Characterization of Torquetenovirus in amniotic fluid at the time of <i>in utero</i> fetal surgery: correlation with early premature delivery and respiratory distress

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorTOZETTO-MENDOZA, Tania Regina
dc.contributor.authorDA-COSTA, A. Charlys
dc.contributor.authorMORON, Antonio F.
dc.contributor.authorLEAL, Elcio
dc.contributor.authorLIMA, Silvia Helena
dc.contributor.authorFERREIRA, Noely Evangelista
dc.contributor.authorHONORATO, Layla
dc.contributor.authorPAIAO, Heuder Gustavo Oliveira
dc.contributor.authorFREIRE, Wilton Santos
dc.contributor.authorMENDES-CORREA, Maria Cassia
dc.contributor.authorWITKIN, Steven S.
dc.date.accessioned2023-10-30T14:35:57Z
dc.date.available2023-10-30T14:35:57Z
dc.date.issued2023
dc.description.abstractTorquetenovirus (TTV) is a commensal virus present in many healthy individuals. Although considered to be non-pathogenic, its presence and titer have been shown to be indicative of altered immune status in individuals with chronic infections or following allogeneic transplantations. We evaluated if TTV was present in amniotic fluid (AF) at the time of in utero surgery to correct a fetal neurological defect, and whether its detection was predictive of adverse post-surgical parameters. AF was collected from 27 women by needle aspiration prior to a uterine incision. TTV titer in the AF was measured by isolation of viral DNA followed by gene amplification and analysis. The TTV genomes were further characterized and sequenced by metagenomics. Pregnancy outcome parameters were subsequently obtained by chart review. Three of the AFs (11.1%) were positive for TTV at 3.36, 4.16, and 4.19 log(10) copies/mL. Analysis of their genomes revealed DNA sequences similar to previously identified TTV isolates. Mean gestational age at delivery was >2 weeks earlier (32.5 vs. 34.6 weeks) and the prevalence of respiratory distress was greater (100% vs. 20.8%) in the TTV-positive pregnancies. TTV detection in AF prior to intrauterine surgery may indicate elevated post-surgical risk for earlier delivery and newborn respiratory distress.eng
dc.description.indexPubMed
dc.description.indexWoS
dc.description.indexScopus
dc.description.sponsorshiplaboratorio de Investigacao Medica em Virologia [LIM 52]
dc.identifier.citationFRONTIERS IN MEDICINE, v.10, article ID 1161091, 8p, 2023
dc.identifier.doi10.3389/fmed.2023.1161091
dc.identifier.eissn2296-858X
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/56107
dc.language.isoeng
dc.publisherFRONTIERS MEDIA SAeng
dc.relation.ispartofFrontiers in Medicine
dc.rightsopenAccesseng
dc.rights.holderCopyright FRONTIERS MEDIA SAeng
dc.subjectamniotic fluideng
dc.subjectfetal surgeryeng
dc.subjectpreterm birtheng
dc.subjectrespiratory distresseng
dc.subjectspina bifidaeng
dc.subjectTorquetenoviruseng
dc.subject.othertt virus-infectioneng
dc.subject.otherbloodeng
dc.subject.otherdnaeng
dc.subject.wosMedicine, General & Internaleng
dc.titleCharacterization of Torquetenovirus in amniotic fluid at the time of <i>in utero</i> fetal surgery: correlation with early premature delivery and respiratory distresseng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalMORON, Antonio F.:Univ Fed Sao Paulo, Dept Obstet, Sao Paulo, Brazil; Hosp & Maternidade Santa Joana, Sao Paulo, Brazil
hcfmusp.author.externalLEAL, Elcio:Univ Fed Para, Lab Diversidade Viral, Inst Ciencias Biol, Belem, Para, Brazil
hcfmusp.citation.scopus0
hcfmusp.contributor.author-fmusphcTANIA REGINA TOZETTO MENDOZA
hcfmusp.contributor.author-fmusphcANTONIO CHARLYS DA COSTA
hcfmusp.contributor.author-fmusphcSILVIA HELENA DE LIMA
hcfmusp.contributor.author-fmusphcNOELY EVANGELISTA FERREIRA
hcfmusp.contributor.author-fmusphcLAYLA HONORATO
hcfmusp.contributor.author-fmusphcHEUDER GUSTAVO OLIVEIRA PAIAO
hcfmusp.contributor.author-fmusphcWILTON SANTOS FREIRE
hcfmusp.contributor.author-fmusphcMARIA CASSIA JACINTHO MENDES CORREA
hcfmusp.contributor.author-fmusphcSTEVEN SOL WITKIN
hcfmusp.description.articlenumber1161091
hcfmusp.description.volume10
hcfmusp.origemWOS
hcfmusp.origem.pubmed37547599
hcfmusp.origem.scopus2-s2.0-85171301131
hcfmusp.origem.wosWOS:001041870900001
hcfmusp.publisher.cityLAUSANNEeng
hcfmusp.publisher.countrySWITZERLANDeng
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