Lack of Tight Association Between Quality of Life and Exercise Capacity in Pulmonary Arterial Hypertension

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorCICERO, Cristina
dc.contributor.authorFRANCHI, Sonia Meiken
dc.contributor.authorBARRETO, Alessandra Costa
dc.contributor.authorLOPES, Antonio Augusto Barbosa
dc.date.accessioned2013-07-30T17:52:30Z
dc.date.available2013-07-30T17:52:30Z
dc.date.issued2012
dc.description.abstractBackground: In pulmonary arterial hypertension (PAH) health-related quality of life (HRQOL) has been investigated over the short-term (weeks) but little is known about patient's perspective over the medium and long term. Objective: To analyze how patients on specific PAH therapies do over one year of observation in terms of HRQOL, and to investigate if possible associations between the exercise capacity (EC) and HRQOL persist over the medium term. Methods: Thirty-four patients on PAH therapies (bosentan and/or sildenafil) were enrolled (age 14 to 58 years, median 35.5 years, functional class II or III), and evaluated at baseline, and 3, 6, 9 and 12 months subsequently using the six-minute walk test and the SF-36 HRQOL questionnaire. Results: The six minute walked distance did not change over the follow-up (387-432 meters, median values, p=0.2775), the same for the functional class and peripheral oxygen saturation. The SF-36 scores also remained stable, with physical health always worse than mental health. Of 40 possible associations between EC and HRQOL, only 12 were significant (30%, p<0.05). Prediction of severely depressed HRQOL based on a walked distance of <235 meters was >90% specific but <43% sensitive. Conclusion: Patients with PAH who remain stable in terms of EC also seem to do so in terms of HRQOL. However, EC and HRQOL are not consistently tied over time, and should be analyzed as different perspectives in the individual patient.
dc.description.abstractFundamento: Na hipertensão arterial pulmonar (HAP) a qualidade de vida relacionada à saúde (QVRS) tem sido investigada em curtos períodos de tempo (semanas), mas pouco se sabe sobre a perspectiva do paciente no médio e longo prazo. Objetivo: Analisar o estado de pacientes em terapias específicas de HAP durante um ano de observação, em termos de QVRS, e investigar se possíveis associações entre a capacidade de exercício (CE) e a QVRS persistem no médio prazo. Métodos: Trinta e quatro pacientes em terapias para a HAP (bosentan e/ou sildenafil) foram selecionados (idade de 14 a 58 anos, mediana de 35,5 anos, classe funcional II ou III), e avaliados no momento basal, e 3, 6, 9 e 12 meses depois, usando o teste de caminhada de 6 minutos e questionário SF-36 de QVRS. Resultados: A distância percorrida nos seis minutos não mudou durante o acompanhamento (387 - 432 metros, valores da mediana, p=0.2775), o mesmo para a classe funcional e saturação periférica de oxigênio. Os escores SF-36 também se mantiveram estáveis, com a saúde física sempre pior que a saúde mental. Das 40 possíveis associações entre a CE e QVRS, apenas 12 foram significativas (30%, p<0,05). A previsão de uma QVRS severamente deprimida com base em uma distância percorrida de 235 metros foi específica em >90%, mas sensível em <43%. Conclusão: Os pacientes com HAP que se mantêm estáveis em termos da CE também parecem fazê-lo em termos de QVRS. Contudo, CE e QVRS não têm ligação consistente com o tempo, e devem ser analisadas como diferentes perspectivas no paciente individual.
dc.description.indexMEDLINE
dc.identifier.citationARQUIVOS BRASILEIROS DE CARDIOLOGIA, v.99, n.4, p.876-885, 2012
dc.identifier.doi10.1590/S0066-782X2012005000079
dc.identifier.issn0066-782X
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/1464
dc.language.isoeng
dc.language.isopor
dc.publisherARQUIVOS BRASILEIROS CARDIOLOGIA
dc.relation.ispartofArquivos Brasileiros de Cardiologia
dc.rightsopenAccess
dc.rights.holderCopyright ARQUIVOS BRASILEIROS CARDIOLOGIA
dc.subjectPulmonary hypertension
dc.subjectquality of life
dc.subjectexercise tolerance
dc.subjectsymptoms
dc.subjectHipertensão pulmonar
dc.subjectQualidade de vida
dc.subjectTolerância ao exercício
dc.subjectSintomas
dc.subject.otherheart-failure
dc.subject.otherhealth survey
dc.subject.otherdouble-blind
dc.subject.othertherapy
dc.subject.otherprostacyclin
