Carvacrol reduces blood pressure, arterial responsiveness and increases expression of MAS receptors in spontaneously hypertensive rats

Página do item simplificado
dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorDIAS, Carlos Jose
dc.contributor.authorCOSTA, Herikson Araujo
dc.contributor.authorDIAS-FILHO, Carlos Alberto Alves
dc.contributor.authorFERREIRA, Andressa Coelho
dc.contributor.authorRODRIGUES, Bruno
dc.contributor.authorIRIGOYEN, Maria Claudia
dc.contributor.authorBORGES, Antonio Carlos Romao
dc.contributor.authorMARTINS, Vicenilma de Andadre
dc.contributor.authorVIDAL, Flavia Castello Branco
dc.contributor.authorRIBEIRO, Rachel Melo
dc.contributor.authorSALGADO FILHO, Natalino
dc.contributor.authorMOSTARDA, Cristiano T.
dc.date.accessioned2023-08-16T18:26:21Z
dc.date.available2023-08-16T18:26:21Z
dc.date.issued2022
dc.description.abstractAim: To analyze the effect of the use of carvacrol in the cardiovascular system of spontaneously hypertensive rats (SHR). Methods: Methods: Twenty animals were allocated in four groups, one group control Wistar receiving only sorbitol, used as vehicle of administration of the carvacrol (Wistar-Vehicle), one control group SHR, also receive only sorbitol (SHR-Vehicle), a third, treated with losartan (SHR-Losartan/50 mg/kg), and the fourth, treated with carvacrol (SHR - Carvacrol/20 mg/kg). Sorbitol, losartan and carvacrol were administered by oral gavage daily for 30-day. Hemodynamic variables, vascular reactivity, biochemical parameters, and expression of Mas and AT1 receptors in kidney tissues were analyzed. Results: SHR- Carvacrol group showed a maximal effect of inhibition of 56% in the curve of norepinephrine. The Emax of the curves with Ca2+ were smaller in the groups SHR-losartan (40.17%) and SHR-carvacrol (35.71%) when compared to the SHR-Vehicle. The carvacrol increased the expression of the MAS receptors in kidney tissue. Conclusion: Thirty days of treatment with carvacrol showed an antihypertensive effect associated with less peripheral vascular resistance. Also, treatment with carvacrol increased the expression of MAS receptors in kidney tissue.eng
dc.description.indexMEDLINE
dc.description.indexPubMed
dc.description.indexWoS
dc.description.indexScopus
dc.description.sponsorshipFundacao de Amparoa Pesquisa e ao Desenvolvimento Cientifico e Tecnologico do Maranhao -FAPEMA [BEPP-01404/21, universal 01352/18, universal 00779/19, universal 00919/17]
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior -Brasil (CAPES) [001]
dc.identifier.citationEUROPEAN JOURNAL OF PHARMACOLOGY, v.917, article ID 174717, 7p, 2022
dc.identifier.doi10.1016/j.ejphar.2021.174717
dc.identifier.eissn1879-0712
dc.identifier.issn0014-2999
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/55040
dc.language.isoeng
dc.publisherELSEVIEReng
dc.relation.ispartofEuropean Journal of Pharmacology
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright ELSEVIEReng
dc.subjectCarvacroleng
dc.subjectCardiovasculareng
dc.subjectHypertensioneng
dc.subject.otheressential oilseng
dc.subject.othersmooth-muscleeng
dc.subject.otherangiotensin-(1-7)eng
dc.subject.othermechanismseng
dc.subject.otherchannelseng
dc.subject.otherthymoleng
dc.subject.othersystemeng
dc.subject.wosPharmacology & Pharmacyeng
