Glycogen synthase kinase-3 in patients with bipolar I disorder: results from a prospective study

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorJACOBY, Anne S.
dc.contributor.authorMUNKHOLM, Klaus
dc.contributor.authorVINBERG, Maj
dc.contributor.authorJOAQUIM, Helena G. P.
dc.contributor.authorTALIB, Leda L.
dc.contributor.authorGATTAZ, Wagner F.
dc.contributor.authorKESSING, Lars V.
dc.date.accessioned2016-10-17T16:41:00Z
dc.date.available2016-10-17T16:41:00Z
dc.date.issued2016
dc.description.abstractObjectivesThe enzyme glycogen synthase kinase-3 (GSK3) is involved in the mechanisms of action of lithium and may play a role in relation to affective states in bipolar disorder. The objectives of the present study were to compare the activity of GSK-3 (measured as levels of phosphorylated GSK-3 [p-GSK-3]) between patients with bipolar disorder in the euthymic state and healthy control subjects, and to investigate whether GSK-3 activity varies with affective states in patients with bipolar I disorder. MethodsIn a prospective 6-12-month follow-up study, we investigated state-specific, intraindividual alterations in the activity of GSK-3 in 60 patients with bipolar I disorder with an acute severe manic index episode and in subsequent euthymic, depressive and manic states and compared this with repeated measurements in healthy control subjects. Data were analyzed using linear mixed-effects models. ResultsFrom baseline to the end of follow-up, blood samples were drawn from the 60 patients during 181 affective states, comprising 60 manic, 11 mixed, 23 depressive, and 87 states of euthymia. A total of 69 blood samples were drawn from 35 healthy control subjects, with two samples from the same subject taken three months apart. In mixed-model analysis, p-GSK-3 was decreased in the euthymic state of subjects with bipolar disorder compared with healthy control subjects (b=0.63, 95% confidence interval [CI]: 0.42-0.96, P=.03). In addition, p-GSK-3 varied with affective states, being increased in depressive (b=1.68, 95% CI: 1.08-2.62, P=.02) and mixed (b=2.07, 95% CI: 1.12-3.84, P=.02) states but not in mania compared with euthymia. ConclusionsThe activity of GSK-3 is altered in euthymic bipolar disorder compared with healthy control subjects and varies with affective states.
dc.description.indexMEDLINE
dc.description.sponsorshipMental Health Services of the Capital Region of Denmark, Denmark
dc.description.sponsorshipAugustinus Fonden [12-5015]
dc.description.sponsorshipOverlaege dr.med. Einar Geert-Jorgensen og hustru Ellen Gert-Jorgensens Forskningslegat [13517-001]
dc.description.sponsorshipDirektor Jacob Madsen og hustru Olga Madsens Fond [5257]
dc.description.sponsorshipA.P. Moller Foundation for the Advancement of Medical Science [12-134]
dc.description.sponsorshipSlagtermester Max Worzner og hustru Inger Worzners Mindelegat
dc.description.sponsorshipDr. Med. Vet. Axel Thomsen og hustru Martha Thomsens legat [XRW649]
dc.description.sponsorshipAssociacao Beneficente Alzira Denise Hertzog da Silva (ABADHS)
dc.identifier.citationBIPOLAR DISORDERS, v.18, n.4, p.334-341, 2016
dc.identifier.doi10.1111/bdi.12400
dc.identifier.eissn1399-5618
dc.identifier.issn1398-5647
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/16297
dc.language.isoeng
dc.publisherWILEY-BLACKWELL
dc.relation.ispartofBipolar Disorders
dc.rightsrestrictedAccess
dc.rights.holderCopyright WILEY-BLACKWELL
dc.subjectbipolar disorder
dc.subjectglycogen synthase kinase-3
dc.subjectGSK3
dc.subjectmania
dc.subject.otherregister-based cohort
dc.subject.otherelevated levels
dc.subject.otherlithium
dc.subject.othermood
dc.subject.otherblood
dc.subject.otherphosphorylation
dc.subject.othersensitivity
dc.subject.otherexpression
dc.subject.otherplatelets
dc.subject.othermarkers
dc.subject.wosClinical Neurology
dc.subject.wosNeurosciences
dc.subject.wosPsychiatry
dc.titleGlycogen synthase kinase-3 in patients with bipolar I disorder: results from a prospective study
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.affiliation.countryDinamarca
hcfmusp.affiliation.countryisodk
hcfmusp.author.externalJACOBY, Anne S.:Univ Copenhagen, Rigshosp, Psychiat Ctr Copenhagen, Copenhagen, Denmark; Univ Copenhagen, Fac Hlth & Med Sci, Copenhagen, Denmark
hcfmusp.author.externalMUNKHOLM, Klaus:Univ Copenhagen, Rigshosp, Psychiat Ctr Copenhagen, Copenhagen, Denmark; Univ Copenhagen, Fac Hlth & Med Sci, Copenhagen, Denmark
hcfmusp.author.externalVINBERG, Maj:Univ Copenhagen, Rigshosp, Psychiat Ctr Copenhagen, Copenhagen, Denmark; Univ Copenhagen, Fac Hlth & Med Sci, Copenhagen, Denmark
hcfmusp.author.externalKESSING, Lars V.:Univ Copenhagen, Rigshosp, Psychiat Ctr Copenhagen, Copenhagen, Denmark; Univ Copenhagen, Fac Hlth & Med Sci, Copenhagen, Denmark
hcfmusp.citation.scopus8
hcfmusp.contributor.author-fmusphcHELENA PASSARELLI GIROUD JOAQUIM
hcfmusp.contributor.author-fmusphcLEDA LEME TALIB
hcfmusp.contributor.author-fmusphcWAGNER FARID GATTAZ
hcfmusp.description.beginpage334
hcfmusp.description.endpage341
hcfmusp.description.issue4
hcfmusp.description.volume18
hcfmusp.origemWOS
hcfmusp.origem.pubmed27325150
hcfmusp.origem.scopus2-s2.0-84976636983
hcfmusp.origem.wosWOS:000379697800003
hcfmusp.publisher.cityHOBOKEN
hcfmusp.publisher.countryUSA
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