Relationship between Brain Age-Related Reduction in Gray Matter and Educational Attainment

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorRZEZAK, Patricia
dc.contributor.authorSQUARZONI, Paula
dc.contributor.authorDURAN, Fabio L.
dc.contributor.authorALVES, Tania de Toledo Ferraz
dc.contributor.authorTAMASHIRO-DURAN, Jaqueline
dc.contributor.authorBOTTINO, Cassio M.
dc.contributor.authorRIBEIZ, Salma
dc.contributor.authorLOTUFO, Paulo A.
dc.contributor.authorMENEZES, Paulo R.
dc.contributor.authorSCAZUFCA, Marcia
dc.contributor.authorBUSATTO, Geraldo F.
dc.date.accessioned2015-12-10T16:49:59Z
dc.date.available2015-12-10T16:49:59Z
dc.date.issued2015
dc.description.abstractInter-subject variability in age-related brain changes may relate to educational attainment, as suggested by cognitive reserve theories. This voxel-based morphometry study investigated the impact of very low educational level on the relationship between regional gray matter (rGM) volumes and age in healthy elders. Magnetic resonance imaging data were acquired in elders with low educational attainment (less than 4 years) (n = 122) and high educational level (n = 66), pulling together individuals examined using either of three MRI scanners/acquisition protocols. Voxelwise group comparisons showed no rGM differences (p<0.05, family-wise error corrected for multiple comparisons). When within-group voxel-wise patterns of linear correlation were compared between high and low education groups, there was one cluster of greater rGM loss with aging in low versus high education elders in the left anterior cingulate cortex (p<0.05, FWE-corrected), as well as a trend in the left dorsomedial prefrontal cortex (p<0.10). These results provide preliminary indication that education might exert subtle protective effects against age-related brain changes in healthy subjects. The anterior cingulate cortex, critical to inhibitory control processes, may be particularly sensitive to such effects, possibly given its involvement in cognitive stimulating activities at school or later throughout life.
dc.description.indexMEDLINE
dc.description.sponsorshipFAPESP - Fundacao de Amparo a Pesquisa do Estado de Sao Paulo [2012/50329-6, 2004/09586-9, 2012/13065-0, 2013/03231-3]
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Cientifico e Tecnologico
dc.identifier.citationPLOS ONE, v.10, n.10, article ID e0140945, 15p, 2015
dc.identifier.doi10.1371/journal.pone.0140945
dc.identifier.issn1932-6203
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/12455
dc.language.isoeng
dc.publisherPUBLIC LIBRARY SCIENCE
dc.relation.ispartofPlos One
dc.rightsopenAccess
dc.rights.holderCopyright PUBLIC LIBRARY SCIENCE
dc.subject.othervoxel-based-morphometry
dc.subject.otherpreclinical alzheimers-disease
dc.subject.othermental-state-examination
dc.subject.othersao-paulo
dc.subject.othercognitive reserve
dc.subject.otherbrazilian population
dc.subject.otherworking-memory
dc.subject.otherstructural mri
dc.subject.otherolder-adults
dc.subject.otherrisk-factors
dc.subject.wosMultidisciplinary Sciences
dc.titleRelationship between Brain Age-Related Reduction in Gray Matter and Educational Attainment
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.citation.scopus26
hcfmusp.contributor.author-fmusphcPATRICIA RZEZAK TENCER
hcfmusp.contributor.author-fmusphcPAULA SQUARZONI DA SILVEIRA
hcfmusp.contributor.author-fmusphcFABIO LUIS DE SOUZA DURAN
hcfmusp.contributor.author-fmusphcTANIA CORREA DE TOLEDO FERRAZ ALVES
hcfmusp.contributor.author-fmusphcJAQUELINE HATSUKO TAMASHIRO DURAN
hcfmusp.contributor.author-fmusphcCASSIO MACHADO DE CAMPOS BOTTINO
hcfmusp.contributor.author-fmusphcSALMA ROSE IMANARI RIBEIZ
hcfmusp.contributor.author-fmusphcPAULO ANDRADE LOTUFO
hcfmusp.contributor.author-fmusphcPAULO ROSSI MENEZES
hcfmusp.contributor.author-fmusphcMARCIA SCAZUFCA
hcfmusp.contributor.author-fmusphcGERALDO BUSATTO FILHO
hcfmusp.description.articlenumbere0140945
hcfmusp.description.issue10
hcfmusp.description.volume10
hcfmusp.origemWOS
hcfmusp.origem.pubmed26474472
hcfmusp.origem.scopus2-s2.0-84949255888
hcfmusp.origem.wosWOS:000363185500133
hcfmusp.publisher.citySAN FRANCISCO
hcfmusp.publisher.countryUSA
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