dc.titleCarvacrol reduces blood pressure, arterial responsiveness and increases expression of MAS receptors in spontaneously hypertensive ratseng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalDIAS, Carlos Jose:Univ Fed Maranhao, Northeast Biotechnol Network Postgrad Program Ren, St Luis, Maranhao, Brazil; Univ Fed Maranhao, Cardiovasc Adaptat Exercise Lab LACORE, St Luis, Maranhao, Brazil; Univ Fed Maranhao, Cardiorenal Adaptat Exercise Lab LACE, Pinheiro, Maranhao, Brazil
hcfmusp.author.externalCOSTA, Herikson Araujo:Univ Fed Maranhao, Hlth Sci Grad Program, St Luis, Maranhao, Brazil
hcfmusp.author.externalDIAS-FILHO, Carlos Alberto Alves:Univ Fed Maranhao, Northeast Biotechnol Network Postgrad Program Ren, St Luis, Maranhao, Brazil; Univ Fed Maranhao, Cardiovasc Adaptat Exercise Lab LACORE, St Luis, Maranhao, Brazil
hcfmusp.author.externalFERREIRA, Andressa Coelho:Univ Fed Maranhao, Cardiovasc Adaptat Exercise Lab LACORE, St Luis, Maranhao, Brazil; Univ Fed Maranhao, Grad Program Adult Hlth, St Luis, Maranhao, Brazil
hcfmusp.author.externalRODRIGUES, Bruno:Univ Estadual Campinas, Phys Educ Coll, Campinas, SP, Brazil
hcfmusp.author.externalBORGES, Antonio Carlos Romao:Univ Fed Maranhao, Northeast Biotechnol Network Postgrad Program Ren, St Luis, Maranhao, Brazil; Univ Fed Maranhao, Dept Physiol Sci, St Luis, Maranhao, Brazil
hcfmusp.author.externalMARTINS, Vicenilma de Andadre:Univ Fed Maranhao, Northeast Biotechnol Network Postgrad Program Ren, St Luis, Maranhao, Brazil
hcfmusp.author.externalVIDAL, Flavia Castello Branco:Univ Fed Maranhao, Grad Program Adult Hlth, St Luis, Maranhao, Brazil
hcfmusp.author.externalRIBEIRO, Rachel Melo:Univ Fed Maranhao, Dept Physiol Sci, St Luis, Maranhao, Brazil
hcfmusp.author.externalSALGADO FILHO, Natalino:Univ Fed Maranhao, Hlth Sci Grad Program, St Luis, Maranhao, Brazil
hcfmusp.author.externalMOSTARDA, Cristiano T.:Univ Fed Maranhao, Northeast Biotechnol Network Postgrad Program Ren, St Luis, Maranhao, Brazil; Univ Fed Maranhao, Cardiovasc Adaptat Exercise Lab LACORE, St Luis, Maranhao, Brazil; Univ Fed Maranhao, Postgrad Program Phys Educ, St Luis, Maranhao, Brazil; Univ Fed Maranhao, Grad Program Adult Hlth, St Luis, Maranhao, Brazil
hcfmusp.citation.scopus7
hcfmusp.contributor.author-fmusphcMARIA CLAUDIA COSTA IRIGOYEN
hcfmusp.description.articlenumber174717
hcfmusp.description.volume917
hcfmusp.origemWOS
hcfmusp.origem.pubmed34953800
hcfmusp.origem.scopus2-s2.0-85122966063
hcfmusp.origem.wosWOS:000754691900001
hcfmusp.publisher.cityAMSTERDAMeng
hcfmusp.publisher.countryNETHERLANDSeng
hcfmusp.relation.referenceAdaramoye OA, 2009, J ETHNOPHARMACOL, V124, P457, DOI 10.1016/j.jep.2009.05.021eng
hcfmusp.relation.referenceAlexander LM, 2006, DRUGS, V66, P1239, DOI 10.2165/00003495-200666090-00006eng
hcfmusp.relation.referenceAnjos PJC, 2013, Z NATURFORSCH C, V68, P181eng
hcfmusp.relation.referenceArunasree KM, 2010, PHYTOMEDICINE, V17, P581, DOI 10.1016/j.phymed.2009.12.008eng
hcfmusp.relation.referenceAydin Y, 2007, PLANTA MED, V73, P1365, DOI 10.1055/s-2007-990236eng
hcfmusp.relation.referenceBakkali F, 2008, FOOD CHEM TOXICOL, V46, P446, DOI 10.1016/j.fct.2007.09.106eng
hcfmusp.relation.referenceMatos VSB, 2017, J BRAS PNEUMOL, V43, P208, DOI [10.1590/S1806-37562016000000144, 10.1590/s1806-37562016000000144]eng
hcfmusp.relation.referenceBastos JFA, 2010, BASIC CLIN PHARMACOL, V106, P331, DOI 10.1111/j.1742-7843.2009.00492.xeng
hcfmusp.relation.referenceCalixto JB, 2000, BRAZ J MED BIOL RES, V33, P179, DOI 10.1590/S0100-879X2000000200004eng
hcfmusp.relation.referenceMelo FHC, 2010, FUND CLIN PHARMACOL, V24, P437, DOI 10.1111/j.1472-8206.2009.00788.xeng
