Olfactory neuroepithelium in the superior and middle turbinates: which is the optimal biopsy site?

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorPINNA, Fabio de Rezende
dc.contributor.authorCTENAS, Bruno
dc.contributor.authorWEBER, Raimar
dc.contributor.authorSALDIVA, Paulo Hilario
dc.contributor.authorVOEGELS, Richard Louis
dc.date.accessioned2014-07-04T12:31:34Z
dc.date.available2014-07-04T12:31:34Z
dc.date.issued2013
dc.description.abstractINTRODUCTION: Olfactory neuroepithelium (ON) biopsy has several therapeutic applications for both disorders of olfaction and neurodegenerative diseases. Successful collection of ON is still anything but routine due to a dearth of studies on the distribution of ON in the superior and middle turbinates. AIM: To determine the location in which ON is most likely to be present in endoscopically removed cadaver superior and middle turbinates as well as the influences of gender, age, and naris side on the presence of ON and the extent to which it is present. METHODS: We conducted a prospective anatomical study. The superior and middle turbinates on both sides endoscopically removed from 25 fresh cadavers (less than 12 h post-mortem). The turbinates were halved into anterior and posterior segments for a total of 200 specimens, which were analyzed after hematoxylin and eosin and immunohistochemical staining. Hematoxylin and eosin-stained slides were subjected to blind examination by 3 independent pathologists, and the presence of ON was graded on a 5-point scale from 0 to 4. Kappa measurement was used to determine the agreement between pairs of observers. RESULTS: ON was present in 82.9% of superior turbinate samples and in 17.1% of middle turbinate samples. Immunohistochemistry detected ON in superior turbinates only by S-100 staining and only in 15 fragments. Gender, age, and naris side had no statistically significant effects on the presence of ON. CONCLUSION: When biopsying ON, the posterior portion of the superior turbinate should be targeted whenever possible because it has the highest concentration of ON among the nasal structures.
dc.description.indexSciELO
dc.identifier.citationINTERNATIONAL ARCHIVES OF OTORHINOLARYNGOLOGY, v.17, n.2, p.131-138, 2013
dc.identifier.doi10.7162/S1809-97772013000200004
dc.identifier.issn1809-4864
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/5866
dc.language.isoeng
dc.publisherFundação Otorrinolaringologia
dc.relation.ispartofInternational Archives of Otorhinolaryngology
dc.rightsopenAccess
dc.rights.holderCopyright Fundação Otorrinolaringologia
dc.subjectOlfactory Mucosa
dc.subjectOlfaction Disorders
dc.subjectTurbinates
dc.subjectBiopsy
dc.subjectHematoxylin
dc.subjectImmunohistochemistry
dc.subject.wosOtorhinolaryngology
dc.titleOlfactory neuroepithelium in the superior and middle turbinates: which is the optimal biopsy site?
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalCTENAS, Bruno:Universidade de São Paulo, São Paulo, BRAZIL
hcfmusp.author.externalWEBER, Raimar:Universidade de São Paulo, São Paulo, BRAZIL
hcfmusp.citation.scopus25
hcfmusp.contributor.author-fmusphcFABIO DE REZENDE PINNA
hcfmusp.contributor.author-fmusphcPAULO HILARIO NASCIMENTO SALDIVA
hcfmusp.contributor.author-fmusphcRICHARD LOUIS VOEGELS
hcfmusp.description.beginpage131
hcfmusp.description.endpage138
hcfmusp.description.issue2
hcfmusp.description.volume17
hcfmusp.origemSciELO
hcfmusp.origem.scieloSCIELO:S1809-48642013000200004
hcfmusp.origem.scopus2-s2.0-84876127842
hcfmusp.publisher.citySÃO PAULO
hcfmusp.publisher.countryBRAZIL
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