Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorHOADLEY, Katherine A.
dc.contributor.authorYAU, Christina
dc.contributor.authorHINOUE, Toshinori
dc.contributor.authorWOLF, Denise M.
dc.contributor.authorLAZAR, Alexander J.
dc.contributor.authorDRILL, Esther
dc.contributor.authorSHEN, Ronglai
dc.contributor.authorTAYLOR, Alison M.
dc.contributor.authorCHERNIACK, Andrew D.
dc.contributor.authorTHORSSON, Vesteinn
dc.contributor.authorAKBANI, Rehan
dc.contributor.authorBOWLBY, Reanne
dc.contributor.authorWONG, Christopher K.
dc.contributor.authorWIZNEROWICZ, Maciej
dc.contributor.authorSANCHEZ-VEGA, Francisco
dc.contributor.authorROBERTSON, A. Gordon
dc.contributor.authorSCHNEIDER, Barbara G.
dc.contributor.authorLAWRENCE, Michael S.
dc.contributor.authorNOUSHMEHR, Houtan
dc.contributor.authorMALTA, Tathiane M.
dc.contributor.authorSTUART, Joshua M.
dc.contributor.authorBENZ, Christopher C.
dc.contributor.authorLAIRD, Peter W.
dc.contributor.groupauthorCancer Genome Atlas Network
dc.contributor.groupauthorLONGATTO-FILHO, Adhemar
dc.date.accessioned2019-01-17T13:37:07Z
dc.date.available2019-01-17T13:37:07Z
dc.date.issued2018
dc.description.abstractWe conducted comprehensive integrative molecular analyses of the complete set of tumors in The Cancer Genome Atlas (TCGA), consisting of approximately 10,000 specimens and representing 33 types of cancer. We performed molecular clustering using data on chromosome-arm-level aneuploidy, DNA hypermethylation, mRNA, and miRNA expression levels and reverse-phase protein arrays, of which all, except for aneuploidy, revealed clustering primarily organized by histology, tissue type, or anatomic origin. The influence of cell type was evident in DNA-methylation-based clustering, even after excluding sites with known preexisting tissue-type-specific methylation. Integrative clustering further emphasized the dominant role of cell-of-origin patterns. Molecular similarities among histologically or anatomically related cancer types provide a basis for focused pan-cancer analyses, such as pan-gastrointestinal, pan-gynecological, pan-kidney, and pan-squamous cancers, and those related by stemness features, which in turn may inform strategies for future therapeutic development.eng
dc.description.indexMEDLINEeng
dc.description.sponsorshipNIH [U54 HG003273, U54 HG003067, U54 HG003079, U24 CA143799, U24 CA143835, U24 CA143840, U24 CA143843, U24 CA143845, U24 CA143848, U24 CA143858, U24 CA143866, U24 CA143867, U24 CA143882, U24 CA143883, U24 CA144025, P30 CA016672]
dc.identifier.citationCELL, v.173, n.2, p.291-304.e6, 2018
dc.identifier.doi10.1016/j.cell.2018.03.022
dc.identifier.eissn1097-4172
dc.identifier.issn0092-8674
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/30101
dc.language.isoeng
dc.publisherCELL PRESSeng
dc.relation.ispartofCell
dc.rightsopenAccesseng
dc.rights.holderCopyright CELL PRESSeng
dc.subject.otherintegrated genomic characterizationeng
dc.subject.otherunknown primaryeng
dc.subject.othercarcinomaeng
dc.subject.otherbreasteng
dc.subject.othersimilaritieseng
dc.subject.othersignatureeng
dc.subject.otherdiscoveryeng
dc.subject.otheraccurateeng
dc.subject.othertooleng
dc.subject.wosBiochemistry & Molecular Biologyeng
dc.subject.wosCell Biologyeng
dc.titleCell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancereng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countryPolônia
hcfmusp.affiliation.countryEstados Unidos
hcfmusp.affiliation.countryCanadá
hcfmusp.affiliation.countryisous
