Is intrauterine exposure to acetaminophen associated with emotional and hyperactivity problems during childhood? Findings from the 2004 Pelotas birth cohort

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorTOVO-RODRIGUES, Luciana
dc.contributor.authorSCHNEIDER, Bruna Celestino
dc.contributor.authorMARTINS-SILVA, Thais
dc.contributor.authorDEL-PONTE, Bianca
dc.contributor.authorMOLA, Christian Loret de
dc.contributor.authorSCHULER-FACCINI, Lavinia
dc.contributor.authorVIANNA, Fernanda Sales Luiz
dc.contributor.authorMUNHOZ, Tiago N.
dc.contributor.authorENTIAUSPE, Ludmila
dc.contributor.authorSILVEIRA, Mariangela Freitas
dc.contributor.authorSANTOS, Ina S.
dc.contributor.authorMATIJASEVICH, Alicia
dc.contributor.authorBARROS, Aluisio J. D.
dc.contributor.authorROHDE, Luis Augusto
dc.contributor.authorBERTOLDI, Andrea Damaso
dc.date.accessioned2019-01-17T13:35:40Z
dc.date.available2019-01-17T13:35:40Z
dc.date.issued2018
dc.description.abstractBackgroundLongitudinal studies have consistently reported that prenatal exposure to acetaminophen can to lead to an increased risk of attention deficit-hyperactivity disorder during childhood. This study aimed to investigate the association between intrauterine exposure to acetaminophen and the presence of emotional and behavioral problems at the ages of 6 and 11years in a low-middle income country.MethodsWe performed a prospective longitudinal population-based study using data from the 2004 Pelotas birth cohort. From the 4231 initial cohort participants, 3722 and 3566 children were assessed at 6 and 11years of age, respectively. The outcomes were assessed using the parent version of Strengths and Difficulties Questionnaire (SDQ). The cut-off points established for the Brazilian population were used to categorize the outcomes. Crude and adjusted odds ratio were obtained through logistic regression.ResultsAcetaminophen was used by 27.5% (95% confidence interval [CI]: 26.1-28.9) of the mothers at least once during pregnancy. The prevalence of emotional problems at 6 and 11years was 13.6 and 19.9%, respectively. For hyperactivity problems, prevalence was 13.9 and 16.1%, respectively. Intrauterine exposure to acetaminophen increased the odds of having emotional (odds ratio [OR]=1.47; 95% CI: 1.07-2.02) and hyperactivity/inattention (OR=1.42; 95% CI: 1.06-1.92) problems in 6-year-old boys. At the age of 11, a small decrease in the effect was observed for both outcomes after adjustment: OR=1.31 (95% CI: 0.99-1.73) for emotional problems and OR=1.25 (95% CI: 0.95-1.65) for hyperactivity/inattention in boys. No association for any phenotypes at both ages was observed for girls.ConclusionThe effect of intrauterine exposure to acetaminophen in emotional and hyperactivity symptoms was dependent on sex in a Brazilian cohort. While it seemed to be important for boys, mainly at 6years of age, for girls, no association was observed.eng
dc.description.indexMEDLINEeng
dc.description.sponsorshipWellcome Trust
dc.description.sponsorshipWorld Health Organization, National Support Program for Centers of Excellence (PRONEX)
dc.description.sponsorshipBrazilian National Research Council (CNPq)
dc.description.sponsorshipBrazilian Ministry of Health, and Children's Pastorate
dc.description.sponsorshipScience and Technology Department / Brazilian Ministry of Health [400943/2013-1]
dc.description.sponsorshipSao Paulo Reseach Foundation - FAPESP [2014/13864-6]
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior - Brasil (CAPES) [001]
dc.description.sponsorshipCNPq (National Council for Scientific and Technological Development)
dc.identifier.citationBMC PSYCHIATRY, v.18, article ID 368, 11p, 2018
