCIENTIFIC REPORTS, v.7, article ID 17990, 12p, 2017
dc.identifier.doi10.1038/s41598-017-18080-9
dc.identifier.issn2045-2322
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/25464
dc.language.isoeng
dc.publisherNATURE PUBLISHING GROUP
dc.relation.ispartofScientific Reports
dc.rightsopenAccess
dc.rights.holderCopyright NATURE PUBLISHING GROUP
dc.subject.otherchagas-disease cardiomyopathy
dc.subject.othertissue-damage control
dc.subject.otherheart-failure
dc.subject.othertherapeutic target
dc.subject.otherinterferon-gamma
dc.subject.othermessenger-rna
dc.subject.otherifn-gamma
dc.subject.othermicrornas
dc.subject.othernrf2
dc.subject.otherglobalization
dc.subject.wosMultidisciplinary Sciences
dc.titleIntegration of miRNA and gene expression profiles suggest a role for miRNAs in the pathobiological processes of acute Trypanosoma cruzi infection
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.affiliation.countryEstados Unidos
hcfmusp.affiliation.countryFrança
hcfmusp.affiliation.countryisofr
hcfmusp.affiliation.countryisous
hcfmusp.author.externalLAUGIER, Laurie:Aix Marseille Univ, INSERM, Fac Med, U1108, Marseille, France
hcfmusp.author.externalCABANTOUS, Sandrine:Aix Marseille Univ, INSERM, Fac Med, U1108, Marseille, France
hcfmusp.author.externalNAVARRO, Isabela Cunha:Univ Sao Paulo, Sch Med, Heart Inst InCor, Lab Immunol, Sao Paulo, Brazil; Univ Sao Paulo, Sch Med, Div Clin Immunol & Allergy, Sao Paulo, Brazil; Iii INCT, Inst Invest Immunol, Sao Paulo, Brazil
hcfmusp.author.externalPEREIRA, Glaucia Vilar:Fiocruz MS, Oswaldo Cruz Inst, Lab Biol Interact, Rio De Janeiro, Brazil
hcfmusp.author.externalPEREIRA, Isabela Resende:Fiocruz MS, Oswaldo Cruz Inst, Lab Biol Interact, Rio De Janeiro, Brazil
hcfmusp.author.externalRUIVO, Leonardo:Fiocruz MS, Oswaldo Cruz Inst, Lab Biol Interact, Rio De Janeiro, Brazil
hcfmusp.author.externalLANNES-VIEIRA, Joseli:Fiocruz MS, Oswaldo Cruz Inst, Lab Biol Interact, Rio De Janeiro, Brazil
hcfmusp.author.externalNAKAYA, Helder:Univ Sao Paulo, Sch Pharmaceut Sci, Dept Pathophysiol & Toxicol, BR-077010 Sao Paulo, Brazil; Emory Univ, Sch Med, Dept Pathol, Atlanta, GA 30322 USA
hcfmusp.author.externalCHEVILLARD, Christophe:Aix Marseille Univ, INSERM, Fac Med, U1108, Marseille, France; Aix Marseille Univ, UMR1090, INSERM, Parc Sci Luminy Case 928,163 Ave Luminy, Marseille, France
hcfmusp.citation.scopus37
hcfmusp.contributor.author-fmusphcLUDMILA RODRIGUES PINTO FERREIRA CAMARGO
hcfmusp.contributor.author-fmusphcFREDERICO MORAES FERREIRA
hcfmusp.contributor.author-fmusphcDARLAN DA SILVA CANDIDO
hcfmusp.contributor.author-fmusphcVAGNER OLIVEIRA CARVALHO RIGAUD
hcfmusp.contributor.author-fmusphcJULIANA MONTE REAL
hcfmusp.contributor.author-fmusphcRAMENDRA PATI PANDEY
hcfmusp.contributor.author-fmusphcMARILDA SAVOIA NASCIMENTO
hcfmusp.contributor.author-fmusphcJORGE ELIAS KALIL FILHO
hcfmusp.contributor.author-fmusphcEDECIO CUNHA NETO
hcfmusp.description.articlenumber17990
hcfmusp.description.volume7
hcfmusp.origemWOS
hcfmusp.origem.pubmed29269773
hcfmusp.origem.scopus2-s2.0-85042353625
hcfmusp.origem.wosWOS:000418562100030
hcfmusp.publisher.cityLONDON
hcfmusp.publisher.countryENGLAND
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