hcfmusp.affiliation.countryisoca
hcfmusp.affiliation.countryisopl
hcfmusp.author.externalHOADLEY, Katherine A.:Univ North Carolina Chapel Hill, Lineberger ComprehensiveCancerCenter, Dept Genet, Chapel Hill, NC 27599 USA
hcfmusp.author.externalYAU, Christina:Buck Inst Res Aging, Novato, CA 94945 USA; Univ Calif San Francisco, Dept Surg, San Francisco, CA 94115 USA
hcfmusp.author.externalHINOUE, Toshinori:Van Andel Res Inst, Grand Rapids, MI 49503 USA
hcfmusp.author.externalWOLF, Denise M.:Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94115 USA
hcfmusp.author.externalLAZAR, Alexander J.:Univ Texas MD Anderson Canc Ctr, Dept Bioinformat & Computat Biol, Houston, TX 77030 USA
hcfmusp.author.externalDRILL, Esther:Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10065 USA
hcfmusp.author.externalSHEN, Ronglai:Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10065 USA
hcfmusp.author.externalTAYLOR, Alison M.:Broad Inst Harvard & MIT, Cambridge, MA 02142 USA
hcfmusp.author.externalCHERNIACK, Andrew D.:Broad Inst Harvard & MIT, Cambridge, MA 02142 USA
hcfmusp.author.externalTHORSSON, Vesteinn:Inst Syst Biol, Seattle, WA 98109 USA
hcfmusp.author.externalAKBANI, Rehan:Univ Texas MD Anderson Canc Ctr, Dept Bioinformat & Computat Biol, Houston, TX 77030 USA
hcfmusp.author.externalBOWLBY, Reanne:BC Canc Agcy, Canadas Michael Smith Genome Sci Ctr, Vancouver, BC V5Z IL3, Canada
hcfmusp.author.externalWONG, Christopher K.:Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02215 USA; Univ Calif Santa Cruz, Ctr Biomol Sci & Engn, Dept Biomol Engn, Santa Cruz, CA 95064 USA
hcfmusp.author.externalWIZNEROWICZ, Maciej:Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02215 USA; Poznan Univ Med Sci, PL-61701 Poznan, Poland; Greater Poland Canc Ctr, PL-61866 Poznan, Poland; Int Inst Mol Oncol, PL-60203 Poznan, Poland
hcfmusp.author.externalSANCHEZ-VEGA, Francisco:Mem Sloan Kettering Canc Ctr, Marie Josee & Henry R Kravis Ctr Mol Onc, New York, NY 10065 USA
hcfmusp.author.externalROBERTSON, A. Gordon:BC Canc Agcy, Canadas Michael Smith Genome Sci Ctr, Vancouver, BC V5Z IL3, Canada
hcfmusp.author.externalSCHNEIDER, Barbara G.:Vanderbilt Univ, Med Ctr, Div Gastroenterol, Dept Med, Nashville, TN 37232 USA
hcfmusp.author.externalLAWRENCE, Michael S.:Broad Inst Harvard & MIT, Cambridge, MA 02142 USA; Harvard Med Sch, Massachusetts Gen Hosp, Canc Ctr, Charlestown, MA 02129 USA; Harvard Med Sch, Dept Pathol, Charlestown, MA 02129 USA
hcfmusp.author.externalNOUSHMEHR, Houtan:Henry Ford Hlth Syst, Dept Surg, Detroit, MI 48202 USA; Univ Sao Paulo, Dept Genet, BR-14049900 Ribeirao Preto, SP, Brazil
hcfmusp.author.externalMALTA, Tathiane M.:Henry Ford Hlth Syst, Dept Surg, Detroit, MI 48202 USA; Univ Sao Paulo, Dept Genet, BR-14049900 Ribeirao Preto, SP, Brazil
hcfmusp.author.externalSTUART, Joshua M.:Univ Calif Santa Cruz, Ctr Biomol Sci & Engn, Dept Biomol Engn, Santa Cruz, CA 95064 USA
hcfmusp.author.externalBENZ, Christopher C.:Buck Inst Res Aging, Novato, CA 94945 USA
hcfmusp.author.externalLAIRD, Peter W.:Van Andel Res Inst, Grand Rapids, MI 49503 USA
hcfmusp.citation.scopus1376
hcfmusp.description.beginpage291
hcfmusp.description.endpage304.e6
hcfmusp.description.issue2
hcfmusp.description.volume173
hcfmusp.origemWOS
hcfmusp.origem.pubmed29625048
hcfmusp.origem.scopus2-s2.0-85044737247
hcfmusp.origem.wosWOS:000429320200007
hcfmusp.publisher.cityCAMBRIDGEeng
hcfmusp.publisher.countryUSAeng
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