hcfmusp.relation.referenceCosta HA, 2021, EXP PHYSIOL, V106, P891, DOI 10.1113/EP089235eng
hcfmusp.relation.referenceDaferera DJ, 2000, J AGR FOOD CHEM, V48, P2576, DOI 10.1021/jf990835xeng
hcfmusp.relation.referenceDocherty JR, 2010, CELL MOL LIFE SCI, V67, P405, DOI 10.1007/s00018-009-0174-4eng
hcfmusp.relation.referenceDurmowicz A G, 1999, Pediatr Rev, V20, pe91eng
hcfmusp.relation.referenceEl-Sayed EM, 2016, J BIOCHEM MOL TOXIC, V30, P37, DOI 10.1002/jbt.21740eng
hcfmusp.relation.referenceFerrario CM, 2011, CURR OPIN NEPHROL HY, V20, P1, DOI 10.1097/MNH.0b013e3283406f57eng
hcfmusp.relation.referenceFerreira AJ, 2010, HYPERTENSION, V55, P207, DOI 10.1161/HYPERTENSIONAHA.109.140145eng
hcfmusp.relation.referenceGao L., 2017, HYPERTENS HYPERTENSI, V117eng
hcfmusp.relation.referenceGREENBERG S, 1982, ARCH INT PHARMACOD T, V258, P208eng
hcfmusp.relation.referenceGURNEY AM, 1994, J PHARM PHARMACOL, V46, P242, DOI 10.1111/j.2042-7158.1994.tb03789.xeng
hcfmusp.relation.referenceKashihara T, 2017, J PHYSIOL-LONDON, V595, P4207, DOI 10.1113/JP273883eng
hcfmusp.relation.referenceKawai T, 2017, PHARMACOL RES, V125, P4, DOI 10.1016/j.phrs.2017.05.008eng
hcfmusp.relation.referenceKjeldsen SE, 2018, PHARMACOL RES, V129, P95, DOI 10.1016/j.phrs.2017.11.003eng
hcfmusp.relation.referenceKuczeriszka M, 2018, AM J HYPERTENS, V31, P504, DOI 10.1093/ajh/hpy006eng
hcfmusp.relation.referenceLlana-Ruiz-Cabello M., 2016, FOOD CHEM TOXICOL, V98eng
hcfmusp.relation.referenceMarin J, 1998, LIFE SCI, V64, P279, DOI 10.1016/S0024-3205(98)00393-2eng
hcfmusp.relation.referenceNELSON MT, 1990, AM J PHYSIOL, V259, pC3eng
hcfmusp.relation.referenceNicolau JC, 2014, ARQ BRAS CARDIOL, V103, P183, DOI [10.5935/abc.20140106, 10.5935/abc.2014S001]eng
hcfmusp.relation.referencePassos-Silva DG, 2013, CLIN SCI, V124, P443, DOI 10.1042/CS20120461eng
hcfmusp.relation.referencePatten GS, 2016, CRIT REV FOOD SCI, V56, P181, DOI 10.1080/10408398.2011.651176eng
hcfmusp.relation.referencePeixoto-Neves D, 2010, FUND CLIN PHARMACOL, V24, P341, DOI 10.1111/j.1472-8206.2009.00768.xeng
hcfmusp.relation.referencePerez-Vizcaino F, 1998, BRIT J PHARMACOL, V123, P847, DOI 10.1038/sj.bjp.0701693eng
hcfmusp.relation.referencePessoa BS, 2013, NAT REV NEPHROL, V9, P26, DOI 10.1038/nrneph.2012.249eng
hcfmusp.relation.referencePiascik MT, 1996, PHARMACOL THERAPEUT, V72, P215, DOI 10.1016/S0163-7258(96)00117-9eng
hcfmusp.relation.referenceRajput J.D., 2017, MOL DIVERS, P1eng
hcfmusp.relation.referenceSampaio WO, 2007, HYPERTENSION, V49, P185, DOI 10.1161/01.HYP.0000251865.35728.2feng
hcfmusp.relation.referenceSantos MRV, 2011, REV BRAS FARMACOGN, V21, P764, DOI 10.1590/S0102-695X2011005000119eng
hcfmusp.relation.referenceSuzuki R, 2014, AM J HYPERTENS, V27, P695, DOI 10.1093/ajh/hpt208eng
hcfmusp.relation.referenceZhang F, 2019, NITRIC OXIDE-BIOL CH, V88, P1, DOI 10.1016/j.niox.2019.03.007eng
hcfmusp.scopus.lastupdate2024-04-12
relation.isAuthorOfPublication124821b6-302b-4392-8a9a-b693916724e1
relation.isAuthorOfPublication.latestForDiscovery124821b6-302b-4392-8a9a-b693916724e1
Arquivos
Pacote Original
Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
art_DIAS_Carvacrol_reduces_blood_pressure_arterial_responsiveness_and_increases_2022.PDF
Tamanho:
2.11 MB
Formato:
Adobe Portable Document Format
Descrição:
publishedVersion (English)
Baixar
Coleções
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - LIM/05
Artigos e Materiais de Revistas Científicas - LIM/59
Artigos e Materiais de Revistas Científicas - LIM/65