dc.subject.othersitaxsentan
dc.subject.otherambrisentan
dc.subject.otherbosentan
dc.subject.otherdisease
dc.subject.othertrial
dc.subject.wosCardiac & Cardiovascular Systems
dc.titleLack of Tight Association Between Quality of Life and Exercise Capacity in Pulmonary Arterial Hypertension
dc.title.alternativeAusência de Estreita Associação entre Qualidade de Vida e Capacidade de Exercício na Hipertensão Arterial Pulmonar
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.citation.scopus8
hcfmusp.contributor.author-fmusphcCRISTINA CICERO
hcfmusp.contributor.author-fmusphcSONIA MEIKEN FRANCHI
hcfmusp.contributor.author-fmusphcALESSANDRA COSTA BARRETO
hcfmusp.contributor.author-fmusphcANTONIO AUGUSTO BARBOSA LOPES
hcfmusp.description.beginpage876
hcfmusp.description.endpage885
hcfmusp.description.issue4
hcfmusp.description.volume99
hcfmusp.lim.ref2012
hcfmusp.origemWOS
hcfmusp.origem.pubmed22936028
hcfmusp.origem.scieloSCIELO:S0066-782X2012001300002
hcfmusp.origem.scopus2-s2.0-84869069356
hcfmusp.origem.wosWOS:000310542300005
hcfmusp.publisher.cityRIO DE JANEIRO
hcfmusp.publisher.countryBRAZIL
hcfmusp.relation.referenceCrapo RO, 2002, AM J RESP CRIT CARE, V166, P111, DOI 10.1164/rccm.166/1/111
hcfmusp.relation.referenceBadesch DB, 2009, J AM COLL CARDIOL, V54, pS55, DOI 10.1016/j.jacc.2009.04.011
hcfmusp.relation.referenceBarst RJ, 2004, AM J RESP CRIT CARE, V169, P441, DOI 10.1164/rccm.200307-957OC
hcfmusp.relation.referenceBarst RJ, 1996, NEW ENGL J MED, V334, P296, DOI 10.1056/NEJM199602013340504
hcfmusp.relation.referenceBoonen A, 2011, CLIN RHEUMATOL, V30, pS3, DOI 10.1007/s10067-010-1634-9
hcfmusp.relation.referenceBredow T, 2008, MIDDLE RANGE THEORY, P273
hcfmusp.relation.referenceChen H, 2011, EUR RESPIR J, V38, P608, DOI 10.1183/09031936.00161410
hcfmusp.relation.referenceChua R, 2006, INTERN MED J, V36, P705, DOI 10.1111/j.1445-5994.2006.01169.x
hcfmusp.relation.referenceDimopoulos K, 2010, CIRCULATION, V121, P20, DOI 10.1161/CIRCULATIONAHA.109.883876
hcfmusp.relation.referenceFujisawa M, 2000, UROLOGY, V56, P201, DOI 10.1016/S0090-4295(00)00623-3
hcfmusp.relation.referenceGalie N, 2008, CIRCULATION, V117, P3010, DOI 10.1161/CIRCULATIONAHA.107.742510
hcfmusp.relation.referenceGalie N, 2005, NEW ENGL J MED, V353, P2148, DOI 10.1056/NEJMoa050010
hcfmusp.relation.referenceGalie N, 2005, J AM COLL CARDIOL, V46, P529, DOI 10.1016/j.jacc.2005.04.050
hcfmusp.relation.referenceGalie N, 2009, CIRCULATION, V119, P2894, DOI 10.1161/CIRCULATIONAHA.108.839274
hcfmusp.relation.referenceGihl AF, 2010, ADV PULM HYPERT, V8, P215
hcfmusp.relation.referenceGirgis RE, 2007, ANN RHEUM DIS, V66, P1467, DOI 10.1136/ard.2007.069609
hcfmusp.relation.referenceHarrison MB, 2002, MED CARE, V40, P271, DOI 10.1097/00005650-200204000-00003
hcfmusp.relation.referenceKeogh AM, 2007, J HEART LUNG TRANSPL, V26, P181, DOI 10.1016/j.healun.2006.11.009
hcfmusp.relation.referenceLacson E, 2010, CLIN J AM SOC NEPHRO, V5, P252, DOI 10.2215/CJN.07231009
hcfmusp.relation.referenceLewis EF, 2001, J HEART LUNG TRANSPL, V20, P1016, DOI 10.1016/S1053-2498(01)00298-4
hcfmusp.relation.referenceMcKenna S, 2006, QUAL LIFE RES, V15, P103, DOI 10.1007/s11136-005-3513-4
hcfmusp.relation.referenceMorgan K, 2007, EUR J CARDIOV PREV R, V14, P589
hcfmusp.relation.referenceOlschewski H, 2002, NEW ENGL J MED, V347, P322, DOI 10.1056/NEJMoa020204
hcfmusp.relation.referenceOrtiz Z, 1999, J RHEUMATOL, V26, P210
hcfmusp.relation.referencePepke-Zaba J, 2008, CHEST, V133, P183, DOI 10.1378/chest.07-0592
hcfmusp.relation.referenceRector T. S., 1987, HEART FAILURE, V3, P198
hcfmusp.relation.referenceRubin LJ, 2002, NEW ENGL J MED, V346, P896, DOI 10.1056/NEJMoa012212
hcfmusp.relation.referenceSimonneau G, 2009, J AM COLL CARDIOL, V54, pS43
hcfmusp.relation.referenceSimonneau G, 2002, AM J RESP CRIT CARE, V165, P800, DOI 10.1164/rccm.2106079
hcfmusp.relation.referenceTaichman DB, 2005, RESP RES, V6, DOI 10.1186/1465-9921-6-92
hcfmusp.relation.referenceTomasz Wesolowski, 2003, Ann Transplant, V8, P47
hcfmusp.relation.referenceWARE JE, 1992, MED CARE, V30, P473, DOI 10.1097/00005650-199206000-00002
hcfmusp.relation.referenceZlupko M, 2008, RESP MED, V102, P1431, DOI 10.1016/j.rmed.2008.04.016
hcfmusp.scopus.lastupdate2024-05-17
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