dc.identifier.doi10.1186/s12888-018-1942-1
dc.identifier.issn1471-244X
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/30034
dc.language.isoeng
dc.publisherBMCeng
dc.relation.ispartofBMC Psychiatry
dc.rightsopenAccesseng
dc.rights.holderCopyright BMCeng
dc.subjectAcetaminophen (paracetamol)eng
dc.subjectPrenatal exposureeng
dc.subjectBirth cohorteng
dc.subjectBehavioral symptomseng
dc.subject.otherpostnatal depression scaleeng
dc.subject.othermiddle-income cohortseng
dc.subject.otherparacetamol acetaminopheneng
dc.subject.otherdrug-useeng
dc.subject.otherdevelopmental exposureeng
dc.subject.otherpsychiatric-disorderseng
dc.subject.otheracetylsalicylic-acideng
dc.subject.otherpregnant-womeneng
dc.subject.otherbrazileng
dc.subject.otherriskeng
dc.subject.wosPsychiatryeng
dc.titleIs intrauterine exposure to acetaminophen associated with emotional and hyperactivity problems during childhood? Findings from the 2004 Pelotas birth cohorteng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalTOVO-RODRIGUES, Luciana:Univ Fed Pelotas, Postgrad Program Epidemiol, Rua Marechal Deodoro 1160,3 Andar, BR-96020220 Pelotas, RS, Brazil
hcfmusp.author.externalSCHNEIDER, Bruna Celestino:Univ Fed Pelotas, Postgrad Program Epidemiol, Rua Marechal Deodoro 1160,3 Andar, BR-96020220 Pelotas, RS, Brazil
hcfmusp.author.externalMARTINS-SILVA, Thais:Univ Fed Pelotas, Postgrad Program Epidemiol, Rua Marechal Deodoro 1160,3 Andar, BR-96020220 Pelotas, RS, Brazil
hcfmusp.author.externalDEL-PONTE, Bianca:Univ Fed Pelotas, Postgrad Program Epidemiol, Rua Marechal Deodoro 1160,3 Andar, BR-96020220 Pelotas, RS, Brazil
hcfmusp.author.externalMOLA, Christian Loret de:Univ Fed Pelotas, Sch Nursing & Publ Hlth, Pelotas, Brazil
hcfmusp.author.externalSCHULER-FACCINI, Lavinia:Hosp Clin Porto Alegre, Porto Alegre, RS, Brazil
hcfmusp.author.externalVIANNA, Fernanda Sales Luiz:Univ Fed Rio Grande do Sul, Postgrad Program Genet & Mol Biol, Porto Alegre, RS, Brazil; Hosp Clin Porto Alegre, Genom Med Lab, Porto Alegre, RS, Brazil; Hosp Clin Porto Alegre, Lab Res Bioeth & Eth Res, Porto Alegre, RS, Brazil
hcfmusp.author.externalMUNHOZ, Tiago N.:Univ Fed Pelotas, Postgrad Program Epidemiol, Rua Marechal Deodoro 1160,3 Andar, BR-96020220 Pelotas, RS, Brazil; Univ Fed Pelotas, Sch Med, Dept Psychol, Pelotas, Brazil
hcfmusp.author.externalENTIAUSPE, Ludmila:Univ Fed Pelotas, Postgrad Program Epidemiol, Rua Marechal Deodoro 1160,3 Andar, BR-96020220 Pelotas, RS, Brazil
hcfmusp.author.externalSILVEIRA, Mariangela Freitas:Univ Fed Pelotas, Postgrad Program Epidemiol, Rua Marechal Deodoro 1160,3 Andar, BR-96020220 Pelotas, RS, Brazil
hcfmusp.author.externalSANTOS, Ina S.:Univ Fed Pelotas, Postgrad Program Epidemiol, Rua Marechal Deodoro 1160,3 Andar, BR-96020220 Pelotas, RS, Brazil
hcfmusp.author.externalBARROS, Aluisio J. D.:Univ Fed Pelotas, Postgrad Program Epidemiol, Rua Marechal Deodoro 1160,3 Andar, BR-96020220 Pelotas, RS, Brazil
hcfmusp.author.externalROHDE, Luis Augusto:Univ Fed Rio Grande do Sul, Dept Psychiat, Hosp Clin Porto Alegre, Porto Alegre, RS, Brazil; Natl Inst Dev Psychiat Children & Adolescents, Sao Paulo, Brazil
hcfmusp.author.externalBERTOLDI, Andrea Damaso:Univ Fed Pelotas, Postgrad Program Epidemiol, Rua Marechal Deodoro 1160,3 Andar, BR-96020220 Pelotas, RS, Brazil
hcfmusp.citation.scopus30
hcfmusp.contributor.author-fmusphcALICIA MATIJASEVICH MANITTO
hcfmusp.description.articlenumber368
hcfmusp.description.volume18
hcfmusp.origemWOS
hcfmusp.origem.pubmed30458756
hcfmusp.origem.scopus2-s2.0-85056802265
hcfmusp.origem.wosWOS:000450797100001
hcfmusp.publisher.cityLONDONeng
hcfmusp.publisher.countryENGLANDeng
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