Complete urological evaluation including sperm DNA fragmentation in male systemic lupus erythematosus patients

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorTISEO, B. C.
dc.contributor.authorBONFA, E.
dc.contributor.authorBORBA, E. F.
dc.contributor.authorMUNHOZ, G. A.
dc.contributor.authorWOOD, G. J. A.
dc.contributor.authorSROUGI, M.
dc.contributor.authorSILVA, C. A.
dc.contributor.authorCOCUZZA, M.
dc.date.accessioned2019-02-21T17:21:07Z
dc.date.available2019-02-21T17:21:07Z
dc.date.issued2019
dc.description.abstractObjective To evaluate sperm DNA fragmentation analysis in non-azoospermic male systemic lupus erythematosus (SLE) patients. Methods Twenty-eight consecutive male SLE patients (American College of Rheumatology criteria) and 34 healthy controls were evaluated for demographic/exposures data, urological evaluation, hormone profile and sperm analysis (including sperm DNA fragmentation). Clinical features, disease activity/damage scores and treatment were also evaluated. Results The median age (33 (20-52) vs. 36.5 (25-54) years, P = 0.329) and frequency of varicocele (25% vs. 32%, P = 0.183) were similar in SLE patients and healthy controls. Sperm DNA fragmentation showed significantly higher levels of cells class III (44 (9-88) vs. 16.5 (0-80)%, P = 0.001) and cell class IV (10.5 (3-86) vs. 7 (0-36)%, P = 0.039) in SLE. The sperm DNA fragmentation index was also significantly higher in SLE patients (62 (31-97) vs. 25.5 (0-100)%, P < 0.001). Conventional sperm parameters (including sperm count, motility and morphology) were similar in both groups. In SLE patients no correlations were observed between sperm DNA fragmentation index and age, disease duration, Systemic Lupus Erythematosus Disease Activity Index 2000 and Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index scores, and cumulative dose of prednisone, hydroxychloroquine, intravenous cyclophosphamide, methotrexate, azathioprine and mycophenolate mofetil (P > 0.05). Further analysis of SLE patients treated with and without intravenous cyclophosphamide showed that total sperm motility was significantly lower in the former group (64% (15-83) vs. 72% (57-86), P = 0.024). The sperm DNA fragmentation index was alike in both groups (52.5 (31-95) vs. 67.5 (34-97)%, P = 0.185). Conclusions To our knowledge, this is the first demonstration that male non-azoospermic SLE patients have increased sperm DNA fragmentation without evident gonadal dysfunction. Intravenous cyclophosphamide does not seem to be a major determinant for this abnormality. Future prospective study is necessary to determine the impact of this alteration in these patients' fertility.eng
dc.description.indexMEDLINEeng
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior [BEX-4722/14-0]
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2014/14806-0, 2015/03756-4]
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico [305068/2014-8, 307226/2014-0, 303422/2015-7]
dc.description.sponsorshipFederico Foundation
dc.description.sponsorshipNucleo de Apoio a Pesquisa Saude da Crianca e do Adolescente' da USP (NAP-CriAd)
dc.identifier.citationLUPUS, v.28, n.1, p.59-65, 2019
dc.identifier.doi10.1177/0961203318815764
dc.identifier.eissn1477-0962
dc.identifier.issn0961-2033
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/30786
dc.language.isoeng
dc.publisherSAGE PUBLICATIONS LTDeng
dc.relation.ispartofLupus
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright SAGE PUBLICATIONS LTDeng
dc.subjectSystemic lupus erythematosuseng
dc.subjectsperm DNA fragmentationeng
dc.subjecttesticulareng
dc.subjectspermeng
dc.subjecthormoneeng
dc.subject.otherrheumatic-diseaseseng
dc.subject.otherclassificationeng
dc.subject.othermanagementeng
dc.subject.otherfertilityeng
dc.subject.otherintegrityeng
dc.subject.otherindexeng
dc.subject.othersemeneng
dc.subject.wosRheumatologyeng
dc.titleComplete urological evaluation including sperm DNA fragmentation in male systemic lupus erythematosus patientseng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.citation.scopus9
hcfmusp.contributor.author-fmusphcBRUNO CAMARGO TISEO
hcfmusp.contributor.author-fmusphcELOISA SILVA DUTRA DE OLIVEIRA BONFA
hcfmusp.contributor.author-fmusphcEDUARDO FERREIRA BORBA NETO
hcfmusp.contributor.author-fmusphcGABRIELA ARAUJO MUNHOZ
hcfmusp.contributor.author-fmusphcGUILHERME JACOM ABDULMASSIH WOOD
hcfmusp.contributor.author-fmusphcMIGUEL SROUGI
hcfmusp.contributor.author-fmusphcCLOVIS ARTUR ALMEIDA DA SILVA
hcfmusp.contributor.author-fmusphcMARCELLO ANTONIO SIGNORELLI COCUZZA
hcfmusp.description.beginpage59
hcfmusp.description.endpage65
hcfmusp.description.issue1
hcfmusp.description.volume28
hcfmusp.origemWOS
hcfmusp.origem.pubmed30509155
hcfmusp.origem.scopus2-s2.0-85059009607
hcfmusp.origem.wosWOS:000454147600008
hcfmusp.publisher.cityLONDONeng
hcfmusp.publisher.countryENGLANDeng
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